Hormone 17-OH-progesterone. 17-OH-progesterone: izinga legazi

Inhloso esemqoka umjikelezo hormone kwabesifazane ngesikhathi umjikelezo wokuya esikhathini uwubufakazi - ukukhiqizwa kwamaqanda. Kule nqubo, ingaphansi kolawulo hypothalamus. Kulokhu, izinto ezilawulwayo imikhiqizo ethakwa le anterior pituitary indlala: FSH futhi LH.

kumiswa ukukhiqizwa kwamaqanda

Esigabeni zangaphambi ovulatory zokwehlukaniswa umjikelezo follicle wesibeletho asitholayo kugucuka eziningana. Lezi zinguquko olwenziwa ngaphansi kwethonya FSH. Kumiswa Ngemuva follicle ifinyelela usayizi othile, kanye umsebenzi ukusebenza LH isiqongo ovulatory. Lokhu kuzokwenza uqalise "nokuvuthwa" esibelethweni (division lokuqala meiotic). Ngemva kwalokhu discontinuity isigaba kwenzeka kwetinhlavu follicle, nangaphakathi lapho iqanda. Isikhawu phakathi isiqongo kanye nge-ovulation esigabeni se-oda amahora 36-48. Phakathi postovulatory isigaba ukufuduka kwenzeka ngokuvamile amaqanda ukuze kwesibeletho tube fallopian. Endabeni ekukhulelweni kuye ngosuku lwesithathu nane embryo lingena singene ingaphakathi lesizalo. Kukhona yenzeka yayo. Uma ekukhulelweni lube khona-ke iqanda emini ishonela tube fallopian.

Izinto ezihilelekile ukuphila insikazi umsebenzi zokuzala

Esikhathini nezindlala endocrine akhiwa compounds eziphila abakhuthele. Ziyakwazi ngokuthi ama-hormone. Kuyinto ngiyabonga kubo nge uhlelo hypothalamic-pituitary-wesibeletho kanye nokuqinisekisa kukhona ukuvivinya kwezitho zokuzala. kwakwakhe ngamunye wenza imisebenzi ethile. Omunye izinto ezihilelekile izinqubo e uhlelo zokuzala, kuyinto 17-OH-progesterone. isigaba Follicular eligeleza nokwanda okuphawulekayo lokuhlushwa yayo. Le ngxube is kuhlelwe izinto eziningi ezincane e esibelethweni. Ukwandisa okuqukethwe ketshezi buyisigaba isiqongo PH. Ngemva kwalokho, phakathi umjikelezo, emakamu kuyehla okwesikhathi esifitshane. Progesterone esigabeni follicular siyehla ekwandeni endometrial zishukunyiswa estrogen. Egcekeni kwaphumela is phansi ukuguqulwa. Imbangela enkulu zokwehlukaniswa iyona ukumisa okungazelelwe zokukhiqiza i-Corpus luteum progesterone umjikelezo ekupheleni. Lesi sandiso yokufakelwa yesigaba luteal stroma endometrial kwakhiwa ukuphendula decidual. Kuyinto efanayo ukuze izinguquko ezenzekayo ekuqaleni sokukhulelwa. Progesterone inikeza ukulawulwa nezindlala e wesibeletho, kunciphe contractility ingaphakathi. Egcekeni futhi kuvimbela esikhathini.

Hormone 17-OH-progesterone. incazelo

Kuyinto steroid eyandulela. Yalo cortisol adrenal kwakhiwa bedle enzyme ezifana 11-b 21-hydroxylase noma hydroxylase. 17-OH-progesterone e abesifazane synthesize androstenedione. Lokhu kwaziswa kuyinto eyandulela kwe-testosterone futhi estradiol. Kumiswa It is in the amaqanda kanye nezindlala adrenal. Igazi progesterone-17-OH ekhona mahhala futhi lesibopho ne amaprotheni yenethiwekhi njengoba transcortin futhi-albumin. In the ukungabikho kokukhulelwa izidakamizwa lokuhlushwa liyancipha. Endabeni yenzeka we iqanda ezikhiqiza amaqanda, luteum Corpus uyaqhubeka ukuwenza ezikhathini zamanje.

