Ukwelashwa kwesifo sokusha kwesibindi sohlobo sokuhlasela kwamasosha omzimba: izindlela, imithi, side effects, izibikezelo

Baningi kithi abaye wezwa izifo ezifana ne-hepatitis sokuhlasela kwamasosha omzimba. Kuyini lokhu zokugula? Kuyinto nezifo ezingamahlala khona okuyinto ukuvuvukala zingaxazululeki enjalo uhlaka kubalulekile ukuba khona kwethu njengoba isibindi. Setha bemvelo, lokhu zokugula abuzange.

Kuthiwani uma lokhu kwenzeka?

Uma uphethwe "isifo sokusha kwesibindi kohlobo sokuhlasela kwamasosha omzimba", kusho ukuthini lokho? Lena zokugula sína izizathu ezingaziwa ngokuphelele, kancane kancane amangqamuzana isibindi. Futhi kule nqubo kusiza siqu uhlelo lesi sifo sokuzivikela. Ngo esigabeni sokuqala lesi sifo kukhona ukuvuvukala parenchyma, ukuthi ingxenye eyinhloko emzimbeni. Le nqubo ngokushesha futhi kungaholela isifo sokusha.

Lokhu kuhambisana yokufa kwamangqamuzana engokwemvelo komgwamanda esinjalo sibaluleke kithi - hepatocytes. indawo yabo ngokushesha igcwalisa nezicubu okwe inelastic zezinzwa. Ngenxa yalokho, isibindi awulona ukwazi qualitatively afeze imisebenzi yabo.

Ungathola amagama ahlukene lesi sifo. Nokho, zokugula ezivame kakhulu kuleli izincwadi zezokwelapha ezisekelwe ekwazisweni ngaleyo ndlela: asebenzayo kwesibindi kohlobo sokuhlasela kwamasosha omzimba. Lesi isifo ezingavamile kuvamile kakhulu emantombazaneni abaneminyaka engama 10 futhi abesifazane abangazange sebethole engu-amathathu.

izimpawu

ukubonakaliswa Clinical yesifo ziyahlukahluka. Ngokwesibonelo, ingxenye yesine yazo zonke iziguli kungekho zimpawu kwesibindi sokuhlasela kwamasosha omzimba akuyona. Futhi ihlala nje umuntu akanayo izinkinga. Ezimweni ezinjalo, lesi sifo ngokuzumayo qhebeza phezulu abantu noma bona abonise zonke izimpawu kwesibindi ezibangelwa amagciwane, noma ezinye izimpawu ezisikisela ukulimala kwesibindi. Esikhathini okufana lokuqala izenzakalo womuntu kuthathela abaphazamisa ebuthakathakeni. Isidumbu sakhe uketshezi ayoba mnyama. Skin futhi nolwelwesi lwamafinyila, yellowing, ukungakuthandi ukudla. Esimeni sesibili, kukhona uhlobo extrahepatic izimpawu. Yingakho odokotela bavame ukuphakamisa khona emzimbeni izifo ezihlukahlukene letindzala ezifana-rheumatoid arthritis, i-lupus, njll

Kodwa ngokuvamile, ukubonakaliswa zifo ukukhathala njengoba ngokweqile, imfiva, ukwanda izinga lokushisa lomzimba kuya degree 39, lymphadenopathy, induna, ubuhlungu besisu, ikakhulukazi ilungelo quadrant engenhla, ukwephulwa kwamalungelo emalungeni, kanye ukukhula asebenzayo we izinwele zonke izingxenye zomzimba . Uma lesi sifo iqala ukuyithukuthelisa zamagama hormone adrenal, okuyinto akhiqizwa ngokweqile, isiguli bangezwa ukwehla kwemisipha izicubu ezinyaweni nezandla, isivinini ukudayela isisindo okweqile, ukubukeka elula izimpawu emathangeni kanye othi awube ezikhanya izihlathi.

