Ama-antibiotics e-fluoroquinolones - abadlali abasebenza ngokuzikhandla ngempilo yakho

Ngo-1962, lapho izidakamizwa zokuqala zalesi sikole zivela, akekho obikezela impumelelo enjalo. Zakhiwe njengendlela yokwelapha izifo ze-urogenital tract, kodwa kamuva zaba izidakamizwa ezithandwa kakhulu. Ekusebenzeni kwezokwelapha leli qembu lezidakamizwa laqala ukusebenza ngokugcwele kuphela kuma-80s ekhulu lama-XX. Namuhla, ama-antibiotic e-fluoroquinolone asemqoka kakhulu ekwelapheni izifo zokuphefumula. Engxenyeni yeRussia, ukuhlukaniswa komhlaba wonke kwalezi zinhlobo zama-antibiotics ngezizukulwane kuyathandwa. Kodwa, ngeshwa, lokhu kuhlukaniswa kwamalungiselelo akuvumeli ukukhomba ukubunjwa kwawo kwamakhemikhali kanye nesenzo sezinyathelo. Ngakho-ke, kaningi mayelana ne-fluoroquinolones (ama-antibiotics) akhulunywa, ahlukanise amaqembu amabili - endala futhi amasha.

Ukuhlukaniswa kwemithi

Imithi yeqembu elidala ihlanganisa izidakamizwa "i-Ofloxacin", "i-Enoxacin", "i-Ciprofloxacin" nabanye. Ama-antibiotic amasha imithi "Sparfloxacin", "Klinafloxacin", "Moxifloxacin". Kodwa-ke, eminye yemithi ethuthukile ayisakhuliswa, njengoba ososayensi betholakale benemiphumela emibi kakhulu lapho basebenzisa.

Ukusetshenziswa kwama-antibiotics

Leli qembu lemithi selisetshenziselwa izifo ze-urinary system, izifo zamathumbu kanye nezifo ezithathelwana ngocansi. Ukuze ukwelashwa kwezifo zokuphefumula, i-fluoroquinolones ayifuni ukusetshenziswa kaningi, nakuba iyakwazi ukuthinta kakhulu izinhlobo ezithile zezifo eziphilayo.

Imiphumela yezidakamizwa

Ama-antibiotic ama-fluoroquinolones aphethwe ngokuphelele yi-tract emathunjini futhi aphezulu agxila emaqenjini amakhemikhali amahora amathathu emva kokusebenza kwawo. Uma udla ngesikhathi esisodwa, ukumunwa okusebenzayo kuzophuza kancane, kodwa isenzo sizobe sisasebenza. Indlela yokwenza izidakamizwa ukuvimbela i-DNA-gyrase ne-topoisomerase IV ye-microbes, ngakho-ke akukho ukulwa nokulwa nezinye ama-antimicrobial agents. Ngokuvamile basebenzisa la ma-antibiotics ezinkingeni zokubeletha (izifo zesimiso sokuzala), ikakhulukazi ngokuvuvukala kwezitho zomzimba, okuvela ngenxa yomsebenzi wezinyunyana ezincane ezifaka umkhondo wesigcawu esingaphezulu. Kutuswa ukuthatha i-quinolones kwisisu esingenalutho, nakuba kuvunyelwe ukuyisebenzisa ngemva kokudla.

Imiphumela emibi

Ama-antibiotics fluoroquinolones azinakekelwa kahle uma elayishwa futhi enomjovo ongenalutho. Ukusabela okubi kwenzeka kaningi, kepha uma kubonakala, kuvame ukuthinta umsebenzi wegciwane lokugaya nokusebenza kwesistimu yezinzwa. Kungase kube nesicefe, isifo sohudo, ikhanda, isizungu, ukuxubana, ukwesaba. Ngokuvamile, leli qembu lemithi elwa namagciwane libhekwa nemingcele ehle kakhulu ye-pharmacokinetic.

Izigaba eziyinhloko zesenzo se-fluoroquinolones

1. Ukungenelela nge-membrane ibe esitokisini.
2. Ukuvinjelwa kwe-DNA-gyrase enzyme.
3. I-biosynthesis ye-DNA.
4. Ukubhujiswa kwe-algorithm yesigaba se- cell.
5. Ukushintsha isakhiwo seseli.
6. Ukufa kweseli.

Leli qembu lama-antibiotics lisetshenziswe kakhulu emithi, futhi ngokusebenzisa kahle linganikeza ukusekelwa okuphumelelayo empilweni yabantu.