Yokusetshenziswa, i-analog "Cefotaxime" kanye nokubuyekeza

"Cefotaxime" (izinkomba ukusetshenziswa, imithetho ukubala imithamo ephezulu, kanye ethandwa kakhulu analogue uzonikezwa ngezansi) kuyinto lulwimi zokwenziwa-antibiotic yesimanje. Kuyinto ukumelana beta-lactamases futhi iyasebenza ngokumelene kokubili igremu-HIV futhi igremu-negative nezilwanyana ezincane. Mechanism ukuphendula kwamakhemikhali ngenxa nokucindezela ikhono izingxenye kwezinqubo ezingokwemvelo ezenzeka ulwelwesi cell kwamagciwane.

Umuthi siya ku umzimba, ibulala ngamabomu cruciform elihlangana peptidoglycan, kudingekile ngakho ngoba-bacterium ukuqinisekisa nokusimama izindonga zemvelo. Njengoba yaziwa, amasosha kanye inhibitor izithako umqali nokunwebeka iseli - lena target kulula kakhulu.

ukukhululwa Ifomu

I nomuthi "Cefotaxime" (imijovo manual kanye infusions presents njengoba nje wesifunda ukulethwa kungenzeka we ketshezi esebenzayo) ihlinzekwa emakethe ezenza imithi ku powder amhlophe noma aphuzi, esebenza njengesikhali isisekelo ukulungiselela yesixazululo. Lona okuthiwa umjovo ampoules.

Lasekuqaleni 10 ml ivolumu izitsha eziyisikhombisa ezenziwe ekhanyayo. Langempela mass reagent ekhona efanayo umkhiqizo iyunithi incike ukugcwaliswa we matrix (0.5, 1.0 noma 2.0 amagremu).

simo pharmacokinetic

Kufanele ngokushesha kuphawulwe ukuthi zonke analog "Cefotaxime" has ezifanayo kodwa ngesikhathi esifanayo pharmacokinetic nolimi lokuqala. Ikakhulukazi, uma sikhuluma ngesilinganiso ukumuncwa izingxenye kusuka kusayithi umjovo, ukumuncwa kwala magciwane, nahlulele by amazwana odokotela abaningi, kuba ngokushesha okuningi kunalokho ukumuncwa kokuqala okufanayo namanje "Duataksa" noma "Tsetaksa". "Phenomenon" Isizathu sitholakala ehlelekile kokuqala isampula-molecule. Ochwepheshe in izimpendulo zabo ukugcizelela yokuthi Indian ejwayelekile ngenhla tifaka "okuphothula ezithaka imithi" ngesimo eziyinkimbinkimbi cephalosporin nemikhiqizo okuyinto kakhulu kubamba umzimba nezinye izithako.

Litholakala ukuthi "Cefotaxime" (ukufundwa livikeleke Umhlahlandlela esemthethweni ukuze umuthi othile, ukuqeda ematfuba yendawo khona ukopha) liveza ezingeni kuqhathaniswa eliphezulu sesibopho ukuthobisa plasma amaprotheni, kuyilapho ubude microbicidal umphumela kuyahlukahluka kungakapheli amahora 11-12. Ukuba ukuqala ukuguqulwa inxusa ngokulinganayo basakaza emzimbeni, kuhlanganise bone (lokuhlushwa esiphezulu nayo ebonwe myocardium futhi esinyeni nenyongo).

Isakhi esiyinhloko okuyinto kuyalinqoba isithiyo esinomhlapho futhi iba yingxenye ebalulekile ye pericardium futhi cerebrospinal fluid. Isilinganiso isigamu-ukuphila emthanjeni ukuvuza ukumnika ingeqi ihora linye kanye imijovo esicutshini - imizuzu eziyikhulu namashumi ayisishiyagalombili. Noma yiziphi nokukhawulela ekuqongeleleni nto ayifani - ingxenye izingxenye ndawonye excreted ku Bile kanye nezinye (90%) - umchamo. Kulo mBhalo, inani lemikhaya metabolites asebenzayo kungagcini 20-30% umthamo esilawulwa, isb mayelana 70% of the solution ukushiya umzimba ngaphandle othola ukulungiswa kwesakhiwo.

