Umuthi 'Avastin "zamehlo: ukubuyekezwa, yokusetshenziswa kanye nokusungulwa

Kwezokwelapha, zikhona izimo lapho amathuluzi zenzelwe ekwelapheni izifo, ukubonisa imiphumela emihle endleleni abanye. Lokhu kwenzeka ngenxa ucwaningo ngaphambi izidakamizwa ifinyelela umthengi. Lokhu kwenzeke ne izidakamizwa zenzelwe wokwelapha isifo somdlavuza izimila, enesihloko esithi "Avastin". Zamehlo kanye nokubuyekeza zokwelapha waphoqeleka ukuba bacabange, ngayiphi injongo kanye nalokho izifo kungcono ukusebenzisa izidakamizwa.

"Avastin"

Ukulahlekelwa umbono - omunye yaba buhlungu womuntu ukuguga iziphuphutheki. Kuze kube muva nje, iningi izinqubo ngaphakathi iso kwaba nzima ukulawula, kodwa eminyakeni yamuva zamehlo etholakale ukuthi baye bavumela ukuvimbela ukuthuthukiswa izifo eziyingozi ekubeni abe yimpumputhe.

Ngenxa yale njongo, asetshenziswa amaqembu elehlukile lemithi, isibonelo, ukusetshenziswa ne yimpumelelo enkulu wokwelapha isifo somdlavuza ejenti "Avastin" zamehlo. iziguli Izibuyekezo ukuqinisekisa iqiniso lokuthi izidakamizwa has ngezinga eliphezulu of nekghono. Kodwa ukuze ukuqonda ukuthi kungenzeka kanjani ngempumelelo, kubalulekile ukuba sicabangele indlela ye iso izifo.

izindlela zokuthuthukiswa isifo

Ukulahlekelwa umbono kungenxa ekwandeni okungavamile igazi liphuma kuma-capillary. Okuphambili imikhumbi ukhule ngokusebenzisa ulwelwesi, ukubhidliza isakhiwo iso. Ngaphezu kwalokho, ngokuchichima imithambo yegazi icuphe ukopha njalo, okungase kuthintwe owenziwe umuntu futhi kuthinte izinga umbono. Broken capillary izibazi, futhi inani elikhulu ezicutshini iphula ngwengwzi iso amandla inqubo.

Leli phuzu angabhekwa ukuqala ongaboni. Okubalulekile, nombono onjalo ekuthuthukiseni zokugula ukuphathwa kwabathintwayo akuyona ngokuphelele elahlekile, njengoba neuropathy ngokujwayelekile balondolozwa. Noma kunjalo, izinga lempilo incipha kakhulu.

Naphezu kweqiniso lokuthi isithombe lesi sifo kubukeka ezicindezelayo kakhulu, nge uphethwe ngesikhathi esifanele zokugula kungenziwa wayeka ukuze alondoloze umbono. Ngenxa yale njongo, futhi ukusebenzisa izidakamizwa "Avastin" zamehlo. Uphenyo iziguli kanye nodokotela waqinisekisa izibalo omuhle.

Kanjani izidakamizwa

"Avastin" iyi-ejenti anticancer, isetshenziswa in Oncology iminyaka eminingi futhi ebonisa imiphumela emihle kakhulu. Indlela okusebenza - e inqubo ivimbela izicubu neziqu, ukuqothuka kwezinwele okungavamile kuphelile cell division. Ngakho-ke, Ukumisa ukukhula imikhumbi igazi, it iqeda izimbangela zesifo ngokwayo.

Kwaphela isikhathi eside kwakukhona ukungabaza ukuthi zinjalo yini zingaba oyifunayo nomphumela oqabulayo Cancer izidakamizwa "Avastin" zamehlo. Uphenyo ososayensi nodokotela bathi isisindo yamangqamuzana isithako yayo asebenzayo siphezulu kakhulu: kuba cishe kathathu mass yezinhlayiya nezinye izidakamizwa ne umphumela ofanayo. Ngakho-ke, ngo-mbono, izidakamizwa kungenzeka ukunqoba ngwengwzi ulwelwesi ungqimba, futhi kungakho ukunikeza imiphumela zokwelapha.