okuhlushwa

17-OH-progesterone anda ekuseni. Ubuncane kwembulwa ebusuku. Emini, ezingeni balo buyahluka. Futhi kwakwakhe lokuhlushwa kuyahlukahluka ngesikhathi umjikelezo wokuya esikhathini. A nokwanda okuphawulekayo ezingeni waphawula ngayizolo ngaphambi isiqongo LH. Lokhu kulandelwa isigaba lokuhlushwa esiphezulu (maphakathi no-umjikelezo). Phakathi nenkathi yokukhulelwa, izidakamizwa okuqukethwe kakhulu anda. 17-OH-progesterone, izinga kwalo kunqunywa ngokuhambisana yobudala izingane kuqukethwe esincane. lokuhlala ezinkulu zitholakala kuphela esikhathini evundile ngokushesha emva kokuzalwa. Kulokhu, e ezizalwa ngaphambi kwesikhathi okuqukethwe nomhlaba ngobukhulu. Phakathi nesonto mpophoma okokuqala uxhumano ezingeni. It yaphawula ukukhuphuka okuqhubekayo phakathi nokuthomba. Phakathi nale nkathi, progesterone-17-OH intsha esikhulakhulile kancane kancane ifinyelela emakamu efanayo kwabadala.

Kungani udinga ukuhlolwa igazi?

17-OH-progesterone umkhiqizo Lesisemkhatsini. Nokho, ngenxa yesifundo sakhe somuntu kuyisinyathelo esibalulekile e sitholakele pathologies ezehlukene. Ngu ubufakazi isifundo zihlanganisa ukungabi nenzalo, hirsutism, umjikelezo iziyaluyalu. Lapho Hyperplasia adrenal njengendlela yokwelapha for iziguli iqondiswa steroid replacement therapy. Ukuze ukuhlola yayo ukuhlaziywa ukusebenza bunikezwe. 17-OH-progesterone wafunda in izinsana. cwaningo wayo lokuhlushwa esolwa 21-hydroxylase ukuntula. Ukuntula lokhu enzyme ebonwe azalwa naso adrenal Hyperplasia hlobo.

Ukulungiselela ukuhlolwa laboratory

Uma udokotela akanayo isikhathi, igazi lukhipha olwesithathu wesihlanu usuku umjikelezo. Leso sifundo saqhutshwa esiswini esingenalutho ekuseni. Akuvunyelwe ukusetshenziswa ikhofi noma itiye. Ivunyelwe ukuphuza amanzi plain. Njengoba esidlweni sokugcina ngaphambi blood donation kufanele kube okungenani amahora ayisishiyagalombili. Ochwepheshe bathi ilapho lapho ibonakala i-hormone cwaningo ezingafanele Isigaba sesibili ku 20-23 ngosuku. Uma isikhathi lomjikelezo izinsuku 42, isampuli igazi Kwenziwa ngosuku th 35. Ngosuku 23 Isigaba sokuqala usaqhubeka. Izinga progesterone kuyehla, kodwa akubonisi ukwehluleka esigabeni luteal noma anovulation. Kwenza akukho mqondo azokuqhubela isifundo emakamu ngesikhathi sokukhulelwa futhi ukuthatha noma yisiphi izidakamizwa. Kulokhu, a eliphezulu 17-OH-progesterone - kuyinsakavukela. okuqukethwe okunjalo ukunakekelwa okufanele kwangaphambi kokubeletha ayidingekile.

ukuhumusha imiphumela

Njengoba kushiwo ngenhla, ezingeni evamile progesterone hormone, 17-OH incike yobudala. Ukubaluleka ubulili tesifundvo. Ubuningi kunqunywa ng / ml. okuqukethwe kahle izingane kuze kuphele inyanga - 0-16,63; izinyanga 1-2-. - 1,8-9,7; 3 izinyanga. - 0,07-1,7. Ezigulini ngaphansi konyaka owodwa - 0-1,65; kuze iminyaka 3 - 0-0,99; kusuka 3 kuya ku-10 - 0,07-1,69. ezingeni kuvumelekile amadoda - 0.5-2.1. Ukuze abesifazane esigabeni follicular - 0,41-2,72; ovulatory - 0,33-2,8; luteal - 0,33-2,8. Ngo senyanga yokuqala kokubeletha progesterone-17-OH kumele khona lokuhlushwa 1,17-5,62; Okwesibili - 1,17-6,7; wesithathu - 1,24-11. Ngo okuqukethwe postmenopausal kahle 0,13-0,51.

