Ukwanda kwe-lactate dehydrogenase: kubangela, ukwelashwa

Ezweni lanamuhla, isayensi ayimi. Izifo zihlolisiswa ngokucophelela, futhi ososayensi bafuna izindlela zokubhekana nazo. Odokotela bavame ukubala ukuba bahlole izivivinyo ezingaqondwa abantu abavamile, kodwa lo mphumela ungaqinisekisa noma uphike ukwesaba kukadokotela. Ngakho ukuhlaziywa kwe-LDH, futhi ikakhulukazi ukwanda kwe-lactate dehydrogenase kukhuluma okuningi. Kuyini, futhi yimiphi imiphumela, sizokhuluma ngokuqhubekayo.

Kuyini i-LDH

I-dehydrogenase yama-lactate ingenye ye-enzyme ebonisa ukuthi kukhona amangqamuzana awonakele. Itholakala kokubili egazini nasemathisini ngezilinganiso ezahlukene. Endleleni yokuphefumula, amaseli abumba usawoti we-lactic acid. I-liquate dehydrogenase ikhuthaza ukushintshwa kwayo ku-pyruvic, okubandakanya inqubo ye-oxidation ephezulu. Ikhuthaza ukukhululwa okusheshayo kwegesi kusuka ku-glucose, okudingekayo ukuze i-muscle contraction, inkambo yezinqubo zemvelo. Umphumela uba yimikhiqizo esuswa kalula emzimbeni - i-carbon dioxide namanzi. Uma kukhona oksijini okwanele, i-enzyme iqoqa, ukuvela kwe-pathologies kuyasheshisa ukubola kwamaseli. Zizoholela eqinisweni lokuthi i-lactate dehydrogenase yanda. Lo mbonakaliso uzwela kakhulu ekubhujisweni kwezinhlaka zamaselula.

I-dehydrogenase ye-lactate, uma ihlelwe ngendlela yokunciphisa inani, itholakala ezingxenyeni nezicubu ezinjalo:

• Ezingweni.
• Imisipha yenhliziyo.
• I-musculature yama-squelette.
• Ama-pancreas.
• Ipeni.
• I-laboratories yamakhemikhali yomzimba wethu yisibindi.
• Ukukhanya.
• E-serum yegazi.

Izinhlobo ze-LDH

I-enzyme lactate dehydrogenase inezinhlobo eziningana ezihlukile komunye nomunye ngama-isoenzymes, futhi zitholakala ezinhlobonhlobo ezahlukene. Kuncike ekugxilweni okukhulu kwe-isoenzyme kulokhu noma kuleso sitho, kunezinhlobo zalesi enzyme:

• I-LDG-1 - ikakhulukazi enhliziyweni nasezigungwini zegazi.
• 2 - ku-leukocytes.
• 3 - emathangeni amaphaphu.
• I-LDH - 4 - iningi ezinsoweni, i-placenta, i-pancreas.
• 5 - etholakale esibindi nasesiswini somzimba.

Ngenxa yalokhu, kungaphetha ngokuthi i-isoenzyme iphakamise izinga le-LDH, futhi inqume lesi sifo.

Uma lokhu kuhlaziywa kunikwa

Kunezimo eziningana lapho kudingeka khona ukulawula izinga le-LDH:

• Ezifweni zesistimu ye- hepatobiliary.
• Ngemuva kwe-infarction ye-myocardial.
• Uma kutholakala izicubu ezahlukene.
• Uma kubalulekile ukunquma uhlobo lwe-anemia.
• Ezifweni nge-hemolysis ephakeme.
• Ngezinhlungu ezibukhali emkhakheni we-thorax.
• Uma kukhona izilonda zesibindi noma izinso.
• Ukuze uhlolwe izicubu namasipha emva kokulimala noma ukugula.

Ithonya lezinto ezibangelwa ukuhlaziywa

Uma udokotela esolwa ukuthi uphakamise i-lactate dehydrogenase, ukuhlaziywa kuphela kungakuphikisa noma ukuyiqinisekisa.

