Prokinetics: uhlu ohlotsheni olusha lwemithi

Okwamanje, imbangela evamile ukuvakashela odokotela - lawa izinkinga pheshana emathunjini. Cishe ngamunye wabo elinesimo kokunikezwa kwe-umsebenzi motor. Noma kunjalo, bangase balwisane njengoba izimpawu zokungenwa ukugula ongakaphathelani isimiso sokugaya ukudla bungene. Kunoma ikuphi, ngeke akwenze ngaphandle prokinetics izidakamizwa iqembu. Uhlu izidakamizwa kuleli qembu akuyona nohlaka eqine. Ngakho-ke, zonke udokotela ukhetha sokulungiselela yabo, kuye ngokuthi isifo. Ngokulandelayo, sihlolisise, lokho prokinetics, uhlu imikhiqizo emisha-isizukulwane, kuvame kakhulu ukuba kusetshenziswe i-ukwelashwa.

Prokinetics: izici jikelele

Izidakamizwa ukuthi ukushintsha umsebenzi motor yaleli pheshana emathunjini bese ukusheshisa ukudla zokuhamba kanye inqubo lokuchitha, nje bangabanye leli qembu.

Njengoba kushiwo ngenhla, uhlu olulodwa kulezi kwemithi Gastroenterology izincwadi alikho. Njalo udokotela lapha ihlanganisa nohlu lwezinkanyezi izidakamizwa. Lezi zihlanganisa izidakamizwa, kanye namanye amaqembu, ezifana antiemetics, antidiarrheals, futhi abanye imithi elwa namagciwane macrolide, peptides hormone. Ukuze uqale ukuthola ukuthi kunani isenzo kwemithi yaleli qembu izidakamizwa.

isinyathelo prokinetic

Okokuqala ziyokuthuthukisa le motility ipheshana wokugaya ukudla, kanye ifa umphumela antiemetic. amalungiselelo anjalo ukusheshisa bethulula isisu namathumbu, ngcono imisipha ithoni ipheshana wokugaya ukudla, zivimbela pyloric futhi Reflux oesophageal. Prokinetics esinikezwa monotherapy noma inhlanganisela nezinye izidakamizwa. Abakwazi ihlukaniswe izinhlobo eziningana ngokuvumelana nesimiso yesenzo.

izinhlobo prokinetic

Isimiso wokusebenza izingxenye ezahlukene pheshana emathunjini kuhlukile izidakamizwa ezifana prokinetics. Uhlu izidakamizwa kufanele ihlukaniswe lezi zinhlobo ezilandelayo:

1. blocker ka Dopamine receptor:

• 1st okukhethwayo kanye isizukulwane 2nd.
• Nonselective.

2. abamelene 5-HT3 receptor.

3. agonists 5-HT3 receptor.

Futhi manje kabanzi ngalezi amaqembu.

Dopamine yokwamukela blocker

Izidakamizwa kuleli qembu zihlukaniswe sokukhohlwa non-abakhethayo. umphumela wabo ukuthi kukhuthaza motor umsebenzi esiswini nilidle izakhiwo antiemetic. Kuyini prokinetic? uhlu izidakamizwa simiswe ngalendlela lelandzelako:

• "Metoclopramide".
• "Bromopride".
• "Domperidone".
• "Dimetpramid".

The main isithako - metoclopramide, babesebenzisa lona ukuze isikhathi eside. Isenzo simiswe ngalendlela lelandzelako:

• Ukwandiswa umsebenzi ephansi sphincter ngomphimbo.
• Ukusheshisa bethulula esiswini.
• Ukwanda izinga ukunyakazisa ukudla ngokusebenzisa emathunjini amancane futhi ikholoni.

Nokho, izidakamizwa ezingekho abakhethayo kungase kubangele eyaba nemiphumela emibi.

Kukhona isizukulwane owaziwa lokuqala prokinetics. Uhlu izidakamizwa:

• "Reglan".

• "Raglan".
• "Perinorm".
• "Tseruglan".

Omunye nemiphumela ethile engathandeki yikhono kubangele izimpawu zesifo isifo i-Parkinson e abadala ezinganeni dyskinetic syndrome, iziyaluyalu kokuya esikhathini kwabesifazane.

