Izidakamizwa "papaverine". Imiyalelo kuzosiza ekusebenziseni

Phakathi kwezidakamizwa eziningi wathembela iziguli iminyaka eminingi, kukhona izidakamizwa ezifana "papaverine". Umhlahlandlela likuchaza ngokuningiliziwe bonke ubufakazi bese izinga isicelo se-alkaloid. Ngokwemvelo, lokhu izidakamizwa kuqukethwe opium. Eminyakeni yamuva, ngokuvamile kakhulu ekhiqizwa synthetically. Le into - crystalline powder, kancane oncibilikayo utshwala, oncibilikayo emanzini kancane. I powder kunobuciko kancane ezibabayo. I ikhambi aqueous yabekwa lokuhlanzisisa izidakamizwa amahora 0.5 ezingeni lokushisa 100 ° C.

Izidakamizwa "papaverine" libhekisela miotropnym antispasmodic. Kunciphisa umsebenzi contractile futhi kunciphisa ithoni imisipha bushelelezi, kunemiphumela antispasmodic futhi vasodilating. Lokhu ukulungiselela isetshenziswa njengenhlangano antispasmodic lapho bushelelezi imisipha spasm (i cholecystitis, pilorospazme, nesifo spastic, zibe of ngomgudu womchamo), semithambo neuropathy, imithambo emaphashini, izitsha ingqondo. Kuze kube muva nje ukulungisa ngokuvamile zokunqanda imivimbo. Ukuthatha imithi "papaverine" imfundo ehlanganisa ulwazi izakhiwo zalo ezinhle, kufanele sikhumbule ukuthi ebulilini, wehlisa ijubane conduction intracardiac, kunciphisa excitability we imisipha yenhliziyo. Umuthi kwehlisa umfutho wegazi.

Nakuba odokotela bavame akunikeze imithi iziguli "papaverine", la mazwi awasho lutho yokuthi lo mshini wezenzo zawo emzimbeni womuntu kuya ekupheleni okwamanje unstudied. Le into - a inhibitor phosphodiesterase --enzyme kubangela ukunqwabelana intracellular ekamu. ekuqongeleleni yayo kuholela ukwehla imisipha nokungcebeleka ithi yayo spastic.

Ngokuvamile lihambisana promedolom enqunyiwe kusho "papaverine" imfundo okuvumela ukuyisebenzisa lihambisana namanye izidakamizwa ukuvuvukala kanye analgesic. Lokhu indlela yokuyelapha ukuqeda ukuhlaselwa angina. Futhi, it is evame ukunikezwa abantu abanesifo lihambisana izindlela platifillin, phenobarbital kanye nezinye izinto.

Ukulungiselela amaphilisi "Papaverine" ukukhululwa (0.04 g) e amaphakethe of 10 nama-PC., In ampoules nge 1 no-2% isixazululo of 2 ml, ku suppositories rectal ukuba 0.2 g Ingqikithi asebenzayo in amaphilisi, engena kalula ngokusebenzisa gistogematicalkie izithiyo, ngokushesha ugxile kusukela pheshana emathunjini. Umuthi is excreted ngu nezinso. Ingxenye - kusukela ehoreni kuya 2 amahora. Kufika 60% isixazululo efana ikhishwe ngendlela compounds ezahlukene (glucuronic acid, phenolic).

Kusho "papaverine" imfundo okuyinto uchaza ngokucacile, kulokho ngemithamo ukuthatha kwezidakamizwa iziguli bobudala obungefani, kudinga ukunamathela ngokuqinile kulezi kwezinkambiso. Isikali okweqile ngokuvamile kuholela nemiphumela emibi ngendlela efanayo. Abadala ngelanga ngokuvamile linqume 3-4 imithi olulodwa umthamo 1 ithebhulethi (0.04 g). Linqume amaphilisi izingane, kuye ngenani leminyaka for 3-4 isilinganiso esisodwa imithamo ezifana:

- iminyaka 0.5-2: 0.25-0.5 ithebhu.

- 3-4:. Ithebula 0.5-1;

- 5-6: 1 ithebhu.

- 7-9:. Ithebula 1.5;

- 10-14: 1.5-2 ithebhu.

Intramuscularly futhi phansi kwesikhumba injected isixazululo at 1-2 ml (1; 2%). Ngokucophelela nangosizo kancane iqondiswa ku vein 2% isixazululo (2.1 ml), njengoba izidakamizwa kungabangela okuvela block atrioventricular, fibrillation ventricular futhi ventricular extrasystoles. Ngesimo suppository usebenzisa esebenzisa 0,003-0,03 g umthamo owodwa (umthamo incike yobudala). Amakhandlela esetshenziswa emva enema noma kuso.

Ukuthatha imithi contraindicated nge hypersensitivity nalokho, hypotension, ukwephulwa of conduction atrioventricular. Musa ukuphuza imithi ngaphandle kokubonisana udokotela wakho. Ngempumelelo noma ukuphepha yayo phakathi nokukhulelwa kanye lactation engakaze isungulwe. Ngakho-ke, lesi sidakamizwa "papaverine", izimpawu okuyiwona isicelo lesi sikhathi akuzona ukuphila, akukuhle ukusebenzisa. Phakathi ukwelashwa kungavunyelwe nophuzo oludakayo.