Umuthi 'Celebrex ": ukubuyekezwa, analogs, yokusetshenziswa, intengo

Ukunqotshwa kwe-emgogodleni, nobuhlungu obukhulu emalungeni zezinzwa izicubu ushintsho imisebenzi ku ngemuva ukuvuvukala - ngeshwa, lezi zifo kwakungamadodana ezivamile esikhathini sethu. On eziyimbangela yalokhu kuthinta yokuphila, zingenzi lutho olunyakazisa evamile ngokomzimba, ufuzo. Ngaphezu sebuhlungwini obunzima wokuthi abantu bahlupheka kulesi simo, isifo enamandla okubhubhisa wonke umzimba, ukuma igazi chemistry ezithinta ukusebenza evamile izitho zangaphakathi.

Ngakho-ke kubalulekile ukuze kuqashwe impilo yakho kanye nesikhathi kanjani lesi sifo. Omunye imithi eminye esebenza ngempumelelo kakhulu, elingelakwaJuda iqembu izidakamizwa ezingekho steroidal ngokuthi nomuthi "Celebrex". Uphenyo odokotela ukuqinisekisa ukusebenza yayo, uma kulinganiswa nokwenu line efanayo izidakamizwa eqeda ukuvuvukala.

Umthelela eyinhloko izidakamizwa

Inzuzo zomuthi kusengathiwa ikhono layo zivimbela ukuvuvukala inqubo umsebenzi emazingeni ahlukahlukeneko wendlela isifo. Uma egazini, umuthi uyakwazi zivimbela inqubo TSOG2 eholela impumuzo ukuvuvukala. "Celebrex" Umuthi unalo impahla analgesic umsebenzi oqinile antipyretic. Ngakho-ke, hhayi kuphela aqede foci ukuvuvukala, kodwa futhi kususa kahle ngisho sebuhlungwini obunzima, kunciphisa imfiva.

Izinzuzo lo mkhiqizo zihlanganisa umphumela wawo sakugcina phezu izinhlayiya zegazi, okungukuthi, izidakamizwa akakubangeli nezinkinga nge igazi ekunqandeni. Uma uthola i-ejenti non-steroidal ukuthi akukho ukucasuka isisu namathumbu, kwanciphisa ingozi izilonda kanye neziguli kolwelwesi.

Ngakho-ke, lo "Celebrex" amaphilisi asetshenziswa kabanzi okuningi kunamanye izidakamizwa NSAID, "naproxen", "aspirin", "i-ibuprofen".

ohlangothini

"Celebrex" Amaphilisi unekhono kukunciphisele ubuhlungu bamalunga, ukuqina uziqede sibhekane ngokuphumelelayo ukuvuvukala ngokweqile. ukuchayeka okunjalo kungenzeka njengamanje ekwelapheni iziguli ukuthi nginesifo i-rheumatoid arthritis, i-osteoarthritis. Effect zomuthi ifinyelela umphumela ibihamba amahora 24-48 emva komthamo wokuqala. Dysmenorrhea izidakamizwa ngempumelelo aqede ubuhlungu, ngisho acute kakhulu. Futhi, it is ngempumelelo esetshenziselwa ngempumuzo ubuhlungu emva kokuhlinzwa (maxillo-ebusweni kanye udokotela wamathambo).

Iziguli ankylosing spondylitis izidakamizwa "Celebrex" ugwema izinqubo sokugembula futhi kuthuthukisa ikhono lomzimba ukusebenza. Lapho sigcina Dynamics emndenini adenomatous polyposis ukusetshenziswa kwezidakamizwa eyabangela ukuncipha okukhulu ngo ukukhula polyp e kapopopo duodenum: ukunciphisa isibalo sabo kanye nosayizi. Odokotela bathi ngemithamo ezanele imithi futhi ukunamathela ekwelashweni zemithi ingafinyelela imiphumela emihle kakhulu nokusetshenziswa "Celebrex" izidakamizwa. Nobufakazi ukukhombisa sakugcina side effects ngenkathi kokuthatha lesi imithi.

Ukuma kanye nendlela okwakheke ngayo izidakamizwa

Kakhulu inhibitor sikhethe capsule gelatin awube mhlophe noma elimhlophe, awayona esobala futhi ziphawulwe emapheshana blue esibhalwe ukuthi "7767" ngakolunye uhlangothi kanti "100" futhi "200" ngakolunye. okuqukethwe Capsule: granulated Umbala omhlophe.

Ukwakheka izidakamizwa zihlanganisa: celecoxib (isithako eyisisekelo), i-lactose, povidone K30, sodium lauryl sulfate, magnesium stearate, sodium croscarmellose. Igobolondo yenziwa ama-titanium dioxide, futhi gelatin ezidliwayo. Uma abaphathi ezifanele zomuthi imijovo intramuscularly bamiswe "Celebrex". Lolu hlobo imithi kukhishelwa ngesimo isixazululo umjovo we-2.2 ml ampoules - ikhemikhali eyisisekelo celecoxib.

