Hydrochloride Loperamide. hydrochloride Loperamide - imfundo manual

Uyini izidakamizwa "hydrochloride Loperamide '? Impendulo oluphelele yalo mbuzo kungatholakala izinto olunikezwa sihloko. Ngaphezu kwalokho, sizokutshela ngokuningiliziwe ngendlela ukuthatha imithi, nini futhi ngaphansi kwaziphi umthamo.

ulwazi olujwayelekile

I nomuthi "Loperamide hydrochloride" buyisidakamizwa lingaze okuhlale asetshenziselwa ukwelapha isifo sohudo oyingozi futhi ezingalapheki. Lesi sidakamizwa okuthengiswa ngaphandle kadokotela futhi ithengiswe cishe kuzo zonke ekhemisi at an ngentengo eqolo.

imiphumela kwemithi

Ukulungiselela "hydrochloride Loperamide" imfundo okuyinto owakhe isidleke sakho phakathi ibhokisi, kunciphisa motility kanye ithoni kwemisipha bushelelezi emathunjini futhi kuvimbela peristalsis yomzimba, anda kakhulu isikhathi elisendleleni elikuqukethe. Ngakho, nomuthi ethulwa uzabalaza umphumela antidiarrhoeal. Kufanele kuqashelwe ukuthi izidakamizwa "Loperamide hydrochloride" iqala ukuthatha isinyathelo masinyane kakhulu. Lapho yokwamukela lokhu izidakamizwa ngaphakathi nomphumela oqabulayo kuthathe amahora mayelana 4-6.

Pharmacokinetics

a nomuthi okunjalo amuncwa umzimba emathunjini kuyinto mpofu ngempela ngokwezinto (cishe 40%). Ngenxa ukufana okusezingeni eliphezulu ukuze receptor izindonga emathunjini, kanye ngezinga eliphezulu biotransformation at indinyana yokuqala ngokusebenzisa amazinga isibindi plasma ingxenye unmodified ngemuva kokuthola izindlela 2 mg (1 capsule) kungaphansi kwama-2 ng / ml. Ubuningi esiphezulu we ketshezi esebenzayo ngemva isixazululo ukusetshenziswa kufinyelelwe emva mayelana 2.5 amahora, futhi ngemva amaphilisi - ngemuva kwamahora 5. Sesibopho ukuthobisa plasma amaprotheni kwenzeka e-97%. Lesi sidakamizwa is akheka esibindini futhi lisuselwa ngokwengxenye elivela emchamweni, njengoba conjugates nge Bile, kanye indle.

Khipha uhlobo imithi ngezithako zawo

Ukulungiselela "hydrochloride Loperamide," ukusetshenziswa elichazwa lapha, is ithunyelwa ifomu:

• Into powder isixazululo.
• amaphilisi 2 mg, ezibekwe ku ibhokisi 50, 30, 20 noma 10 izingcezu.
• 2 mg amaphilisi ibekwe ku iphakethe 30, 20 noma 10 izingcezu.
• Gelatin amaphilisi kanzima ophuzi, okuyinto aqukethe powder emhlophe ahlanganisa asebenzayo - hydrochloride loperamide. capsule ngasinye siqukethe 2 mg lomcebo asebenzayo. Ngaphandle nomuthi emelelwa iqukethe ukubunjwa yayo futhi izithako asizayo: talc, corn isitashi, i-lactose, magnesium stearate futhi Silica colloidal. Gelatin amaphilisi ayatholakala ngokukhangisa, ngaphatha ibhokisi elinezincwadi 20 noma 10 izingcezu.

Kukuphi lapho aqukethe esebenzayo isithako hydrochloride loperamide? Ukusetshenziswa kwalesi ketshezi kwemithi ivumela izidakamizwa ezifana "Imodium" futhi "Diara". Nokho, iphesenti salo kulezi ukwakhiwa lincane kakhulu kule nomuthi esesikhulume ngazo.

Izidakamizwa "hydrochloride Loperamide": ukuthi kusho ukuthini?

Ngokusho imiyalelo, umuthi liyadingeka ukuthatha kulezi zimo ezilandelayo:

• Ukuze kulesetayelekile esihlalweni ileostomy.
• Lapho iziyaluyalu umzimba kanye ukumuncwa emathunjini, okuyinto zibangelwa noshintsho olusheshayo kanye ezinkulu ekudleni noma ukwakheka evamile ukudla (isibonelo, phakathi ukudla, bathatha uhambo).
• Njengoba umuthi asizayo ngo sohudo ezithathelwanayo.
• Njengoba ukwelashwa lingaze for uhudo oyingozi noma ezingamahlalakhona (iguliswa ngemisebe, izidakamizwa noma imvelaphi ngokomzwelo).

Izimo ukusetshenziswa imithi

Kwezinye izimo, awukwazi ukusebenzisa izidakamizwa "loperamide" (amaphilisi)? Imiyalelo unikezwa imithi uthi akulona Kunconywa:

• isimiso emathunjini;
• uhudo, esiqubukile ngenxa uhudo, acute enterocolitis pseudomembranous noma ezinye izifo yaleli pheshana wokugaya ukudla;
• diverticulosis;
• acute izilonda emathunjini;
• hypersensitivity.

Kufanele kuqapheleke futhi ukuthi lezi izidakamizwa antidiarrheal izingane kufanele libekwe kuphela engu-4. Ngaphezu kwalokho, ngokwezinto imiyalelo, kusho "loperamide" is contraindicated ku senyanga yokuqala sokukhulelwa futhi ngesikhathi lactation. Ngokunakekela okukhulu isidakamizwa ezinqunyiwe yokwehluleka kwesibindi.