Ngezinye izikhathi iziguli isifo kwenzeka ngokuzumayo, kubonakala babazi wabe kanzima kakhulu. Konke lokhu kuhambisana okuvela kwesibindi fulminant, elibangela ukufa okusheshayo amangqamuzana amaningi hepatic. Lokhu, kuholela ekwakhekeni okusheshayo ubuthi, esilimaza, bese sihlasela ubuchopho. Kunzima kakhulu, uma ungakakwenzi kakade uvele ukusha kwesibindi kohlobo sokuhlasela kwamasosha omzimba (izimpawu), ukwelashwa. Izibikezelo ezimweni ezinjalo, odokotela ukunikeza ezingezinhle kakhulu ukuze isiguli.

izinhlobo izifo

Ukwelashwa kwesifo sokusha kwesibindi sohlobo sokuhlasela kwamasosha omzimba kuba encike ngqo kwi zilwane zayo. A uhlobo oluthile isifo kunqunywa khona kule serum igazi uhlobo oluthile omzimba. Kulokhu, kukhona izinhlobo ezintathu sokuhlasela kwamasosha omzimba ukusha kwesibindi kohlobo ezingamahlalakhona B:

1. Uhlobo lokuqala ukuhlonza amasosha omzimba nezifo-actin namaprotheni, amaprotheni, bushelelezi imisipha amaseli, amasosha antinuclear.

2. Ukuze uhlobo lwesibili yesifo libhekene khona amasosha microsomes, emangqamuzaneni nezinso isibindi.

3. Uhlobo lwesithathu zokugula sitholakale amacala ukuthola amasosha ketshezi ukuthi unesibopho amaprotheni zamagama, isb ukuba hepatic antigen encibilikayo.

zokugula Izimbangela

ukusha kwesibindi kohlobo sokuhlasela kwamasosha omzimba - ubulwelwe lapho uhlelo umuntu sokuzivikela iqala umzabalazo esebenzayo nge siqu izicubu zabo engumqemane namaseli. Yini simile izimbangela zalesi simo? Lo mbuzo, ezokwelapha zesimanje Awukwazi ukuphendula okwamanje. Nokho, ososayensi baye basikisela ukuthi ukuhluleka ezinjalo umzimba ozivikela ukunikeza ngaphambilini ezithwalwa izifo ezahlukene viral, ezifana ne-hepatitis A no B no-C, i-herpes, Epstein-Barr igciwane.

Abanye abacwaningi baye bazwakalisa umbono, nokuthi ekuthuthukiseni izifo ezihlukahlukene sokuhlasela kwamasosha omzimba, indima esemqoka udlalwa ngu isakhi esithile. Nokho, kuyafaneleka ukuthi isifo ezinganeni ezingaphansi kweminyaka engu-10 Cishe ungalokothi itholiwe.

ukuhlola

Ukwelashwa kwesifo sokusha kwesibindi sohlobo sokuhlasela kwamasosha omzimba kuyoba nemiphumela engcono uma isifo itholwa i-ekuseni waqala ukuthuthukiswa yayo. Nokho, zokugula uphethwe kunzima kakhulu. Ngokuvamile, odokotela kokutshelwa ngokukhubazeka kwengane ukubeka kuphela ngenkathi kancane kancane ukukhipha khona ezinye izifo. Ukuze wenze lokhu, udokotela ihlaziya izimpawu isiguli yakhe nemlandvo wetekwelashwa kwakhe zokuphila kwakhe. Konke lokhu kwenzeka phakathi nengxoxo. Kulokhu, uchwepheshe uthola ukuthi uyakuhlupha umuntu, futhi isikhathi eside kangakanani-ke ihlala.

Ngokulandelayo, behlolwa kwenziwe, phakathi kwesikhathi lapho udokotela ehlola isikhumba nolwelwesi lwamafinyila, kulinganisa lokushisa lomzimba lesiguli, futhi rattles ithinta isibindi wokuqonda ubuhlungu kanye nokwanda ngobukhulu. Uma kutholakala esolwa kokuba izifundo zokugula laboratory eqhutshwa ngayo. Ziklanyelwe ukuba kutholakale izinga ngibopha globulin futhi umsebenzi we AST enzyme. Linikeza isiqondiso futhi ukuhlaziywa immunological kwegazi. Hlola futhi ukusha kwesibindi kohlobo A no B no-C Udokotela unikeza isiqondiso coprogram. Ucwaningo sezinyawo isheke khona undigested izinhlayiyana zokudla.

