"IFN-Lipint": ukubuyekezwa, imfundo, analogs, isicelo, intengo

Kusho "IFN-Lipint" kuyinto izidakamizwa elwa namagciwane ukuthi sidaliwe ngesisekelo interferon. Ukwakheka lokhu ekwakhiweni uhlanganisa omisiwe isakhi sokuzakhela-alpha-2 womuntu interferon-beta. Umuthi, efana nezinye izidakamizwa, okuyinto isakhiwo sihlanganisa lokhu kwakwakhe ikhuthaza siqu uhlelo umuntu sokuzivikela. Ukusebenza kwale ukuthaka imithi Kwenziwa izilonda ezihlukahlukene ezithathelwanayo lapho buthaka impilo siqu. Ngokwesibonelo, ngokuhamba immunotherapy, izifo letindzala.

"IFN-Lipint" lisetshenziswa:

• Lapho efeza ngesikhathi Igagasi zokuvimbela SARS.
• Endabeni izifo letindzala, ezifana atopic dermatitis, isifuba somoya kanye nokunye okufana nalokho. D.
• Ngo-viral ukusha kwesibindi kohlobo B - kuzo zombili oyingozi futhi ezingalapheki.

"IFN-EU Lipint" itholakala ifomu powder. Ukuze umfuma sengezwe ngokushesha ngaphambi sebenzisa distilled noma abilisiwe amanzi, bese zonke ngamandla zazamazama. Ngokusho imiyalelo, umuthi Kunconywa ukuthatha isigamu sehora ngaphambi kokudla. Nokho siqu isicelo isikimu ngqo isiguli ngasinye, udokotela ubophekile ukuba ukupenda ngokuningiliziwe. Njengomthetho, inkambo Imininingwane yokwelashwa akuyona wenyanga eyodwa.

izinhlobo ukukhululwa ekhona, intengo

• Powder lyophilized 500,000 IU / ml (Temlomo) - intengo ruble 700.
• Ukulungisa lyophilized powder slurry 1,000,000 IU (Temlomo) - intengo ruble mayelana 1000.
• Ukuze kulungiswe ukumiswa the lyophilised powder 250,000 IU (Temlomo) - intengo ruble mayelana 410.

"IFN-Lipint": nozakwabo

Lesi sidakamizwa ine analogue ezilandelayo:

• "Infagel".
• "Viferon-wamafutha".
• "Viferon".

izinkomba

Lyophilized powder 1 million IU 250 000 IU ukusebenza kwangaphakathi Kunconywa kulezi zimo ezilandelayo:

• Ukulapha nokuvikela acute viral izifo zokuphefumula kanye nemfuluwenza.
• yi-multiple sclerosis.
• Sarcoma Kaposi okuphathelene AIDS.
• Clasmocytoma.
• Mycosis fungoides.
• umdlavuza izinso.
• myeloma amaningi.
• Inguquko ifomu granulocytic wegazi ezingelapheki kanye myelofibrosis.
• thrombocytosis zamabanga aphansi naphezulu.
• Active viral sokusha kwesibindi sohlobo C.
• wegazi Myeloid efomini ezingamahlalakhona.
• Hairy iseli wegazi.

Powder lyophilized 500,000 IU / ml "IFN-Lipint" njengoba amafutha asetshenziswa viral lesion nolwelwesi lwamafinyila kanye integuments ka kwasendaweni ezahlukene.

Ifomu asebenzayo we ekwakhiweni suppository isetshenziswa ukwelashwa nge izifo ezifana:

• Izifo ezithathelwanayo ukuvuvukala kwezingane, kufaka nokutholwa ababelethwa kungakafiki isikhathi nomntwana osanda kuzalwa.
• Meningitis.
• Sepsis.
• Umkhuhlane, SARS, kubandakanya yezinkinga kwegciwane.
• Chlamydia, inyumoniya ezibangelwa amagciwane kanye ezibangelwa amagciwane.
• ukutheleleka Intrauterine - ukutheleleka enterovirus, CMV ukutheleleka, i-herpes, i-chlamydia, candidiasis, kuhlanganise mycoplasmosis visceral.
• Viral kwesibindi kohlobo B, C, D e abadala kanye nezingane, kuhlanganise ekuhlanganisweni hemosorption futhi plasmapheresis viral ukusha kwesibindi kohlobo ezingamahlalakhona isibindi sibe sesomile futhi degree okunzima umsebenzi.

