"Macropen": analogue, yokusetshenziswa, ngempela

Uyini izidakamizwa "Macropen"? Kuvele Analogue of ithuluzi, layo amafomu wokukhishwa, izindlela isicelo, izimpawu, contraindications futhi side effects izokwethulwa ngezansi. Siphinde bakutshele ukuthi ukhuluma ngani izidakamizwa, iziguli kanye kungaba bengahlala nezingane.

Ukwakheka, emabhokisini ukuma

Ukulungiselela "Macropen" (izindlela analog uzobe ngemuva kwalokhu ecacisiwe) ikhiqizwa amafomu ezimbili ezihlukene. Ake sixoxe ngazo ngokuningiliziwe.

• Granules senzelwe ukumiswa (udle). Umuthi ayiqukethe ukungcola ebonakalayo, it has umbala owolintshi kanye nephunga ukukhanya banana. Isithako asebenzayo of lo mumo kuphuma acetate midecamycin. nomuthi sihlanganisa izinto ezihambisana ezifana methyl parahydroxybenzoate, mannitol, propyl parahydroxybenzoate, sodium saccharin, citric acid, abicah antifoam, anhydrous sodium hydrogen phosphate, hypromellose, banana ukunambitheka, nombala ophuzi. Umuthi kuqukethwe amabhodlela ngengilazi amnyama. Basuke ezibekwe inqwaba amakhadibhodi abe ephelele nokushintsha kokudla nokufakwa spoon.
• "Macropen" amaphilisi-mbumbulu. Manual ithi leli fomu zomuthi simhlophe, nxazonke, ijamo kancane biconvex nge imiphetho beveled. Ngakolunye uhlangothi kukhona notching amaphilisi. Uphiko asebenzayo sokulungiselela enjalo kuphuma midecamycin. Njengoba excipients esetshenziswa polacrilin potassium, microcrystalline cellulose, magnesium stearate futhi talc. Le ndlela lesi sidakamizwa "Macropen" Analogue of it ( "Azithromycin" uhlobo) zidayisa ibhamuza amaphakethe, okuyinto ezibekwe inqwaba amakhadibhodi.

I izakhiwo pharmacodynamic zomuthi

Kwethulwa i Analogue zomuthi "Macropen" ngokwalo kubhekwa indlela yeminye imithi elwa namagciwane. Basonta iqembu macrolides.

Umgomo we operation umuthi onjalo ukuthi kuvimbela amaprotheni zamagama kumaseli kwegciwane ngemithamo emincane ezikhandla nomphumela bacteriostatic, futhi ezinkulu - amagciwane.

I okusezingeni eliphezulu ukusebenza zokwelapha zomuthi waphawula amagciwane Gram-HIV ezifana Staphylococcus, Clostridium, Listeria futhi Streptococcus korinobakterii futhi Gram - Bacteroides, Campylobacter, Helicobacter, haemophilus influenzae, Moraxella.

Ngaphezu kwalokho, lesi sidakamizwa "Macropen" Analogue of ngokuvamile kakhulu yaphathwa khona ala magciwane intracellular: ureaplasma, chlamydia, mycoplasma.

Pharmacokinetics

izidakamizwa "Macropen" Kuyoze esikuthola? Manual ithi ngemuva kokuthatha izidakamizwa ngaphakathi it ngokuphelele neqondakala ngokushesha esuka pheshana emathunjini.

I lokuhlushwa eliphezulu kakhulu izidakamizwa egazini serum siyenzeka emva 1-2 amahora. Kulelizinga ke inakekelwa kuze amahora 6.

ukudla ngesikhathi esisodwa eyanele akuphazamisi ukumuncwa zomuthi, futhi akusenzi lokuhlushwa yayo egazini. Kule ndaba, kunconywa ukuthatha leli khambi ngaphambi kokudla.

Inani eliphelele izidakamizwa ezitholakala indlala parotid, amaphaphu isikhumba. Izidakamizwa umzimba kwenzeka esibindini. Ingabe wabonisa kanye Bile futhi ngokusebenzisa nezinso.

Izinkomba amaphilisi kanye ukumiswa

Kungani akunikeze imithi "Macropen"? Analogs futhi engabizi futhi ngempumelelo kakhulu izidakamizwa ezifweni, okuyinto zibangelwa nezilwanyana ezincane nozwelo ketshezi esebenzayo:

• izifo kohlelo genitourinary (isib Mycoplasma, Ureaplasma, chlamydia);
• Izifo ezihlobene nokuphefumula (pneumonia, pharyngitis, namathansela, sinusitis, otitis, ukucinana kwemigudu yokuphefumula);
• izifo zesikhumba kanye nolwelwesi lwamafinyila;
• ukukhwehlela whooping futhi idiphtheria;
• enteritis, okuyinto zazibangelwa Campylobacter.