Ukuxilonga Kwenziwa uma kunesidingo. Kuhlanganisa kokuxilongwa ultrasound esiswini, emphinjeni kanye duodenum 12 nokusetshenziswa imishini endoscopic. Lolu cwaningo kuhloswe ukukhipha khona izimila omsakazo ezahlukene. Isiguli ithunyelwe biopsy isibindi, lapho izicubu isampula elincane esithathwayo yomzimba Histology yayo.

Uma ezikhonjwe sokuhlasela kwamasosha omzimba ukusha kwesibindi kohlobo uphethwe futhi ukwelashwa udokotela, zonke izincomo wathola kufanele libukwe nakanjani. kulokhu kuphela sikwazi ukukhuluma izibikezelo evumayo ekukhuleni isifo.

ikhambi zokugula

Uma i-hepatitis sokuhlasela kwamasosha omzimba (izimpawu) awabonakali nokwelashwa yalesi sifo isibe esibalulekile, udokotela angase asebenzise izindlela eziningana. Amanye awo yilawa:

- ukuthobela ukudla okuqinile;

- therapy yezokwelapha;

- ukuqhuba ukuhlinzwa.

Cabanga bonke yalezi zindlela ngokuningiliziwe.

ukudla

Ukwelashwa nokuvikelwa kwesibindi kohlobo sokuhlasela kwamasosha omzimba, ubani esigabeni oyingozi, eyenziwa ngaphansi esiqinile embhedeni ukuphumula. Phezu okuvela esigabeni ukuthethelelwa nesineke ngokwanele ukuhlela umsebenzi wakho futhi ukuphumula, ukugwema gcwele hlobo (ezingokomzwelo nezingokomzimba) yokukhathala. Ngaphezu kwalokho, kubalulekile ukususa umphumela kwesibindi izidakamizwa ezahlukene ezinobuthi, ezihlanganisa notshwala namakhambi okwelapha izidakamizwa, sihoxiswe lelo gunya. Esikhathini inkathi ukuthethelelwa Akubalulekile futhi ukuqhuba kanye Physiotherapy ukwelashwa ezithinta indawo isibindi. Okunqatshelwe futhi balneotherapy.

Ukuze kulesetayelekile ngezimo zesiguli kubalulekile umsoco ofanele. Ngokusebenzisa ekwelapheni kwesibindi kohlobo sokuhlasela kwamasosha omzimba, gastroenterologists ukutusa ukusetshenziswa ukudla (ithebula № 5). Kuhlanganisa isobho lemifino inyama mafutha (izinkukhu, yenkomo). Ukudla kweziguli izinhlanzi ukudla kungenziwa kufakwe nezitini noma abilisiwe. Ukudla, okuyinto Kunconywa ezimweni lapho ukwelashwa edingekayo of kwesibindi kohlobo sokuhlasela kwamasosha omzimba, kufaka phakathi imikhiqizo efana ephansi fat iyogathi noshizi, futhi uma kungenjalo ukungabekezelelani, ke ubisi nobisi imikhiqizo. Uma upheka abantu abaphethwe isifo sokusha kwesibindi kohlobo sokuhlasela kwamasosha omzimba, kubalulekile ukusebenzisa ibhotela kanye nowoyela zemifino kuphela izinto eziningi ezincane. Kufanele kube okulinganiselwe kanye ukusetshenziswa amaqanda. Abakwazi zifakwe Ukudla izikhathi 2 noma 3 kuphela phakathi nesonto lika-1-2 amaqanda ngosuku.

Akukho ukudla izivimbelo akubhekwa maqondana nemifino-non-esidi izithelo. Nokho, ukusetshenziswa kwazo, kanye nazo zonke ezinye ukudla kuvunyelwe, kumelwe nakanjani ube ububanzi ezinengqondo.