Ngu abakhethayo izidakamizwa lesibili isizukulwane yizidakamizwa ne esebenzayo izidakamizwa domperidone. Le mithi musa baxabane ezinzima ezingezinhle, kodwa kungenzeka ngaphezulu:

• Ukozela.
• Ubuthakathaka.
• Ukukhathazeka.
• Ubuhlungu bekhanda.

Kungenxa yalesi sizathu ukuthi izidakamizwa kanye asebenzayo izidakamizwa domperidone - prokinetics engcono. Uhlu izidakamizwa:

1. "Motilium".
2. "Domidon".
3. "Motinorm".
4. "Motoriks".
5. "Gastropom".

Isizukulwane esisha prokinetics

Ngu isizukulwane abakhethayo yesibili ejenti prokinetic zihlanganisa esebenzayo izidakamizwa itopride hydrochloride. izimali ezinjalo baqashelwa sibonga kakhulu umphumela zokwelapha kanye ukungabikho side effects, ngisho ukusetshenziswa isikhathi eside. Ngokuvamile, odokotela linqume:

• "Itomed".
• "Ganatom".
• "Itopride."

Lokhu zingachazwa ngezinqubo sezindawo ezinhle hydrochloride itopride:

1. Ngcono motor futhi baphume umsebenzi esiswini.
2. Ukwandisa kwesinye nenyongo.
3. Khulisa lobubhalo kanye ithoni kwemisipha ezincane nezinkulu emathunjini.
4. Nyusa nokuqedwa ka Reflux duodenal.

prokinetics emathunjini

Lezi zihlanganisa prokinetics - agonists 5-HT3 receptor. I asebenzayo izidakamizwa - tegaserod. It has a nethonya elihle motor futhi baphume umsebenzi kapopopo emathunjini amancane. Kunomthelela ukuzinza kwesitulo, kunciphisa izimpawu of wamathumbu engaphathekile.

Akukona kubangele ukwanda ingcindezi akunamthelela yisimiso senhliziyo nemithambo yegazi. Nokho, kukhona inombolo ezanele amathuba okuba nemiphumela engemihle. Ngezinye izikhathi eziningana kwandisa ingozi yokushaywa unhlangothi, pectoris angina, zokuhlasela anginal. Okwamanje, imithi ngalolu ketshezi esebenzayo ikhishiwe ukusuka ekukhiqizeni bantfu eliveni lakitsi kanye kwamanye amazwe nezifundo. Lokhu kufaka prokinetics ezilandelayo (uhlu izidakamizwa):

• "Tegaserod."
• "Zelmak".
• "Fractal".

Abamelene 5-NTZ receptor

Prokinetics leli qembu ofanele ukwelashwa kanye nokuvimbela isicanucanu nokuhlanza. Ngezinye reception yabo kunciphisa isikhathi sokuhlala ukudla esiswini, kukhuphuke isivinini ukudla zokuthutha umphakathi ngokusebenzisa amathumbu, normalizes ithoni ikholoni.

Kube acetylcholine ukukhululwa, kanye motor umsebenzi ngcono pheshana emathunjini. Okwamanje bayindlala kakhulu phakathi iziguli odokotela namuhla prokinetics. Uhlu izidakamizwa isizukulwane esisha:

• "Tropisetron."
• "Osetron".
• "Ondansetron".
• "Silansetron".

Kufanele kuqashelwe ukuthi abamelene 5-NTZ receptor ungenalo nomphumela oqabulayo, uma ukuhlanza kubangelwa apomorphine.

Le mithi bubekezelelwa kahle, nakuba kukhona neminye imiphumela emibi:

• Ubuhlungu bekhanda.
• Ukuqunjelwa.
• Flushing.
• ukushisa komzimba.

Enye plus le mithi - abanayo nomphumela okulalisayo, musa uxhumana neminye imithi musa zibangela ushintsho endocrine ukuthi ingangqubuzani umsebenzi motor.

