Umuthi 'Ingaron ": ukubuyekezwa odokotela, yokusetshenziswa, analogs

Buthakathaka amasosha omzimba kungabangela izinkinga eziningi zempilo. Ngemva umzimba olungavikelekile - ukukhanya "isizinda" kwezilwanyana ezincane pathogenic. Ngenxa yalokho - ukuthuthukiswa izifo, kunzima ukuba aphathe, okungase kubangele umonakalo ongalungiseki ezempilo, futhi ngezinye izikhathi ngisho ukubangela ukufa. Ukubuyisela namasosha omzimba futhi ulawule isimo, wasebenzisa ejenti immunomodulatory, njengokuthi "Ingaron". Odokotela ngalokhu ukulungiselela ziyaphikisana, ngakho zama ukwakha umbono, kokuba wafunda e Imininingwane ngokuningiliziwe umkhiqizo ngaphezulu.

Kwemithi isinyathelo ejenti

Ngesisekelo izidakamizwa immunomodulatory kuyinto gamma-interferon ehlanganisa 144 amino acid, ngokunembile, isidumbu yabo. Izifiso zakhe zokuqala ezintathu (Cys-Ezobuchwepheshe-Cys) esikhundleni Met. Zona efanayo gamma-interferon ingenye compounds ezibaluleke kakhulu ezihilelekile ukusabela mzimba umzimba. Receptor ngoba babe natural killer cells, ama-macrophage, T lymphocyte, futhi neutrophil. Kulokhu-ke egcekeni acid acid (gamma-interferon) kusiza inqubo ukusebenza effector nemisebenzi amaseli ngaphezulu njengoba amagciwane, cytotoxicity, futhi zamagama superksidnyh nitroxide ezizivelelayo cytokines banezimfanelo isinyathelo eqeda ukuvuvukala kanye amagciwane. Kuvalelwe iphakethe umkhiqizo "Ingaron" manual libuye lithi main liyithinta ngokuqondile namagciwane isithako esebenzayo. Lokhu ibangelwa iqiniso lokuthi acid acid kwakwakhe sivimba ukufanisana RNA ne-DNA amagciwane kuyizinhlayiyana zabo ezivuthiwe. Ngaphezu kwalokho, interferon gamma has a evelele cytotoxic nomthelela amaseli ukuthi igciwane. Kuyaqapheleka futhi ukuthi izidakamizwa kuvimbela amaprotheni zamagama inqubo ukuvuvukala ngokwandisa Inkulumo zezakhi zofuzo C2 futhi C4.

Khipha ifomu kanye nokwakheka izidakamizwa

imithi Itholakala izinhlobo ezimbili kuphela. Okokuqala - lyophilisate, esetshenziselwa ukulungiselela isixazululo kwezokuphatha ongama bese esicutshini. Interferon gamma kwalokho, izidakamizwa kufakwe excipient mannitol. izidakamizwa Itholakala lolu hlobo izitsha eziyisikhombisa ukuthi Agcwele amakhadibhodi amabhokisi 1, 5, 10 futhi amayunithi 20. It okukhishwa imithi ngaphandle kadokotela.

Ngokuqondene ifomu lesibili zomuthi, ukubunjwa yayo nsé kuqala. Kodwa lapha wasebenzisa leli lyophilizate, okuyilona elisebenzayo futhi zahlanganiswa ku izitsha eziyisikhombisa ukulungiselela amathonsi ngoba intranasal abaphathi. Ngasinye pack of amakhadibhodi ngokuhlanganyela ukulungiselela eziyisisekelo yakhiwa amanzi umjovo i ampoule noma umfuma 5 ml. Le ngxenye eyengeziwe kuyinto kuphela isixazululo nokulungiselela.

Kuze kube manje, nezinye izinhlobo ukukhululwa zomuthi akuyona, ngakho musa ukufuna ezinye izinhlobo "Ingaron" izidakamizwa Pharmacy. Izibhebhe kungukuthi oluqanjwe embonini eyenza imithi yezokwelapha.

Ukuze linqume izidakamizwa njengoba isixazululo imijovo ongama bese esicutshini?

Ngaphambi kokucabangela le izinkomba for reception yaleli fomu zomuthi, kufanele kusho ukuthi kubalulekile ukusebenzisa kunqunyiwe ngudokotela. Phela, indlela yokuphathwa umthamo esetshenziswa incike uhlobo sifo busebenze.