Pharmacokinetics

Umuthi wayegxile sibalelwa igazi esimweni ukudla futhi ifinyelela ukusebenza esiphezulu emva amahola angu 2-3 ukufunda. Nokho, ukusetshenziswa izindlela kanye nokudla okunamafutha kungasibambezela ekuqongeleleni yayo for 1-2 amahora. Ngakho-ke kubalulekile ukuba nodokotela asikisele isikhathi sokuthatha imithi.

Uma esegazini, izinto asebenzayo musa ukuhlanganisa uxhumano nomsebenzisi abomvu egazi, kodwa lo mshini akuphazamisi ekuzuzweni kwemiPhumela lokuhlushwa oyifunayo zomuthi emzimbeni. Izidakamizwa akheka esibindini ngu namachibi futhi glucuronidation ezihilela CYP2C9 enzyme. Lokukhipha kusho nge umchamo futhi indle ngendlela metabolites elula, futhi-3% kuphela ayinto asebenzayo uhlala ingashintshiwe.

Izidakamizwa "Celebrex", analogue zazo zifana ukubunjwa, wathola izindlela, owabangela umonakalo okuncane impilo, ngenxa yekhono layo ukuze ugxile ngangokunokwenzeka futhi cishe iqedwe ngokuphelele emzimbeni. With somzimba waphawula lokuhlushwa ephakeme kwezidakamizwa egazini, futhi lesi simo siyenzeka ezingaphezu kuka kwabesifazane. Akwaziwa ukuthi kungani, kodwa futhi abantu abamnyama waphawula Dynamics efanayo. Ngakho-ke, la maqembu iziguli ebekiwe umthamo engezansi imithi ekuqaleni ukwelashwa.

izinkomba

Njengoba non-steroidal anti-inflammatory ejenti ukuze izidakamizwa ukwelashwa lingaze okunqunyiwe "Celebrex". Izinkomba ukusetshenziswa:

• rheumatoid arthritis;
• osteoarthritis;
• spondylitis;
• algomenorrhea;
• ahlekise (kwezikhathi zokulotshwa-op, iqolo, izifo zemisipha);
• esetshenziswa ekwelashweni kwe-adenamotoznogo polyposis.

Kufanele kuqashelwe ukuthi ukwelashwa okufanele kungaba kuphela nika udokotela ngesisekelo socwaningo.

Izindlela zokuphatha izidakamizwa

Ukuthatha izidakamizwa kumelwe ibe ngaphakathi, kungakhathaliseki ukuthi ukudla. amaphilisi Chewable akufanele kube, udinga ukuba baphuze amanzi plain. Kufanele kuqashelwe ukuthi izinkinga zenhliziyo singenzeka nokuphathwa ezingamahlalakhona zomuthi. Ngakho-ke, odokotela ukunquma "Celebrex" esikhathi esifushane ukwelashwa. ochwepheshe lezivakashi ukuqinisekisa ukuthi umthamo esiphezulu ukuze athole ukwelashwa eside kumele singeqi 400 mg ngosuku!

• Ukwelashwa osteoarthritis - ezanele umthamo kuyinto 200 mg ngosuku. Ithuba umthamo owodwa noma waqhekeka waba ezimbili (ngezikhathi ezithile).
• Rheumatoid arthritis - umthamo okulindeleke mg 100 noma 200 ukuba izikhathi 2 ngosuku. Lapho amafomu olunzima - kuze kufinyelele 400 mg kabili ngelanga.
• Ankylosing spondylitis - 200 mg ngelanga, 1 noma 2 ngemithamo ahlukaniswe. Ngokuzikhethela udokotela angase umthamo senyukela uvikelekile ngokwanele
• Dysmenorrhea nobuhlungu eqinile - iqala ukwelashwa nge 400 mg ngelanga futhi wanezela nesinye mg 200 ngosuku lokuqala okwelashwa, uma kunesidingo. Ezinsukwini ezilandelayo, kumele uthathe mg 200 kabili ngosuku.

Ubude besikhathi sokwelashwa kunqunywa udokotela ukuba khona.

Izimo ukusetshenziswa kwezidakamizwa

Ngaphezu kungenzeka komzimba nezinto nabavoti zomuthi, khona imingcele banqatshelwe usebenzisa izidakamizwa "Celebrex" ngaphansi kwazo:

1. isifuba somoya bronchial, urticaria, iguliswa nezinye ama-NSAID.
2. Isikhathi nasezinkingeni ezilandela ngemva kokuhlinzwa emva aortkoronarnogo dlula.
3. isilonda peptic (exacerbation).
4. GI ukopha.
5. Okuvuthayo wamathumbu isifo.
6. ukuhluleka Inhliziyo.
7. Sinzima esingamahlalakhona hepatic.
8. esingamahlalakhona kwezinso.
9. Nokukhulelwa kanye lactation.
10. Akunconyelwe ukusetshenziswa kweminyaka engu-18.
11. Hypersensitivity ukuze nabavoti zomuthi kanye sulfonamides.

