"Trimetazidine-Biocom MV": yokusetshenziswa, ukwakheka, analogs kanye nokubuyekeza

I nomuthi kuyalithinta esizibonakalisa izinqubo esasizosheshisa umzimba okwenzeka izitho neurosensory futhi myocardium. Ngaphambi kokuba uqale ukwelashwa, kumele wazi ukuthi yini ehilelekile umuthi "Trimetazidine-Biocom MV". Yokusetshenziswa, indlela yokwakheka izidakamizwa - ulwazi oluwusizo, okuyinto kuwufanele ukufunda.

Ifomu ukukhululwa kwezidakamizwa, izingxenye zalo

Umuthi kungokwalabo ukukhululwa Ushintshe kusho kukhishelwa ngesimo amaphilisi camera, ekhiqizwa ngesisekelo trimetazidine dihydrochloride. Ibhamuza iqukethe amaphilisi 10 kule iphakethe kungaba kusuka 1 kuya 6. Omunye sibhebhe sinamaphutha 35 mg ingxenye eyinhloko. Ukwakheka kulekelelwa magnesium stearate, povidone, aerosil, hypromellose ne-calcium hydrogen phosphate dihydrate.

Titanium dioxide, Macrogol eziyingxenye esemqoka igobolondo ithebhulethi "Trimetazidine Biocom-CF". Yokusetshenziswa zemibiko ngaphezu kwalezi izinto igobolondo siqukethe hypromellose futhi abomvu yensimbi oxide.

imiphumela kwemithi

ithuluzi Antihypoxanth ikuvumela ukubuyisela umzimba evamile amaseli, okuye kwenzeka ngenxa izinguquko olunzulu ukuthuthukiswa isimo sokugembula (ischemia, hypoxia). Tablets kuvimbe kuncishiswe inani ATP kumaseli neqhaza ngcono iziteshi ulwelwesi ion, transmembrane ukunyakaza sodium ne-potassium ion. Ukulondoloza homeostasis yeselula esikhathini ukwelashwa usebenzisa nomuthi "Trimetazidine Biocom-CF". Yokusetshenziswa libike ukuthi izidakamizwa kunciphisa izinga lapho inqubo namachibi of acid okunamafutha, kanjalo lapha kukhona okukhulu glucose namachibi wenziwa Ukuvikelwa esivimba amanzi ngokumelene ischemia. Isenzo zomuthi kusekelwe ukushintsha inqubo namachibi ne acid okunamafutha ukuze glucose.

Umuthi, nokugcina inkambo evamile izinqubo umzimba, kahle unomthelela izitho neurosensory futhi inhliziyo, kunciphisa kobukhulu ukwephulwa transmembrane ion flow ukuthuthukiswa ischemia. Acting on ijwabu inhliziyo, izidakamizwa kunciphisa izinkomba ezifana ukufuduka, kokuziphatha polynuclear neutrophil. Ngokuphathelene umphumela izidakamizwa "Trimetazidine-Biocom MV" imfundo manual kufaka phakathi idatha ezimela nethonya elihle myocardium iye kabana ischemia. izidakamizwa Hemodynamic has nhlobo ithonya.

Pharmacokinetics

Absorption senzeka cishe ngokuphelele futhi ngokushesha. Ukuxhumana-plasma amaprotheni engasho lutho (16%), izinga bioavailability 90%. Ngu kwemukelwa amaphilisi kuze kube ngomzuzu lapho ezingeni lomcebo asebenzayo emzimbeni kuba esiphezulu, wenabisela cishe amahora amabili. Kuyaziwa ukuthi izidakamizwa sihamba kalula ngokusebenzisa izithiyo igazi-izicubu. Isigamu-ukuphila owenziwa amahora angaba mahlanu. Umuthi kusukela umzimba isuswa izinso, iningi akashintshi ezakheke ngayo.

ubufakazi

imfundo 'Trimetazidine Biocom-CF "(amaphilisi) ingasetshenziswa nokuqalisa ukuphathwa eside CHD. Inhloso yayo okuboniswe kulezi zimo ezilandelayo:

• isidingo nokuqalisa izinyathelo uma okuvela ukuhlaselwa angina;
• isiyezi, khona lapho lihlotshaniswa izilonda semithambo;
• iziyaluyalu cochle-vestibular kokuba imvelo ischemic (Ukuwohloka ukuzwa);
• izifo chorioretinal semithambo, ephelezelwa ischemia.

angina prophylaxis engenziwa usebenzisa umuthi owodwa noma Ukusebenzisa yokwelapha eziyinkimbinkimbi.

Izimo

Ngokuphathelene ezimweni lapho imithi ethatha engathandeki "Trimetazidine-Biocom MV" imfundo manual, ukubuyekezwa iqukathe idatha ekhombisa ukungabi nakwenzeka imithi yokwelapha kulezi uthi:

• ukuzwela ngokweqile main ingxenye nezinye izithako izindlela;
• ibele;
• ngesikhathi abantwana.

Njengoba ukuphepha ukusetshenziswa kwezidakamizwa ezinganeni (eneminyaka engaphansi kwengu 18) futhi ukuphumelela ukwelashwa nge ukusetshenziswa yayo sasungulwa, iziguli anjalo lokhu kusho ukuthi ngeke esimisiwe.

