"Plagril": yokusetshenziswa, odokotela yangempela. Izidakamizwa analogue "Plagril"

Izifo uhlelo senhliziyo nemithambo yegazi ku imithi yesimanje mhlawumbe kwasekuqaleni. Izinga lokufa kusukela lezi zifo kuyinto eliphakeme kakhulu. Kunezinkinga kule ndawo ezingaba uhlupho umuntu kusukela ekuzalweni. Nokho, kukhona labo lapho ukuthuthukiswa komuntu kuletha eside "umnikelo". Omunye isifo ezinjalo - isifo sokuqina kwemithambo yegazi. Uma le nkinga sihlasela kakhulu imithambo nezimo futhi nokunwebeka imisipha hlobo. Ingqikithi yalo isifo kulelo, ngenxa yokwephula wamaprotheni ne lipid umzimba buthelela imithambo cholesterol imali kanye nabavoti ezithile lipoproteins. kwakhiwa Ngakho zingcwecwe atherosclerotic. Ngokuhamba kwesikhathi, ezicutshini isitsha izindonga kulezi zingcwecwe ukwandisa, okuholela ukuvaleka mafutha anciphisa isikhala esingaphakathi we Umthambo kuze occlusion.

Ukuze kusizwe la iziguli, abacwaningi baye basungula uhlu izidakamizwa ezingaba khona ijubane noma ngokuphelele ukucindezela inqubo ukulinganiswa (compounds, kunenze nisondelane) ka-platelet. Izinto nge amakhono zokuphumula ezinjalo zibizwa ngokuthi antiplatelet (antithrombotics). Omunye izidakamizwa ezinjalo kuba "Plagril".

Sakhiwo Ukwakheka

Umuthi itholakala amaphilisi camera nge pink ifilimu enamathela. Izibhebhe letiyindilinga, biconvex. Kolunye uhlangothi kule mpi baminyana embossing "C 127". The main isithako zomuthi - clopidogrel. Phela, endaweni izidakamizwa "Plagril" INN (International Nonproprietary Igama) nsé igama ingxenye main - clopidogrel. Okuqukethwe ivolumu iphilisi ngalinye - 75 mg. Ngaphandle Izingxenye ezisemqoka nomuthi kukhona excipients: microcrystalline cellulose, mannitol, sodium croscarmellose, colloidal Silicon dioxide, i-magnesium stearate. Abakhiqizi isidakamizwa e ibhamuza amaphakethe of izingcezu 10.

Mshini kwezidakamizwa

Umuthi kuyinto inhibitor ethize (zivimbela - avimba, wokufihla noma iyiphi inqubo) ukulinganiswa (kwakwakhe) nama-platelet. It has isinyathelo koronarorasshiryayuschee. Inqubo deceleration platelet wokuhlanganisa (cishe 40%) kuyabonakala emva 2 amahora ngemva ukungenisa isidakamizwa ngesikhathi umthamo mg 400. Ukuze kuzuzwe ukusebenza kahle esiphezulu (60% okusithiyayo of wokuhlanganisa) nemiphumela kusukela amaphilisi "Plagril", imiyalelo ukusetshenziswa ngokuvumelana nesidingo yokwelapha izinsuku 4-7. Umthamo Imininingwane ngelanga kufanele kube kusuka 50 kuya 100 mg. Kulokhu, antiplatelet umphumela izothatha umjikelezo lonke impilo platelet (7 kuya ku-10 izinsuku). Zingakapheli izinsuku eziyi-5 emva izidakamizwa ukuhoxiswa ngesilinganiso platelet wokuhlanganisa, futhi opha isikhathi emuva ukusebenza kokuqala.

Excreted "Plagril" izinso kanye emathunjini (50% no-46% ngokulandelana). deducing Period - amahora 120 ngemva kokuphathwa.

I abathengi eyinhloko "Plagrila"

Kukhona iqembu elikhethekile iziguli inhliziyo ababoniswa ukusebenzisa imithi "Plagril". Imiyalelo ziyadingeka ukuthatha izidakamizwa kubantu abaphethwe isifo sokuqina kwemithambo yegazi. Imithi sisebenza isilinganiso zokuvimbela ukuze kuncishiswe ingozi yezinkinga ezihambisana ne thrombosis kubantu abaye baba isilethikusebenza noma unhlangothi ischemic. Kuyiqiniso ngoba iziguli ezivela occlusion (Ukuwohloka permeability) imithambo neuropathy.

