I-Analog "Texamena" yasekhaya. Umyalo wokusetshenziswa kwe- "Texamena"

"I-Texamen" - I-NPVS, omelela i-oxicam. Isidakamizwa siqeda ukuvuvukala nobuhlungu, kunganciphisa umkhuhlane. Ngezansi incazelo yesidakamizwa esithi "Texamen", ama-analogs, imiyalelo yokusetshenziswa.

Ifomu lokukhishwa, ukwakheka

Isidakamizwa singathengwa kumathebulethi kugobolondo futhi ngesimo sesisombululo somjovo. Isithako esisebenzayo yi-tenoxicam (20 mg). Izinto ezisizayo zifaka isitashi esenziwe ngaphambili, i-magnesium stearate, i-talc. I-Lactose isetshenziselwa njengesithako esengeziwe. Igobolondo le-tablet liqukethe i-yellow iron oxide, i-polyethylene glycol 400, i- titanium dioxide, i- hydroxypropylmethylcellulose.

Izakhiwo zamakhemikhali zokulungiselela

Kokubili ukulungiselela kwangempela kanye nomfanekiso we "Texamena" okhethwe udokotela kuzovumela ukukhipha ubuhlungu, ukuvuvukala nokushisa, ukuphazamisa ukuhlanganiswa kwamaplatelets. Isenzo sesidakamizwa sisekelwe ekuvimbeleni umsebenzi we-COX-1 ne-COX-2 isoenzymes. Ngokusebenzisa izidakamizwa emzimbeni kunciphisa inqubo yokukhiqiza i-prostaglandins, endaweni evulekile engaphansi kwamangqamuzana egazi amhlophe aqoqa. Umphumela wokulwa nokuvuvukala ubonakala cishe ngesonto elilodwa ngemuva kokuqala kokwelashwa. Isenzo somkhiqizo wokwelapha siqhubeka isikhathi eside.

Ukwamukelwa kwenzeka ngokushesha, isidakamizwa sitholakale ngokuphelele, kodwa le nqubo iqhubeka kancane uma ithebhulethi ithathwa ngaphambi kokudla. Ukutholakala kwe-bioavailability kuyinto 100%, kukhona cishe ukuxhumana okuphelele namaprotheni akhona eplasma yegazi. Ukuhlushwa okukhulu kwesidakamizwa kunqunywe amaminithi angu-120 ngemuva kokusetshenziswa kwayo. Isikhathi sempilo senziwa emahoreni angu-72. Izingxenye ze "Texamena" ziwela emzimbeni we-synovial. Isidakamizwa sinamandla okudlula izivimbela ze-histohematological. I-metabolism yenziwa esibindi, ngenxa ye-hydroxylation, i-5-hydroxyteneoxicam yakhiwa. Iningi lezidakamizwa lithengiswa yizinso (imetabolites engasebenzi), okunye - ngesibindi (bile).

Izinkomba zokusetshenziswa

Kokubili i-original kanye ne-analog ye "Texamena" (imijovo, amaphilisi) anqunyelwe ukususwa kwesifo sobuhlungu, esichazwe kancane noma ngokulinganisela:

• Izinwele, amazinyo;
• Izilonda zesikhumba ngenxa yokushisa;
• Ukulimala okubangelwa ukulimala;
• I-Algodismenorea;
• I-Migraine;
• I-Neuralgia;
• I-Myalgia;
• I-Arthralgia.

Isidakamizwa siboniswa nge-tendovaginitis, i-bursitis, i-osteoarthritis, isifo se-rheumatoid arthritis. "I-Texamenom" ithatha i-spondylitis e-ankylosing. Isetshenziselwa ukuqeda i-articular syndrome ne-gout ngenkathi kunzima.

Ukungafani

Kuloluhlu - hypersensitivity ezingxenyeni zomuthi, ubudala beminyaka (engaphansi kweminyaka engama-18), ukubeletha ingane, ukuncelisa. Ukumiswa kwe-Analog "Texamena", uma ukwelashwa ngesidakamizwa sokuqala akumukeleki. "I-Texamen" ayisetshenziselwa amacala alandelayo:

• Ukulimala ohlelweni lwe-hematopoietic;
• Izimo ezinengqondo zezixhobo zokugqoka;
• I-gastritis enamandla;
• Izilonda zomuthi wamathumbu - ukuphuma kwegazi, ukulimala emvelweni we-erosive ne-ulcerative (izimo ze-pathological in the anamnesis nazo ziphikisana nokuphathwa kwe- "Texamenom");
• Ukuzwa ukukhubazeka;
• Hypocoagulation;
• Ukungabi ne-glucose-6-phosphate dehydrogenase;
• I-Hemophilia;
• I-Triad "i-aspirin";
• I-Renal ne-hepatic insufficiency.

Kudinga ukuqapha njalo isimo sezempilo ekwelapheni iziguli ezisebekhulile, iziguli ezine-diabetes mellitus, umfutho wegazi ophakeme, ukuqhubekela phambili ku-edema, ukwehluleka kwenhliziyo.

Ukwelashwa kwe- "Texamenom"

Kokubili okokuqala kanye nomfanekiso we "Texamena" (imijovo, amaphilisi) asetshenziselwa ukunquma umthamo ngamunye ngesiguli ngasinye. Ngokuvamile, ithebhulethi eyodwa idliwe ngaphakathi. Imithi ingashadile futhi kufanele iphathwe ngesikhathi esifanayo nsuku zonke ngemuva kokudla. Ukusetshenziswa isikhathi eside kwesidakamizwa kudinga u-10 mg we-ejenti yokusetshenziswa kwansuku zonke. Iziguli ezine-gout uma kuhlaselwa okunamandla kunconywa ukuba kuthathe izimali ezingama-40 ezinsukwini ezimbili zokuqala, isikhathi sonke (izinsuku ezinhlanu) - eyodwa tablet ngosuku.