Njengoba i interferon-ukulungisa kusho "IFN-Lipint" (intengo letinikwe lapha ngenhla) isetshenziswa uma lezi zifo ezilandelayo:

• ukutheleleka urogenital (Human Papillomavirus ukutheleleka, mycoplasmosis, isitho sangasese somuntu wesifazane candidiasis yansukuzonke, vaginosis webhaktheriya, trichomoniasis, ureaplasmosis, vaginosis webhaktheriya, CMV ukutheleleka, i-chlamydia).
• ukutheleleka Phindaphinda noma eyinhloko mucosa kanye isikhumba.
• Umkhuhlane nezinye izifo sibi zokuphefumula futhi ODS, kuhlanganise yezinkinga e abadala kwegciwane.

Izimo

Izidakamizwa "IFN-Lipint" (intengo incike kundlela ukukhululwa) unomthwalo Izimo ezilandelayo:

• Kahle umsebenzi izinso, isibindi noma isimiso sokujikeleza kwegazi.
• Hypersensitivity.
• ukusha kwesibindi kohlobo Okungalapheki ezigulini wathola nje kokuba ukwelashwa immunosuppressive (kwasinda short-term pre-ukwelashwa nge steroid).
• isilethikusebenza.
• ukusha kwesibindi kohlobo Okungalapheki okubangelwa decompensated isibindi sibe sesomile.
• Sinzima isifo senhliziyo (kuhlanganise umlando).
• Isifo sokuwa noma ezinye sezinzwa uhlelo iziyaluyalu.

Ngaphezu kwalokho, "IFN-Lipint" (. Izibuyekezo sokulungiselela, bheka ngezansi), ezinye ukulinganiselwa ukuze ukusetshenziswa:

• ukuzwela High kuya engenayo yezingxenye izidakamizwa.
• Ibele.
• Ukukhulelwa.

side effects

Lyophilized powder for temlomo 1,000,000 IU 250 000 IU "IFN-EU Lipint" (intengo lincike ukuma ukukhululwa) has okulandelayo side effects:

• ukusabela isikhumba nomzimba (isb, ukulunywa futhi isifuba).
• ukuphazamiseka kokulala.
• Ukwethuka.
• ukwazi kahle.
• Ukozela.
• Ukucindezeleka.
• retinopathy Ischemic.
• ukuphazamiseka visual.
• Isiyezi.
• Ukusha Kwesibindi Kohlobo.
• Okungavamile kokusebenza kwesibindi.
• Isilungulela.
• peristalsis Eliphakeme.
• Ukubhodla.
• Ukuqunjelwa.
• Ubuhlungu besisu.
• Chills nomkhuhlane
• Isifo sohudo.
• Ukuncipha komzimba.
• Umlomo owomile.
• Shintsha ukunambitheka.
• Ukuhlanza nokukhishwa isicanucanu.
• Ukujuluka.
• Ubuhlungu amalunga omzimba.
• Ikhanda elibuhlungu noma ubuhlungu bemisipha.
• imnyama.
• Ukucobeka.

"IFN-Lipint" lyophilized powder izingane 500 000 IU / ml:

• Wamafutha - side effects Kuye kwaphawulwa.
• Suppositories - akuvamile wabonakaliswa ukusabela nomzimba (isb, ukulunywa noma ukuqubuka).

ukuxhumana

Interferon-alpha kunciphisa umsebenzi cytochrome P-450, esithinta umzimba warfarin, propranolol, diazepam, theophylline, Chime, phenytoin cimetidine kanti ezinye izidakamizwa cytotoxic. Futhi kungase kwandise cardiotoxicity, neurotoxicity noma imiphumela myelotoxic kwezidakamizwa, okuyinto sebeqalile ukukuqaphela kanyekanye ne noma ngaphambi kwalokho.

Ngaphezu kwalokho, isidingo sokugwema ekuphathweni concomitant "IFN-EU Lipint" (intengo eboniswe ngenhla) nezidakamizwa anomthelela yokucindezela isimiso sezinzwa esiyinhloko, kanye nezidakamizwa immunosuppressive (kuhlanganise nezinhlobo parenteral futhi ngomlomo corticosteroids).