Ngohlelo nge acetylsalicylic acid (aspirin) ungasetshenziswa "Plagrila" ukuze kuvinjelwe yezinkinga thrombotic e kulabo abaphethwe sibi syndrome senhliziyo. Lokhu kungabandakanya abantu nge angina (ifomu engazinzile), nge isilethikusebenza ngaphandle wave kumiswa Q. Ungasebenzisa izidakamizwa ezigulini kwavele stenting. Ingqikithi yalo msebenzi - ukufakwa kule ethintekile isitsha stent (mncane kahle ekubambisaneni metal tube), okuyinto kamuva Ayihaba ibhaluni ekhethekile, ngaleyo ndlela kwande permeability bomkhumbi kanye nokwenza ngcono igazi ligeleze inhliziyo.

izindlela isicelo: Isikali

Medicine "Plagril" iziguli zingafundwa ngomlomo, kungakhathaliseki Ukudla. In iziguli othola isilethikusebenza, unhlangothi ischemic noma uphethwe esungulwe mayelana patency we ukuwohloka kwemithambo yegazi, umthamo we-75 mg kuthathwe kanye ngosuku. Inkathi yokwelapha ukwelashwa emva Q-wave isilethikusebenza okungatheni kungase kuhlale kufikela kuzinsuku ezingu-35. Ngo-stroke ischemic, kuye ngobucayi isimo, ikhambi, angase isukela izinsuku ezingu-7 ukuze ezinyangeni eziyisithupha.

Lapho imivimbo ngendlela engazinzile, futhi isilethikusebenza ngaphandle kumiswa Q-wave uqobo ohlotsheni esezingeni amaphilisi simiswe ngalendlela lelandzelako: kuqala, yesikhathi esisodwa ukulayisha umthamo 300 mg, kulandele 75 mg ngelanga kanye ungabuqeda nge aspirin (75 ukuba 325 mg ngelanga). Ngenxa edonsa aspirin kwandisa ingozi ukopha, umthamo esiphezulu eyodwa kumele singeqi mg 100. imithi - enyakeni 1.

reception "Plagril" Ukwelapha antiplatelet nalo wabonisa i-acute isilethikusebenza. Linqume amaphilisi ukuthatha at umthamo we-75 mg, ngosuku olulodwa. Kunconywa ukuba uqale ukwelashwa nge kokuqala ukulayisha umthamo lihambisana acetylsalicylic acid. Mhlawumbe parallel ethatha thrombolytics (noma ingase ingakwamukeli kalula lokho).

Uma iziguli seniliwelile engu-75 umkhawulo yobudala, "Plagril" (efana clopidogrel futhi ziyamukeleka) uqokwa ngaphandle kokuqala ukulayisha umthamo. Ngemva ukubukeka ukuphathwa inhlanganisela zimpawu kumele uqale kusenesikhathi. Inkambo kufanele kuhlale okungenani amaviki 4.

Okungenzeka imiphumela engemihle

Phakathi Inkambo yokwelashwa ukulungela "Plagril" imfundo manual yazisa ukuthi ezihlukahlukene imiphumela engemihle engase kusukela izinhlelo ezahlukene eziyishumi nemitshingo.

igazi ekunqandeni isistimu ingakwazi ngokuvamile aphendule ukubukeka ukopha emathunjini. Ngaphansi njalo angagcina oluhambisana unhlangothi, ngopha emakhaleni futhi, ngokuvamile, ukwanda ukopha isikhathi. Ezimweni ezingavamile, kungase kubonakale hematomas, hematuria.

ekhombisa abahlukahlukene kusukela uhlelo hemopoietic. Lezi zihlanganisa eosinophilia, neutropenia, thrombocytopenia. Kuyaphawuleka mancane amathuba ukuthuthukisa granulocytopenia, anaemia elula noma aplastic.

On the ingxenye ephakathi neuropathy isimiso sezinzwa kungenzeka ikhanda, isiyezi, paresthesia, inzululwane (ukulahlekelwa ibhalansi, ephelezelwa umuzwa Ukujikeleza lezinto ukuzungeza umzimba wonke, noma okuphambene nalokho - emzimbeni ukuzungelezisa), ukuhhema, ukudideka. Izimo zethu zihluke kakhulu ezingavamile, kodwa amacala izigigaba ezingezinhle zenzeka ne esimiso senhliziyo nemithambo yegazi, ngokuya kunciphisa umfutho wegazi, ukuthuthukiswa vasculitis. Bronchospasm futhi pneumonitis interstitial - lokhu kungaba ukuphendula umgudu wokuphefumula ukwamukela izidakamizwa.

