Lymphoma Follicular: izimpawu, izimbangela, ukwelashwa. Inkathi ukuthethelelwa futhi lokubuya kwesifo lymphoma follicular

Lymphoma sibizwa ngokuthi isifo esithinta nezicubu lymph. Kulokhu, amaseli ethintekile baqala ukuhlukanisa futhi bephikisa avuse ukuphazamiseka e ukusebenza evamile izitho zangaphakathi namalungu omzimba womuntu. iqembu elingalodwa izifo ezifana: isifo Hodgkin sika (noma okuthiwa isifo Hodgkin sika) kanye lymphoma-non-Hodgkin sika (kuhlanganise follicular-non-Hodgkin lymphoma).

Uhlelo lymph. Yini lena

Ingxenye omzimba somzimba wethu ingamanzi lymph, umsebenzi oyinhloko okuyinto - isivikelo zonke izinhlobo izifo nezinye izifo. Kuyinto inethiwekhi iziteshi lapho uketshezi ihamba elisebunyeni - lymph. Ngokuhamba capillary waphawula lymph node lapho izindlala zamanzi is okucetshiswe amaseli akhethekile - lymphocyte. Kukhona zenyathi eziningana. B lymphocyte banesibopho amasosha omzimba atholwe khona ezifweni ezithathelwanayo. Xhumana ne lwegciwane, abasusa imiphumela yaso futhi uyigcine inkumbulo yami. B lymphocyte - zingabameleli ebalulekile ekwakhekeni umphumela omuhle ngokugoma. Iningi (80%) lymph zimumethe T lymphocyte. Bazi ukuthi banesibophezelo ukubhujiswa zonke izinhlobo amagciwane. NK-maseli etholakala lymph e esincane (kufika ku-10%). Umsebenzi wawo oyinhloko - ukubhujiswa amaseli ayo ezilimele (kufaka kule isifo esinjengo lymphoma follicular).

Kangakanani inqubo abulalayo ohlelweni lymph

inqubo Neoplastic ucala kutfutfukisa emangqamuzaneni uhlelo lymph (B cell). Lesi sifo sitholakale umuntu ikakhulukazi kwasebekhulile, ezinganeni zenzeka ezimweni ezingajwayelekile. lymphoma Follicular wathola igama layo ngenxa yokuthi ngokuyinhloko kuthinta follicle izinwele. Isikhathi esining impela, izimila kuyagcinwa entanyeni, emakhwapheni, imbilapho. I engavamile walesi lymphoma wukuthi iziguli ukufuna usizo sekwephuzile. Amaseli ethintekile ukungena kwezitho zangaphakathi, zikhala ngezinye umsebenzi wabo. Nakuba lymphoma follicular iiia ngokwanele ihambelana kahle ukwelashwa, ezigabeni kamuva ukuxilongwa ungavumeli ukuba ngokuphelele ukuqeda lesi sifo.

Ezinye izinto okungenzeka lesi sifo

Izizathu ngqo anomthelela emdlavuzeni, ochwepheshe abakwazi ukushayelwa. Nokho, kukhona izinto ezimbalwa ukuthi amathuba okuba umdlavuza. Omunye wabo - zofuzo, chromosome. Ukusebenza kwezimo ezingezinhle, contact unomphela nge ayingozi futhi kungaba kulethe isimo ezifana lymphoma follicular. Izimbangela zesifo kungenzeka kanje: yokuchayeka emisebeni, immunodeficiency buthakathaka komzimba, futhi isifo sokuhlasela kwamasosha omzimba. Abanye ochwepheshe ukuhlukanisa izinto ezifana ukubhema, ukudla imithi ethile, ngisho ukukhuluphala.

symptomatology lymphoma

Follicular izimpawu lymphoma kuyinto kunalokho ebuthakathaka, ikakhulukazi esigabeni sokuqala. Okokuqala, bekulokhu kunokwanda abanye e-lymph. Nokho, ziyisici kobuhlungu. Akumangalisi ukuthi ukuvuvukala kancane ngezikhathi ubalekela ke kuyabuya. Leli qiniso kufanele aqaphele ngokukhethekile. Khulisa amayunithi futhi sternum. Ngaphandle-ke ungaboniswa ukukhwehlela, iphika. Ithuba encane run-off ubuso. Kwezinye izimo, ukuhlupheka futhi ubende. Follicular izimpawu lymphoma ungaba lalivamile: kwesisindo, ukukhathala jikelele, ubuthakathaka umzimba. Nokho, lezi zibonakaliso - ngaphandle kunokuba umthetho, basuke ebonwe nesineke eyodwa kuphela kweziyishumi. izigaba Okuningi ezinzima zalesi sifo zinezikhathi ukulimala isimiso sezinzwa, ikakhulukazi umnkantsha. Ngesikhathi iphuzu elifanayo isiyezi, isicanucanu futhi kungenzeka nokuquleka.

