MPV ekucubunguleni yegazi kusho? MPV: okulotshiweyo ukuhlaziywa

Igazi lomuntu line kuhlanganisa sebuningini amaseli ahlukene (izakhi kwakhiwa), futhi bonke ekufezeni imisebenzi ethile. Lesi sihloko sizosisiza sikhulume ngokuthi kusho ukuthini MPV ekucubunguleni wegazi futhi yini amazinga salo esivamile.

Izinhlayiyana zegazi

Ama-platelet I ezincane kunazo egazi. Sinenkosi awanayo i-nucleus, kodwa enze imisebenzi eminingi ebalulekile. Umsebenti wabo oyinhloko adlulisele viscosity ezithile igazi ukubuyisela ubuqotho odongeni umkhumbi lapho umonakalo. Uma lokhu kwenzeka kumiswa izinto ezithile (fibrinogen), i-platelet zidluliselwa ku ifomu asebenzayo ngaphansi kwazo. Kulesi simo, ikhono cabaza, futhi banamathelane futhi odongeni bomkhumbi ezilimele, ukwakha ihlule (uhlobo ipulaki, okuyinto siphetha endaweni ezilimele futhi ikhuthaza hemostasis).

kumiswa platelet kwenzeka umnkantsha futhi ngenxa yokuthi ukuphila kwabo kwezinsuku 10 for kwendikimba evamile kudinga njalo ukukhiqiza amangqamuzana amasha. Uma sinqamukile ibhalansi phakathi kokubhujiswa kanye kumiswa platelet entsha, kukhona ukuthambekela opha (encishisiwe platelet count) e ngumuntu, noma - ukuze ngokweqile thrombus kumiswa (ngamazinga aphezulu). Ukuhlolwa kwegazi inquma inani corpuscles ilitha noma microlitre ngayinye. I platelet ukubala amabanga evamile kusuka ⁹ 180h10 320h10 ⁹ / L kwabadala.

ivolumu Mean platelet

Izinkomba ukuthi ukucacisa kwegazi jikelele, namuhla athé ukwehluka kulawo abekade eminyakeni eminingana edlule. Ngakho, kukhona izifinyezo eziningi engaqondakali kubantu engaqaliwe. Enye yalezi awazisayo MPV eliyimfihlakalo ukuhlolwa igazi. Empeleni, konke akunzima kangako. Ngaphansi kwalo isifinyezo efihla sibalo, kunqunywa isilinganiso platelet ivolumu.

Ngenxa esifushane uma kuqhathaniswa impilo zegazi kanye njalo yabo igazi zamagama kwabantu sonke isikhathi kukhona izakhi okwenyanga okuyizinto emazingeni ahlukahlukeneko wendlela ukuphila umjikelezo yabo. Ngalesi amaseli abasha futhi uvuthwa, nama-platelet, umjikelezo kabani ukuphila sekuzophela isakhiwo, hhayi kuphela kuhluke ngobukhulu kanye saturation izinto eziphila abakhuthele, kodwa futhi athwale ezahlukene umthwalo sokusebenza. MPV e ukuhlolwa igazi, ukuthola ukuthi mangaki platelet ezinobukhulu obuhlukahlukene usegazini okwamanje.

Amanani Jwayelekile MPV

Ukuze sithole kusho ivolumu platelet eyenziwa amasampuli igazi emthanjeni. Ngemva kwalokho, 5 ml ukuphenya Fluorescent cytometric indlela. Imiphumela iba yinhlanganisela yokukhandleka histogram - ijika okubonisa MPV e ukuhlolwa igazi. Norm lokhu Inkomba luyehluka in the uhla kusuka 7.5 kuya ku-11 FL. Ishadi kukuvumela zisanda inani zegazi ezahlukene obujwayelekile. Okuqukethwe evamile lamaseli abavuthiwe okufanele kungene u-90% zegazi, abasha - hhayi ngaphezulu kuka-0.8%, esiwohlozayo - 0.2%, ubudala - 5.6%. Ngakho predominance lamaseli beya usekhuluma le-histogram okuqukethwe kwesokunxele bese oyithandayo lamaseli ubudala - ngakwesokudla. Kumele kukhunjulwe ukuthi izinguquko ezithile esikhathini MPV izinkomba (ukuhlaziywa igazi) emagama Imiphumela singabeka isamba nangaphansi inombolo evamile eliphelele platelet.

