"Sodium dichloroacetate": Ukwakheka, imibono kanye yokusetshenziswa

Ngenxa ososayensi baseNyuvesi Alberta luhlobo yasungulwa e-Canada, lanqoba umdlavuza. Kungaba kuphela onqotshwa ukusebenza isifo mitochondrial eziye zacindezelwa. izidakamizwa aqanjiwe "sodium dichloroacetate," ngokuvumelana ososayensi, ukuba sibhekane nale nkinga futhi benenkinga izinhlobo eziningi umdlavuza.

kuphumelela kakhulu izidakamizwa uphawu ekulweni umdlavuza kwamaphaphu, ubuchopho kanye nesifuba. Emuva ku 30s kwekhulu lamashumi amabili, ososayensi baye baphetha ngokuthi kwezinso ukusebenza mitochondria amaseli zisenza sibe zomdlavuza. Mitochondria kukhona organelles ezibalulekile kwengqamuzana ephilayo, futhi kuze kube muva nje, ososayensi babekholelwa ukuthi ukubhujiswa kwabo - akusona isizathu nomdlavuza ngokuphawulekayo, futhi umphumela. Ngakho-ke, kusukela ngo-2005 Michelakis owangabaza lo mbono, isivivinyo waqala umsebenzi amangqamuzana sodium dichloroacetate.

Laboratory izifundo zomuthi

zocwaningo nangama ukuhlolwa ezilwaneni luye lwabonisa ukuthi lesi sidakamizwa "sodium dichloroacetate" kuyinto Activator enzyme mitochondrial ukuthi ukuyiveza ngenxa ezinye izifo kungakhathaliseki ukuthi hlobo lomdlavuza. Ukuncishiswa amangqamuzana omdlavuza ibangelwa normalizing imisebenzi organelles. Umuthi sihluke kakhulu ngekhemikhali ukuthi akuyona ezinobuthi futhi akusho abacindezelayo ku amaseli enempilo isiguli.

UProfesa Michelakis uphawula ukuthi sikwazi ukwenza izinto ezihlukahlukene we ketshezi eziqukethwe umkhiqizo, kwenza kube nokwenzeka ukubhekana amafomu kakhulu zomdlavuza, kwasinda sarcomas. Imithi kuyalithinta imfundo umdlavuza, esingenakubalwa ehlaselwe neminye imithi. Ingqikithi zomuthi ingeyona yimiphi weenhlahla ekhona, ngakho izidakamizwa akuyona patent. Lokhu kwamlimaza kakhulu ukuyikhokhela yakhe.

Laboratory ucwaningo wabonisa ukuthi izidakamizwa, ukunikela imiphumela ukulawula ku amangqamuzana omdlavuza ngaphandle kokuphazamisa okunempilo ngesikhathi esifanayo ku izingxenye zomzimba.

Lapho ukuqala ukuthatha izidakamizwa?

Kubalulekile kakhulu wokwelapha isifo somdlavuza kusho "Sodium dichloroacetate" sithathwe uma isimo somzimba namanje egculisayo. Ungalindi ukudlula izifundo eziningana, ngelashwa nangemithi, okuyinto has a ekubhujisweni abalulekile. Ngaphezu kwalokho, amangqamuzana omdlavuza kwenza babe amasosha omzimba kuya amakhemikhali. Sekuyisikhathi eside odokotela waqaphela. I ambalwa izifundo zokuqala ngamakhemikhali benza nethonya elihle ku-inkambo isifo, olandelayo, kunalokho, ayizwakali. Ngakho-ke, lo muthi kufanele ziqale ukuthatha ngokushesha ngangokunokwenzeka, ngisho ngokuhlanganyela izifundo yokuthakwa kwamakhemikhali. Nokho, umthamo kumele singeqi 15 mg ngayinye isisindo 1 kg.

Ukulungiselela "sodium dichloroacetate": isakhiwo

Ukwakheka izidakamizwa - usawoti sodium ka dichloroacetic acid. Sol kuyinto ekwakhiweni ngesimo le monohydrate, ukuthi u-12% - .. Water acacisa.