It is nhlobo phakathi ukwelashwa ukuthatha utshwala.

kungenzeka umthamo

Umuthi esithathwayo isigamu sehora ngaphambi ukungenisa ukudla. Ngokuba nokuvimbela SARS kanye Umkhuhlane - 1 capsule (500 000 IU) ngosuku phakathi nenyanga, izikhathi 2 ngesonto. Ekwelapheni SARS kanye Umkhuhlane - 1 capsule (500 000 IU) nsuku zonke izinsuku 5, izikhathi 2 ngosuku. Lapho kungenzeka ukugwinya kunzima ukuvula ngokucophelela capsule futhi uthathe okuqukethwe nge inani elincane amanzi.

Umthamo nokuPhatha

Lokhu nomuthi iqondiswa ngomlomo. Ngaphambi isicelo yayo ngqo okuqukethwe isitsha kuthiwa kungezwe chilled abilisiwe noma distilled amanzi (1.2 ml). Ngenxa yalokho, cishe imizuzu engu 1-5, kunyakaze mass homogeneous kufanele ivele khona.

1. Endabeni acute ukusha kwesibindi kohlobo nomuthi esithathwayo imizuzu engu-30 ngaphambi ukudliwa kokudla ngu isikimu elandelayo:

• Izingane ezivela 3 kuya eminyakeni 7 - isidakamizwa esithathwayo izinsuku ezingu-10, isikhathi esingu-1 ngelanga 500 000 IU. Ngemva kwezifundo kwamakhemikhali ukuhlolwa kwegazi "IFN-Lipint" izingane (intengo incike kundlela ukukhululwa) isetshenziswa isikhathi eside - ngaphambi ukuqala alulame ngokugcwele emtholampilo.
• Izingane abaneminyaka engama-7 ubudala kanye nabantu abadala - izinsuku ezingu-10 izikhathi ezingu-2 ngosuku, 1 million IU.

2. Endabeni kwesibindi kohlobo B okungamahlalakhona amafomu lokuziphindaphinda (esebenzayo noma angasebenzi), kuhlanganise kwesibindi kohlobo B okungamahlalakhona, elihlobene ne glomerulonephritis, umuthi kufanele kuthathwe imizuzu engu-30 ngaphambi kokuthatha ukudla, njengoba kulandela:

• Izingane ezivela engu-3 kuya ku-7 ubudala kufanele nithathe lesi imithi izinsuku ezingu-10, izikhathi 2 ngosuku nge 000 IU 500, bese - 1 inyanga 1 isikhathi ngelanga (mhlawumbe ebusuku) ngosuku, 500 000 IU.
• Izingane abaneminyaka engama-7 ubudala kanye nabantu abadala - izinsuku ezingu-10 izikhathi ezingu-2 ngosuku, 1 million IU-ke 1 inyanga 1 isikhathi ngelanga (ebusuku) ngosuku.

3. Uma kwenzeka yokwelapha ethile, kufanele "IFN-Lipint" (imibono ngezansi) esetshenziswa emizuzwini engu-30 ngemuva kokudla e kwasa kanje:

• Endabeni atopic somoya abadala - kwezinsuku ezingu-10 nsuku zonke 500 000 IU. Khona-ke, phakathi kwezinsuku ezingu-20 ngemuva kosuku ku 500,000 IU. Ubude obuphelele izinsuku ezingu-30.
• Endabeni rhinoconjunctivitis iguliswa - izinsuku 10 nsukuzonke 500 000 IU.

4. Ngenjongo nokwelashwa acute izifo zokuphefumula futhi umkhuhlane lo imithi esithathwayo isigamu sehora ngaphambi kokudla. "IFN-Lipint" ukuze ukusetshenziswa imfundo kuqinisekisiwe, kufanele uphuze kanje:

• Ekwelapheni acute izifo zokuphefumula futhi umkhuhlane - ezinsukwini ezingu-3 nsuku zonke izikhathi 2 ngosuku nge 000 IU 500.
• Ngenhloso nokuvinjelwa Ari noma umkhuhlane - ne ukuvelela abagulela ukufa imithi azithathe inyanga engu-1 izikhathi 2 ngesonto 1 isikhathi ngelanga 500 000 IU.

ukweqisa izidakamizwa

Cases kokweqa Isikali zomuthi uyalandelwa. Mhlawumbe kuphela ukwanda ezihlobene umthamo-side effects. Overdose enikeziwe ukwelashwa lingaze.

amagama afanayo

"Eberon Alpha P", "IFN-EU Lipint" ngabantwana "Realdiron", "ALFARON", "Layfferon", "Intron-A."