Kufanele kuqashelwe ukuthi lolu izidakamizwa lunqunywe ukuze iziguli abangakwazi ukubekezelela-antibiotic ejenti penicillin akuzange kusize.

Izimo ukusetshenziswa kwezidakamizwa

kumakhophi Foreign futhi ezifuywayo "macrofoams" kanye izidakamizwa ngokwalo Kunconywa:

• luvelo midecamycin;
• ukungakhuli ezinzima hepatic;
• abaneminyaka kuze kube iminyaka emithathu (amaphilisi).

Izindlela kwesicelo kanye umthamo amaphilisi

kufanele ngisebenzisa kanjani izidakamizwa "Macropen" (okufanayo)? Yokusetshenziswa uzokwazisa iziguli ukuthi izidakamizwa ngesimo amaphilisi inikwe imfuyo njalo kanye amahora 8.

Izingane enesisindo esingamakhilogremu angaphezu 30 kg kanye nabantu abadala izidakamizwa Kunconywa ukuthatha 400 mg kathathu ngosuku. Ubuningi umthamo wansuku zonke abadala 1600 mg.

Ingane enesisindo esingaphansi 30 kg banikwa 20-40 mg ngayinye kg. Ngesikhathi umthamo ofanayo nsuku zonke imithi sehlukaniswe izikhathi 3. Ngo ngamagciwane okunzima, lemali ngenhla zomuthi zingandiswa ukuze mg ngayinye kg 50.

Nokushintsha kokudla nokufakwa kanye nokushintsha kokudla nokufakwa ukumiswa

Indlela ukwamukela ukumiswa, "Macropen"? Analogs (izingane) kanye ithuluzi ngokwayo ziyoncibilika emanzini ethafeni. Leli fomu ebekiwe kuye isisindo sengane. Umuthi esithathwayo kabili ngosuku.

• nge isisindo 0-5 kg - mayelana 3,75 ml yesixazululo olungiselelwe;
• ukala 5.10 kg - mayelana 7.5 ml;
• nge isisindo 10-15 kg - mayelana 10 ml;
• nge isisindo 15-20 kg --15 ml;
• nge isisindo 20-25 kg, mayelana 22.5 ml.

Ukusebenzisa izidakamizwa ezinganeni

Ngo Pediatrics sikhuluma ngokuhoxiswa izindlela ke kubhekwe ngempumelelo kakhulu futhi ephephile. Odokotela acishe never zishayisane engemihle.

Izidakamizwa "Macropen» kuyaqabukela kunomthelela dysbiosis, okuyinto kuvamile impela ekumisweni namanye amanxusa ama-antibiotic.

Ekwelapheni "Makropenom" izingane ayibeki umncele ezengeziwe imithi elwa-fungal.

Lokhu kusho izingane ikhiqizwa ifomu ekhethekile (elimbudumbudu). A kumiswa akuthinti ukunambitha kuhle. Kule ndaba, ngesikhathi nokwelashwa kweziguli ezincane abakaze nezinkinga imithi.

Kufanele kuphawulwe ukuthi kukhona impela eningi okubuyayo kubazali abathi ukuthi nomphumela oqabulayo yalesi izidakamizwa uhlale okusezingeni eliphezulu, ngisho nalapho abanye imithi elwa namagciwane penicillin akuzange kusize engenamandla.

imiphumela emibi ngemva kokungenisa

Ukwemukelwa izimali ayivamile ukubangela ukusabela ezingezinhle. Nokho, kwezinye izimo, umuthi usengakwazi neqhaza ukuvela kwezinhlobo zalo kwezinso ezilandelayo:

• On the ingxenye ipheshana wokugaya ukudla: stomatitis, ukungakuthandi ukudla, ukuhlanza, jaundice, isicanucanu, umuzwa ukusinda esiswini, kukhuphuke isibindi transaminase umsebenzi, isikhathi eside uhudo olubi (nesifo pseudomembranous).
• komzimba: bronchospasm, ukuqubuka kwesikhumba, ukukhishwa isikhumba silume, ukuqubuka futhi eosinophilia.
• Okunye: ukucobeka kanye ubuthakathaka.

izidakamizwa ekuhlanganyeleni

Lapho ukuphatha kanyekanye ne izidakamizwa "Carbamazepine" incipha ukuguqulwa yayo esibindini futhi kukhulisa lokuhlushwa igazi. Lokhu inhlanganisela yemithi kwandisa ingozi nemiphumela anobuthi wale mithandazo (ataxia, nokugcinwa urinary, amajaqamba).