Ukudla, Kunconywa ngumuntu Ngubani ekwelapheni isifo sokusha kwesibindi kohlobo sokuhlasela kwamasosha omzimba, khipha kusukela ekudleni ukudla okuthosiwe, okunamafutha inyama, ukudla okulula okunosawoti futhi okubabayo, Sorrel futhi isipinashi, ukhokho nekhofi eqinile, utshwala, kanye izimpahla okusemathinini. Amandla ngaleyo ndlela kufanele kube wamaqhuzu njalo. Kubalulekile ukudla okungenani kane ngosuku, futhi kungcono uma ukudla okumele izikhathi eziyisithupha. Kubalulekile futhi ukuhlonipha ukudla okunomsoco ukuze umzimba uthola zonke izinto ezidingekayo ukuze ke.

Ukusetshenziswa kwezidakamizwa

Uma impatho kwesibindi sokuhlasela kwamasosha omzimba, udokotela ngekulandzelana kwetintfo letenteka kuzoncika esigabeni nenkambo isifo. Kodwa noma kunjalo, ngaphezu ukusetshenziswa Ukudla, iziguli iqondiswa imithi edingekayo. Kuye salokho okubonakalayo ngo isiguli ukuxilongwa "autoimmune ukusha kwesibindi kohlobo" umtholampilo, ukwelashwa onguchwepheshe angabelwa izidakamizwa eziningi.

Sikhishwe yokuthi imbangela enkulu yokuqothulwa kwehlathi lesi sifo Hyper-kusebenze futhi ukungasebenzi umzimba ozivikela, kusukela uye wakwenza ukubhubhisa amaseli enempilo kwesibindi, therapy udokotela kufanele lifake namaphilisi ahlasela icindezela amasosha omzimba. It imunosupressivnye mithi hormone futhi eqeda ukuvuvukala. Lezi ngokuyinhloko zihlanganisa izidakamizwa ezifana "Prednisolone" futhi "Azathioprine". Le mithi amabili asetshenziswa labo izimo lapho ekwelapheni isifo sokusha kwesibindi kohlobo sokuhlasela kwamasosha omzimba. Ngokuhamba yokwelapha bona angaqoka noma eceleni noma ndawonye.

Ngokuqondene 'prednisolone ", lokhu izidakamizwa has a spectrum ezibanzi umsebenzi. It has nethonya elihle zonke izinhlobo inqubo umzimba, futhi inikeza umphumela kahle eqeda ukuvuvukala. Ngaphansi kwethonya izidakamizwa kunciphisa umsebenzi inqubo sokugembula. Lokhu kungenxa kokubili ithonya ngqo ejenti immunosuppressive ku-K-amaseli bese ukuyenga umthelela wabo umsebenzi suppressor ka-T-lymphocyte.

Kuphela ebulilini zomuthi ukwazi ukunikeza ngempumelelo, kwatholakala ukuthi nginesifo i-hepatitis sokuhlasela kwamasosha omzimba ukwelashwa uma (izimpawu). Izibikezelo lesi sifo kulezi izimo, umuhle. Ngakho, ngo-zokwelapha ngesikhathi uya khona Yiqiniso usebenzisa izindlela kwemithi "Prednisolone" kuphawula nokuncipha umfutho kanye nokuvama ukusabela immunopathological nasemkhakheni izicubu isibindi.

Omunye imithi kwesibindi sokuhlasela kwamasosha omzimba - "Azathioprine". Ukuzivikela komzimba ithinta ngu abacindezela indlela ngenkuthalo ekuthuthukiseni ukufaniswa amasosha omzimba kanye nokuqedwa nokuqedwa amaseli ukuvuvukala.