Manje, ake sixoxe ngalokho kusho avuke futhi bayasilela MPV.

Igazi yokuhlola: MPV behliselwe phansi

Le ndlela kungabonakala nasemkhakheni uma ukuhlolwa kwegazi ne evamile count platelet ngokuphelele ivolumu isilinganiso komzimba lingaphansi kunalokhu okujwayelekile. Lokhu kubonakala histogram predominance abalulekile lamaseli ubudala. Kulokhu, MPV ongaphakeme ekucubunguleni wegazi eyobonisa ukuthi isimo esiyingozi njengoba thrombocytopenia (platelet ukubala esingaphansi 100x10 ⁹ / L), uma kungenzeka ukopha olubanzi ngenxa kwehle igazi ekunqandeni.

Izimbangela kulesi simo kungaba yokuba izici zofuzo eziyingozi, izifo igazi kanye nezinye izitho, ukusetshenziswa kunemithi noma amaphilisi owaphuzayo. Ngo mshini thrombocytopenia kukhona amaphuzu amathathu amakhulu:

• zincishiswe noma ukumisa zamagama lamaseli abasha - lokhu kungenzeka ngesikhathi pathologies ezahlukene isibindi, yegilo, ukuntuleka kwegazi emzimbeni, ukudakwa ezibangelwa ukweqisa noma ezinye ezinobuthi, kanye ekwamukelweni izidakamizwa ezithile;
• Uma platelet ubhujiswe ngokushesha kunokuba kwemiqondo - kungase kube umphumela pathologies ezithile mzimba (purpura thrombocytopenic), eqonda coagulation intravascular, ukumpontshelwa igazi;
• ukwephulwa platelet ukusatshalaliswa - esimweni esejwayelekile, cishe isigamu platelet ungaphakathi uhlobo edepho, indima eyadlalwa ubende, e izifo ezithile (sofuba, i-hepatitis) Inombolo platelet imali ongafinyelela 90%.

Izimpawu ejwayelekile MPV ongaphakeme

I symptomatology obuhambisana isimo, lapho MPV ekucubunguleni wegazi lehliselwa, ngenxa izici ezimbili: kahle igazi ekunqandeni izindlela futhi ngakhula permeability izindonga semithambo. It livezwa izici ezilandelayo:

• ukopha ongama amaningi, ngokuvamile itholakala phezu phambi emikhawulweni, esiswini, esifubeni;
• umongozima njalo;
• zabesifazane kokuya esikhathini eside esinda;
• ukopha ngwengwzi.

MPV buyaqina

Nokho, kunezimo lapho ukuzimisela MPV igazi (ukuqaqwa) sikhombisa esingeqile amazinga evamile platelet. Kwezinye izimo lemali yabo kungaba idlule kakhulu 400h10 ⁹ / l. isimo okunjalo thrombocytosis kukhona isihloko kungaholela zokugula kuyindaba ebalulekile ephathelene ne-thrombosis owengeziwe. Hlukanisa isihlobo thrombocytosis (Ukufundwa idlula mkhawulo evamile at 100-200 eziyinkulungwane. Units) futhi esibucayi lapho kokweqa izindinganiso evamile ibonisa kabili CBC. MPV kungenziwa ngcono ngakho ngenxa yezizathu ezihlukahlukene, ngakho-ke kuyadingeka ukuba ukuqhuba more ngokujulile luhlolo, ukuthola imbangela thrombocytosis bese uzama ukukulungisa.

