"Nexium": analog ezishibhile, imiyalelo, ukubuyekezwa. Indlela "Nexium"?

Esikhathini sethu, lo zokugula we pheshana emathunjini sekuvame. I izimpawu zesifo hhayi kuphela ibakhathaze nobuhlungu, kodwa futhi kungaholela eziyingozi. Sengathi isiguli epigastric ubuhlungu, isilungulela, ukubhodla, ukuqunjelwa. Ukuqeda lesi sifo, kubalulekile ngesikhathi ukuba bahlolelwe futhi uqale ukwelashwa. izidakamizwa Abaningana impela ezivamile futhi ezithandwayo ukushabalalisa izinkinga nge esiswini kubhekwa "Nexium". Yokusetshenziswa, real - lonke ulwazi uzokwazi ukufunda kulesi sihloko.

ukukhululwa Ifomu

I nomuthi engena iqembu ATPase inhibitor. Iyatholakala ngesimo pink amaphilisi. The main izidakamizwa ketshezi Ukwakheka uku umthamo 20 esomeprazole futhi mg 40. izingxenye Ukusekela yilezi:

• crospovidone;
• glyceryl monostearate;
• yensimbi oxide colorant orange futhi ebomvu;
• magnesium stearate;
• microcrystalline cellulose;
• macrogol;
• titanium;
• talc.

Izibhebhe kukhona ibhamuza aluminium kuya ku-7 izingcezu ngamunye. Phama izinyanda kusho ukulawula ukuvulwa wokuqala 1, 2, 4 amabhamuza ngamunye. Indlela "Nexium," utshele udokotela wakho ngaphambi kokuqala inqubo yokwelashwa. Imininingwane Isifingqo nayo izofakwa kukhonjisiwe ngezansi.

umphumela

Main izidakamizwa izidakamizwa kubhekwa omeprozola isomer, kunciphisa umphumela hydrochloric acid esiswini ngu okusithiyayo ezithile proton futha kumaseli parietal. Umkhawulo umsebenzi izidakamizwa waphawula imizuzu ayisithupha ngemva ukungenisa. Ukuthatha amaphilisi ngeviki ngezinye umthamo mg 20 kungase kuqashelwe ukuthi ngokwesilinganiso incipha nge hydrochloric acid ku uketshezi esiswini - emlonyeni ekubeni ukunambitheka zihlobane obuphatheka ngesandla.

Umthelela zokwelapha iyona okusithiyayo of hydrochloric acid cishe 100% eziguli emva izifundo ezimbili. Futhi ngesikhathi ukwelashwa edilini ngokuhlanganyela ngemithi elwa namagciwane isiguli wokuqeda ngempumelelo Helicobacter pylori izinduku, okuyinto kubangela ukuthuthukiswa izilonda. Ngaphambi ukwelashwa kufanele wafunda emuthini imiyalo 'Nexium' ukusetshenziswa. Analogs ziyoba nemiphumela efanayo emzimbeni.

Pharmacokinetics

Esomeprazole akuyona amelana ezindaweni ene-asidi. Ngakho-ke, izibhebhe embozwe ifilimu ekhethekile abuthonywa juice esiswini. Ngemva ukusetshenziswa kwezidakamizwa ngokushesha ugxile kusukela esiswini. umsebenzi walo omkhulu kufinyelelwe emahoreni amabili. Cishe ngo-100% nakanjani plasma amaprotheni. Uma kanye izidakamizwa ukuthatha ukudla, esiswini kuyehla futhi kubambezela inqubo ukumuncwa. I metabolites ezinkulu izidakamizwa azinamphumela phezu uketshezi kwamanyikwe.

Ngo ngesimo metabolites izidakamizwa excreted ku umchamo, bese kuphela ingxenye encane yawo - ne indle. Ezigulini esezikhulile umzimba alishintshi lapho ethola izimali "Nexium". uzakwabo eshibhile - "esomeprazole" - has pharmacokinetics efanayo.

