"Ursofalk": analogue, yokusetshenziswa nokukhululwa ifomu

Nomuthi "Ursofalk" imfundo manual elimchaza ngokuthi umuthi nge spectrum ezibanzi umsebenzi, esesikhundleni, phakathi kwabanye, hepatoprotective, cholelitolitic, izakhiwo immunomodulatory. Futhi, izidakamizwa iyehlisa amazinga egazi cholesterol.

impahla esebenzayo

Isithako asebenzayo we nomuthi izenzo ursodeoxycholic acid. Kuyinto samanje kwezinye inani Bile womuntu, kodwa ngenxa izifo ezithile isebenze isibindi zamagama, futhi ngenxa yalokhu okuqukethwe izidakamizwa e Bile zingancishiswa.

Ursodeoxycholic acid njengoba isakhi esiyinhloko likhona hhayi kuphela ukulungiswa "Ursofalk". Analogs kokuqanjiwe futhi kwemithi-izakhi - lemithi ngokuthi "Ursosan", "Ursol", "Urdoksa". Ukuxoxa kakhudlwana ngezansi.

imiphumela zokwelapha izindlela "Ursofalk"

• umphumela Choleretic kuyinto ukwehla inani hydrophobic Bile acid kanye ukwandisa ukukhululwa kwabo mafutha anciphisa isikhala esingaphakathi emathunjini. Ngaphezu kwalokho, izidakamizwa ngenxa kokuba ekukhulumisaneni ne ileum incipha receptor hydrophobic ukumuncwa acid anobuthi.
• Immunomodulating isinyathelo kubangelwa yokuthi ursodeoxycholic acid uyakwazi ukunciphisa nkulumo hepatocytes hla molecule ekilasini lokuqala, futhi cholangiocytes - hla molecule isigaba sesibili. Futhi imithi kunciphisa synthesis cytokines pro ukuvuvukala.
• Umthelela cytoprotective yikhono izinto asebenzayo ukuze ukungena ungqimba lipid we ulwelwesi cell, okuholela cell ulwelwesi kuzole izakhiwo olwawuvikele ayathuthuka.
• umphumela Hypercholesterolemic kusekelwe ukuncipha le ileum ukumuncwa futhi ukwehla cholesterol zamagama esibindini, kanye excretion yayo kule Bile.

Ngaphandle imiphumela ngenhla, lesi sidakamizwa "Ursofalk" (yokusetshenziswa kufakazelwa) yakha a crystal liquid nge-molecule cholesterol ukuthi kunciphisa lithogenicity Bile. Ngenxa ukuguqulwa cholesterol compounds encishisiwe kumiswa amatshe kuyinto nokonakala kwabo.

Pharmacokinetics

Ukulandela ekuphathweni ngomlomo izidakamizwa emathunjini amancane amuncwa umzimba ursodeoxycholic acid, ukumuncwa ubuswa ezokuthutha abakhuthele ileum engxenyeni esibulalayo, futhi ezokuthutha yokwenziwa - ku jejunum futhi ileum engxenyeni engenhla. Cishe 60-80 amaphesenti umthamo uthola emgudwini wegazi.

Ingqikithi asebenzayo metabolised esibindini futhi ngokwengxenye disintegrates emathunjini, okuyinto kuholela ekwakhekeni enobuthi eziyisikhombisa-keto lithocholic acid, okuyinto, yona, angena egazini futhi ngezinga elincane detoxifies isibindi. Isigamu-ekuphileni impilo yezidakamizwa - ezintathu - izinsuku ezinhlanu. It is ikakhulukazi excreted ku indle njengoba metabolites.

Izinkomba ukusetshenziswa

Ukulungiselela "Ursofalk" imfundo manual ekhombisa elisetshenziswa izifo kwesinye inyongo kwesibindi, ephelezelwa ukwanda igazi cholesterol, cholestasis, isibindi imisebenzi ethile nokuncishiswa. Phakathi kungenzeka izifo ezifana okukhulunywa isifo sokusha biliary (primary), biliary Reflux kolwelwesi, sclerosing cholangitis (primary), biliary Reflux esophagitis, isifo sokusha kwesibindi kohlobo of omsakazo ezahlukene,-cystic fibrosis.

Umuthi ezinqunyiwe khona amatshe atholakala enyongweni, kodwa uma befinyelela rentgennegativnye ububanzi, ubungako bawo ingeqi amamilimitha angu nanhlanu, kanti isiguli akusho ukuphazamisa ukusebenza gallbladder. I nomuthi liyasetshenziswa esimweni esibindini obabubangwa (isib utshwala poisoning), zokugula yayo ephelezelwa cholestasis (ezinganeni), dyskinesia biliary, atresia ka intrahepatic Bile mapayipi. azithathe yakhe iziguli okunomsoco parenteral, ukuze aqede yokujama tsi of Bile, kanye kubantu abanesikhathi uhlinzwe ukuze ukufakelwa isibindi.

