Avidity - kusho ukuthini? Avidity IgG amasosha Cytomegalovirus: izici decrypting

Manje kunanini ngaphambili, kubalulekile ukuba sisheshe kanye nokuvinjelwa kwezifo ezithathelwanayo. Lokhu kudinga eliphezulu namasu ngokushesha zokuxilonga. Ngokwesiko umtholampilo isebenzisa izindlela serological sokunquma kobukhulu inqubo yokuthi bafudukela izifo ezibangelwa amagciwane, amagciwane kanye fungal. Kodwa lolu vivinyo akuzona ebucayi ngokwanele ukuba akwazi ukuhlukanisa ukutheleleka okuyisisekelo, bathelelane futhi uhileleke. Ngakho-ke, ososayensi yesimanje ezihlongozwayo indlela yokunquma avidity ka IgG-amasosha omzimba.

Avidity: kusho ukuthini?

Hlukanisa imiqondo ziyezwana futhi avidity. Affinity - isici thermodynamic quantitatively echaza amandla ukuxhumana we omzimba kanye antigen okufanayo. Futhi, avidity inquma amandla ubuhlobo obuphakathi kwabo antigen futhi omzimba. Lezi imiqondo zihlobene ngokuqondile nomunye. Lapho antigen izingcezwana njalo, namandla uxhumano. Hlukanisa avidity ongaphakeme kanye eliphezulu.

Okuchaza avidity okusezingeni eliphezulu? Ake siphenye. Lapho antigen ufake umzimba okokuqala, bona sikhuthaze B cell akhiqiza immunoglobulin, ayisiza. Okokuqala-ke Igm, kodwa ke esikhundleni IgG. Ngemva Ungowokuqala okuxhunyanwa naye kokusondelana, futhi kungakho avidity, ongaphakeme, njengoba nje izindlela ukuzivikela komzimba ukuzivumelanisa lwegciwane entsha. Ngemva kwamasonto eziyisikhombisa, IgG «ovuthiwe», acace kakhulu, futhi ngenxa yalokho, le avidity okusezingeni eliphezulu. Futhi manje, esimweni kabusha ukutheleleka, izivikeli mzimba uzolunga ukuphendula ngokushesha izinsongo.

avidity inkomba

Level avidity engaphansi inversely ku umthamo antigen yini neziphathelene nesimo ezingeni yokwanda koshintsho e amangqamuzana omuntu. I umncane umthamo kokuqala, ayanda kokusondelana, futhi okuphambene nalokho.

Khona-ke pathophysiology futhi ngokuzivikela komzimba ezifweni lapho sibhekene lo mkhuba ukwehla amasosha omzimba ekhula. Sasicabanga futhi esephetha isilinganiso esithile, ngokuthi avidity Inkomba. Kusho ukuthini avidity Inkomba? Lesi sibalo sikhombisa umsebenzi eyisihlobo immunoglobulin ukuhlanganisa uxhumano nomsebenzisi antigen. Inkomba kubanga eliphakathi 15 futhi amaphesenti angu-50 obonisa ukutheleleka okuyisisekelo, uma inani idlula 50 per cent, ke isiguli isivele wahlupheka ngenxa yalesi sifo.

rubella

Igciwane rubella ine nomthelela omubi kakhulu embungwini, ngakho-ke kubalulekile ukuthi noma ngabe umama okhulelwe wayegula nalesi sifo, noma ngaphambi kokukhulelwa kufanele zigonywe. Ukuze zokuxilonga ukusetshenziswa serological ukuhlolwa ngoba ziyezwana amasosha le antigen. Uma immunoglobulin, ayisiza cishe ngokuphelele ngenxa izinhlayiya viral, ngakho avidity okusezingeni eliphezulu amasosha omzimba. Lokhu kungase kubonise noma igciwane langaphambilini, kanye nokuvikeleka ezinhle ngemva ngokugoma.

Ngezinye izikhathi, ngenxa ukukhuthazwa lymphocyte ukufaniswa igciwane rubella itholwa zamanga ukusabela okuhle kwawo immunoglobulin M. Ngaphezu kwalokho, umphumela onjalo kungabonakala kulezo ziguli lapho aphakeme igazi isici samathambo. Kuphela kukhona khona amasosha omzimba abe avidity ongaphakeme. Kusho ukuthini? Lokhu kungenziwa kubhekwe njengobufakazi bokuthi igciwane samabanga aphansi esinezingane rubella igciwane. Ngo zokubelethisa kuyinkomba oqondile ukuba ngisikhiphe isisu.

toxoplasmosis

Njengomthetho, lokhu ukutheleleka ifihlekile, futhi ukubonakaliswa izimpawu zokwelashwa kanye zokugula aluthola (isib, ezifana zingavuvukalanga lymph node) inenani ongaphakeme zokuxilonga, uma udinga ukuthola isikhathi esingakanani umuntu egula. Ukunqunywa IgG avidity amasosha omzimba kakhulu ethize futhi indlela ngozwela sitholakele toxoplasmosis acute okuyinto kubalulekile uma behlola omama abakhulelwe ukuba kuqedwe ingozi engase ilethwe toxoplasmosis azalwa naso ezinganeni.