Izinkomba kanye contraindications

Imithi angabelwa ngenxa yezizathu ezilandelayo:

• gastroesophageal isifo Reflux ;
• ekhuluma izimbangela erosive Reflux esophagitis;
• yokwelapha yesondlo iziguli emva ukuphulukisa izilonda ukuvimbela exacerbation;
• ekwelapheni pathologies esiswini kanye isilonda duodenal lihambisana namanye izidakamizwa;
• izinyathelo zokuvimbela lokubuya kwesifo izilonda peptic elihlobene ne-bacterium Helicobacter pylori;
• eside ukululama ngemva ukopha kakhulu esiswini;
• ukuphulukisa izilonda elihlobene ne NSAID;
• hypersecretion pathologic.

Izimo:

• fructose ukungabekezelelani, okuyinto lezinceku;
• ukwehluleka sucrose kanye glucose;
• yobudala engaphansi kwengu-12;
• yobudala Wezingane sebeneminyaka engu-12, ngaphandle iziguli gastro-oesophageal Reflux isifo;
• reception eziyinkimbinkimbi ne "ATV" futhi "nelfinavir";
• ukwehluleka kwezinso;
• hypersensitivity kuya izidakamizwa main - esomeprazole.

Ngaphambi kokuqala ukwelashwa, kuyinto efiselekayo kahle sizihlole zonke izinkomba kanye contraindications, okuyinto has a isikhungo sokwelapha "Nexium". Russian analogue futhi kumele kusetshenziswe ngemva kokukhuluma nodokotela.

Isikali

Izibhebhe zithathwa ngomlomo ngaphandle ukuhlafuna futhi ephuza esincane ketshezi. Umuthi imbozwe ifilimu ekhethekile olumelana juice esiswini. A iphilisi ayikwazi behlukana. Labo iziguli abangakwazi ukugwinya wonke imithi, udinga chaza ke ngesigamu ingilazi yamanzi ngaphandle igesi, futhi ngemva kwezinye isikhathi isiphuzo. Ukuze isicelo eside walabo hlupheka esophagitis erosive iqondiswa mg izidakamizwa 20 ukuze ugweme ukuphinda. Umuthi kumele kuthathwe kanye ngosuku.

Ekwelapheni gastroesophageal Reflux isifo e abadala nezingane enesisindo esingamakhilogremu angaphezu 30 kg iqondiswa izidakamizwa e umthamo 20 mg ngosuku. Uma kungakapheli inyanga izimpawu azizange zinyamalale, kubalulekile ukuqhuba ukuhlolwa eyengeziwe. Ngemva yokutakula, ungathatha amaphilisi uma kunesidingo, lapho kwakukhona izimpawu. Umthamo kulokhu 20 mg kanye ngelanga. Labo ezigulini ukuthatha ama-NSAID basengozini, elihlobene ne isilonda esiswini, kuphela emva kokubonisana udokotela kuyadingeka ukusebenzisa imithi "Nexium". Analogs Izibuyekezo - konke lokhu Imininingwane kucaciswe ngaphambi kokuqala ukwelashwa.

Lapho pathologies ulcerous elihlobene ne-bacterium Helicobacter pylori, umuthi elisetshenziswa yokwelapha eyinkimbinkimbi 20 mg ngosuku. amoxycillin Ngaphezu kwalokho babelwe (1 g) kanye clarithromycin (500 mg). yokwelapha Inxanxathela Kwenziwa izinsuku eziyishumi.

Ukuze kislopodavlyayuschey seziguli othola ukopha kakhulu esiswini, indlela esiyakuqokwa ngaphansi umthamo 40 mg ngelanga inyanga eyodwa.

Ukusebenzisana neminye imithi

Umuthi is hhayi Kunconywa uma uthatha imithi ezilandelayo:

• "Ketoconazole";
• "Digoxin";
• "Saksinavir";
• "Phenytoin";
• "Voriconazole";
• "Warfarin".

Uma isiguli kuthatha omunye lezi zimali, kubalulekile ukwazisa udokotela ngaphambi kokusebenzisa imithi "Nexium". analog eshibhile uyoba izinkomba efanayo.