I-ejenti

Umuthi kufanele okungenani zizogcinwa nalapho kufinyelela khona izingane ezincane, avikelwe elangeni indawo. Ngakho izinga lokushisa isitoreji kumele singeqi 8 ° C.

izincomo ezithile

Umuthi akunamthelela ikhono lokulawula ngemishini engaba yingozi futhi izimoto. Uma uhlangabezana komzimba kufanele afune usizo lwezokwelapha ngokushesha.

njengoba ezikhishwe

"IFN-Lipint" izingane (izinkomba ngezansi) ikhishwe kuphela kadokotela lukadokotela.

Izibuyekezo Ochwepheshe

Lesi sidakamizwa kanyekanye akanalo nje anticancer nomsebenzi namagciwane, kodwa futhi nekhono ukubuyisela izivikeli mzimba. yokusetshenziswa kwawo kabanzi ithole ukuze bayothola ukwelashwa yayo viral ukusha kwesibindi kohlobo B, njengabanye izidakamizwa elwa namagciwane kunangaphambili wamiswa, ngakho consequently ithemba ngaphezulu umphumela namagciwane. izinsuku ezingu-5 emva isifo jaundice akabange esabhekwa ebekiwe.

Ngaphezu kwalokho, lokhu izidakamizwa isetshenziswa endabeni meningoencephalitis amagciwane, kodwa kuphela izinsuku zokuqala ezine lesi sifo. Enye "IFN-Lipint" ngenkuthalo esetshenziselwa conjunctivitis ezibangelwa amagciwane kanye keratitis. umsebenzi Antitumor ikuvumela yokunika leli izidakamizwa kwamanye izinhlobonhlobo umdlavuza, ikakhulukazi izifo igazi umdlavuza. Imiphumela Excellent kuye kwakhishwa ekwelapheni ka-multiple sclerosis.

Kwaphawulwa ukuthi izigaba ezithile kweziguli kabi ibekezelelwe ukusetshenziswa kwalesi izidakamizwa: kukhona ukukhathala, ubuthakathaka, imfiva, Ukugodola. Nokho, naphezu kwakho konke lokhu, indlela yokwelashwa, ezimweni eziningi, okudingeka uqhubeke.

Ngezinye izikhathi ukwelapha unya elibukhali zegazi kanye leukocyte, odinga ukulawula igazi ukuhlaziywa nokubona emitholampilo (2-3 izikhathi phakathi nesonto). Naphezu imiphumela emibi, njengoba umthetho, ukudamba ngokushesha zomuthi siqedwa, ngoba ukuqedwa ngesinqumo sawo kufanele athathwe kuphela onguchwepheshe, ubeke "IFN-EU Lipint". Lokhu kungenxa yokuthi izinzuzo olulindelekile mkhulu kangangokuthi isinqumo yokuqeda kudingeka bacabangele kanye esinokulinganisela kakhulu.

izinzuzo

• Ngesikhathi inhliziyo yalesi izidakamizwa lesayensi nokuthuthuka, okuyinto waklonyeliswa Russian Prize kaHulumeni.
• Uma kuqhathaniswa nezinye izinto izidakamizwa, "IFN" Kumele kuthathwe ngomlomo (ngomlomo). Lokhu isici kubalulekile ikakhulukazi Pediatrics.
• interferon Liposomal uphelele zokuvimbela eziphuthumayo SARS kanye Umkhuhlane, lapho kwakukhona ukuxhumana igciwane, kodwa izimpawu zesifo akudingeki noma ngokulambisa kuphela obonakalayo.
• Liposomes ukukhuthaza kwegazi isikhathi eside e-interferon igazi.
• "IFN" izenzo njengenhlangano inductor, okungukuthi, kunomthelela ekuthuthukiseni interferon lalo.

Ukulungiswa kufaka interferon isakhi sokuzakhela, olwasungulwa zofuzo ubunjiniyela amasu ngaphandle kwesibeletho. Ngamanye amazwi, lokhu izidakamizwa akuyona imikhiqizo yegazi yemvelo futhi ayinakuhlala ukutheleleka enobungozi.

Izixwayiso

Njengoba kushiwo ngaphambili, ngokuhamba kokuthatha lesi imithi ukugwema inhlanganisela yayo nge immunosuppressants, kanye nemithi ukuthi azinakwenzeka phezu CNS. Kuwo wonke kubaluleke kakhulu ukuqapha umsebenzi kwesibindi kanye nezinto igazi kwakhiwa. Ukuze kancane ekudambiseni izimpawu zomkhuhlane (side effects), okungcono kanyekanye ne yokwamukela lokhu ukulungiselela nika paracetamol.