izinkomba ngoba

Laba basizi is kahle emile njengesiqondiso ngisho blocker izinqubo ezithathelwanayo kanye ukuvuvukala egijima ezincane, ikakhulukazi ebucayi ukuze cefotaxime. Futhi ubufakazi lokhu izifundo zokwelapha hhayi kuphela - esiphethweni esifanayo zingenziwa ngemva kokufunda ukubuyekezwa omuhle eziningi posted on the website, isihloko okuyinto izidakamizwa ngempumelelo ukulwa namagciwane. Front isinyathelo kwemithi zomuthi e ngokwanele ububanzi, kodwa kaningi "on emehlweni" ukuwa esingamahlalakhona noma oyingozi iziyaluyalu kwezinso okwenzekayo ngomgudu womchamo, kanye engenhla nezifo zokuphefumula.

Mangisho ukuthi, ngisho noma ngabe ungubani ngokuphelele of the ukwakheka i analog "Cefotaxime", kungakhathaliseki "Tsefasin" noma "Tsetaks" alinakunikezwa ukusebenzisa esekelwe mibandela engenhla. Iqiniso liwukuthi abantu abaningi bathambekele imithi ejwayelekile kuphela "ikhophi isihlobo 'imodeli kwamakhemikhali iphethini yokuqala yokuziphatha, ngakhoke ngqo ikhadi imithi ukuthi uyakucabangela isheduli umthamo" kabili "kumelwe abale uchwepheshe abanolwazi.

Umkhiqizo yokuqala Kunconywa ukuba isetshenziswe uma:

• isiguli unesifo zokugula umgudu wokuphefumula ifomu i-pneumonia, ithumba noma ukucinana kwemigudu yokuphefumula, nezinye imithi elwa namagciwane Ungasingenisi elamukelekile;
• isiguli egajwe okuqhubekayo webhaktheriya meningitis;
• ukuhlolwa waqinisekisa khona endocarditis;
• esikhathini postoperative ayikwazanga ligweme izinkinga ezingase zivele ngesimo ekubhujisweni ebalulekile kwesikhumba kanye / noma ulwelwesi kwezitho ezibalulekile;
• izinto ezithwala izifo wazinza e wethambo, futhi imijovo esicutshini nezidakamizwa-omqondofana isidingo ukuthonywa ngokungafanele phezu kwabo;
• Gram-negative noma igremu-HIV lwangena kushe futhi ukutheleleka sokucasuka isikali (kufika ku sepsis);
• kukhona isidingo izinyathelo.

ochwepheshe Independent bavame ukuba bakholelwe ukuthi kuncane noma iyiphi Analogue "Cefotaxime" akwazi nokukwenza eshiwo ngokucacile Dynamics omuhle nge isifo saseLyme. Kuyinto Ekhumbula kuwufanele eyayichaza yokuqala, kuncike isicelo njalo, ne umsebenzi ukuze ubhekane kahle (imibono, anikezelwe ezicashile Yiqiniso zokwelapha, iziguli ezibekwe phezu izinkundla).

Sebenzisa umthamo

"Cefotaxime" imfundo (imijovo, ngokuvumelana odokotela abathile neziguli akuzona njengoba ngempumelelo njengoba ukusetha weThrojani) ibekwe njengenhlangano abakhethayo ukulwa isinyathelo ngamakhasimende ezinzima izifo ezibangelwa amagciwane antibiotic. Njengoba kushiwo ngaphambili, kukhona ezintathu reagent ukulethwa izifunda: by ukuvuza ukumnika noma jet, kanye ngokusebenzisa ujove esicutshini. imithetho Enobunye ukulungiswa uketshezi ukusebenza alikho, ngakho-ke kubalulekile ukunquma kusengaphambili imodi yokuphathwa zomuthi.