Izidakamizwa "Azathioprine" kuthinta kokubili okuyinhloko kanye secondary amasosha omzimba. Nokho, ukwelapha lesi yokwelapha ochwepheshe abaningi ke umphumela enganele. Lokhu kungenxa ukuhlukumeza izidakamizwa isebenze, kanye ukusheshisa inqubo kokubhujiswa kwalo ngo-amacala isifo sesibindi. Ukuxazulula le nkinga ngokuhamba yokwelapha is kanyekanye abelwe ukuyokhonza kwelinye izidakamizwa hormone - "Prednisolone". Uyakwazi ukwenza kusebenze umphumela "azathioprine". Ngaphezu kwalokho, imiphumela emibi emva kokwelashwa kwesifo sokusha kwesibindi sohlobo sokuhlasela kwamasosha omzimba ku eziyinkimbinkimbi besebenzisa izidakamizwa ezimbili kane ezincane njengoba kuqhathaniswa nalabo abona othile ewunikela ngesikhathi "prednisolone" elilodwa kuphela. Lokhu kubonisa ngokucacile isidingo ngale ndlela yokwelapha.

Ukusetshenziswa kwezidakamizwa ezimbili ngesikhathi esifanayo kuvimbela ukuthuthukiswa ukuvuvukala futhi ivumela amabutho okuvikela umzimba ngokuzimela ukuqeda glitches ekhona. Ngeshwa, ukuthatha lezi izidakamizwa, iziguli bephoqeleka ukuba ngemva kwezinyanga eziyisithupha kuya eminyakeni 4. Nokho, odokotela ungayeki kwanoma yisiphi isiqinisekiso ukuthi le nkambo kuyoba eyodwa kuphela. iziguli eziningi zithola ukuphinda ke ngaphezu kwesikhathi esisodwa esikhathini esithile ekuphileni kwabo.

Lokhu algorithm sisetshenziswa yokwelapha kanye lokhu ikakhulukazi ezimweni lapho ukwelashwa kwesifo sokusha kwesibindi sohlobo sokuhlasela kwamasosha omzimba ezinganeni.

Ukuqeda kofermentativnye zokugula nezidakamizwa umzimba ingasetshenziswa. Bayisibonelo Vitamin okunjalo futhi izakhiwo multivitamin, njengoba "kokarboksilazu", "Riboksin" kanye nabanye abaningi. Ekwelapheni ezisetshenziswa futhi gepatoprotektory eziqukethe ukubunjwa yabo phospholipids. Lawa izidakamizwa njenge "Livolin", "Esentsiale", "Geptral" kanye nabanye abaningi. Ngokusho kochwepheshe, injongo lezi zimali kumele kwenziwe kuphela at the stage of ukuthethelelwa, uma kungekho ukuvuvukala evelele.

Ukuze unekhemikhali imikhiqizo anobuthi umzimba yilezo ngawo kwesibindi akakwazi ukubhekana, odokotela linqume emthanjeni yokwelapha ukumnika. Ngokuvamile, izimo ezinjalo, umuthi "Reosorbilakt" noma nosawoti. Inqubo wenziwa ngaphansi kokulawula njalo wegazi kanye nomchamo okukhiphayo.

Alternative uhlelo ukwelashwa

Ukwelashwa usebenzisa inhlanganisela yemithi ezifana "prednisolone" futhi "Azathioprine" is wayisebenzisa zokwelapha cishe ezinhlanu emashumini. Ukwelapha okunjalo kuyokwenza ukwandisa isilinganiso sobude bokuphila iziguli kwesibindi sokuhlasela kwamasosha omzimba.

Nokho, Okwamanje, bonke ngaphezulu abavusa empikiswaneni ukusetshenziswa kwezinye izikimu abaye baba isikhathi iziguli kancane futhi abangele ayinayo imiphumela eminingi engemihle. Ngokwesibonelo, izazi sicabangele ukuthi kungenzeka ukuthi kungase ukuphathwa kwenziwe i-hepatitis sokuhlasela kwamasosha omzimba "Budenofalk". Kuyinto izidakamizwa okuqondene iqembu glucocorticosteroids isizukulwane 2nd. Ngaphezu kwalokho, it has sakugcina side effects kanye amaphesenti ayisishiyagalolunye is metabolised yi isibindi kakade ngesikhathi ndima therethrough kuqala. Lokhu kusiza ukubuyisela impilo iziguli isifo sokusha kwesibindi sokuhlasela kwamasosha omzimba.

