"Menopur": imfundo, intengo, ukubuyekezwa, incazelo, amanani

Kungani ngidinga imithi "Menopur"? Imfundo yokulungiswa, izindlela zayo zokusebenzisa kanye nemilinganiselo izochazwa kulesi sihloko. Kuzo uzofunda nokuthi yiziphi izibonakaliso ezikhona kulo muthi, kungakhathaliseki ukuthi unemiphumela emibi kanye nokuphikisana, ukuthi iziguli zithini ngakho, yiziphi izindleko zayo, njll,

Ukwakhiwa, uhlobo lokukhululwa komkhiqizo wokwelapha

Ngamuphi uhlobo umuthi "Menopur" odayiswe? Imiyalo yokusetshenziswa kwemithi iqukethe ulwazi ukuthi ukulungiswa kuyatholakala ngesimo se-lyophilizate, okuhloswe ukulungiselela isisombululo sokujola okufakwe ngaphakathi .

Lesi sidakamizwa siwuphawu olumhlophe noma olusebenzayo olumhlophe ngaphandle kokuhogela. Futhi, i-solvent engabalabala nebala iyasetshenziswa kuyo.

Umuthi "Menopur" uqukethe? Imfundo ithi into esebenzayo yemithi i-follicle-ivuselela, kanye nama -hormone wokuqondisa. Ihlanganisa izinto ezisizayo ngendlela ye-polysorbate 20, i-lactose monohydrate, i-sodium hydroxide ne-hydrochloric acid.

I-solvent yisisombululo se- sodium chloride (isotonic).

Ukupakisha kokulungiselela

Isidakamizwa sithengiswa emigodini engu-2 ml. Kanye nayo kufika i-solvent (i-ampoule ne-1 ml yezinto). Ku-carton eyodwa kungaba amasethi angu-5 noma angu-10.

Isenzo semithi yesidakamizwa

Iyini imithi "Menopur"? Imiyalo yokusetshenziswa ibonisa ukuthi le mithi iyindlela yokuhlanzwa kwe-gonadotropin yomuntu (ukuyeka esikhathini sokuya esikhathini). Iyingxenye yeqembu lama-menotoropine, futhi iqukethe i-LH ne-FSH ngesilinganiso se-1 kuya ku-1. Imithi itholakala emcimbini wesifazane kuma-postmenopausal abesifazane.

Ngokwebulili obuhle, le-agent ivuselela ukwanda kwe-endometrium, ukuvuthwa nokukhula kwama-ovarian follicles, futhi kubangele ukwanda izinga le-estrogens egazini.

Ngokuqondene nobulili obunamandla, lesi sidakamizwa senza ukwanda kwe-testosterone. Ngaphezu kwalokho, ivuselela i-spermatogenesis ngokuthinta amaseli we-tubules (seminal).

Pharmacokinetics yokulungiselela ukwelashwa

Isidakamizwa esithi "Menopur" sithatha isikhathi esingakanani? Isiqondiso sithi ukuhlushwa okukhulu kwe-FSH egazini kufinyelelwa cishe amahora angu-7-24 ngemva kokujova kwe-intramuscular. Ngemva kwalokho, ivolumu yayo iyancipha kancane kancane. Ingxenye yokuphila yama-menotropin amahora angu-5-12.

Izimpawu zokusetshenziswa kwemithi

Imfundo yokulungiselela "Menopur" ithi ayikwazi ukusetshenziselwa abamele ababuthakathaka kuphela, kodwa nakwabamele abesilisa abanesibindi esinamandla.

Ngakho-ke, ake sicabangele izinkomba zokusetshenziswa kwabesifazane:

• Ukwenza amasu okuzala (abasizayo) ngenhloso yokuqala kokukhulelwa (okungukuthi, ukugqugquzela ukukhula kwezintambo);
• Ukuze ukwelashwa kokungazalwa, okungenxa yezifo ze-hypothalamic-pituitary (ukugqugquzela ukukhula kwe-follicle yokuqala ephezulu).

Ngamiphi izinhloso amadoda anika umuthi "Menopur"? Ukufundiswa, ukubuyekezwa, uhlelo lokusebenza kuzonikezwa ngokuqhubekayo. Ngokuqondene nobufakazi, kufaka phakathi okulandelayo:

• Ukukhuthaza i-spermatogenesis (Kunconywa ukuthi kuhlangane nemithi ye-chorionic gonadotropin).

Ingabe kukhona ukuphikisana nemithi?