Umkhiqizi, ngokukhethekile, uncoma ukulandela lesi algorithm:

• okwesikhathi imijovo / th: 1 igremu powder ziyoncibilika e 4 ml amanzi, lidocaine noma novocaine;
• ngoba umjovo emthanjeni: 1 g lomcebo kuyadingeka ukuncibilikisa emanzini oyinyumba (4 ml);
• I-/ e ukumnika: egabheni amabili amagremu cefotaxime udinga ukwengeza 100 ml NaCl (0.9%) noma okufanayo amaphesenti amahlanu glucose.

Delivery reagent isikhathi:

• ngesikhathi / m imijovo: 5-10;
• ngesikhathi / esethulweni jet: 5.3 imiz;
• uma usetha weThrojani: 50-60 imiz.

Ukubalwa umthamo olinganiselayo futhi ukuhlela ukwakhiwa reception elilungile Kwenziwa ngamunye. Ucabangela engu lesiguli kanye isisindo somzimba wakhe, kanye nohlobo ukutheleleka kanye komqondo nezinga lokukhula kwengane yayo. Ngaphezu kwalokho, kwentelwa kutsi letichibiyelo wenza emlandweni zokwelapha.

Noma kunjalo, iziqondiso nokho inikeza ulwazi kuma rates isilinganiso isicelo "cefotaxime" izidakamizwa. Imijovo (luthuli buhlanjululwe, wachaza ngokuningiliziwe ngenhla, kodwa, kuyathakazelisa ukuthi cishe yonke impendulo ubuswa umqondo wokuthi umjovo - inqubo kubuhlungu ngempela futhi singathandeki, ngisho nazo zonke izincomo umenzi), ikakhulukazi, ezinqunyiwe izimo ayinzima, egqekeza amahora 4-12 futhi umthamo owodwa we-1-2 amagremu. Ukuze ezibucayi futhi subcritical ebalulekile zimo / isingeniso (ngesilinganiso 2 g njalo ngemva kwamahora 4, kodwa hhayi ngaphezulu kuka-12 g / ngosuku).

Odokotela bezingane e eziyalezweni Ukukhetha uholwe abasha isisindo nesineke umzimba kanye Imininingwane umzimba yokusabela ( "okuvamile" - kusuka amabili kuya kwayisithupha jet imijovo; 50-180 mg / kg).

side effects

Lapho ukwabela nomuthi "Cefotaxime" (imijovo izilinganiso akuzona njengoba ezithophayo njengoba ukuvuza ukumnika, ngoba ngokuvamile isingeniso / m kuhambisana ubuhlungu; ngenxa yalesi sizathu, njengoba "kuphela" is ngokuvamile procaine noma lidocaine) ayikwazi ayifakiwe atypical isinyathelo izingxenye uhlelo futhi izitho lesiguli.

kuvunyelwe:

• "Izimpendulo" nomzimba ngendlela ezinkulu urticaria, angioedema noma candidiasis;
• izinkinga ezingeni pheshana emathunjini (ukuhlanza, isicanucanu, akuvamile - jaundice cholestatic);
• iziyaluyalu egazini (nokwehla count platelet, anaemia hemolytic m. p.).

imiphumela ngokweqile

ukwanda ngokweqile e imfuneko nsuku igcwele dysbiosis futhi encephalopathy; futhi kungenzeka abakhipha isikhumba esicasulayo.

Umsebenzi eyinhloko ukuqinisekisa ukuthi stop reagent ukulethwa emzimbeni. Ezinye izinyathelo ezidingekayo ukuze usimamise isimo ephonsa ukusetshenziswa kwemikhiqizo desensitizing kwemithi (ngokuqashwa udokotela).