Njengoba i-ejenti prophylactic iqondiswa izidakamizwa "Ursofalk" (izidakamizwa analogs futhi ingasetshenziswa Kulezi zimo) kanyekanye ne yokwamukela izidakamizwa okungenzeka zibulale ukusebenza kwesibindi (zokuvimbela inzalo hormone, izidakamizwa kanye nomphumela cholestatic).

Khipha ifomu kanye nokwakheka

amafomu amabili ukukhulula izidakamizwa has "Ursofalk": ukumiswa (akukho analogue, akhiqizwa Switzerland) kanye amaphilisi (analogs akhiqizwa eJalimane). Le nguqulo yokuqala ye izidakamizwa isetshenziswa ngokuyinhloko izingane noma abantu nobunzima ukugwinya. Gelatin amaphilisi kukhona opaque, kanzima, ikhava umzimba zipendwe ezimhlophe, ngaphakathi - elimbudumbudu omhlophe noma powder. Itholakala amaphakethe of izingcezu 10, 25, 50 noma 100. Ukumiswa Ubuye nombala omhlophe, elinesimo ukungaguquguquki eyohlobo, iqukethe air Bubbles, it has a iphunga lemon. Itholakala amabhodlela 250 namamililitha, ephelele okuvalelwe yokulinganisa spoon.

250 mg ursodeoxycholic acid kuqukethwe ukulungiselela capsule, esilinganayo empahleni asebenzayo ekhona namamililitha ezinhlanu (owodwa Ketha) slurry "Ursofalk". I isiraphu yakhiwa izingxenye asizayo: glycerol, anhydrous citric acid, xylitol, propylene glycol, i-sodium chloride, microcrystalline cellulose, benzoic acid, lemon ukunambitheka, sodium citrate, amanzi ahlanzekile, sodium cyclamate. izithako Secondary e amaphilisi ethulwa colloidal Silicon dioxide, ama-titanium dioxide, i-sodium lauryl sulfate, corn isitashi, magnesium stearate, gelatin, amanzi ahlanzekile.

Indlela "Ursofalk"

I nomuthi esimweni olulodwa reception uya khona ufisa ukuthola kusihlwa. Capsule kugwinyiwe, ngaphandle ukuhlafuna, wageza phansi ngamanzi ngobungako kwesokudla. Njengoba sekuphawuliwe kakade, imithi "Ursofalk" izingane kungcono ukusebenzisa ngesimo ukumiswa (isiraphu). I Isikali kumele ibalwe udokotela, esekelwe esimweni lesi sifo futhi izici umzimba wesiguli. Izinsana (nge isisindo amakhilogremu amahlanu) kumele banikezwe sokulala ikota wokulinganisa spoon slurry.

Ngokuvamile i-isibindi umthamo wansuku zonke abadala kuyinto 10-15 mg ngayinye isisindo amakhilogramu umzimba, inkambo yokwelapha ithatha izinyanga eziyisithupha kuya eminyakeni emibili, is hhayi Kunconywa kuleli cala amakhefu e reception nomuthi. Kubantu abanalesi biliary Reflux oesophagitis noma biliary Reflux kolwelwesi nsuku zonke umthamo "Ursofalk" izidakamizwa - 250 mg ukwelashwa - eziyishumi - izinsuku eziyishumi nane. Lapho sclerosing cholangitis futhi ziphathwe yisifo sokuqina biliary ngelanga, ngokuvamile linqume ethola 10-15 mg ngayinye isisindo amakhilogramu umzimba, kodwa uma kunesidingo, umthamo lenyuke kuya ku-20 mg ngayinye 1 kg. Ukwelashwa kuvame ukuthatha ngemva kwezinyanga eziyisithupha kuya eminyakeni emibili. Iziguli ezine-cystic fibrosis imithi nsuku zonke ngesikhathi umthamo 20-30 mg amakhilogramu esisindo phezu izinyanga eziyisithupha ngayinye iminyaka emibili. Endabeni esibindini obabubangwa kuboniswa ukuthi bathwale izidakamizwa umthamo wansuku zonke we 10-15 mg amakhilogramu esisindo ngalinye eziyisithupha - izinyanga eziyishumi nambili.