Uma usebenzisa izidakamizwa ebulilini, isiguli singase ukuthuthukisa ubuthakathaka, isicanucanu nezinye izimpawu zokudakwa. isihlungu Specific emuthini khona. Ngakho-ke, kulesi simo babelwe yokwelapha lingaze futhi basekelane. Dialysis kuyinto ingaphumeleli, njengoba isakhi esiyinhloko zomuthi cishe 100% elihlobene ne Amaprotheni egazi.

Nokukhulelwa kanye lactation

Ukusetshenziswa "Nexium" ngesikhathi yokuzala iye kancane wafunda. Ingasatshenziswa kuphela ezimweni ezingavamile lapho izinzuzo elindelekile ukuba umama okhulelwe mkhulu ingozi embungwini. Ngokusho imiphumela nomthelela omubi izifundo isilwane babungekho ubufakazi ku-embryo ezingase avuse hypoplasia noma deformity. Ngesikhathi sokuncelisa ibele kungcono uyeke ukusebenzisa izidakamizwa. Umuthi engena ubisi. Uma udinga ukwelashwa, kungcono ukuba ayiyeke le lactation.

Lapho ethola imithi engalungile kulandela izimpawu ezingemnandi ingaqala:

• okuvela komzimba nezinto, kuze ukushaqeka anaphylactic;
• isiyezi;
• migraine;
• ubuhlungu epigastric;
• ukuba buthakathaka kwezicubu;
• thuthuva ubuthongo;
• webele;
• umsebenzi so-renal.

Ephambi kwezinduna izimpawu enqabayo kufanele wazise udokotela wakho. Indlela "Nexium" ukuze ugweme ukweqisa izidakamizwa, ungakwazi ukutshela udokotela edilini lomshado.

Izixwayiso

Umuthi kufanele igcinwe kude nezingane ezingeni lokushisa akukho ephakeme kuka-degree angu-30. I kadokotela ekhemisi. Akunconyelwe izingane ezingaphansi kweminyaka engu-12, ngaphandle isidingo ekwelapheni gastroesophageal Reflux isifo. Ezigulini ezine-ukuhluleka okunzima kwezinso, umthamo kumele singeqi 20 mg ngosuku.

Ngokuhamba ukwelashwa kufanele uyekwe kusuka izimoto ukushayela futhi umsebenzi elihlobene ne okuhlushwa. Ngokuvamile isiyezi wabonakaliswa ngenxa yokwamukela amaphilisi. Oku kufanele wafunda ukulungisa "Nexium" imfundiso. Izibuyekezo abonisa ukuthi side effects ngokuvamile eba ezigulini sidebeselele izincomo.

uzakwabo eshibhile - isidakamizwa "esomeprazole"

Umuthi libhekisela eqenjini antiulcer, i-proton futha inhibitor kuyinto. Futhi i-ejenti asebenzayo kunciphisa uketshezi of hydrochloric acid. A yi omuhle siyenzeka ngehora ngemuva kokuthola 20 noma 40 mg zomuthi. Uma zingakapheli izinsuku ezinhlanu ukuthatha imithi nsukuzonke, kungenzeka ukuba ukunciphisa izinga hydrochloric acid cishe 80%.

Umuthi ingahlalisekanga endaweni ene-asidi. Ngakho-ke, elimbudumbudu kanye amaphilisi camera nge enamathela ekhethekile okungase mbeni le uketshezi esiswini. Ngezinye 98% izidakamizwa sibopha ukuthi Amaprotheni egazi. Umphumela ofanayo has umuthi "Nexium". Eshibhile analog "esomeprazole" cishe ezifanayo ukubunjwa.

Izinkomba kanye contraindications

"Esomeprazole" angabelwa kulezi zimo ezilandelayo:

• ekwelapheni esophagitis erosive;
• izinyathelo ngesikhathi iyelapheka Reflux erosive esophagitis;
• lingaze ekwelapheni Gerd ;
• lihambisana imithi elwa namagciwane ukubulala amabhaktheriya Helicobacter pylori, elibangela izilonda esiswini kanye nezilonda duodenal.