Ososayensi okwamanje bahlola izindlela zokunciphisa ubuthi zomuthi kubhekwe futhi ukusebenza yayo ekulweni umdlavuza.

isidakamizwa

Kuyadingeka ukuba bazi, uma unquma ukuthenga izidakamizwa "sodium dichloroacetate." Indlela ukuthatha izidakamizwa ukusiza umzimba ogulayo, ososayensi baye bathola kakade. Kususelwa 1 kg isisindo - 25-50 mg usuku lonke. Ukusebenzisa izidakamizwa iminyaka emibili ngesikhathi 50 mg kungabangela peripheral neuropathy, Ngakho-ke umthamo umthamo lancipha 25 mg, okwathuthukisa ukumisa izenzakalo ezingajabulisi.

Uma izidakamizwa umthamo 25 mg ngayinye 1 kg esisindo kubangela ukuqunjelwa, ukucanuzela kwenhliziyo, ukuba ndikindiki eminweni, nobunzima ukuphefumula (futhi kungaba avuse ukucindezeleka, ukundindizela, isiyezi, ukozela, ukuchama kaningi, ukukhathazeka), umthamo kufanele ibe ngu- 10 mg ngayinye 1 kg esisindo . Ngezinye izikhathi abazincomayo jikelele ukuyeka ukuphuza ke izinsuku ezimbalwa. Khona-ke aphinde kudingekile ukuba babuyele umthamo ofanayo - 25 mg ngayinye 1 kg esisindo ngosuku. Ezimweni owaziwayo we citric acid, okwakwenza kube lula ukuthola izenzakalo wehlise peripheral neuropathy ngemuva kokuthola "sodium dichloroacetate" ukulungiselela. Iziyalezo zisebenzisa isidingo ukuba alulaze le nomuthi kubhekwe ngamanzi (100-150 ml). Lokhu Kulula ukwenza, ngoba umuthi in ifomu powder. Wena kumelwe sizame ukugwema ukusho isikhumba ukuxhumana umkhiqizo - kungaba ngalesi siyingi kubangele ubuhlungu.

Sebenzisa umuthi kule lysis izimila

Umuthi kungabangela lysis izimila ebulalayo e-acute wegazi lymph, lymphoma-non-Hodgkin sika, acute mielotsiticheskoy wegazi, umdlavuza webele, cell carcinoma, i ezingamahlalakhona wegazi lymph, nomdlavuza wamasende, cell carcinoma, i medulloblastoma.

Lysis of isimila esibulalayo esibizwa ngokuthi i-apoptosis ngokushesha kakhulu amangqamuzana omdlavuza (yokufa kwamangqamuzana engokwemvelo), ephelezelwa ziwohloke abukhali isimo sempilo (ezimweni ezehlukile, kungabangela ukufa). Ezimweni ezinjalo, kumelwe ngokushesha limise izidakamizwa kanye nodokotela. Ngemva kwezinsuku ezimbalwa, mhlawumbe, bavunyelwe ukuze uqhube ukusetshenziswa kwezidakamizwa, kanti ukunciphisa umthamo.

Ulwazi mayelana izidakamizwa ukungavumelani kusho "Sodium dichloroacetate" nezinye izidakamizwa Akubangelwa eseyintsha yayo (ngaphandle - imithi "Lasix").

Sebenzisa kanyekanye ne zezinkambi kofeinizirovannymi, ebulilini uvithamini B1, inhlanganisela citric acid, coenzyme Q, futhi-alpha-lipoic acid ungeze ngempumelelo.

Ukuphumelela lomuthi

Kusebenta nomuthi "sodium dichloroacetate" kuxhomeke ezicini eziningana. Iyehlisa izakhiwo zayo zokwelapha we Isimo esibi isiguli. Ngokwesibonelo, lapho ngenxa yokugula abathintekayo izitho ezibalulekile, noma labhujiswa bedle ngamakhemikhali. Futhi, musa batusa ukusetshenziswa kwezimali, uma isiguli aliphumi, njalo usezinhlungwini, kuthatha izidakamizwa.