Ukwahlukanisa izifo zomdlavuza izigaba ukugeleza

Kunezinhlobo eziningana lymphoma. Okokuqala - follicular. Okuqukethwe follicle kulokhu 75%. Uma kukhona kule ezahlukene 25-75%, lokhu zenyathi follicular-ehlasela umzimba. Ngo uhlobo ehlasela umzimba inothi ngaphansi kuka-25% follicle. lymphoma Follicular (iiia) senzeka ngezigaba eziningana. Ngesikhathi besanda kuqala, endaweni eyodwa kuphela ethintekayo zamanzi. Isigaba sesibili elinesimo inqubo sokugembula ezihilela izingxenye ezimbili noma ngaphezulu (kodwa ohlangothini olufanayo diaphragm). Lapho wesithathu-degree abathintekayo endaweni nhlangothi zombili diaphragm. Isigaba olunzima ezine. Izinguquko zenzeka izibilini izinhlelo (nomnkantsha, isibindi, njll). Ngezinye izikhathi zesi-lymphoma esiteji engeza izinhlamvu ezingu-A noma-B Lokhu kubonisa ukuthi follicular lymphoma izimpawu uhlobo elandelayo: "B" - kukhona ushintsho lokushisa komzimba (ngokwanda ngezikhathi ezithile), ukuncipha emzibeni, ngijuluka ebusuku. Lymphoma c Isiqalo "A" - idatha izimpawu zingasekho.

Izindlela ekuxilongweni lymphoma

Okokuqala, uchwepheshe (onco-eyisazi) uqhuba luhlolo ezibukwayo isiguli. Kuphoqelekile luhlolo histological isampula. Ukuze wenze lokhu, a biopsy wenziwa. Ucezu ethintekile lymph node sisuswa futhi kuhlolwa ngesibonakhulu. Kuyaphawuleka ezintathu uhlobo cytological yesifo ezidinga ukwelashwa okuhlukile. Uhlobo lokuqala libhekene khona centroblasts abafinyelela kwabahlanu emkhakheni Ngenxa microscope, kwesibili - kumayunithi 15. Uhlobo ukushaqeka cytological yesibili kudinga nokwelashwa ngamakhemikhali ngoba ngokwanele nolaka. Follicular lymphoma 3a cytological uhlobo has onalesi sifo ezingezinhle kakhulu. Emkhakheni wezingalo Ngenxa microscope ungabona izimila ebanzi. Ngaphezu kwalokho, isiguli kumele anikeze igazi (isimila omaka, ukuhlaziya jikelele), kudlule kokuxilongwa ultrasound izitho zangaphakathi, CT noma i-MRI. Ukuze ukwazi ukubona ukuthi washaya isimiso sezinzwa esiyinhloko, umgogodla labetibambile kocingo elilodwa ukuze kuqhutshekwe nocwaningo phezu amangqamuzana omdlavuza.

lymphoma Follicular. ukwelashwa

Eminyakeni yamuva, inani leziguli nge kokutshelwa ngokukhubazeka kwengane liye landa kakhulu. Njengomthetho, phambilini akazange azibone neziqu, ngcono amathuba lesiguli ukulondoloza impilo nokuphila kwabo njengento. Lymphoma libhekene kahle evilaphayo isiphelile, ngakho-kwezinye izimo udokotela ukhetha umdlalo sokulinda, ukubukela zonke izinguquko emzimbeni womuntu. Lokhu kungenxa yokuthi kokubili imiphumela emibi yokwelashwa ngamakhemikhali nokuhlinzwa akuyona ihlolwe ngokuphelele futhi ube izinhlangothi zazo ezimbi. Follicular lymphoma ukuthethelelwa ingahlala iminyaka eminingi. Uma ngentuthuko umdlavuza iqala, imishanguzo kufanele kwenziwe ngokushesha. Phakathi izindlela eyinhloko ukwelashwa kufanele kwenziwe ngemisebe, amakhemikhali okwelapha, imithi izidakamizwa. Kuye ohlotsheni lymphoma, ukuchayeka lesifunda kungavimbela umuntu uyahluleka uma elwa kungenzeka. Ngo esigabeni sokuqala isifo ubude ukuthethelelwa ezilotshwe iziguli eziningi.