Izizathu okwandisa MPV

imithi yesimanje kwenza kube nokwenzeka ukunquma hhayi kuphela ukwanda kwenani ingqikithi izinhlayiya zegazi, kodwa futhi uthole ukuthi yini imibono yabo ngesikhathi esifanayo wabusa. Ngokuvamile kubalulekile ukuxilonga izifo. Ngokwesibonelo, isibalo abasha platelet lenyuka ngemva kokuhlinzwa noma amasignali ukopha zangaphakathi noma nokunwetshiwe ukopha. Emazinga lasetulu platelet amadala bakhuluma ngani inqubo umdlavuza. umumo esiwohlozayo lwanda iziyaluyalu inqubo hematopoiesis. Thrombocytosis uvame ukuhambisana uthi ezilandelayo:

• exacerbation izinqubo okungalapheki ipheshana wokugaya ukudla, uhlelo lwamathambo;
• izifo igazi;
• ukuhlinzwa;
• Oncology;
• njengoba side effect kwezidakamizwa ezithile.

MPV ezinganeni

Ngokuvamile, isilinganiso ukusebenza ezingeni zegazi izingane abahluke ngayo kulabo abakwamanye abadala ezingaphansi kweminyaka engu-unyaka owodwa kuphela. Ngemva kwalokho, okuqukethwe igazi salezi zici sinezici efanayo, kungakhathaliseki ubulili. Ngokwazi izinsana, banayo amagugu evumelekile ubhekwa isukela 100 ukuze 400h10 ⁹ / L. Ekunqumeni MPV kule ukuhlaziywa wegazi rate ezinganeni kuyinto 150-350h10 ⁹ / l unyaka.

MPV ekukhulelweni

Ukukhulelwa kudinga sowesifazane umzimba ukuhlela yonke imisebenzi, futhi lezi zinguquko ngokuyinhloko ezithinta isimiso sokujikeleza kwegazi. Isidingo kumiswa ezengeziwe (esinomhlapho) ukuzungeza kudinga okwandisa inani legazi ivolumu. Isilinganiso amanani ejwayelekile zegazi owesifazane okhulelwe kubhekwa isikhawu 150-380h10 ⁹ / L. Nokho, ngeziphambeko kusukela kuyinsakavukela kulesi simo kungaholela emiphumeleni engathí sina. Lokho kungenxa yokuthi phakathi lonke isikhathi sokukhulelwa owesifazane kufanele avivinywe laboratory njalo.

Uma ukukhulelwa kuhambisana toxemia ezinzima ke ukuhlanza nezinye izifo emathunjini kungaholela amanzi emzimbeni, nakho kuzothinta ezingeni platelet - ke uyovuka ngqo. Ekukhulelweni izinkomba akufanele idlule 400h10 ⁹ / l, ngaphandle kwalokho angase aqale izinqubo sokugembula okuholela platelet agglutination kanye kumiswa amahlule esegazini. Ngesikhathi kusaqalwa lezi zifo kungaholela ekulahlekelweni ezingenzeka embungwini, kanye kamuva iyindlela amahlule izitsha imilenze, ephelezelwa ukuthuthukiswa varicose emithanjeni. Ukuze ugweme lokhu, ungasebenzisa igalofu wamathambo.

Hhayi amazinga kancane esiyingozi futhi yehlise platelet ngezansi 140h10 ⁹ / l. Okwakuhlalwa kuzo lapho kusaqalwa ke kungabangela ukopha ngisho ingozi ukulahleka fetus. Izenzo thrombocytopenia ngesikhathi sokukhulelwa kungaba ukulinyazwa emzimbeni ngisho nangemva kuthintwa encane, ukopha izinsini, umongozima. Ngezinye izigaba kamuva thrombocytopenia kungadala omkhulu ukopha ngesikhathi sokubeletha bese okuvela ukopha izingane.

Ngakho, izinga isilinganiso platelet kuyinto Isikhombisi esibalulekile isimo umzimba womuntu. Uvumela ekuseni ukucacisa kungenzeka nesenzakalo yesifo esithile futhi likwazi ukuthatha izinyathelo abakwazanga ukuyivimbela.