Immunomodulating izidakamizwa "Ingaron" kuyingxenye yokwelapha eziyinkimbinkimbi amafomu njalo viral isifo sokusha kwesibindi kohlobo B no-C, isifo sofuba yamaphaphu, izifo oncological, ukutheleleka nge-HIV / AIDS. Kaningi indlela enqunyiwe iziguli urogenalnogo chlamydia, ezingamahlalakhona prostatitis, esithweni sangasese gerpevirusnoy ukutheleleka ezimise okwama-tile. Ngathola izidakamizwa isicelo "Ingaron" kule ukwelashwa kanye nokuvimbela obuntu papilloma virus, kanye nezinkinga ezithathelwanayo in iziguli isifo granulomatous.

Ukusetshenziswa isixazululo intranasal ekuphathweni

Leli fomu zomuthi ngokuvamile sisetshenziswa emikhakheni ehlukahlukene imithi. Nokho, ngokuvamile kutuswa njengoba prophylaxis kanye nokwelashwa amagciwane ahlukahlukene Umkhuhlane, kuhlanganise H5N1 kanye H1N1, okuyinto njengoba "inyoni" umkhuhlane ezaziwayo. Ezikhathini eziwumshayabhuqe umuthi kusiza izivikeli mzimba ulwe Amagciwane isifo.

Lapho sisetshenziswa ndawonye kusho yokwelapha eziyisisekelo yokutakula kwenzeka ngokushesha okungaka. Ngaphezu kwalokho, seziguli ezithola izindlela "Ingaron" ngenxa yezinkinga umkhuhlane achazwayo kuphela ezimweni angawodwa.

Ulungiselela isixazululo umjovo kanye uhlelo sokuphuzisa

Njengoba kushiwo ngenhla, umthamo izidakamizwa okumelwe uyabele udokotela ukuba khona, uphethwe waqondisa isifo zaba namandla kakhulu. Ngaphezu kwalokho, isazi ugcizelela ukunakwa lesiguli indlela yokuphathwa kwe-ejenti kanye nesikhathi sokwelashwa.

Futhi kusukela nomuthi ekhiqizwa ngesimo a lyophilisate ngaphambi nje kokuba isicelo yalo ukuba kahle ukulungiselela isixazululo umjovo. Ngenxa yale njongo, okuqukethwe omunye isitsha buhlanjululwe in 2 ml amanzi umjovo.

Esikhathini ukwelashwa kuhlangene yamafomu njalo viral ukusha kwesibindi kohlobo B noma C, kanye / izifo negciwane lesandulelangculazi kanye nesifo sofuba yamaphaphu umthamo wansuku zonke sokuba iziguli omdala kufana 450-500 eziyinkulungwane. IU. Imijovo zenziwa 1 isikhathi ngosuku, njalo ngemva kosuku noma nsuku zonke. Kuye kobukhulu Yiqiniso isifo ukwelashwa kungase kube kusuka 30 kuya 90 izinsuku, futhi uma kunesidingo kungaba, udokotela, ukuphinda kwezinyanga ezimbalwa. Ukuvimbela ukuthuthukiswa yezinkinga in iziguli isifo granulosa, bona ukhethe usuku noma nsuku zonke izinkulungwane 500. IU "Ingaron" izidakamizwa. Izibuyekezo lodokotela abonisa ukuthi umkhuba omuhle siyenzeka uma usebenzisa izidakamizwa izinsuku 2-3. Kodwa nakhu inkambo imithi yokwelapha lesi sifo kufanele okungenani 5 imijovo. Ngokuphathelene iziguli ezinezinkinga umdlavuza-ke, kuye ngobucayi isifo, umthamo avareji nsuku zonke zingahluka kusuka 400 kuya 600 ayizinkulungwane. IU. Kodwa isikhathi sokwelashwa kunqunywa ngamunye futhi kushintshwe kakade inqubo yokwelashwa ngokuhambisana imiphumela zokwelapha.

Abantu abaye batholakala bene-izifo ezifana gerpevirusnaya ukutheleleka, chlamydia urogenital noma herpes zoster, ebekiwe 5 imijovo ongama Njalo ngemva kosuku olulodwa. isilinganiso I umthamo wansuku zonke zomuthi ngaphansi izifo ngenhla omdala kufanele kube izinkulungwane 500. IU.

