"Budesonide": yokusetshenziswa futhi analogue. "Budesonide" ephefumula: ukubuyekezwa, intengo

Asthma lifaka wokuqala emhlabeni phakathi yizifo ezihlobene nokungabikho hyperactivity kwesimiso somzimba sokuzivikela ezifweni. Ukwelapha kwakha omningi izidakamizwa. Elinye ithuluzi sinjalo "budesonide". Analogs yalesi izidakamizwa futhi ivame ukusetshenziswa for ekwelapheni broncho-obstructive syndrome. Ngakho-ke yini lo muthi?

Kuyini "Budesonide"?

Lesi sidakamizwa kungokwalabo iqembu glucocorticoids imuncwe. Leli thuluzi kuyinto analog zokwenziwa kwemiqondo emzimbeni wethu (e-adrenal cortex) hormone. Hlobo luni umphumela has "Budesonide"?

Yokusetshenziswa zomuthi ibonisa ukuthi ejenti kwandisa umthamo asebenzayo receptor beta-adrenergic e yomoya.

Ngaphezu kwalokho, amabhlogo izidakamizwa isenzo prostaglandins ukuvuvukala futhi leukotrienes, avimbele ukuthuthukiswa ukuvuvukala e mucosa bronchial.

It uzabalaza nemiphumela yaso ngemva kokuphathwa nsuku zonke phezu izinsuku eziningana (ngokuvamile mayelana 5-7 izinsuku).

Kuyinto omunye izidakamizwa main ekwelapheni ezinzima somoya bronchial futhi ezingalapheki obstructive isifo samaphaphu. Ezigabeni zokuqala yentuthuko lezi zifo asisebenzi.

Pho-ke, "Budesonide" has nethonya kuhlose amaseli?

pharmacodynamics

Umuthi ngokusebenzisa ephefumula isicelo, ugxile kahle ebusweni iphaphu (ebusweni le mucosa acinene cishe ifinyelela kwegazi).

Ubuningi plasma lokuhlushwa izidakamizwa siyenzeka kungakapheli imizuzu 45 ngemva ephefumula. amaphesenti angu-85 azo zonke izidakamizwa engenayo sibopha ukuthi igazi albumin esele ingxenye excreted zinjalo.

Icutshungulwe nge kwesibindi. Excreted kusuka emzimbeni pheshana emathunjini (ku Bile) kanye nomchamo.

Iziguli lezi zindikimba zokugula yabukela eside alibale izidakamizwa egazini, nokuthi yini edale lesi ukuthuthukiswa iningi ngenxa yezinkinga ukweqisa izidakamizwa hormone glucocorticoid.

Kungenzeka ukusebenzisa izidakamizwa e ifomu tablet for ekwelapheni letindzala ezicutshini (kodwa amaphesenti 10 kuphela inani zomuthi ongene pheshana emathunjini kungaba nomphumela zokwelapha).

Ingase futhi ingasetshenziswa ekwelapheni izifo ze-non-sokuvuvukala mucosa acinene ngenxa yesikhathi eside ungenzi isenzo wendawo.

izinkomba

Nokho, kwezinye izimo, unganikezela "Budesonide"? Yokusetshenziswa uhlu izifo main lapho le mithi ingasetshenziswa:

• isifuba somoya bronchial. Umuthi baba ngiyabonga eyayithandwa umphumela wawo eqeda ukuvuvukala kanye nekhono zivimbela umsebenzi ka balamuli ukuvuvukala.
• isifo Crohn. Ukuze ekwelapheni lesi sifo zisebenzisa ifomu tableted zomuthi. Umuthi kunikezwa ntombazane ukuthethelelwa amafomu okuncane noma okusesilinganisweni lesi sifo.
• Ukwelashwa rhinitis. Ibonisa esabelweni ifomu intranasal ka budesonide ngicele impumuzo izimpawu hay fever kanye rhinitis iguliswa. Umenzeli kakhulu ekwelapheni lesi sifo "Budesonide Formoterol".
• Ukuvimbela yokuphindela polyposis, mucosa acinene. Umuthi isetshenziswa ngasekuqaleni isikhathi nasezinkingeni ezilandela ngemva kokuhlinzwa. Cishe 95 amaphesenti amacala kuvimbela kabusha nentuthuko ka polyposis.