I nomuthi "hydrochloride Loperamide": yokusetshenziswa

Amaphilisi kanye amaphilisi lomuthi ukuze uyiswe ngomlomo ngaphandle nut. Umthamo zomuthi incike yobudala isiguli isifo zaba namandla kakhulu.

Ngo sohudo acute e abadala njengoba komthamo wokuqala iqondiswa 4 mg zomuthi bese - by 2 mg ngemva sokuzikhulula ngamunye (uma kwesitulo namanje ketshezi).

Ngo ukucubuluza okungapheli umthamo sokuqala 2 mg. ukwelashwa abasekelayo abadala kufanele zakhiwe ukuze sezinyawo imvamisa lesiguli kwaba 1 noma 2 izikhathi ngosuku. esiphezulu I umthamo wansuku - 16 mg.

Umthelela oqabulayo ukuthatha izidakamizwa ezifana eba emahoreni angama-48. Uma Nokho, izinsuku 2-4, usebenzisa 16 mg zomuthi nsuku zonke, awukwazi sifinyelele elamukelekile, kufanele ngaso sonke isikhathi xhumana nodokotela, owawakhulula becabanga uphethwe. Ukusebenzisa izidakamizwa kungaba liphindwe, kodwa kuphela ukwelashwa uma othize noma ukuzincisha ukudla akusho kujwayeleke kwesitulo.

Njengoba for the izingane, umuthi onjalo kumele kusetshenziswe iminyaka 4 kuphela ubudala. Umthamo kubuye sincike engu-isiguli nokugasela ngamandla kwalesi sifo.

Izinsana kusukela eminyakeni 4 kuya ku-7, umuthi kumele inikezwe 3-4 izikhathi usuku 1 mg. Isikhathi yokuyelapha izinsuku 3. Izingane kusukela kwabaneminyaka engamashumi 7 kuya ku-12 iqondiswa kane 1 ithebhulethi ngosuku izinsuku ezingu-5. Ngo-acute sohudo kokuqala umthamo izingane kufanele kube 1 capsule. esiphezulu I umthamo wansuku zonke izingane - 8 mg.

Uma ingane sohudo waphawula ngemva kwesenzo sokuzikhulula ngamunye isikhathi eside, njalo kufanele uziyale 1 capsule, kodwa hhayi ngaphezulu kuka-6 mg ngayinye 20 kg esisindo ngosuku. Uma ingane akusho ukuya ethoyilethi amahora angaphezu kuka-12, futhi ngemva ukuzinza of sezinyawo reception eyethulwe izidakamizwa belulekwa ukuba ayeke.

izidakamizwa ukweqisa izidakamizwa

Endabeni ka ukweqisa izidakamizwa nale izidakamizwa e isiguli esilandelayo ngeziphambeko kungabonakala nasemkhakheni:

• abahluphayo nokudidiyela ukunyakaza;
• constriction balezi zingane;
• stupor;
• ukozela;
• anda lwamathambo imisipha ithoni;
• wamathumbu isimiso;
• ukucindezeleka zokuphefumula.

Ukwelapha okunjalo sokugembula uthi odokotela bavame izidakamizwa "Naloxone 'lisetshenziswa kanyekanye yokwelapha lingaze.

side effects

Kufanele kuqashelwe ukuthi ngemva isicelo ekulungisweni "hydrochloride Loperamide" iziguli zingase zibhekane ezahlukene engemihle. Isikhathi esining impela zivele ngokusebezisa isikhathi eside zomuthi. Ngakho nomuthi emelelwa kungabangela imiphumela eminingi engemihle njengezindlela elandelayo:

• ukubuyisa;
• electrolyte kwezinso;
• ukuhlanza;
• amajaqamba emathunjini;
• isiyezi;
• gastralgia;
• isicanucanu;
• hypovolemia;
• ukozela;
• nomlomo owomile.

Ezinganeni, umuthi ngokuvamile kubangela ukungakhululeki lapho esiswini, kanye ukuqubuka. Kakhulu akuvamile nomuthi "hydrochloride Loperamide" kungase kube nomthelela nokugcinwa urinary isimiso emathunjini.

Uma emva kwezinsuku 2 kulezi zinkanyezi musa zinyamalale, kanti isiguli engazizwa kangcono, kufanele ngaso sonke isikhathi xhumana nodokotela abazakuba ukuqoka ezinye (ezifanayo) umkhiqizo. Ukube ubukhona umuthi kungasizi, kungcono ukuze uhlole izifo kubangele isifo sohudo.

izidakamizwa ekuhlanganyeleni

Ngokusho imiyalelo, kuyilapho isicelo amalungiselelo "Loperamide hydrochloride" futhi "Cholestyramine" kahle kokuqala kungase wehlise. Uma udinga ukusebenzisa izidakamizwa phansi nokucindezelwa ngezindlela zokuthi "Co-trimoxazole" noma "Ritonavir", ngalesosikhathi you azi ukuthi bioavailability kwalo kakhulu anda.

Izixwayiso

Izidakamizwa "hydrochloride Loperamide" Kumele kuthathwe ngokucophelela okukhulu e ukungakhuli hepatic. Futhi hhayi Kunconywa ukuyisebenzisa kulezi zimo emitholampilo lapho okusithiyayo of peristalsis emathunjini. In the ukungabikho umphumela ezanele zokwelapha emva kwezinsuku 2 ngemva nokuphathwa izidakamizwa kuyatuseka ukuba uthuthukise sitholakele udokotela nekugwema ezithathelwanayo genesis sohudo.