Yikuphi izifo ukhombe

Njengoba kuchazwe ngenhla, prokinetics elisetshenziswa monotherapy noma ngokuhlanganyela antibiotic. Odokotela bazi ukuthi kukhona izifo lapho ukuqashwa kukaNksz prokinetic izikhathi eziningana kwandisa ukuphumelela ukwelashwa. Kuleli qembu yilezi:

1. Izifo wokugaya ukudla nge kahle motor umsebenzi.
2. Gastroezofagelnuyu isifo Reflux.
3. Esiswini (isilonda duodenal).
4. gastroparesis Idiopathic.
5. Ukuhlanza.
6. Ukuqunjelwa.
7. Engaphathekile wamathumbu syndrome.
8. gastroparesis Diabetic.
9. Ukubhodla.
10. Isicanucanu ezibangelwa ukusebenzisa izidakamizwa futhi emisebeni yokwelapha, ukutheleleka, iziyaluyalu ukusebenza, ukungondleki.
11. Dyspepsia.
12. dyskinesia Biliary.

Ubani akufanele bathathe

Ukuze amalungiselelo prokinetics kukhona contra-izinkomba:

• Hypersensitivity ukuze ketshezi asebenzayo.
• Isisu noma ukopha emathunjini.
• Perforation isisu noma amathumbu.
• Ileus.
• yokwehluleka kwesibindi olunamandla, izinso, iziyaluyalu.

Hhayi reception Kunconywa, uma umsebenzi kudinga ukugxila okukhulu kanye okuhlushwa, kanye nalabo oshayela imoto. Ngokunakekela linqume prokinetics abadala.

omama abakhulelwe nabancelisayo

A amazwi ambalwa ngifuna ukusho mayelana nokuthatha imithi ngesikhathi sokukhulelwa. Ucwaningo luye lwabonisa ukuthi prokinetics bathambekele ukungena ubisi lwebele, ngakho kwesikhathi yokwelashwa nalezi imithi akufanele uqhubeke ibele.

Ngo senyanga yokuqala kwabakhulelwe abesifazane ngokuvamile ukuhlanza nesicanucanu. Kulokhu, ungakwazi babela le mithi njengoba prokinetics. Uhlu imikhiqizo kwabesifazane abakhulelwe Kuyoba kuhlanganisa kuphela labo abangenawo ziyingozi empilweni owesifazane okhulelweyo umbungu.

Inzuzo ngayo idlule zonke izingozi kunokwenzeka. Prokinetics metoklopromid ne-ejenti asebenzayo lingasetshenziswa kuleli qembu kuphela kadokotela. Trimesters kamuva yokukhulelwa prokinetiki hhayi oqokwe.

Okwamanje, leli qembu izidakamizwa ngesikhathi sokukhulelwa aluboniswa ngenxa inani elikhulu amathuba okuba nemiphumela engemihle.

Prokinetics izingane

Prokinetics zisebenze esebenzayo isithako metoclopramide ezinganeni kufanele sobenno ngokuqapha, njengoba kukhona ingozi okuvela dyskinetic syndrome. It ezinqunyiwe kuye isisindo sengane.

Uma udokotela wezingane ukhombe prokinetics, "Motilium" ngokuvamile afakwe ohlwini. Ubizwa kahle kubekezelelwe futhi has a lot of okubuyayo. Kodwa kungenziwa tinkhulumo kulamanye prokinetics. Uhlu izidakamizwa izingane ingaqukatha gama elilandelayo okwamanje:

• "Domperidone".
• "Metoklopromid".

Kuyaphawuleka ukuthi izingane ezingaphansi kweminyaka engu-5 ukulungiselela "Motilium" Kunconywa ukuba isetshenziswe ngendlela ukumiswa. Umuthi ezinqunyiwe kuye isisindo ingane, ngesilinganiso 2.5 ml ngayinye 10 kg bodyweight. Uma kudingeka, umthamo zingandiswa, kodwa izingane ezindala konyaka owodwa. Futhi, izidakamizwa ikhishwe ngendlela lozenges.

Prokinetics izingane enqunywe wumgomo, uma ingane yakho ine:

• Ukuhlanza.
• Isicanucanu.
• Esophagitis.
• ukugaya Slow.
• izimpawu Dyspeptic.
• regurgitation njalo.
• Gastro-ngomphimbo Reflux.
• Dysmotility yokusetshenziswa pheshana emathunjini.

