Isifo sokuhlasela kwamasosha omzimba kuba purpura thrombocytopenic

Ngokokuqala ngqá i sokuhlasela kwamasosha omzimba purpura thrombocytopenic, achazwa 1735 Verlgofa ababebona isifo eminyakeni eyishumi 'intombazane. Okwamanje ngaphansi leli fomu igama kuhlanganiswe sokuhlasela kwamasosha omzimba thrombocytopenia, imbangela autoaggression lapho ehluleka. Babonakala oluhambisana diathesis nge ukuntula elingalodwa platelet. Ukwabela ifomu oyingozi futhi ezingalapheki lesi sifo.

izimbangela

Acute purpura thrombocytopenic ahlupheke ikakhulukazi izingane ezineminyaka engu-2 kuya ku-9. purpura Thrombocytopenic ezinganeni libhekene kuqala okuzumayo ukululama ngokushesha. Ukuthuthukiswa ukubonakaliswa emitholampilo sivame ukukhuthaza izinhlelo igciwane lohlobo elingenhla ipheshana zokuphefumula noma ipheshana wokugaya ukudla. Ngo-10% ezifo ahlobene ne-ukuthuthukiswa varicella igciwane, Epstein-Barr igciwane, ukugoma, BCG immunotherapy. Platelet ukubhujiswa ngenxa yokusabela mzimba umzimba kunokuba isenzo igciwane.

amafomu Okungalapheki ka thrombocytopenia ehlala njalo izinyanga ezingaphezu kuka 6 ibizwa idiopathic purpura thrombocytopenic. Imbangela sifo akwaziwa. Thrombocytopenic purpura ngokuvamile iqala eminyakeni yokuthomba, ukuthomba. Kwande abesifazane.

ukubonakaliswa Clinical avele kancane kancane. Libhekene ngenkambo onesifo-yansukuzonke noma nokunwetshiwe lesi sifo. isisekelo Pathogenetic yesifo sikhulu futhi asheshisa platelet ukubhujiswa ngokusetshenziswa autoantibodies ngokumelene nawo.

emitholampilo isithombe

On isikhumba iziguli zikhala microcirculatory ukopha uhlobo njengoba punctate ukuqubuka petechial encane hematoma ongama, purpura phezu mucosa ngomlomo. Libhekene ukopha ka nolwelwesi lwamafinyila kwekhala, izinsini. Izinguquko esikhumbeni ngokuvamile zitholakala phezu phambi emikhawulweni isiqu, yasenhla nemithombo yasenzansi. Ngokuvamile kumiswa ukopha esikhulu endaweni yomkhuleko umjovo. Ngezikhathi ezithile kungase kube ukopha phakathi sclera futhi retina, ngopha ipheshana wokugaya ukudla. Ngo abesifazane, kukhona nokopha e ezikhiqiza amaqanda. Ngo amafomu okunzima kwezinso isifo ukopha kungenzeka.

purpura Thrombocytopenic kungaholela yezinkinga eziyingozi ezifana ukopha palsy futhi ukopha subarachnoid. Isici kuyinto omuhle cuff isivivinyo Konchalovsky ngumsebenzi-LEED: kumiswa nokopha ezindaweni isikhumba kokucindezelwa. Lymph node, isibindi kanye ubende hhayi lakhulisiwe.

ukuhlola

Isici esiyinhloko elabhorethri ukunciphisa isibalo platelet. igazi ekunqandeni Isikhathi umthetho. Heparin plasma aye athuthukiswa. Ezimweni eziningi, kunqunywa ukwanda of immunoglobulin G -platelet. Ngemva ukopha abalulekile ichazwa acute oluhambisana igazi.

ukwelashwa

Uma kutholakale ukuthi une-thrombocytopenic purpura, iziguli ziqala imishanguzo corticosteroids. Phakathi ukwelashwa, iziguli yabukela kwenyuka kwemtfwalo platelet ukubala kuze ukuthethelelwa okuphelele. Ukuswelakala kokusebenza ngokuhlanganyela ukusebenza kwe corticosteroids futhi immunomodulators ebekiwe delagil. Nge ukwehluleka ukwelashwa ngoludala ezinyangeni ezingu 6 ukuncoma kokwenza splenectomy.

Esinye isici esibangela yokwelapha - Ukuphatha ebulilini immunoglobulin ngoba umjovo emthanjeni izinsuku 5. Lezi amalungiselelo okunqanda amasosha omzimba ezenza futhi ususe amagciwane, amagciwane kanye nezinye antigen.

Ngo 80-90% eziguli nokuvulwa nokuguqulwa kwenzeka ezinyangeni ezingu 1-4. Kwezinye izimo, purpura thrombocytopenic kungathatha izinyanga ezingu-12. Lesi sifo onesifo relapsing: ukopha nezikhathi kushintshane izinkathi ukuthethelelwa.