Ukuze sisekele isimiso somzimba sokuzivikela futhi usize ukuze sibhekane ezingamahlalakhona iziguli prostatitis Kunconywa zonke izinsuku ezimbili ukujova lesi sidakamizwa "Ingaron". Inkambo yokwelashwa - 10 imijovo ayizinkulungwane 100 IU ..

Lapho warts anogenital imithi injected phansi kwesikhumba Njalo ngemva kosuku olulodwa for 100 ayizinkulungwane. IU. Isikhathi yokwelapha kuncike eyinkimbinkimbi kakhulu lesi sifo, kodwa hhayi ngaphansi kuka 5 imijovo.

ikhambi uhlelo izabelo for intranasal isicelo

Ngaphambi kokufaka isicelo leli fomu kusho lyophilisate kungenziwa oncibilikiswe 5 ml yamanzi okushunyekiwe iphakethe umkhiqizo. Isixazululo kwaphumela lwagxiliswa nge pipette ku ekhaleni.

Uma ubona izimpawu zokuqala kakhulu Umkhuhlane noma SARS izidakamizwa "Ingaron" manual uncoma ukusebenzisa izikhathi 5-8 ngosuku 2 amathonsi ngamunye ndima acinene. Ubude yokwelashwa ngokuvamile 5-7 izinsuku.

It kuzokhumbuleka ukuthi nokuvimbela izifo ezibangelwa amagciwane kanye ezibangelwa amagciwane we zokuphefumula ipheshana izindlela futhi asetshenziswa. Ngokwesibonelo, ngemva kokuthintana umuntu ogulayo noma supercooling izidakamizwa izinsuku 10 wangcwatshwa ekhaleni izikhathi 1 usuku 2-3 amathonsi. Ukuze siqhube le nqubo uhlanzekile elandelayo amavesi acinene akuyona imizuzu engaphansi kuka-30 ngaphambi kokudla. Uma uthole umuntu ogulayo ebulala eyodwa, njengoba imithi zokuvimbela kwanele iconsa "Ingaron" ekhaleni kanye kuphela.

Ukuze imithi ngokulinganayo basakaza, kungcono uhlikihla amaphiko ekhaleni imizuzu eminingana ngemva instillation.

ekuphathweni esicutshini zomuthi izingane

ngokuvamile Gamma interferon kuyingxenye yokwelapha eyinkimbinkimbi izifo eziningi izingane. Ngakho, wamiswa njengombonisi ogulayo kancane emva ukususwa papillomas nge papillomatosis zokuphefumula.

nomuthi esicutshini Kunconywa iziguli acute ukusha kwesibindi kohlobo B. I umthamo wansuku zonke zomuthi ibalwa esimweni ngasinye kusekelwe eqinisweni ukuthi kilogram of isisindo isiguli ngasinye kufanele kube encane ayizinkulungwane 10. IU. Imijovo zenziwa 1 isikhathi ngosuku izinsuku 7-10, umthamo lancipha ngesigamu ngemva kwesikhathi esibekiwe. Inkambo yokwelashwa iyaqhubeka amasonto 3, kanye imijovo zenziwa kanye kwezinsuku ezimbili.

Sebenzisa "Ingaron" izingane asebenzayo ukusha kwesibindi kohlobo B. ukugula oyingozi futhi ezingalapheki eside lokhu iziguli ezincane iqondiswa imijovo intramuscularly obuyizinkulungwane 10. 1 IU ngayinye esisindo kg kabili ngesonto. ukwelashwa okunjalo kusuka 1 kuya 2 izinyanga, kodwa izinhlobo eziphambili noma okunzima sifo singase siwathole izinyanga 6.

Uma ingane unesifo asebenzayo -hepatitis D (HDV), futhi lapho azikho izimpawu isibindi sibe sesomile, umuthi elibekelwe ayizinkulungwane 5. 1 IU ngayinye kg isisindo umzimba. Iqondiswa kabili ngesonto. Inkambo yokwelashwa - 8 imijovo, futhi futhi kungaba e izinyanga 1-6.

Kodwa uma lezi zimpawu isifo sokusha namanje ekhona kwesibindi kohlobo esebenzayo, bese kabili ngesonto, wajova izidakamizwa ngesilinganiso 5 izinkulungwane. IU kilogram of isisindo sengane ngayinye. Imijovo senziwe phakathi kwezinsuku ezingu-30, futhi uma kukhona izimpawu decompensation kamuva, ukuphinda inkambo izinyanga 2.