Uma ungakwazi ukubeka umuthi "Menopur" (lyophilizate)? Imiyalo yokusetshenziswa ihlanganisa ukuphikisana okulandelayo:

• I-tumor yesifunda se-hypothalamic-pituitary;
• Ukuthuthukiswa okungavamile kwezitho zangasese, kanye nokuba khona kwama-fibroids, okungahambisani nokukhulelwa;
• Izifo ze-adrenal kanye ne-thyroid;
• Hyperprolactinemia;
• Ukwandiswa kwe-Ovarian (okuqhubekayo), ukutholakala kwama-cysts (uma lesi sifo singahlanganiswa nesifo se-polycystic ovary syndrome);
• Umdlavuza we-ovaries, isisu noma izigulane ezincelisayo;
• Umsuka omhlophe ongabonakali;
• Ukuhluleka okuyinhloko kwama-ovari;
• Isikhathi sokukhulelwa;
• I-Cancer ye-prostate gland, kanye nezinye izifo (i-androgen-dependent) ngobulili obunamandla;
• Isikhathi sokufaka isicelo;
• Ukuzwela (okwenyuka) kumamotropin, kanye nemithi equkethe i-FSH noma i-LH.

Ukulungiselela imithi "Menopur": imiyalelo yokusetshenziswa, isifinyeto

Incazelo yalo muthi inikezwe ngenhla. Ngokuphathelene nalesi sigaba salesi sihloko, kuyokutshela ukuthi ngabe isidakamizwa sithathwe kanjani.

Isidakamizwa senziwa nge-intramuscularly. Isixazululo sokujola silungiswa ngaphambi kokusetshenziswa, usebenzisa i-solvent efakwe kulesi kit.

Uma kwenzeka ukuthi udokotela oya khona engakaqashiwe omunye ukwelashwa, kunconywa ukuba uhambisane nalolu hlelo olulandelayo.

Abesifazane

Ukuze uphathe ukwelashwa, okubangelwa ukutholakala kwezinkinga nge-hypothalamic-pituitary esifundeni, ukuze kukhuthazwe ukukhula kwe-follicle yokuqala, umthamo wesidakamizwa uhlelwe ngabanye. Umthamo omuhle wezidakamizwa, kanye nobude besikhathi sokwelashwa kukhethwe ngokusekelwe kuma-ovarie akhiwe, ukuhlolwa kwemitholampilo kanye ne-estrogen level. Ngandlela-thile, kuwuhlu lokugcina lokuhlukunyezwa kokuvuthwa kwe-follicle.

Ngakho kufanele usebenzise kanjani umuthi "Menopur"? Indlela yokuphatha kanye nomthamo wezidakamizwa ihlale iboniswa emiyalweni enamathiselwe. Umthamo wokuqala wesidakamizwa ungaba ngu-75-150 IU (noma ama-vial 1-2 ngosuku).

Uma kungekho ukuphendula kwama-ovari, khona-ke inani lemithi liye landa kancane kancane ekukhuleni kwe-follicles kanye nokwanda kwezinga le-estrogens. Le dosi ishiywe ingashintshi kuze kube umzuzwana lapho ukuhlushwa egazini lalabo abagcina khona kufinyelela inani lokungakafiki. Njengoba ukwanda okweqile ezingeni le-estrogens ekuqaleni kokugqugquzela, umthamo we-agent kumele unciphise.

Ngemuva kokujola kokugcina ngemva kwezinsuku ezimbili, ama-5-10 ama-IU hCG ajojowe kanye. Yenza lokhu ngenhloso yokunciphisa ukuvuthwa.

Amadoda

Abamele abesilisa abasebenzisa ubulili abanamandla kufanele basebenzise kanjani izidakamizwa "Menopur"? Imfundo ithi ukukhuthazwa kwe-spermatogenesis, amadoda adinga ukuphatha ama-1-3 ama-IU hCG kathathu ngesonto. Yenza lokhu kuze kube yizinga le-testosterone elijwayelekile . Ngemva kwalokho, izinyanga eziningana kathathu ngesonto, imithi ilawulwa ku-75-150 IU (noma ama-vial 1-2).

Imiphumela emibi yenkambu yokusetshenziswa kwezidakamizwa

Manje uyazi ukuthi imiphi imithi imithi "Menopur" kufanele isetshenziswe. Imiyalo, isicelo, ukubuyekezwa kuhanjiswe kulesi sihloko. Kodwa-ke, ngifuna ukuqaphela ukuthi lesi sidakamizwa singabangela iningi lemiphumela emibi.