Ngokuvamile imithi "Plagril" (ukubuyekezwa kodokotela neziguli uqinisekise leli qiniso) iyaphendula wokugaya ukudla. Basabela kanjani umzimba kubonakala ukuthuthukiswa yesifo sohudo, dyspepsia, ubuhlungu besisu. ukusabela Ngaphansi ezivamile kungenzeka ezifana isicanucanu, ukuhlanza, ukuqunjelwa, yokudleka kolwelwesi lwesisu oyingozi futhi esiswini kanye izilonda duodenal, ukubuyisa. nesenzakalo ezingavamile kodwa kungenzeka izifo ezifana nesifo, pancreatitis, stomatitis, isifo sokusha kwesibindi, ukunambitheka ezishintshwe ukuthuthukiswa yokwehluleka kwesibindi oyingozi.

uhlelo Osteo-kwemisipha ongamemezela ngokwayo samathambo, myalgia. Nakuba kwenzeka akuvamile. Glomerulonephritis bungase bubangelwe ukusabela kohlelo urinary. Dermatologists basikisela ukuthi umphumela kungenzeka a "Plagrila" kuyinto ukulunywa, ukuqubuka bullous, ukuqubuka erythematous, ulele planus, eczema. Mhlawumbe ukuthuthukiswa ziyabagulisa ngesimo angioedema, anaphylaxis, ukugula serum. Of okuvame side effects kungenzeka imfiva, ephakeme serum creatinine kuphawulwe.

Ukusetshenziswa "Plagrila": yini okumelwe siyibheke

Uma isimo oluthile engathandeki antiplatelet ithonya, noma kuthiwa ukuhlinzwa, kuzomele ukhansele ukuphathwa nge "Plagril". Yokusetshenziswa uncoma ukwenza izinsuku okungenani 7 ngaphambi kokuba uhlinzwe. Ngemva ukuqedwa zomuthi ukumisa ukopha kwavele kwaqala kuyodingeka isikhathi esiningi. Iziguli kufanele waxwayisa ngakho engiyalela ukwazisa udokotela mayelana zonke ukopha okungajwayelekile. Esikhathini isithakazelo isiguli ukwazisa udokotela mayelana nokwelashwa "Plagrilom" kulezo zimo, uma ukuba aphinde ahlinzwe, noma isiguli inikezwa kunoma umuthi omusha.

Ngokuhamba yokwelapha yezokwelapha kubalulekile ukugcina ukulawula nemingcele simiso homeostasis (platelet ukubala, izivivinyo womsebenzi obusebenzayo, APTT). Umsebenzi obusebenzayo kwesibindi kanye kufanele njalo elibukhali esikalini njengoba ngeziphambeko ezinzima ngomsebenzi wayo ukwandisa ingozi oluhambisana diathesis.

Ukuthaka imithi, isithako kabani main clopidogrel ( "Plagril" analogs), is hhayi Kunconywa kulabo abaye babhekana i infarction acute esivimba amanzi, okungenani phakathi namasonto amabili okuqala kuqala. Ochwepheshe bezokwelapha musa batusa "Plagrilom" Ukwelapha uma isiguli angina engazinzile, nge unhlangothi ischemic e yenhliziyo ukuhlinzwa dlula.

Nge ethile ngokuqapha ziyadingeka ukuthatha izidakamizwa kubantu abakhubazekile ekusebenzeni nezinso.

Ukuze aphebeze lokho-reception "Plagrila"?

imfundo 'Plagril "(amaphilisi) eyenqabela iziguli ezine hypersensitivity noma ukungabekezelelani kuya izingxenye ngabanye main nasizayo we nomuthi. Musa thatha izidakamizwa ngasiphi izifo ungalokothi uphuze ukuze ukopha (esiswini kanye izilonda duodenal, hyperfibrinolysis, umdlavuza wamaphaphu, isifo sofuba njll). A isisekelo esiqinileko ukuze non-ukusetshenziswa "Plagrila" kukhona ukwehluleka oyingozi hepatic, oluhambisana syndrome. Ngaphezu okungenhla, is contraindicated ukuthatha imithi kwabesifazane abakhulelwe nabancelisayo. Hhayi ukuze linqume izidakamizwa ezinganeni ezingaphansi kweminyaka engu-18 ubudala.