Imithi contraindicated nge uzwakalise isibindi womuntu kanye nokwehluleka ukusebenza kwezinso, lapho inkomba ezifana creatinine imvume is kakhulu ziyancipha (15 ml / min noma ngaphansi). Akukhona nje ukucacisa izinkomba kanye contraindications ukwelashwa benethuba "Trimetazidine-Biocom MV". Izindleko Ubuye ezinye ukubaluleka lapho ekhetha nomuthi yokwelapha. On kuzoxoxwa kamuva.

ukwelashwa izidakamizwa

usayizi olulodwa umthamo kunqunywa udokotela (ngokuvamile hhayi ngaphansi kuka-40 mg kodwa hhayi ngaphezulu kuka-60). Emahoreni angu 2-3 liyadingeka ukwenza izindlela eyamukelayo. Isikhathi yokwelapha Kumiswa eceleni for izikhathi ezahlukene.

side effects

Ngaphambi ukwelashwa, kubalulekile ukuba bajwayelane kungenzeka ukusabela ezingezinhle ngemva ukungenisa amaphilisi umzimba "Trimetazidine Biocom-CF". Yokusetshenziswa izindlela, esekelwe lapho ukwelashwa babe imiphumela emibi ibandakanya njengemithi yokungezwani komzimba nokuthile, obonakala njengenhlangano i ukuqubuka silume futhi isikhumba, nezinye ukusabela ukuthi kukhona okungahambi kahle emzimbeni. Phakathi ukwelashwa, ezimweni ezingajwayelekile kakhulu, ezinye iziguli kufanele isicanucanu, gastralgia ukuhlanza kwenzeka, ziphawuleka.

Amacala ukweqisa izidakamizwa ezinzima ungazange umiselwe, kanye nokwenzeka nesenzakalo yabo akunakwenzeka. Ngenxa yalokho yokudlula umthamo watusa kungabonakala nasemkhakheni ngamanzi ebusweni, hypotension.

Izixwayiso

Ukwelapha akuvimbeli ikhono ukushayela futhi kungangqubuzani wenze imisebenzi ekwenzeni edinga okusheshayo ukusabela ngokomzimba futhi lengqondo.

Tablets ayifanele nokuqedwa ukuhlaselwa angina futhi ingasetshenziswa kuphela ngezinhloso zokuvimbela iziguli abaphethwe ukuhlaselwa okunjalo.

I nokwelashwa kweziguli senhliziyo kuyinto ukwehla imfuneko nsuku nitrate.

Izindleko izidakamizwa analogue, ukubuyekezwa

Kumelwe ukuba zihlolwe ngaphambi ukwelashwa kusho "Trimetazidine" imfundo manual. Inani futhi kuyinto ukwaziswa okubalulekile futhi acabangele lapho ekhetha izidakamizwa ngoba impatho (prophylaxis), izinkinga zenhliziyo (yenhliziyo Umthambo isifo). Izindleko esikiselwayo umuthi ruble 100-165. amaphilisi 30 futhi ruble 189-208. amaphilisi angu-60.

I Analogue zingasetshenziswa "Preductal", "Antistius" noma "Trimethyl". Okungenzeka izidakamizwa ukwelashwa "Medarum", "Rimekor". Udokotela kungase kuthathe indawo imithi ngokumisa "Prekard", "Angiozyme", "Trimitard MV". Kukhona ukuthi kungenzeka kokuphatha "Tridukardom", "Predizinom", "Trimektalom" noma "Metagardom". Ukwahlulela ukubuyekezwa, analogu ethandwa kakhulu kuba "Preductal" Lesi sidakamizwa siyasebenza, kodwa kuyabiza ngaphezu "Trimetazidine". Yokusetshenziswa, intengo ebonisa ukuthi ukwelashwa izidakamizwa kuyazuzisa, ukubuyekezwa uqinisekise kusebenta le yokwelapha.

Ngo ukubuyekeza we nomuthi kubikwa ukuthi izidakamizwa kahle aqede ubuhlungu enhliziyweni, ke wenza umsebenzi yayo ngokuphelele. Ngenxa umthamo njengoba iziguli kanye nodokotela, imakwe ushintsho oluhle, isb, umzimba labantu abathola imishanguzo, azibonayo kangcono umsebenzi. Abantu abaningi bathi ngemva kwezinsuku ezimbalwa ukwelashwa balahlekelwa dyspnea, tachycardia senzeka, umfutho wegazi ukubuya evamile. Ngokuvamile bebonisa intuthuko ephawulekayo ngosuku lwesine yokwelashwa, ekusebenziseni samanje izimali "Trimetazidine-Biocom MV". Yokusetshenziswa, intengo ebonisa ukuthi imithi alitholakali nje kuphela kodwa futhi ngempumelelo, ngaphezu, inaso ubuncane kungenzeka ukusabela ezingezinhle ukuthi ingabe ngokuvamile angakhuli. Ukuvela side effects ebonwe Ezimweni ezingavamile.

Ngakho, sikunike ulwazi mayelana izidakamizwa "Trimetazidine-Biocom MV". Analogue, intengo, umhlahlandlela, izibuyekezo mayelana imithi manje zaziwa. Umuthi kumele aqokwe uchwepheshe futhi abayisebenzisa ukusetha umthamo. Isidingo esikhundleni nomuthi njengoba kunqunywe udokotela kuzinto eziningi. Iziqondiso ikuvumela ukwenza ukwelashwa okuphumelelayo kakhulu ngaphandle ukulimala.