Ukuhlolwa kwegazi kwe-LDH kwenziwa ekuseni ngesisu esingenalutho. Igazi lisuswa emthanjeni. Ngaphambi kokuya ekamelweni lokunakekelwa, akudingeki ukudla okukhethekile. Kudingeka kuphela ukwazi ukuthi kunezici ezingaphazamisa umphumela. Yini engathinta ukunemba komphumela wokuhlaziywa:

1. Ukungena kwe-vitamin C kunganciphisa izinga le-LDH egazini.
2. Ukusetshenziswa kwe-electropulse therapy ngesikhathi sokuhlaziya.
3. Izinkinga zesikhumba.
4. Okuqukethwe kotshwala kwegazi.
5. I-Thrombocytosis.
6. Ukusetshenziswa kwe-hemodialysis.
7. Ezinye imithi, njenge-"Aspirin", "iMithramycin", i-anesthetics, i-fluorides ingandisa izinga le-enzyme.
8. Umsebenzi owenziwe ngokweqile.

Lezi zici zingathinta umphumela, kepha lokhu akusho ukuthi umzimba unenqubo yokwelapha.

Ngaphambi kokuthola okuqukethwe kwe-enzyme egazini lakho, udinga ukubonana nodokotela, yiziphi izidakamizwa okufanele zikhanseliwe ngaphambi kokuba uye esibhedlela.

Kubaluleke kakhulu ukuthutha nokugcina igazi ngendlela efanele, ngoba ukungahambisani nokuholela kungabangela i- hemolysis yegazi, futhi ngenxa yalokho, ukwanda kwe-lactate dehydrogenase.

Izindinganiso ezijwayelekile ze-LHG kubantwana nakubantu abadala

Okuqukethwe kwe-lactate dehydrogenase kuyashintsha ngobudala. Umuntu omdala umuntu uba, abaphansi bayaba. Ngakho, ukuhlushwa kwe-LDH:

• Izinsana - kufika ku-28.9 mk / litre.
• Kusukela ku-1 unyaka kuya eminyakeni engu-3 - kufika ku-14.2 mkat / l.
• Kwabafana abaneminyaka engama-7 ukuya eminyakeni eyi-12 - kuze kube ngu-12.7 mkat / l.
• Amantombazane aphakathi kweminyaka engu-7 kuya ku-12 - kuze kube ngu-9.67 mk / litre.
• Amadoda - kufika ku-11,4 mkat / l.
• Abesifazane - kufika ku-7.27 mk / litre.

Izinkomba ze-LDH zingaba ziphakeme futhi ziphansi kunokujwayelekile.

Ukwanda kwe-lactate dehydrogenase - izimbangela

Izinga eliphezulu liyabonakala kwabesifazane abakhulelwe futhi ngokuzikhandla ngokweqile ngokomzimba.

Uma, ngenxa yokuhlaziywa, i-dehydrogenase ye-lactate yanda. Izizathu zalokhu ukuthuthukiswa kwalokhu okulandelayo:

• I-infarction ye-myocardial.
• Izifo ezithathelwanayo zesibindi.
• I-cirrhosis yesibindi.
• I-oncology.
• I-pancreatitis enhle.
• Izifo ezithathelwanayo zezinso.
• I-anemia.
• I-leukemia.
• Izimo lapho kukhona ukubola okukhulu kwe-cell: ukushuswa, hypoxia enamandla, ukushisa okukhulu kwendawo.
• Ukulimala okukhulu.
• Izifo ze-muscular system.

Noma kunjalo, lokhu kuhlaziywa akuqinisekisi nje ukuthi kukhona ukukhubazeka emzimbeni. Ukuhlolwa okwengeziwe kuyadingeka. Ngokutadisha umsebenzi we-isoenzymes, isazi sizokwazi ukukhomba ukuthi lesi sifo sendawo.

Inani lezinhlawulo ze-LDH isoenzyme

Uma sicabangela ngokuningiliziwe ukwanda kwe-lactate dehydrogenase yohlobo oluthile, kungenzeka ukuthi sibone ukuthi kungenzeka yini ukuthuthukisa izifo.