Izenzakalo ezimbi

Ukusabela okungafunwa komzimba kungabuka ohlelweni lwezinzwa, zezinhliziyo nezomzimba. Ukusabela okungekho okungalungile kwe-hemopoiesis emudlalweni osetshenziswayo, isibonelo, isifaniselo se "Texamena". Ezimweni ezingavamile, i-allergies ivela, ebonakala yi- Lyell syndrome, i- Stevens-Johnson syndrome , i-edema kaQuinck, i-urticaria, i-itching, i-ursh rash. Ngezinye izikhathi ezinye izinkomba zebholabhuthri ziyashintsha Phakathi kweminye imiphumela emibi - i-edematous syndrome, ukujuluka ngokweqile, ukuphazanyiswa kwezinso, bronchospasm. Uma kwenzeka ngokweqile, ukwelashwa kwenziwa ukuze kuqedwe izimpawu zakhe.

Imiyalo ekhethekile

Phakathi nenkathi yokwelapha, ukulawulwa kwegazi kuyisidingo, kuyadingeka ukuhlola njalo isimo sezinso, isibindi, ukucacisa izinga le-glucose yegazi, inkomba ye-prothrombin. Ngezinye izikhathi udokotela angachaza i-analog ye "Texamena".

Ezimweni lapho kunesidingo ukucacisa ama-17-ketosteroids, ukwelashwa kuphazanyiswa okwesikhashana. Isidakamizwa kufanele simiswe izinsuku ezimbili ngaphambi kokuhlolwa. Ukukhanselwa kwalo kuyadingeka ngaphambi kokwenza ukungenelela kokuhlinzwa (izinsuku eziningana ngaphambi kokuhlinzwa).

Ngesikhathi sokwelashwa akukhuthazwa ukuba enze umsebenzi onoyingozi, ekusebenziseni kokubheka kanye nokusabela okusheshayo kwengqondo okudingekayo.

Ukwamukelwa kwalesi sidakamizwa kuhlotshaniswa nengozi yamanzi nokugcinwa kwe-sodium, ukuphuma kwabo isikhathi eside emzimbeni. Umphumela onjalo ungakwenzeka ngokusebenza ngesikhathi esisodwa kwe "Texamena" kanye nezidakamizwa zokwelapha iziguli ezinokukhubazeka kwenhliziyo nomfutho wegazi ophezulu.

Iziguli ezinesifo sofuba zingaba nomlando we- nephrotic syndrome, i- papillary necrosis, nephritis yangaphakathi.

Izindleko zezidakamizwa, izilinganiso, izibuyekezo

I-Analog "Texamena" eshibhile kunothuluzi lokuqala. Isixazululo singathengwa ama-ruble angu-205-215. Izindleko ezilinganiselwe zamathebulethi yi-ruble angu-270-300. Ama-analogues akhiqizwa ngezinto ezifanayo ezisebenzayo nezifanekisayo ezinomphumela ofanayo. Kunomunye ongaphandle esikhundleni se- "Tenikam", lesi sidakamizwa sinemithi efanayo esebenzayo njenge "Texamen". Ungathenga i-analogue yasekhaya "Texamena". Okumele ukhethe - udokotela kufanele anqume.

"I-Naise" iyimithi yokwelashwa yangaphandle, ingaba nomuthi wokuqala. Ekubunjisweni kwalesi sifaniso kunomunye umuthi osebenzayo, noma kunjalo, isenzo semithi sinomphumela ofanayo ne "Texamena". Ngosizo lwakhe ungakhohlwa ngobuhlungu isikhathi eside futhi ngokushesha ususe inqubo yokuvuvukala.

I-Analog "i-Texamena" yasekhaya ayibubi kakhulu kunokungeniswa. "I-Texamen" inenani elikhulu labafaka endaweni, ukukhetha ithuluzi elifanele lenziwa ngokubambisana nodokotela. Kungashintshwa ngokuthi "Naproxen", "Polcortolone", "Flamax" noma "Naklofen". Ukwelashwa okungenzeka ngokusetshenziswa kwe- "Endoxan", "Polyoxidonium", "Prednisolone", "Nalgezina." Njenge-analog, ukusetshenziswa kwe "Feloran" kuvunyelwe.

Isifaniso se "Texamena" isiRashiya - "Diclofenac". Lona indawo eyaziwa kahle kakhulu yezidakamizwa zakuqala. Ngenxa yesicelo sayo, umphumela ofanayo wokwelapha ufezwa. "I-Diclofenac" inezindleko eziphansi, ngakho-ke kuyisisombululo esingabizi, kodwa, ukwelashwa ngezidakamizwa ezinjalo kungalimaza isimo sesisu. Ngenxa yalesi sizathu, odokotela abayinikezi iziguli ezinenkinga yemathunjini. "Diclofenac" ingumfanekiso onokwethenjelwa, kodwa hhayi wonke umuntu.

Njengoba ubufakazi bubonisa, abaningi "Texamen" bamiswa ukuqeda ubuhlungu syndrome. Impendulo yesiguli ihle, okubangelwa ukugcwaliseka kwemisebenzi yezidakamizwa. Imiphumela emibi ngokuvamile ayihlali.