Baby abaphethwe ezinjalo izifo ezingamahlalakhona webhaktheriya efana ukucinana kwemigudu yokuphefumula, enteritis, laryngitis noma pharyngitis ukhombe 10 000 IU amakhilogramu esisindo ngayinye. Futhi ngenyanga eyodwa ingane kufanele zithole 2-3 imijovo masonto onke. ukwelashwa okuphindaphindayo oyinikezwe izifundo udokotela kungaba kwenziwe ngaphambili kuka izinyanga 3.

ukukhishwa Perifocal imithi Kiddies

Uma seziguli ezisencane kutholakala ukuthi uphethwe yini keratoacanthoma, i-squamous noma-basal cell carcinoma, ingxenye yokwelapha eziyinkimbinkimbi lu- zihlanganisa gamma interferon. nsuku zonke zayo iqondiswa ngqo ngaphansi maphakathi ukuvuvukala at 100-250 eziyinkulungwane. IU izinsuku 10. Lapho ukusabela ukuvuvukala wendawo zinzima umjovo Kwenziwa kwezinsuku ezingu-1-2. Lapho sebephothulile yokwelashwa nge "Ingaron" impendulo evela odokotela batusa ethwele cryodestruction ukuhlanganisa umphumela zokwelapha.

Kwezinye izimo, izingane enqunyiwe Ukuphatha subconjunctival umuthi?

Kaningana, imithi isetshenziswa zamehlo ngenxa nokwelashwa kweziguli iminyaka 7. Ngakho, lapho keratoiridocyklites futhi stromal keratitis udokotela wakho angase akukhuthaze umjovo subconjunctival ka interferon gamma. Umthamo kanye nokuvama ukwelashwa lithembela ngokuphelele kobukhulu ukuthuthukiswa isifo. Isingeniso ekulungisweni wenziwa khona ngaphansi izinzwa wendawo futhi lisetshenziswa ukuze kubulawe izinzwa, ngokuvamile 0.5% isixazululo tetracaine. Inani kungaba kusukela imijovo 10 kuya ku-20.

isicelo ngezihloko ezihlukene izidakamizwa

Futhi kusho "Ingaron" (ukubuyekezwa odokotela uqinisekise lolu lwazi) ngesivinini yokutakula kweziguli keratitis olukha phezulu kanye conjunctivitis. Zifakwe ikhambi izifo ezifana endaweni.

Ukulungisa isixazululo okuqukethwe eyodwa ampoule kuthiwa buhlanjululwe in 5 ml i-sodium chloride futhi ezako amahora 12 lapho kuthiwa esiqandisini. Sebenzisa kuphekwe "Ingaron" (amathonsi) izikhathi 6-8 ngosuku. Nge ukunyamalala izimpawu ukuvuvukala sebethule kulinganisela sehla 3-4 izikhathi. Isikhathi salesi ukwelashwa kufanele singadluli ezingu-14.

Ukulungisa contraindicated?

Kungakhathaliseki ifomu, imithi Kunconywa ukuba asebenzise abantu nge ukungabekezelelani ngabanye ukuba interferon gamma, noma yimiphi angezelelweko izingxenye imithi. Musa thatha izindlela kanye nabesifazane abakhulelwe.
It is nhlobo ukusebenzisa "Ingaron" isifo sikashukela kanye nezifo sokuhlasela kwamasosha omzimba isixazululo umjovo ongama bese esicutshini. Ikhala amathonsi kungukuthi iqondiswa iziguli kuze iminyaka 7.

imiphumela emibi yemithi kanye overdosing

Njenganoma iyiphi izidakamizwa, i-ejenti "Ingaron" (amaconsi futhi imijovo) linenani amathuba okuba nemiphumela engemihle. Ngakho, ukusabela iguliswa wendawo singenzeka nokuphathwa ongama noma esicutshini zomuthi. Ezimweni eziningi, ukuthi kuziveza ngesimo ububomvu kwesikhumba, ephelezelwa ubuhlungu omnene. Kwezinye iziguli, ukwelashwa kungase kubangele imisipha ubuhlungu nokushisa komzimba okukhulu.

Ezimweni lapho umkhiqizo isetshenziswa ngemithamo mkhulu kunezinhliziyo 000 IU 1000, wandise nengozi yokuba emuva kokutshengisa izimpawu zomkhuhlane ezifana ubuhlungu bekhanda, ukukhathala, arthralgia futhi pyrexia. Futhi uma degree of okubonakalisa nezici okuchazwe lapha incane, asikho isidingo ukulapha lingaze. Ezimweni lapho zimpawu sinconywa engayitholi kusho "paracetamol".