Kodwa ngokocwaningo, "Avastin" lingena kahle kuwo wonke izingqimba retina, lokhu kwehlisa izinga lwempi wegazi capillary. Nge uphethwe esifike ngesikhathi futhi yokwelashwa ingatholakala okuqalwe ukuze alondoloze ngokugcwele umbono.

side effects

Uma sicabangela izidakamizwa "Avastin", yokusetshenziswa, ukubuyekezwa kanye analogue nge Umhlahlandlela ukusetshenziswa ukhuluma kuphela mayelana reception internal ngokuvamile kwenzeka wokwelapha isifo somdlavuza. Ngakho-ke, imiphumela emibi izidakamizwa zimi kanje:

• ukopha zangaphakathi;
• nomfutho wegazi ophezulu;
• ukushayisana ipheshana wokugaya ukudla;
• proteinuria;
• dermatitis;
• peripheral;
• asthenia.

Uhlu amathuba okuba nemiphumela engemihle uma usebenzisa izidakamizwa ngesikhatsi ukwelashwa ubanzi kakhulu, njengoba uma usebenzisa noma iluphi umuthi wokwelapha isifo somdlavuza.

Isicelo zamehlo

Kodwa kulokhu izidakamizwa akuyona iqondiswa ngemithambo yegazi, futhi ngqo le Vitreous. Futhi okwesibili, umthamo sihluke kakhulu ukuthi esetshenziswa in Oncology. Ngokwesibonelo, ijovwe ngemithambo yegazi mayelana 500 mg zomuthi, kuyilapho iso - mg 1.25 kuphela.

Nokho, uhlangothi umphumela ethola "Avastin" sikhona: ukopha endaweni umjovo, evutha ukuzwa futhi Ukubhidliza concomitant. Ayikho izimpawu zokugula okungathí sina enqabayo sezihlonziwe noma ocwaningweni noma umkhuba.

nokushintsha kokudla nokufakwa

1.25 Isikali mg iqondiswa emzimbeni Vitreous kanye ngenyanga, noma izikhathi ezintathu noma ezine. Ungabese ukuhlola umphumela ukwelashwa "Avastin" zamehlo. Izibuyekezo iziguli abonisa ukuthi ngokushesha ngemva Yiqiniso ngcono acuity ezibukwayo ebonwe 4 10 Izikhonzi. Ngo 6 out of 10 abantu abaphathwa kuholela sinjalo umbono, okungukuthi, ukuze wehlise izinga ebangeni lelilandzelako nekunika ekwandeni capillary nezibazi.

Umthelela wukuthi retina iba izacile, okungukuthi, kwandisa permeability yayo namandla ijwabu. Ngokuvamile, isiguli uzizwa ubungcono acuity ezibukwayo emva umjovo wokuqala kanye imijovo okwalandela kuphela baqinise umphumela. Kukangaki udinga uphindwe umjovo, kuye anatomy yomuntu. Ngokwezibalo, inkambo esilandelayo imijovo kwenziwe izinyanga 2-3.

Izimo

Umuthi akuvunyelwe hhayi Kunconywa izingane, abesifazane abakhulelwe nabancelisayo. Futhi, ukunakekelwa okukhulu okufanele sisetshenziswe "Avastin" uma kwenzeka ukuthi kukhona okuthile okungavamile ku isibindi kanye nezinso, ikakhulukazi esingamahlalakhona obusebenzayo izitho.

Kodwa kumelwe acabangele yokuthi lezi Izimo zisebenza kuphela uma iqondiswa ngemithambo yegazi, futhi lapho benikeza umjovo ku iso, bangase babe engasasebenzi. Kunoma ikuphi, isinqumo ukuqokwa izidakamizwa "Avastin" zamehlo, ukubuyekezwa ingatholakala kunoma iyiphi umtholampilo ezifanele, udokotela kufanele senze okufanayo.

Nokho, kufanele sikhumbule ukuthi ukusetshenziswa classical zomuthi, odokotela kakhulu belulekwa ukuba bazivikele ukuze ugweme nokukhulelwa okungafunwa. Ukusebenzisa izidakamizwa njengoba ikhambi for amehlo, futhi, kufanele ucabangele lokhu kwaziswa, bamane nje benza zokuhlela umndeni.

analogs

Ezweni ngendlela ukulondoloza umbono esetshenziswa isikhathi eside, kodwa le njongo esetshenziswa nezinye izidakamizwa ezifana Macugen futhi Lucentis. Kodwa eminyakeni yamuva nje kuye kwaba nezifundo ezingasho ukuthi bathi "Avastin" siyasebenza kakhulu zamehlo. Kodwa inqobo nje uma kungekho ulwazi mayelana nemiphumela yesikhathi eside besebenzisa izidakamizwa ekwelapheni iso, kuzoba ngokusemthethweni umuthi wokwelapha umdlavuza izimila.