Okumele kuqashelwe kufanele asebenzise izidakamizwa kanye nokugcinwa uketshezi emzimbeni, izifo kohlelo eziphathelene nenhliziyo, isifo sikashukela.

side effects

Naphezu potency high zomuthi, isikhathi eside noma azilungile reception imodi umthamo kungaba imiphumela emibi izidakamizwa "Celebrex". Nobufakazi ukukhombisa ezivamile (njalo) izimpawu ezifana:

• komzimba kuhlanganise amawala, urticaria, pruritus.
• Ukubuyisa, dyspepsia, edema, ukuqwasha.
• Khwehlela, rhinitis, Umkhuhlane-like ukusabela kanye zokuphefumula ipheshana izifo.
• Pheshana urinary nezifo.

Kakhulu kangakanani kukhona anda ukukhathazeka, ukuntuleka kwegazi emzimbeni, tinnitus, ukushiselwa, arrhythmia, unomfutho wegazi ophakeme. Ezinye iziguli zalotshwa ulceration ka ipheshana wokugaya ukudla, edema angionevropatichesky, ukwakheka bulla esikhumbeni, exacerbation of pancreatitis noma sokuthuthuka, ukudideka. Zonke lezi zimpawu singenzeka kuphela lapho Inkambo yokwelashwa kuyinto kafushane (amasonto 12, esingeqile 800 mg umthamo ngamunye). Kodwa endabeni yokwelashwa eside (eminyakeni engu-3) kuyagcinwa:

• Ezivamile: ukukhungatheka ngezinsimbi zesihlalo, umfutho ophakeme wegazi, izifo kwezindlebe, angina, isilethikusebenza, isicanucanu, dysphagia, prostatitis, creatinine anda.
• Okuningi ezingavamile: arrhythmia, angina, unhlangothi ischemic, isifo sokuqina kwemithambo yegazi, unenkinga, ukopha lwesitho sangasese sowesifazane, izilonda emlonyeni, dysmenorrhea, ukwanda elithwala umoya-mpilo, ukwehla hematocrit.

Ukuxhumana zomuthi nezinye izidakamizwa

I nomuthi ngenkuthalo biotransformed ezihilela P450 2C9 (cytochrome). Ngakho Kungenzeka ukuxhumana ngqo zomuthi namanye amanxusa:

1. ukusetshenziswa concomitant izidakamizwa "Warfarin" kwandisa ingozi ukopha ebulalayo.
2. Ukulungiselela "Ketanazol" futhi "fluconazole" ukwandisa lokuhlushwa asebenzayo izidakamizwa celecoxib sikhiqize inani eliphindwe kabili.
3. Ukuthola blocker noma ACE inhibitor ama-NSAID angiotenzita kungase kuzinciphise umphumela yabo antigipertinzivny
4. imikhiqizo Inhlanganisela equkethe lithium, kungaba ukwandisa ezingeni igazi.
5. Akuvunyelwe kanyekanye ukusebenzisa izidakamizwa "Celebrex" analogs equkethe celecoxib, nezinye ama-NSAID!

izidakamizwa analogue

Kuyaphawuleka ukuthi "Celebrex" izindleko izidakamizwa hhayi kakhulu, intengo salo ngokwesilinganiso ruble 400 450. 10 amaphilisi (100 mg umthamo). Nokho, ukwelashwa okunjalo ngempela eqolo ukulapha lesiguli eside. Kulokhu, kwemvume udokotela, ukhombe ejenti equkethe celecoxib. Ukuze izidakamizwa "Celebrex" analogue kokulandelayo:

• izidakamizwa "Ranselak";
• izidakamizwa "Revmoksib";
• amaphilisi "Flogoksib";
• capsule "Artoksib".

Lezi analogs aqukethe ketshezi asebenzayo efanayo futhi abe ithonya kakhulu ezifanayo zokwelapha ekwelapheni izifo. Qaphela ukuthi i-umthamo ezanele i Analogue esabelwa futhi kuphela udokotela ukuba khona. Kulokhu udokotela uyazicabangela nezinsiza yenziwe ngohlobo oluhlukile e analogs, ziqukethe izithasiselo ehlukahlukene njengoba kuqhathaniswa izidakamizwa "Celebrex". Ukufundiswa libuyekeza odokotela basikisela ukuthi kungenzeka ukusabela iguliswa yisiguli kuya excipients imithi ehlukene neqembu elilodwa.