Imiphumela izifundo zokwelapha yabonisa lotawulungisa ukuthi izidakamizwa "Budenofalk" isetshenziswa lihambisana "azathioprine" ntombazane futhi silondoloze ukuthethelelwa kulabo bantu kwesibindi sokuhlasela kwamasosha omzimba abangakazizwa kwadingeka izimpawu isibindi sibe sesomile. Kulesi yokwelapha phezu ukuvela ezincane, kunokuthi ngemva ukusetshenziswa 'Prednisolone "engemihle.

Ngokwabacwaningi, izidakamizwa uyakwazi egcwele indinganiso entsha basemtholampilo ukunakekelwa elisetshenziswa anawo kwesibindi sokuhlasela kwamasosha omzimba.

ukwelashwa kuhlinzwa

Kulezo zimo lapho ukusetshenziswa ukwelashwa iminyaka emine ayilithuthukisanga ngezimo zesiguli futhi akusho kujwayeleke pokazatelt igazi layo kwamakhemikhali, isiguli wenziwa ukuhlinzwa.

Kuyinto ukusebenza ukufakela isitho lokuthi sika. Njengomthetho, lokhu kuthatha ingxenye isibindi bomdabu igazi labantu.

amakhambi abantu

Ukusetshenziswa kwezimali, okuyinto iresiphi sidalwe quacks okusekelwe izithako zemvelo, okuvumela kuhlengwe Bile, ukuqeda isicanucanu futhi izimpawu zokudakwa, kanye ukususa ubuhlungu.

Kumele kukhunjulwe ukuthi uma umuntu itholwa ukusha kwesibindi kohlobo sokuhlasela kwamasosha omzimba, ekwelapheni amakhambi abantu ukuletha kuphela impumuzo izimpawu zesifo, kodwa ayibulale is akuvumeli ngokugcwele. izindlela ezinjalo ngempumelelo kuphela lapho pathologies ukuthi zingelashwa kalula. Lokhu kusebenza nokohlobo A noma uhlobo anobuthi.

Sekutholakele ekulweni ukuvuvukala esibindini amakhambi ahlukahlukene nethonya choleretic. Kusukela kubo ukulungiselela infusions kanye Iziphungo. amakhambi ezinjalo:

- izimpande sembabazane namaqabunga;
- Mint anise;
- Yarrow;
- imbewu horticultural of fennel;
- wort iSt John sika;
- birch eshiya.

Kusukela amakhambi ungenisa amacala ukuthi athathe ngaphambi kokudla. Kuvele ukumnika tea rose okhalweni esikhundleni. Selani ngokusebenzisa straw ngoba lokhu ejenti kunomphumela omubi izinyo koqweqwe lwawo.

nethonya elihle isibindi juice imifino ehlukahlukene, ngoba iqukethe esiningi amavithamini kanye izakhi yezimbiwa. Juice ingasetshenziswa for ekwelapheni isifo sokusha kwesibindi kohlobo B ekhaya:

- Jerusalem i-artichoke;
- amazambane eluhlaza;
- isanqante, buhlanjululwe ngamanzi;
- isilimo esidliwayo esinamagatsha anamanzi dandelion amaqabunga;
- beet eluhlaza, hlambulula ngamanzi.

ukuba nombono ongafani ngeke

Ukusinda leziguli sokusha kwesibindi sokuhlasela kwamasosha omzimba, ezimele ngokuphelele we ukushuba ukuvuvukala ezazenzeka isibindi. Ezimweni omnene, u-80% abantu sekuyiminyaka engaphezu kwengu-15. Nokho, ngenxa yokuntuleka kwezinhlelo ezibanzi yokwelapha ephelele futhi yokugula okunzima kuphela ezimbalwa ezisindayo isihlale iminyaka engaphezu kwemihlanu.