Kufanele kuqashelwe ukuthi ezinyangeni zokuqala kakhulu ukuphila umzimba wengane futhi yonke imisebenzi yayo kungukuthi kakhulu, ngakho yonke imithi okufanele zithathwe ngaphansi kokuqondisa esiqinile nokulawula udokotela. Endabeni ka prokinetics ukweqisa izidakamizwa kungadala zezinzwa side effects kwezinhliziyo zezinsana nezezingane ezincane.

ethandwa kakhulu kubazali izinsana isebenzisa ukulungiselela amakhambi, okuyinto ngcono ukugaya bese kunciphisa ukubuyisa. It ugxilisa ngesisekelo izithelo fennel "Plantex".

Kuwufanele kokusho amazwi ambalwa mayelana prokinetic isitshalo.

abasizi yemvelo

Ngakho izwe ikhambi yisiphi isifo kungatholakala kwezinye izitshalo, badinga kuphela ukwazi - kulokho. Ngakho, lesi sitshalo prokinetics eyaziwa, okuyinto zishukumisa emathunjini ipheshana motor umsebenzi. Nazi ezinye zazo:

• Fennel.
• Chamomile.
• Sambucus nigra.
• Dill.
• Oregano.
• Motherwort.
• Dandelion.
• Melissa.
• Cudweed.
• Ukhova.
• olhovidnaya lalesi sihlahla.

Uhlu izitshalo ukusiza ukuthuthukisa motility pheshana emathunjini, kuhlanganisa inqwaba yezinye izinhlobo izitshalo. Kufanele kukhunjulwe ukuthi kuzo izithelo ezithile nemifino nomphumela ofanayo:

• Rutabaga.
• Ikhabe.
• Iklabishi.
• Izaqathi.
• Beet.
• Ithanga.
• Cranberries.
• Amagilebhisi.

izakhiwo prokinetic azibonakali kahle kulezi imifino, lapho ukuthatha kubo ayo ukulungele fresh.

Kuyaphawuleka ukuthi akufanele ithathe isikhundla izifo izidakamizwa isitshalo ngesikhathi izinkathi exacerbation futhi ngaphandle kokukhuluma nodokotela.

side effects

Kubalulekile kakhulu ukuthi isizukulwane esisha prokinetics unezindawo ezimbalwa kude side effects kuka-lokuqala isizukulwane izidakamizwa nge esebenzayo isithako metoclopramide. Nokho, nemithi amasha kunemiphumela emibi:

• Ubuhlungu bekhanda.
• Ukucasuka.
• Umlomo owomile, ukoma.
• Spasm imisipha abushelelezi pheshana emathunjini.
• Isifuba, ukuqubuka, ukulunywa.
• Hyperprolactinemia.
• Izingane engaveza izimpawu extrapyramidal.

Ngemva ukuqedwa imiphumela izidakamizwa emibi ngokuphelele.

Uma udokotela utjho prokinetic, izidakamizwa uhlu kungafaka izidakamizwa eziningi anamagama ahlukene kodwa unesimo asebenzayo. Kulokhu imiphumela emibi kuyoba okufanayo.

Izici ukusetshenziswa prokinetic

Kakhulu ngokucophelela kufanele sinikezwe abantu prokinetic ne yokwehluleka kwesibindi ukusebenza futhi ngimpofu nokusebenza kwezinso. Iziguli ezinjalo kufanele kube ngaphansi kweso lwezokwelapha esiqinile.

Ngekusetjentiswa eside iziguli prokinetic futhi kufanele uvakashele udokotela wakho kaningi. Nge ngokucophelela ukusetshenziswa prokinetics izingane, ikakhulukazi enyakeni owodwa.

Isexwayiso oludingekayo izidakamizwa kuleli qembu ezigulini esezikhulile.

Ekwelapheni prokinetic akufanele benze umsebenzi odinga ukunakwa impendulo esheshayo.

Ngaphambi ethatha njalo kufanele ubonane nodokotela. Kule incike impilo yakho. Akukhona imithi edingekayo ukuze esikhundleni Analogue yayo isitshalo ngaphandle kokuqale kokubonisana udokotela wakho.