Kuze kube manje, ku faka-isitatimende alisho lutho mayelana nokwelashwa esweni. Ngakho-ke, komthombo ulwazi ukusetshenziswa "Avastin" izidakamizwa zamehlo - ukubuyekezwa. Inani lentengo lomuthi kuyinto ngempela abaqotho, okwenza kube ethengekayo kuqhathaniswa nontanga.

Igama elithi "analog" ngokuvamile libhekisela umuthi has a isakhiwo esifanayo, isithako efanayo esebenzayo. On wemithi emakethe Russian izidakamizwa lapho, okungase kunqunywe ngokuqhathanisa Ukwakheka, kokuba wafunda imibhalo, ezifaka phakathi exhunywe izidakamizwa "Avastin" imfundo manual. Analogue, zibe intengo kusuka ezingabizi ngempela eqolo, abe uhlu ezifanayo izinkomba. Kodwa indlela efanayo isinyathelo kungenxa ezinye izingxenye.

Le mithi, engatholwa ngasiphi ikhemisi, zihlanganisa:

• "Arzerra."
• "Atsellbiya".
• "Vectibix".
• "Lyophilisate Herceptin".
• "Herceptin".
• "Campath".
• "MabThera".
• "Pereta."
• "Removab."
• "Rituximab".
• "Erbitux".

Ukuba semthethweni isicelo

imithi Esemthethweni namuhla alikukhuthazi usebenzisa "Avastin" zamehlo. Izibuyekezo iziguli kaningi yiba nesimo esihle, kodwa kukhona degree osindayo ingozi, okuyinto kudingeka wazi.

Kukhona ukuphikisana elihlobene ne izidakamizwa "Avastin": Ukufundiswa ukusetshenziswa zamehlo (abameleli Izibuyekezo isayensi kweminye imithombo kanye) ayivumeli ukusetshenziswa kwezimali ekwelapheni iso. Umenzi zomuthi ngokusemthethweni uthi lowo neither yasekuqaleni futhi inguqulo komuthi ojwayelekile "Bevacizumab", ekhiqizwa eRussia akufanele isetshenziswe zamehlo. Ukuqinisekiswa lolu lwazi ingatholakala kusayithi Roszdravnadzor.

Kodwa ngezinsiza ezithile, ezifana sites anikezelwe zamehlo, ngokuvamile ungathola ulwazi ukuthi izidakamizwa iphumelela kakhulu izifo esweni. Lokhu kungenxa yokuthi ucwaningo lwesayensi ku ukusetshenziswa kwalesi izidakamizwa yayiqhutshelwa futhi kwenziwe kuze kube manje, okubonisa imiphumela emihle. Nokho, ngaphambi kokuba ulwazi olufanele ukuphepha ephelele isidakamizwa isizinda kahle eliphezulu, imiyalelo nizoba ifakwe esigabeni "Izinkomba Zokusetshenziswa".

ukusebenzisa

Kule ndaba, "Avastin" lisetshenziswa kuphela ezimweni eziphuthumayo, lapho okunye kuyinto ukulahlekelwa okuphelele umbono. Ngo sokuhlola, omunye imitholampilo Russian wathola ukuthi umjovo we "Avastin" akazange kungaholela emiphumeleni engathí sina, hhayi ongaboni kahle futhi akuzange kuholele ngobumpumputhe. Kodwa iziguli bakhalaza edwengula nokusha emehlweni.

Ngakho, "Avastin" - izidakamizwa ngempumelelo kakhulu wokwelapha isifo somdlavuza izimila. Prakthiza ukuthi baba thatha "Avastin" zamehlo, izilinganiso iziguli ogxile omuhle. Kodwa lapho izinqumo okudingeka iphendukele ukusetshenziswa kuphela labo izidakamizwa ukuthi eziklanyelwe ukuxazulula inkinga ethile, ikakhulukazi imikhiqizo eyenza imithi emakethe kakade, kukhona amathuluzi akhethekile ukuthi kunganciphisa Ukulandelana retinopathy sikashukela kanye ifomu ezimanzi Ukuqedwa kwe-AMD.

Ngakho-ke, "Avastin" ingasetshenziswa kuphela ezimweni ezimbi kakhulu ngaphansi eduze kweso lwezokwelapha.