Ngokwe-Izimo nomkhiqizi

Ngokusho ulwazi olunikezwe esitatimendeni olusemthethweni, "cefotaxime" (imijovo izingane, ngokuvamile ebekiwe emva kokufinyelela izinyanga 30 ubudala, ngaphambi asesebenzisa I / ukumnika) kufanele isetshenziswe:

• ngesikhathi sokukhulelwa;
• hypersensitivity kuya izithako;
• the ukuvulwa kanye lokuvala ukopha;
• Uma iziqephu enterocolitis kakade emelelwa emlandweni.

izidakamizwa ekuhlanganyeleni

Esikhathini Umhlahlandlela yasekuqaleni igxile iqiniso lokuthi abanye izixazululo ngaphansi kwanoma yiziphi izimo akufanele iqondiswa ndawonye (kudivayisi eyodwa wezokwelapha) kanye izindlela antibiotic "cefotaxime".

Imijovo (ngokusebenzisa ukuvuza ngokuya nokuxhumana kwemithi kanye izingxenye nezinye izidakamizwa, akuhlukile umjovo / m), ikakhulukazi, kungaba avuse ukulimala izinso, uma "umlekeleli" lochazwe ukulungiselela enze noma yimuphi aminoglycoside noma isisu iluphu. Ngakwelinye ihlangothi, interlocks uketshezi ijabulise zivimbela kakhulu inqubo ukuhoxiswa reactant inikezwe kudaleke ukwanda emakamu yayo.

Inhlanganisela nge antiplatelet futhi engathandeki ngenxa ingozi ebangela ukopha.

isikhundla isiqondiso Special

"Cefotaxime" (analogs tableted, ngokuvumelana Izibuyekezo namazwana ayisasebenzi) ngezinye izikhathi wenza Kumbusa zamanga isampula futhi "Spoofs" umchamo kokuhlahlela glucose kweqiniso.

Lapho eside therapy metering ingxenye yokwakheka igazi kufanele sigcwaliswe hhayi ngaphansi kuka 1 isikhathi ezinsukwini ezingu-10.

Ezinsukwini zokuqala zokwelashwa akusho ukubeka eceleni ifomu ezinzima sohudo. Futhi, Izici, ezifana analog "Cefotaxime" (izingane ezingaphansi kweminyaka engu-engu-12 okukhulunywe ngayo "understudy" is hhayi Kunconywa), ngokuthi "Fagotsef" umfanekiso ofanayo sokucindezeleka ezivamile ingasaphathwa.

Ukuphuza utshwala ngesikhathi yokwelapha ngesisekelo the reagent akuvunyelwe nakancane.

Yikuphi ngempela fanekiso ukuba "Cefotaxime" ukutusa ukusetshenziswa ochwepheshe abazimele?

Amazwana "Sefotake" futhi "Tsefantrale" lapho bekhuluma we kuchazwe umkhiqizo kwemithi elixutshwe. Ukwahlulela ukubuyekezwa, injongo yabo Ofundele kaningi ngaphezu ukubhala phansi kadokotela izinkomba ukuthenga okufanayo efanayo "Tsefabola" noma "intela ku-BID." Nokho, ezinye iziguli bavame ukuba bakholelwe ukuthi umphumela oqabulayo amasampula okukhulunywe ongacaciswanga kahle futhi amathuba ukuthuthukiswa ukusabela atypical uhlasela okusezingeni eliphezulu.

Lapho izinkundla umbuzo ophakamayo njengoba lokhu kwabathinta "cefotaxime" lokho akuzange ubuhlungu, odokotela abaningi ukweluleka:

• ukuhlolwa, futhi akuyona impendulo ukuthi ukuqaleka isithako ethize (uma lesi sifo esiqhubekayo procaine buhlanjululwe powder, khona-ke isizathu sokukholelwa ukuthi ukuqaleka - phetho yokungezwani komzimba kunokuba imiphumela ngqo lomcebo);
• funa enye indlela ehloniphekile.

Ukuhlaziya imicabango yabantu ebonisa ukuthi iningi "inhlonipho" phakathi omqondofana ukhishwa "I Lorax." Nokho, ngaphambi esikhundleni esisodwa reactant kwenye kumelwe ngaso sonke isikhathi uxhumane onguchwepheshe.