"Vaidaz" (azacitidine): amanani, ama-analogues. Kuphi ukuthenga Vaidaz eshibhile?

"Vaidaz" i-antimetabolite, etholakalayo njenge-lyophilizate (i-powder ekhethekile) yokumiswa noma ngisho nokumiswa okwenziwe ngokulungele ukuphathwa okuncane. Into esebenzayo yezidakamizwa okuthiwa i-azacitidine, engena emzimbeni, ichitha ama-enzyme aphethwe izinqubo zamangqamuzana emangqamuzaneni omdlavuza, futhi ngaleyo ndlela ayeke ukukhula nokuphazamisa ukusebenza.

Izinkomba

Ukulungiselela "Vaidaz", imfundo lapho isicelo esizohlinzeka khona ngokuqhubekayo esihlokweni sethu, sinikezwa iziguli ezikhulile ezihluphekayo:

• I-myeloid leukemia evamile;
• I-Myelodysplastic syndrome;
• I-leelemia ye-myelomonocytic engapheli.

Njengomthetho, ukwelashwa ngale nsizakalo kwenziwa ngaphansi kwesimo sokuthi ukufakelwa kwezitshalo kungenakwenzeka ezigulini ezinezinhlamvu ze-hematopoietic stem.

Kungani umuthi ojwayelekile owenziwa ngokuthi "Vaidasa" intengo iphansi kunomkhiqizo okhonjisiwe

Akuyona imfihlo ukuthi izidakamizwa eziningi eziphikisanayo zinenani eliphezulu. Lokhu ngezinye izikhathi kuholela iziguli abaqokwe ukuba zibhekene nengozi, njengoba kunephakheji engaphezu kweyodwa ukuthenga.

Ezimweni ezinjalo, ama-generics ayasindisa. Lezi zilungiso ngokubunjwa okufanayo okufanayo futhi ngaphandle kokukhiqizwa kusetshenziswa ubuchwepheshe bomkhiqizo owuphawu oluyinhloko. I-firm that produces them buy a layisensi, kodwa ayisebenzisi imali ekuthuthukiseni kwabo, ukuhlolwa kwemiphumela yomuthi kanye nomkhankaso wokukhangisa, ngakho-ke intengo yesidakamizwa esijwayelekile iphansi kakhulu kuneyomuthi obhalwe uphawu.

Ngakho-ke, inkampani yaseNdiya iNatco Pharma ikhiqiza i-XPREZA emakethe yasendaweni - isizukulwane somuthi "Vaidaz", ongayithenga kusayithi WWW.ONKO24.COM . Lapha, iziguli ezinamanani angabizi zinikezwa inqwaba yemithi esekelwe esibhedlela engakwazi ukuqhubeka nokuthuthukisa ikhwalithi yokuphila kwabaguli abagulayo kakhulu.

Izici zesicelo nesilinganiso somuthi

Isidakamizwa esithi "Vaidaz" sijojowe ngaphasi kwehlombe, ithanga noma isisu. Futhi indawo yemijovo kumele ibe yinto ehlukile, futhi indawo yejojo ngayinye elandelayo kufanele ibe kude kwamaphesenti angama-2.5 ukusuka owedlule.

Sicela uqaphele ukuthi lesi sidakamizwa akufanele sijojelwe ezindaweni zokuxhumana, ukubomvu, ukulimaza noma umonakalo owodwa.

Ngaphambi komjovo we "Vaidaz", kutuswa ukuthatha izidakamizwa ze-antiemetic.

Kuzo zonke iziguli ngesikhathi sokuqala ukwelashwa, kungakhathaliseki ukuthi inani legazi lilingani, isilinganiso sokuqala singama-75 mg / m² kuwo wonke umzimba futhi siphathwa ngesonto, nsuku zonke. Khona-ke kukhona ikhefu izinsuku ezingu-21, emva kwalokho umjikelezo uphindaphindiwe.

Ngokuvamile, isiguli sidinga imijikelezo engu-6. Kodwa ukwelashwa kuqhutshwa kuphela uma ukusebenza kwethebula kubonakala, noma kuze kuvele izibonakaliso zokuqhubeka kwe-pathology.

Ukulungiselela isisombululo somjovo

Ukwenza inqubo, kubalulekile ukuchitha okuqukethwe ebhodleleni emanzini okujova (4ml). Ngemuva kokuthola ukuhlushwa kwe-25 mg / 1 ml, ukumiswa kumele kugxilwe ngamandla kuze kube yinto efanayo futhi ingaphenduki. Uma kunesidingo, ukuthola umthamo wezingaphezu kuka-100 mg, kufanele uthathe amabhodlela amabili e-Vaidaz.

Ukungafani

Kwezinye izimo, ukuqokwa kwesidakamizwa "Vaidaz" Imfundo ehlinzekwe kulesi sihloko ayivunyelwe. Njengomthetho, lokhu kwenzeka kulabo abagulayo:

• With metastases ezivamile kwesibindi;
• Ebusheni;
• Labo abanokuzwela okwedlulele kumuthi osebenzayo omkhulu wezidakamizwa noma ezinye izingxenye zawo;
• Ngesikhathi sokukhulelwa ne-lactation.

Sebenzisa ngokucophelela le mpendulo kulabo abanezifo zenhliziyo, amaphaphu, izinso nesibindi.

Imiphumela emibi

Imiphumela emibi kaningi lapho ukwelashwa nomuthi "Vaidaz", imfundo ibiza lokhu okulandelayo:

• I-nausea nokuhlanza;
• Ukuqokwa noma isifo sohudo;
• Ubuhlungu besisu;
• I-Anorexia;
• Usizi nosizi;
• Ukubuthwa, ubuthakathaka;
• I-Fever;
• Ukukhathazeka, ukuphazamiseka kokulala;
• Ukuphefumula;
• Ukubamba;
• I-Petechiae;
• I-Arthralgia;
• I-Nasopharyngitis;
• I-pneumonia;
• I-Anorexia.