Hyperplasia adrenal

Kuyinto zokugula azalwa naso sokuhlasela kwamasosha omzimba. Ngokuvamile eba ngenxa nokuntuleka enzyme ehilelekile synthesis steroid. Ukungabi compounds kungase kudingeke ngamazinga ahlukene zaba namandla kakhulu. Isakhasa e Hyperplasia azalwa naso eba virilization (kumiswa izici wesilisa e abesifazane). Ezimweni ezimbi kakhulu, i ukuntula enzyme kuphakamisa nokwephula e synthesis steroid, usawoti ukulahlekelwa, okungaba okuyisimo esisongela ukuphila. ukuntula olungaphelele enzyme etholakale abadala, kungase futhi kube azalwa naso ngokwemvelo. Kulokhu, okokuqala ukwephulwa zenzeka ifomu esicashile, futhi ngaso sonke isikhathi Kutholwe ebuntwaneni. zamagama kahle enzyme ungaba uhlamvu ezithuthukayo. Ngaphansi kwethonya izici ezingezinhle sokugembula kwandisa nge ematfuba izinguquko tekusebentisa morphological e nezindlala adrenal, ukubonakaliswa ezifanayo azalwa naso syndrome. Ngenxa iphazamiseke ukuthuthukiswa ngokobulili kuthomba. Ngo eziningi progesterone, 17-OH ibheka umsebenzi wayo ku synthesis androgens. Lezi zinto zehlela afundwa esewusana nokuvuselela amantombazane ukubonakaliswa izici ngokocansi uhlobo besilisa. Ngakho-ke, ukutadisha lokuhlushwa yayo kubalulekile ekutholeni ukuphumelela ukwelashwa wathola.

Eyingozi kakhulu ukuntula enzyme 21-hydroxylase

Ukungabi kwakwakhe ziphephile encishisiwe aldosterone kumiswa. Lokhu i-hormone adrenal inikeza isiqondiso lamanzi kanye nosawoti ibhalansi, ukubambezeleka emzimbeni kasawoti. Ngo izinsana, kukhona "ukulahlekelwa esibucayi." Ukuze isimo esinjalo libhekene i ekuqongeleleni uketshezi in inqwaba. Ngesikhathi esifanayo umzimba ngenkuthalo ukuhoxisa usawoti kudingeka. Ngenxa yalokho, okuqukethwe potassium uqala ukwandisa, kanye sodium - ukwehla. Kwengxenye enzyme esingamahlalakhona libhekene kusulwe isithombe emtholampilo. Izinsolo ukuntula avele ngemuva ukwephulwa zokuthomba futhi ukukhula esikhathini sokuthomba, zisencane amadala - ne ukungazali kanye kahle ngesikhathi nomjikelezo wokuya esikhathini, amantombazane - ne hirsutism.

isiphetho

Umsebenzi hormone ocansini ingenye zezici ezinquma akuzona kuphela ekusebenzeni kwenqubo nekutala abesifazane. Ukusabela compounds, azinze futhi umsebenzi evamile, iqhaza kuzinqubo ezahlukene, kanye khona i okuhlushwa elilungile kunemtselela ukuthuthukiswa jikelele umzimba nempilo jikelele. I Ochwepheshe baxwayisa ngokuthi yimuphi ukuphambuka kusuka amazinga akhona njengamanje kanye kwezokwelapha akuzona uphawu zokugula njalo. Kule ndaba, esimweni ngasinye ke akudingi ukwelashwa. Nokho, odokotela batusa ukuba banikele njalo igazi ukuhlaziywa laboratory, kudlule izivivinyo. Ezinye izifo ube nohlobo esicashile futhi uphethwe okungazelele kuholela nemiphumela emibi ngendlela efanayo. Okubaluleke kakhulu yisimo sokuthokoza abesifazane hormone. Hhayi zikhonjwe ebuntwaneni iziyaluyalu ngeminyaka iqhubeka, okubangela ukuphazamiseka ekusebenzeni amasistimu zokuzala nezinye emzimbeni. Kwezinye izimo, ukungazali - yezinkinga eziphuthuma kakhulu namuhla - kuwumphumela ukuxilongwa sekwephuzile. Ezigulini ethola replacement therapy, futhi kudingeka njalo bayohlolwa kanye nokuhlolwa kwegazi. Imiphumela ungavumeli kuphela ukuhlola ngempumelelo oqabulayo izidakamizwa, kodwa futhi ukulungisa uhlelo lokusebenza.