I-Homocysteine - iyini le nto?

Ngo-1932, i-amino acid njenge-homocysteine yachazwa okokuqala. Iyini le nto? Umkhiqizo we-methionine metabolism, isakhi esine-sulfur esine-sulfur esingenakuphikiswa emzimbeni womuntu.

I-Homocysteine - iyini?

Naphezu kokuthi ukutholakala kwalokhu kwenzeka okwenzeka ekuqaleni kwekhulu lama-20, ukuhlanganiswa kokuqukethwe okwandisiwe nezifo ezihlukahlukene kwatholakala kamuva. Kuphela kwamashumi eminyaka yamuva kunolwazi olubonakala ukuthi homocysteine ithinta ukuthuthukiswa kwezifo ezihlukahlukene zokukhulelwa, izifo zenhliziyo kanye nezifo zesifo. Iyini le nto futhi kungani ingalimaza umzimba womuntu kangaka kabi? Le-amino acid ayitholakali kuma-protein. Ikhona e-plasma yegazi. I-metabolism yayo iyathinteka yizinhlobo eziningi ze-enzyme eziyinkimbinkimbi, kanye ne-folic acid nama-vithamini B. Uchungechunge lwempendulo eguquguqukayo olwenzekayo esibonelweni, emathunjini amancane, izinso kanye nasezinhlakeni. Uma kukhona ukwephulwa kwezinqubo zokuqubuzana, ukuntuleka kwe-enzyme ephula i-homocysteine itholakala. Lokhu kusho ukuthini ngomzimba womuntu? Ukwakhiwa kwe-amino acid kuba yisisusa sezinqubo eziyingozi ezizobangela umphumela we-pathologi ngokuhamba kwesikhathi.

Izinhlobo ezahlukene ze-hyperhomocysteinemia

Kuye ngokugxila egazini le-amino acid engasetshenzisiwe, izinhlobo ezimbi, ezilinganayo nezomzimba zesifo zihlukile. Isizathu sokuqala singaba pathologies yefa. Ifomu elilinganiselwe ngokuvamile liwumphumela wokukhubazeka okweqhwaba kanye nokuntula kwevithamini B12. Uhlobo oluthile lwe-hyperhomocysteinemia lwenzeka ngokufakelwa kwezinso, ukuhluleka kwezinso, ukungaboni kahle kwamahomoni wegciwane, nokudla imithi ethile. Okuyingozi kakhulu ukungalingani kwaleli-amino acid lapho ethwele ingane.

Homocysteine nokukhulelwa

Le-amino acid, eningi kakhulu, equkethwe egazini, ivuselela ukuthuthukiswa kwe-thrombi. Uma homocysteine ephakanyisiwe ekukhulelwe , kufanele ulindele izinkinga eziningana zezinkinga. Imininingwane yalokhu isenzo sokuzivikela akuqondi kahle. Kodwa izazi zezinkinga ziyazi kahle into eyodwa: i-thrombogenis iyingozi kakhulu ekusakazeni kwegazi kwe-fetus, ingabangela ukwephulwa kwe-placentation. Lokhu kungabangela ukukhubazeka ekufakweni kombungu. Futhi ngenxa yalokho - ukukhulelwa kwesisu nokungasebenzi.

I-Homocysteine: kanjani ukudlula ukuhlaziywa kokuqukethwe kwaleli-amino acid?

Njengoba le nto ingumkhiqizo ophakathi wokushintshaniswa kwamanye ama-amino acid, kubalulekile ukucabangela ukutholakala kwezidakamizwa zokulungiswa kwe-metabolism egazini. Hlola ukuhlolwa kwesisu esingenalutho, awukwazi ukuphuza noma yini ngaphandle kwamanzi. Nciphisa usuku ngaphambi kokutadisha ukudla okunamafutha kanye okuthosiwe. Utshwala obungenakuvunyelwa. Ukuzikhandla ngokomzimba, ngisho nokulinganisela, akusifisi. Ngemuva kweminyaka engama-30, kuyadingeka ukuthi ngezikhathi ezithile unike igazi ku-homocysteine, ngokuhambisana nemiphumela yokulungisa ukudla kwabo. Lokhu kuzosebenza njenge-prophylaxis enhle kakhulu yokushaya isifo, ukucindezeleka kwengqondo kanye ne-atherosclerotic izilonda zamathambo.