Ukwanda kwe-LDH-1 noma i-LDH-1 / LDH-2 isilinganiso kungenzeka ngaphansi kwezimo ezilandelayo:

• I-infarction ye-myocardial elula.
• I-anemia ye-hemolytic megaloblastic.
• I-necrosis eqondile yezinso.
• Lapho kukhona izicubu zesicansi sobulili besilisa nabesifazane.

Ukwanda kwe-LDH-5 kuyisici lapho:

• Izifo zesibindi.
• I-Cancer.
• Ukulimala kwemisipha yamathambo.

Ukwanda kwe-LDH-2 ne-LDH-3 kuvame ukugcinwa lapho:

• I-Ostrom leukemia.
• Granulocytosis engapheliyo.

Ukwanda kwe-LDH-3, mhlawumbe ingxenye ye-LDG-4 ne-LDG-5, kungenzeka, uma kukhona:

• Isifo sezinso.
• Ukumbumbuluzela kokuzibamba.
• Ukuhluleka kwenhliziyo, ukuthuthukisa nokubandakanya amathishu emaphaphu.

Ukwanda kwe-LDH-4 LDG-5 kuyatholakala uma kutholakala ukuthi:

• Ukuhlukumeza kwegazi ngenxa yomsebenzi wezinhliziyo ezimbi.
• Ision kwesibindi.
• Ukulimala kwemisipha.

I-LDH ezinganeni

Uma sikhuluma ngezingane, kufanele sicabangele ubudala bomntwana. Izingane ze-LDH rates ziphakeme. Futhi, ngaphambi kokuya kudokotela, kubalulekile ukuthi ulandele ukuthi yiziphi amalungiselelo ingane ezithathayo futhi ugcine umsebenzi wakhe womzimba. Uma i-lactate dehydrogenase yanda emntwaneni, izimbangela zingabangelwa enye ye-pathologies echazwe ngenhla. Kumele kukhunjulwe ukuthi uma ingane isifo sofuba, ingathinta futhi umphumela, ikakhulukazi ngokukhulunywa nge-eczema noma ubuhlungu besifo somzimba. Ukulimala kanye nemivimbo kungaphazamisa ukuhlaziywa, kanye nokutholakala kwe- anemia enganeni.

Uma umphumela wokuqala uphakeme kunokujwayelekile, udinga ukubuyisela ukuhlaziywa ukuqinisekisa ukuthi kunembile. Uma kunjalo, i-lactate dehydrogenase yanda enganeni, khona-ke ukuhlolwa okuphelele kuyadingeka. Omunye lo mbonakaliso awunikeli ilungelo lokuthola ukuxilongwa kokugcina nokuqokwa kokwelashwa.

Ukwelashwa kwezifo kanye nezinguquko ku-LDH

Uma ukwanda kwe-lactate dehydrogenase, ukwelashwa kwesifo kunganciphisa kancane kancane le nkhomba.

1. Ezingxenyeni ezinkulu ze-renal i-LDH yanda, isifo esingapheli sesifo sihlala sivamile. Ikhula ngemva kwe-hemodialysis.
2. Njengoba i-cirrhosis yesibindi ne-hepatitis engapheli, izindinganiso ze-LDH zivamile, ngesikhathi sokukhushulwa kwesifo, amanani akhula.
3. Nge-anemia, i-LDH isetshenziselwa ukuxilongwa ngokuhlukana.
4. Ngesifo senhliziyo, i-LDH iphakama, futhi emva kwezinsuku ezingu-10-14 ibuyela emuva evamile. Ukulawula le enzyme kuvumela udokotela ukuhlaziya inkambo yokwelapha.

Uma kuqala isifo se-lactate dehydrogenase, ukwelashwa okuphumelelayo kwe-anemia, i- leukemia, izifo zesisu, umsebenzi we-LDH wehla.

Lokhu akulona ukuhlaziywa okulula, okuyinto iningi lethu lingacabangi. Futhi yena, kuvela, angatshela okuningi kudokotela olaphayo.