Yini abakucabangayo "Ingaron" ukulungiselela odokotela?

Emuva ngo-1957, ngenxa yemizamo lososayensi, yatholakala futhi wafundelwa ngokuningiliziwe interferon. Kusukela ngaleso sikhathi bebaningi kakade amaphepha zesayensi ezabhalwa ngokubaluleka lokhu multicomponent compounds yemvelo ezindaweni ezihlukahlukene imithi. Futhi uma ukusetshenziswa interferon e izifo ezifana ne-hepatitis noma umdlavuza izimila, kwafakazelwa ngokugcwele njengokuyiqiniso eziningi izifundo zokwelapha, abheke ukuthi kungenzeka reception yayo emakhazeni futhi esikhathini sethu isihloko impikiswano. Ake sizame ukuqonda ukuthi kungani izinkanyiso imithi emhlabeni nezingxoxo mayelana sekungamashumi amaningi eminyaka efanayo. Iningi odokotela ku post-ayimpoqo etuswa izimpawu zokuqala SARS safaka izidakamizwa "Ingaron" ekhaleni. Izibuyekezo lodokotela ngenkathi ukhuluma ngani ukuqala okusheshayo nomphumela oqabulayo futhi ukwandisa umzimba ozivikela.

izinkanyiso Western imithi banemibono okuphambene ngokuphelele le nkinga. Abanaso ukuphika kusizakale interferon ne-SARS, kodwa okugcizelela ukusabela ezingezinhle, okungase kubangele "Ingaron" - fafaza noma amaconsi. Ngemva kwesikhathi eside ukuze kuvikelwe ezimweni eziningi ikhona yini imbangela yokucasuka kanye Ukuwohloka mucosa acinene, ukubukeka ukopha nokuthimula, kanye imbangela ukwehla elibukhali inani egazi amhlophe bese igazi (leukopenia).

Ngaphezu kwalokho, "Ingaron" (iconsi) - umhlahlandlela futhi yazisa nge-ke - kungabangela ukusabela, akachazeki kusukela izimpawu komkhuhlane. Kuyinto kule qiniso futhi ubheke nodokotela bamazwe aseNtshonalanga ungayisebenzisi gamma interferon ku nokwelashwa kweziguli umkhuhlane ne-SARS.

Ethembele Izibuyekezo yayihlukene odokotela, kunzima kakhulu ukukhuluma mayelana zibheke "Ingaron" lisho ukuthini.

analogue imithi

Kuze kube manje, izidakamizwa esekelwe interferon ngokwanele. Ukuze uchaze ezininginingi enjalo kungaba yokuthi kusukela ekuqaleni zezakhi acid acid kuye kwaba kuka kwamashumi amahlanu. Futhi zonke kunodokotela ngenkathi kwabathatha ukudalwa izidakamizwa okusha okuthuthukisiwe.

Njengoba imithi "Ingaron" analogue aqukethe ingxenye interferon. Esaziwa kakhulu lawa amathuluzi ezifana "Laferobion", "Ingaron A", "Human Interferon", "Avonex", "Alfaferon" et al. Zonke imithi ebhalwe ngenhla ngokusekelwe eBhayibhelini aqukethe ingxenye kwakwakhe acid acid - interferon. Basuke kabanzi emikhakheni ehlukahlukene imithi ezweni lethu for ekwelapheni izifo eziyinkimbinkimbi omsakazo ezibangelwa amagciwane kanye ezibangelwa amagciwane. Kodwa kuyafaneleka ukuthi, naphezu imvelaphi yezinto eziphilayo izidakamizwa, ukusebenzisa ngokwakho ngeke kukusize ngalutho kuso. Phela, ngamunye wabo Izimo yayo futhi ungakulimaza lomuntu ogulayo. Iwusizo umuthi othile okusekelwe interferon kufanele azimisele kuphela onguchwepheshe. Imisebenzi udokotela kufakwe ekubalweni imishini umthamo kanye kukhethwa indlela yokuphathwa. Esikhathini imithi oyinikiwe, kungakhathaliseki izidakamizwa waqokwa "Ingaron" analogue esekelwe gamma-interferon noma imikhiqizo equkethe-alpha-interferon, onguchwepheshe uzoqapha ukugeleza Dynamics lesi sifo futhi ngamunye ulungise isikhathi sokwelashwa.