"Ursofalk" imithi. analogs

Isici ngokuqhathanisa imithi kanye nezidakamizwa efanayo ukwakheka kanye izakhiwo kwemithi.

• Izidakamizwa "Ursosan". Lo mkhiqizo enziwa Czech Republic futhi eJalimane, itholakala kuphela ngesimo amaphilisi. Lo mshini wezenzo in imithi efanayo. Nokho, abelaphi, hepatologists, ezithathelwanayo isifo odokotela ku umbuzo lapho izidakamizwa kungcono, "Ursosan" noma "Ursofalk" ngazwi linye bathi Kungcono ukukhetha yesibili. iziphetho ezinjalo zenziwa ochwepheshe ngesisekelo siqu imibono yabo emitholampilo lobuya iziguli. Medicine "Ursofalk" idluliswe kulula kuka-analog kubhekwe, izophinda normalizes isimo sokusebenza kwesibindi. Kodwa ungakhohlwa mayelana nezici siqu umzimba, kunabantu kusho "Ursosan" kusiza kangcono. Ngaphezu kwalokho, izidakamizwa kuwufanele eshibhile kancane: pack amaphilisi 50 izobiza ruble 650-830, kuyilapho i-50 amaphilisi nemithi "Ursofalk" kuyodingeka bakhokhe ruble 850-1200.
• "Urdoksa" lisho ukuthini. Imithi ejwayelekile ikhiqizwa kumazwe. Nokho, ekukhiqizeni corporation ezithaka imithi ukuthenga izithako ezidingekayo phesheya, kanti eRussia kukhona kuphela inqubo izidakamizwa yokukhiqiza. Iphinde itholakala amaphilisi, intengo izingcezu 50 uyahluka ruble 440-960. Bobabili mithi pharmacologically efanayo, e-ekhiqizwa abalulekile umehluko ukusebenza ningagcini.
• "Ursol" imithi. Medicine, njengoba kwaba njalo endabeni langaphambilini, senziwa eRussia. Nokho, abantu abaningi bathi zonke lezi zimali ingabe kangcono uncibilike amatshe esinyeni nenyongo. Kodwa kukhona labo babe ukuphumelela ukwelashwa lalilide uma lithatha izidakamizwa "Ursofalk". Amaphilisi akheke ngendlela efanayo, ngakho makudle omunye kukho kunzima. Uma ugxila intengo, kungcono ukuthenga izidakamizwa "Ursol" ke ushibhile - 460-905 ruble ngoba amaphilisi 50.

side effects

nomuthi "Ursofalk 'ebekezelele ngokubhekakade Pretty kahle iziguli. Analogs izidakamizwa futhi libhekene tolerability ezinhle. Kwezinye izimo, ngesikhatsi ukwelashwa kukhona calcification of amatshe atholakala enyongweni ukuthuthukisa izigqiki mushy, ubuhlungu epigastric. Ngaphezu kwalokho, ungase ukuthuthukisa yokungezwani komzimba ngesimo pruritus, urticaria. Imibiko ukweqisa izidakamizwa abikwe kuze kube manje.

Izimo

High ukuzwela siqu izingxenye izidakamizwa isisekelo zokuchithwa ukusetshenziswa. Imithi is contraindicated kubantu nge cholangitis, noma occlusion we fibrosis Bile imbobo, cholecystitis oyingozi. Musa linqume izidakamizwa ukuze iziguli ukuhlukumeza umsebenzi motor we gallbladder, Bile colic.

Nokukhulelwa kanye lactation

Ngokocwaningo olwenziwa, ursodeoxycholic acid akusho abonise mutagenic, teratogenic, umsebenzi embryotoxic, kodwa amandla abo okuphila umlilo ukungena isithiyo gematoplatsentarny futhi kuthinte Yiqiniso yokukhulelwa engakaze wafunda kuze kube sekupheleni. Ngakho-ke, ingabe kufanele ngithathe imithi "Ursofalk" ngesikhathi ukuzalwa kuphela uma kunesidingo futhi udokotela. Experience in ukusetshenziswa imithi esikhathini lactation ayitholakali.

Ukusebenzisana neminye imithi

ukwelashwa Ngesikhathi antacid ukulungiselela ehlanganisa aluminium hydroxide, futhi imithi "Colestipol" futhi "Cholestyramine" kuholela wehlise ukumuncwa letindzala we ketshezi esebenzayo. Umuthi kungaguqula lokuhlushwa e-plasma izidakamizwa "Tacrolimus". Uma kukhona isidingo ukusetshenziswa ngokuhlanganyela kwemithi enjalo kufanele kuthathwe ngezikhawu okungenani amahora amabili.