Lapho co-zinikwa umuthi "warfarin" kwandisa ingozi ukopha, nge "ergotamine" futhi "ergometrina" - waphawula neuropathy spasm semithambo (kungenzeka ischemia nezilonda ezingapholi wemikhawulo), kanye ne "cyclosporine" - kwandisa ingozi nephrotoxicity.

imiyalelo ezikhethekile ethola izidakamizwa

Ngokusho imiyalelo, kubhekwe indlela has izici ezilandelayo:

• Njengoba e ukusetshenziswa namanye amanxusa elwa namagciwane, yesikhathi eside ukuphathwa "Makropenom" isiguli singase ukuthuthukisa amagciwane yokumelana nomuthi.
• Uma imithi kubangela isifo sohudo eside, kubonisa ukuthuthukiswa yesifo pseudomembranous.
• Phakathi eside therapy kuyadingeka ukuqapha umsebenzi enzyme isibindi. Lokhu kunjalo ngokukhethekile iziguli ukusebenza kahle ka lesi sitho.
• into enjalo, ezifana mannitol (ezitholakala okusanhlamvu) kungenzeka imbangela yesifo sohudo.
• Lapho khona yokungezwani komzimba ukuze acetylsalicylic udayi acid ophuzi, likhona yokwakheka ukulungiselela kungaba ezenza abantu basabele ngendlela nomzimba (isb bronchospasm).

Izidakamizwa "Macropen": analogue kwezidakamizwa amanani abo

Okwamanje analogs isithako esebenzayo ku izidakamizwa kokubuyekezwa alikho. Ngokuphathelene amafa bohlanga kwemithi efanayo (macrolides isizukulwane 2nd), phakathi kwabo kukhona imithi ezilandelayo: "Azithromycin", "Clarithromycin" futhi "Josamycin". Babuye elisetshenziswa izifo ezibangelwa amagciwane. Kodwa ngaphambi kokusebenzisa lezi imithi ukwelapha izingane kanye nabantu abadala, kubalulekile ukuba babonane nodokotela noma udokotela wezingane njengoba kungenzeka ube ngezindlela ezahlukene kakhulu ekuphathweni, umthamo kanye nemiphumela engemihle.

Inani amaphilisi kanye ukumiswa "Macropen" (analogue Izibuyekezo sokulungiselela kuthiwa okuxoxwe ngazo kulesi sihloko) kuyinto ruble 270-360. Uma ezifana nezindleko-antibiotic siphezulu kakhulu, sincoma ukuthi esikhundleni salo "azithromycin". intengo yaso ruble 85-100 kuphela.

Ngokuphathelene izidakamizwa, njengokuthi "Clarithromycin" futhi "josamycin", ukubaluleka kwazo ingaphezu kwe-yokuqala (ruble 380).

nobufakazi

Uphenyo imithi "Macropen" ikakhulukazi omuhle. Abaningi babo kwakungabantu kokushiya nesineke ngemva nokuphathwa yezidakamizwa itheku.

Ezimweni eziningi, ukusebenza kahle eliphezulu zomuthi siyenzeka kuphela aphoyintimenti ngezinkulumo zakhe ezazifike ngesikhathi. Uma uthatha le izidakamizwa njengoba kukhonjisiwe imiyalelo (ukwelashwa ubude amasonto 1-2), isimo zeziguli liyathuthuka ngokushesha ngokwanele. Njengomthetho, ukwelashwa okunjalo isiguli akadingi lubhoboze. Kubalulekile kakhulu ukuqeda yonke inkambo yokwelapha. Kungenjalo, ukutheleleka bangaba ezingamahlalakhona.

Kufanele kuphawulwe ukuthi zikhona amaningi nokubuyekezwa ukumiswa yokuvuma (izingane ezincane). Ezimweni eziningi, abazali bayo uyaneliseka ngemiphumela yokwelashwa. Ngokusho kwabo, umuthi usizo ngokushesha ngokwanele lapho ukhwehlela, kufaka phakathi okwathatha isikhathi eside kangako.

Ezimweni ezingavamile, ukuvimbela isifo sohudo wengane futhi unike probiotics ezifana "Baktisubtil" futhi "Linex".

Ngesikhathi yokwamukela, ukubika nemithi ethile, abanye abazali bathi ukubukeka izingane okulandelayo side effects: ukozela, isicanucanu nokuhlanza. Ezimweni ezinjalo, imithi kukhanseliwe futhi salandelwa okulingana ivikeleke nakakhulu.