Amalungiselelo analogue

Ezimakethe ezithaka imithi namuhla, iqembu izidakamizwa ejenti antiplatelet ( "Plagril" omqondofana nokuqukethwe kwalo yezingxenye asebenzayo main) iyatholakala ngokwanele kakhulu. Ngaphezu 3 kweshumi izidakamizwa - ejenti antiplatelet babe isithako efanayo esebenzayo (clopidogrel) futhi ngesikhathi umthamo ofanayo (75 mg). Ngaphandle abakhiqizi Russian ukukhiqiza izinkampani Indian antiplatelet zemithi, amabhizinisi Hungary, Israyeli, Malta, France.

"UDkt Reddies Laboratories" "Plagril" ngokwalo ukhiqiza inkampani Indian. Ngu mfanekiso, singase ingahlanganisa French "Plavix" German "Clopidogrel Ratiopharm," Hungarian "Clopidogrel-Richter," Israeli "Clopidogrel Teva," Maltese "Liporel" Macedonian "Listab 75". "Zilt" kungenziwa behlukene futhi elalidume kunawo wonke futhi kabanzi ziphoqa ejenti Russian.

"Zilt" - Russian "Plagril"

The main izidakamizwa esebenzayo ekulungisweni "Zilt" ( "Plagril" ngokuthi okuhambisana ngokugcwele) kuyinto clopidogrel. Imithi kungokwalabo iqembu ejenti antiplatelet. Umthamo kokuqala (elisho "Zilt" - 400 mg) emva 2 amahora ngemva kokuphathwa siyehla platelet wokuhlanganisa. Njengoba nje "Plagril", "Zilt", uma ukuthola 50-100 mg ngelanga izonikeza umphumela esiphezulu zokwelapha emva kwezinsuku 4-7.

Nomuthi akheka esibindini. I yokwakheka igazi ka metabolites asebenzayo kutholwa. Balinganiselwa ku-50% "Zilta" excreted ngu izinso, asele 46% zingakapheli izinsuku 5 emva eyamukelayo zizokhishwa ngokusebenzisa emathunjini.

Izinkomba yokusebenzisa le "Zilta" ziyefana e "Plagrila": nokuvinjelwa thrombus kwetinhlavu iziguli othola isilethikusebenza, unhlangothi ischemic noma anokugula okuthile Umthambo patency.

umbono umthengi

Njenganoma yimuphi izidakamizwa, le "Plagrila" has kokubili ukuhlolwa omuhle abathengi, kokubili Izibuyekezo emihle nemibi. Kuneziguli esikuye izidakamizwa useqokwe for ekwelapheni angina futhi waziveza umuthi kahle. Nge ukusebenzisa kwayo kokuhlasela senzeka nome ungakhiphi nhlobo, noma baba kakhulu kancane. Ndawonye namakhasimende kokuhlaziywa nemithi "Plagril" impendulo evela kodokotela.

Nokho, ungakwazi ukuhlangabezana nokubona mayelana engemihle okubangwa ukusetshenziswa imithi. Abanye abantu wabhala mayelana nokubonakala nokulinyazwa, abanye ngokucacile wabonakaliswa igazi. Kwakumelwe iziguli kanye ngezigameko zekhanda ezinamandla, futhi ezahlukene kakhulu izinkomba iziyaluyalu e isimiso sokugaya ukudla bungene. Ezingavamile, kodwa kungenziwa wezwa sezihambile inqubo ethola "Plagrila" isilonda esiswini noma isilonda duodenal.

Ngokuvamile, kufanele kusho ukuthi izidakamizwa "imiyalelo Plagril 'ukusetshenziswa ibekwe njengoba izidakamizwa sina ngokwanele aluhambisani ne yonke imithi. Ingabe uhlu sasivumela olubanzi Izimo, kungabangela eziningi side effects kusuka ezihlukahlukene izinhlelo eziyishumi nemitshingo. ukusetshenziswa engalawuliwe zishukumisa negative ngokwanele (futhi ngezinye izikhathi engelapheki) nemiphumela impilo isiguli.

Isiphetho kuzo zonke okungenhla kuyabonakala namanje. "Plagril" ngenkambo ukwelashwa kufanele aqokwe udokotela ukuba khona. Futhi ukhetho best ukwelashwa ngalo muthi - esibhedlela ngaphansi kweso ochwepheshe. kulokhu kuphela esingayiphila nethonya elihle zomuthi nge ingozi sakugcina side effects.