Kuze kube muva nje, kuphela serologic etholakalayo Assay ukunquma kobukhulu inqubo kwaba ukuhlonza M ekilasini immunoglobulin futhi anda titer ka IgG. Uma esikhathini esingaphansi kwesonto inani immunoglobulin G anda kane noma ngaphezulu, liwubufakazi ongaqondile ukuqhubekela phambili kwesifo.

Ngisho ne ukuhlolwa serological udokotela kunzima ukunquma nini umuntu uthelelekile, njengoba immunoglobulin M G ungase uqhubeke isikhathi eside egazini. Ngakho-ke, indlela enokwethenjelwa kuphela ukucacisa avidity. Kusho ukuthini? Kokusondelana ephansi futhi ngaleyo ndlela avidity Toxoplasma ngaphambilini ukungena emzimbeni. Ngaphezu kwalokho, kamuva nje wavula indlela uhlukanisa ongaphakeme ziyezwana futhi ziyezwana okusezingeni eliphezulu amasosha omzimba ukuze bakhululeke nokubalwa ekutholeni uhlobo ukutheleleka.

I-Herpes igciwane simplex

Abantu abaningi emhlabeni igciwane herpes simplex. isifo kothile kwenzeka ifomu esicashile, kodwa izimpawu kakhulu kuyagcinwa, ngisho noma ezincane. Ngaphezu kwalokho, kukhona ezinye nezinkinga kanjani ukucacisa avidity ka-herpes. Lokho kusho emsebenzini? Lokhu igciwane libhekene omzimba atypical, kungenzeka emzimbeni impilo, enika imiphumela eyiphutha-HIV kanye zamanga-HIV. ezingezinhle Amanga zinqunywa lapho immunoglobulin, ayisiza abumane noma lapho serum e trace amanani. Imiphumela Amanga-HIV kwenzeka ngenxa isikhathi eside afundwa amasosha omzimba kungakhathaliseki isifo.

Ngaphezu kwalokho, it has a antigen cross-esisheshayo ukuthi ukulingisa indlela histocompatibility antigen ka kwezicubu zomzimba evamile, nezinye izinhlobo herpes igciwane. Enye basabele kahle amanga zinqunywa ukutheleleka yesibili ne human immunodeficiency virus.

cytomegalovirus ukutheleleka

Lokhu virus ibangelwa ezijwayeleke kakhulu isisu ekukhulelweni ekuseni. Ingozi yokutheleleka incike ezingeni masosha omzimba umama ngesikhathi ebamba isisu. Uma ukutheleleka kokuqala kwenzeka ngo senyanga yokuqala, amathuba ngalesi sifo lingamaphesenti 50.

Kusho ukuthini avidity ngoba CMV? Njengakuwo wonke Kwezinye izimo, ukunqunywa kokusondelana ka IgG nge Igm ukusabela okuhle ukuqinisekisa ngokunembile noma ukuphika ukuba khona oyinhloko CMV ukutheleleka. Ngaphezu kwalokho, kuvumela ukuba ugweme izinqubo buhlungu futhi kuyabiza ngoba umama okhulelwe.

Hepatitis C virus

Ukuxilongwa kwesibindi esekelwe sokunquma nakomaka ezicacile ezibonisa ukuthi kwakuyokwenziwa ukuthuthukiswa inqubo ukutheleleka. Kulokhu, Igm singenzeka kamuva kakhulu kunalelo IgG, noma kanyekanye nabo. Kunzima ukunquma ukuqala sifo isikhathi ukutheleleka okuyisisekelo.

I yedwa ongumholi onokwethenjelwa ukuhlaziywa serological kuyinto serokoversiya futhi avidity IgG ku. Kusho ukuthini? Uma Inkomba avidity uphansi, lokhu isiqinisekiso ngqo nesifo eyinhloko. Endabeni nokunquma avidity okusezingeni eliphezulu IgG ekilasini amasosha omzimba ngokuqiniseka bangathi ukusha kwesibindi kohlobo esingamahlalakhona noma kuthuthwe.