Kunciphisa nekusebenta nokulungiselela kanye namandla isifo ukunqotshwa isibindi. Lapho-ke asikwazi ukumelana nokushintsha kwamandla abafileyo isimila cells kanye nemikhiqizo noqhekeko awela igazi, isimo siba more xaka.

Ngezinye ongaphakeme umthamo ukuphumelela izidakamizwa liphansi, lapho ezinkulu umthamo yi iba lubonakale. Kodwa kukhona ezinye izinto ezandisa le ngozi. Ngezinye ebulilini, kungase kwenzeke ukuthi imikhiqizo ukubola isimila isibindi abakwazi ukubhekana. Lokhu kuzokwenza ukudakwa, isicanucanu nokuhlanza. Ngakho-ke, kufanele umthamo abakhethiwe kahle.

Kuphi ukuthenga?

Kuthiwani uma omunye umuntu kufanele ukuthenga izidakamizwa "sodium dichloroacetate"? Kuphi ukuthenga? Iyatholakala kubhekwe umuthi e-Canada, ngakho ungakwazi oda usebenzisa izinsiza-intanethi kusuka abakhiqizi. Kukhona ithuba ukuthenga nabathengisi izidakamizwa e-Russia, ukuthenga ke e-Canada. Intengo umuthi akuyona high, ngakho uyithenga angakwazi ukukhokhela iziguli okuqondene kwezakhi nomphakathi.

Izibuyekezo sokulungiselela

Umphumela omuhle lesi sidakamizwa "sodium dichloroacetate" okuyinto libuyekeza uqinisekise ukuthi, usukela ezigulini eziningi umdlavuza. Umuthi isetshenziswa ngesikhathi esifanayo ne-ne Yiqiniso ngamakhemikhali, neminye imithi ukuthi akazange sinciphise ekulenzeni libe namandla. Abanye odokotela abakholelwa nokuvulwa iziguli zabo. Bamangala lapho iziguli ayesezibhebheni lungisa. Abaningi iphuzu yokungabi side effects ngenkathi ngokuthatha izidakamizwa.

Izibuyekezo ezingezinhle zimbalwa kakhulu. Bonke ukhombe ukwehluleka lesi sidakamizwa "sodium dichloroacetate." Kuyini lokhu? Kuyaziwa ukuthi Kwezinye iziguli lesi izidakamizwa akuzange kusize ukuqeda lesi sifo. Abanye abantu baye baphawula ukuvela isifo Ukuphinda.

Kanjani ukuqinisekisa ubuqiniso izidakamizwa

Ubuqiniso "Sodium dichloroacetate" izidakamizwa zibonisa izici eziningana: liqukethe zinhlayiya ezimhlophe, ukunambitheka ababayo. Uma umbala zinhlayiya aphuzi, le nomuthi has a ukhwaliti ongaphakeme, futhi akukho Kunconywa. Lapho Ukuqedwa izidakamizwa amanzi, akufanele alahlekelwe ukunambitheka yako ebuhlungu. Lapho buhlanjululwe ukuba slurry powder kuthiwa ngezikhathi isetshenziswa isikhumba ibhodi lemisindo noma ebusweni engaphakathi ehlombe ngezikhawu 1 iminithi phakathi nemizuzu engu-10, bese ngemva kwakhiwa isikhathi edging is indawo avulekile. Futhi emva 5-10 amahora kule ndawo iyoba elibomvu ngaphezulu futhi icacile. Ngemva kwezinsuku ezimbalwa kule ndawo isikhumba ungase uqale ikhasi. Le ndlela yokuqinisekisa Kunconywa ukuba asebenzise esimweni kakhulu: ngokungeza luyibhuqu lwezinyawo sulfuric acid esetshenziselwa izimoto ibhethri, ukuphendula kwenzeka nokuziphendukela kwemvelo ngenxa yokushisa nokungcola iphunga dichloroacetic acid. imithi Self has cishe awekho iphunga. Ayanda izinga lomuthi, iphunga kancane. Uma ukunambitha powder, kuzobangela ukuba ndikindiki thunzi futhi iyathambisa.