Izimo:

• Hypersensitivity emuthini;
• ukhulelwe;
• lactation;
• esingamahlalakhona ezinzima kwezinso;
• yobudala kuze kube iminyaka engu-16.

Indlela ukuthatha imithi?

Esimisiwe 'esomeprazole "ngomlomo. Umthamo Kumiswa umuntu ngamunye ikhumbula ngobucayi isifo. Ngokuvamile kuba 20 noma 40 mg kanye ngelanga. A iphilisi ayikwazi ezokuhlafunwa noma behlukana. It ihlanganiswa ne enamathela ekhethekile esiza izidakamizwa ugxile esiswini. Uma ungeke ukwazi ukugwinya wonke imithi, kungashiwo ziyoncibilika ingilazi yamanzi namanje noma liphekwe nokuphekwa ngamanzi, futhi ngemva kwemizuzu engu-30 ukuba baphuze.

Ngo kwezinso zokugula ejenti alinganisiwe ngesilinganiso 20 mg ngosuku. algorithm ezifanayo edilini lomshado kusho "Nexium". analogue Yalutho ngokuvamile ube izincomo efanayo.

side effects

lezi zimpawu ezingemnandi kungakheka kunoma engafanele ngokuthatha izidakamizwa:

• ikhanda;
• isiyezi;
• isicanucanu;
• ukuba buthakathaka kwezicubu;
• thuthuva ubuthongo;
• komzimba;
• eliqhaqhazelayo et al.

Izibuyekezo amalungiselelo 'Nexium' futhi "esomeprazole"

Iziguli eziningi uncamela luphathwe ukusetshenziswa kwalezi zimali. okulingana IsiRashiya sinamagama ngenani ethengekayo, okuyinto ruble angu-30 iphakethe ngalinye. Kodwa amazwe original has a izindleko kahle eliphezulu (mayelana 800 ruble). Ngokusho iziguli, le mithi omkhulu ezibalweni, ngakho akukho isidingo overpay ngoba "Nexium". Ukufundiswa kumakhophi, izindleko zabo - konke lokhu kwaziswa, kuyatuseka ukufunda ngaphambi kokuba baqale ukusebenzisa ukwelashwa.

Izidakamizwa echazwe bubekezelelwa kahle, ube phakathi nesikhathi esifushane ungakwazi okudambisa ubuhlungu, okuyinto ngenxa yokuqukethwe eliphezulu hydrochloric acid e juice esiswini. nabo basize zarubtsovyvatsya isilonda futhi zibangele uyahluleka uma elwa nokuphuza yansukuzonke. Lihambisana imithi elwa namagciwane isiguli kuqeda amabhaktheriya Helicobacter pylori, okuvame ukuholela izilonda esiswini kanye duodenal.

ebekiwe kuphela udokotela ukuqala ukwelashwa "Nexium" lisho ukuthini. Eshibhile analog "esomeprazole" futhi kumele kusetshenziswe awuwedwa.

Isithako asebenzayo akakubangeli yokulutheka kanye nokuqaleka izimpawu. Tablets elula ukuthatha. Banezinhliziyo igobolondo okungahambisani ngalesi siyingi kubangele ubuhlungu we ulwelwesi lwamafinyila esiswini kusiza izidakamizwa ngokushesha ugxile. Kwithebhulethi ngamunye (pink umbala) ibhalwe ngumkhiqizi, esivikela izidakamizwa ovela inkohliso. gastroenterologists Abaningi ukusetshenziswa emikhubeni yabo besebenzisa izindlela "Nexium" futhi okuphikisana nalo eshibhile - isidakamizwa "Ezomkeprazol" - ukwelapha izifo esiswini of etiologies ezahlukene. Ochwepheshe uqaphele ukuthi imithi ezichazwe ngenhla ibonisa imiphumela emihle yokwelapha.