Ethwele nokwelashwa ngamakhemikhali

ngelashwa nangemithi Aggressive (nezidakamizwa okungcono eziningi) e kusaqalwa lymphoma kungaba kakhulu ukunciphisa amathuba Ukuphinda. Kwaphela isikhathi eside le ndlela ayebhekwa ukwelashwa eyinhloko umdlavuza. Ukwelashwa ngamakhemikhali nokushiswa kuhloswe ukubhujiswa isimila cells ngesikhathi ukubuyabuyelela yabo. Inhlanganisela ukwakhiwa bangathonya inqubo division zibe izigaba ezahlukene, ngakho ukusetshenziswa yabo ngemphumelelo. Nokho, imiphumela emibi yokwelashwa ngamakhemikhali has imiphumela elimazayo ku nezinye izitho (isikhumba, izinwele, nokunye. N.). Uhlushwa lezi izidakamizwa umnkantsha. Phakathi ukwelashwa, umuntu uba usengozini yokuthola izifo ezithathelwanayo zingavela nemihuzuko amaningi kanye ukopha. imithi yokwelapha bavame ukubanga ukukhiqizwa ethuthukisiwe ye uric acid, okuyinto kuholela ekwakhekeni ezinso. Nokho, zonke ukusabela ezingezinhle zinyamalale ngemva kwamasonto ambalwa emva Yiqiniso. Kufanele kuqashelwe ukuthi imithi ethile nokwelashwa ngamakhemikhali kunganciphisa isidoda count amadoda, ingqondo ukungazali kwabesifazane.

Ukwelashwa nge Monoclonal Amasosha Omzimba

lymphoma Follicular iphathwa, nezidakamizwa ezintsha ezifana efana amasosha omzimba monoclonal. Bona ngenjongo ukubhubhisa kuphela amaseli lymphoma. Le nqubo ephumelela kakhulu lihambisana nokwelashwa ngamakhemikhali. amasosha omzimba Monoclonal kancane ukunciphisa ubuthi amakhemikhali. Iziguli waphawula ubude ukuthethelelwa lymphoma follicular. Kwezinye izimo, kungenzeka ukusabela iguliswa, ngakho ekuphathweni lokuqala amasosha omzimba kwenzekani isikhathi eside impela. Ngaphambi ukwelashwa isiguli edingekayo izinga izidakamizwa antiallergic.

isifo Ukuphinda

Danae isifo elinesimo inchubekelembili kancane okwakuhlalwa kuzo lapho kusaqalwa, inkathi ukuthethelelwa ingahlala iminyaka engu-20. Ngokuvamile yansukuzonke lymphoma follicular ebonwe uhlobo 3a Cytology. Kulokhu, kungase kudingeke ekunqandeni iseli ukufakelwa. Lokuthi kungaba umzalwane (usisi), kanye nezihlobo ezingebona igazi. Inqubo wenziwa iziguli abaneminyaka engaphezu kuka-70, okuyinto phendula kuhle ukuba imiphumela emibi yokwelashwa ngamakhemikhali futhi ube nesimo eyanelisayo impilo. Ngemva ukufakelwa, ngcono kuyagcinwa cishe ngemva kwengxenye iziguli. Ukusinda kuxhomeke ezicini eziningi. Okokuqala, nesigaba lesi sifo kubalulekile, izinguquko morphology (ukuqagela follicular lymphoma kunalokho ongakuthandi isinyathelo sesine). Kufanele kuqashelwe ukuthi ukubhekana kangcono isifo intsha. Kubalulekile ukuqaphela lymphoma ngesikhathi, ngakho ungadikibali izivivinyo zokuvimbela ongoti.