• Uhlelo lwe-endocrine: ukwanda (okubukhali) kwe-estrogens kanye nomchamo, i-mastalgia, ukwakheka kwe-cysts yama-ovari, ukunyuka ngokulinganisela kwama-ovaries, i-gynecomastia (kubameleli bezocansi ezinamandla).
• Ipheshana lokugaya: ukuhlanza, ubuhlungu be-colicky, isicanucanu.
• Ukusabela kwendawo: ubomvu, ukuvuvukala, nokushaya endaweni yesiphathimandla.
• Ukungezwani komzimba: ukushisa kwesikhumba, umkhuhlane, i-arthralgia, ukwakhiwa kwama-antibodies, okuholela ekunciphiseni ukuphumelela kokwelashwa.
• Abanye: i-oliguria, inzuzo yesisindo, ukuncipha kwengcindezi, ukukhulelwa okuningi.

Kumele kuqashelwe ukuthi ukusetshenziswa kwesidakamizwa esibucayi kungabangela ukubonakala kwe-ovarian hyperstimulation syndrome. Izibonakaliso zokuqala zokuphambuka okunjalo zifaka ubuhlungu (ezichazwe) phansi kwesisu, ukuhlanza, ama-ascites, ukutholakala kwesisindo, isisindo senhliziyo, i-hypovolemia, ukungalingani kwe-electrolyte, i-hydrothorax, inani le-erythrocyte, inani le-hemoperitoneum ne-thromboembolic syndrome.

Imiyalo ekhethekile yokusebenzisa umkhiqizo

Yini okudingeka ukwazi ngaphambi kokusebenzisa isidakamizwa "Menopur"? Imfundo, izibuyekezo zithi ngaphambi kokuqokwa kwale mithi isiguli sidinga ukwelashwa okufanele (uma kunesifo se-correx, i-concomitant hypothyroidism, i-hypothalamic-pituitary region tumor, i-hyperprolactinaemia).

Ngaphambi kokufakwa kwe-infertility therapy, kuyadingeka ukuthi kuhlolwe isimo sama-ovari. Ukuze wenze lokhu, yenza i-ultrasound, futhi ubuyekeze izinga le-estradiol egazini. Phakathi nenkambo yenkambo, lezi zifundo kufanele zenziwe nsuku zonke noma zonke izinsuku.

Kumele kukhunjulwe ukuthi ngemuva kokusetshenziswa kwezimali ze-hMG, kunokwenzeka ukuthi kuthuthukiswe ukucindezelwa kwama-ovari. Njengomthetho, kuba ngokomzimba kuphela emva kokulawulwa kwezidakamizwa ngenjongo yokugcoba futhi kubonakale ngendlela yokwakheka kwama-cysts amakhulu. Ezimweni ezinjalo, iziguli zingathola i-hydrothorax, ascites, i-thromboembolic syndrome, kanye ne-hypotension.

Uma izimpawu zokuqala ze-ovarian hyperstimulation zivela, ukwelashwa nomuthi kufanele kumiswe ngokushesha.

Uma uphathwa nge-hMG, ngokuvamile ukukhulelwa okuningi kwenzeka.

Kulabo abamele ubulili obunamandla nezinga eliphezulu le-FSH egazini, le mithi ayisebenzi.

Iyini izindleko zomuthi?

Kungakanani umuthi "Menopur"? Imfundo, intengo yalesi thuluzi ithulwe kulesi sihloko. Izindleko zalo muthi ziphezulu kakhulu. Ku-vial 1 yesidakamizwa kuzodingeka unikeze ngo-1000-1400 ama-ruble aseRussia. Uma sicabangela inkambo yokwelashwa ejwayelekile ezinsukwini ezingu-5-10, ukwelapha okunjalo kubiza isiguli kakhulu.

Ukubuyekeza mayelana nomuthi

Kukhona inani elikhulu lempendulo emihle mayelana nomuthi "Menopur". Ngokusho kwabo, lesi sidakamizwa sithinta kakhulu ukungasebenzi, izikhathi eziningana zandisa amathuba okukhulelwa. Ngendlela, isibalo esikhulu seziguli emva kokusetshenziswa kwalesi sidakamizwa siqala ukukhulelwa okuningi.

Ukulimala okuphela komuthi okukhulunywe ngawo kuyindleko. Iziguli eziningi azikwazi ukukhokhela lo muthi. Nakuba ochwepheshe bemithi bathi inani lale mithi lifanelekile ngokuphelele. Ngemuva kwalokho, ngemuva kokusetshenziswa kwayo okulungile, kunamathuba amakhulu okukhulelwa okulinde isikhathi eside futhi, ngenxa yalokho, ukuzalwa kwengane elinde isikhathi eside. Ngakho-ke, imibhangqwana eminingi encane engakwazi ukukhulelwa umntwana, ngaphandle kokungabaza, ukuthola le ndlela.