Izifo ashiwo izinqubo main, lapho esimisiwe 'budesonide ".

Ngezinye izikhathi, lesi sidakamizwa ingasatshenziswa ukuvimbela ukuthuthukiswa obstructive wamaphaphu nesifo. Ezimweni ezinjalo zihlanganisa iziguli izifo emsebenzini noma umsebenzi izimo zokusebenza ezingase zibe yingozi. Kodwa kufanele sikhumbule ukuthi ngisho usebenzisa izidakamizwa tekuvikela, akufanele sikhohlwe nokushintsha kokudla nokufakwa ngokucophelela izidakamizwa, njengoba kungenjalo ingozi eliphezulu ukuze uthole nezinkinga nezindlala adrenal, futhi ukuhoxiswa syndrome glucocorticoids.

Nokho, kwezinye izimo, ukusetshenziswa kwalo contraindicated?

Izimo

Kungaphansi kwaziphi izinqubo kanye izifo, ungasebenzisi "Budesonide"? Yokusetshenziswa zomuthi kubonisa lezi zifo ezilandelayo:

• ukuzwela Ukwandiswa emuthini noma izingxenye zalo. Ingozi yokuba angioedema.
• Ifomu asebenzayo isifo sofuba.
• Izifo zokuphefumula umsuka fungal.
• izinqubo olunamandla ezithathelwanayo ngo pheshana emathunjini.
• Sinzima esingamahlalakhona hepatic.
• yobudala Wezingane.

Kuzo zonke lezi zifo, ukusetshenziswa corticosteroids akuvunyelwe. Lokhu kungenxa yokuthi i-izidakamizwa noma ikhuthaza inqubo babhebhethekisa noma sibe sibi busebenze. Izingane ayikwazi ukusebenzisa lolu izidakamizwa ngoba obungathikazisa ukukhiqizwa bokuphila hormone glucocorticoid ngenxa ngongakwazi ukukhokha izikweletu we- cortex adrenal.

Kukhona ezinye ukulinganiselwa, lapho ngokucophelela okukhulu kumele kusetshenziswe "budesonide". Imiyalelo isicelo uxwayisa ngokuthi ngokucophelela kufanele asebenzise izidakamizwa ukuze abantu umfutho wegazi ophakeme, isifo sikashukela, pheochromocytoma, abanonya isilonda esiswini kanye isilonda duodenal.

isicinganani

Okwamanje akukho izidakamizwa, ukusetshenziswa ezazingathandi ziye zasungula ethile side effect. Ngeshwa, "Budesonide" futhi umuthi nge spectrum kahle esikhulu izigigaba ezingezinhle of wesenzo.

Uma usebenzisa "budesonide" lapho ephefumula, main side effects yokusetshenziswa sayo kuyoba iziyaluyalu inkulumo (dysphonia), hoarseness, nomlomo owomile, ukukhwehlela, nakuba ukuthuthukiswa bronchospasm.

Lapho ezithathwe ngomlomo, kungenzeka okucindezeleka, isiyezi, kanye nobuhlungu.

Isimiso senhliziyo nemithambo yegazi bangase basabele ukwethulwa "Budesonide" ukuthuthukiswa vasculitis, ukwanda letindzala blood pressure, tachycardia.

Umuthi kungadala futhi okubi kakhulu izifo emathunjini - izilonda, pancreatitis. Ngaphezu kwalokho, kukhuthaza ukuthuthukiswa izifo dyspeptic.

Uphatha kabi uhlelo zemisipha. Mhlawumbe ukukhumuzeka kwamathambo, myasthenia gravis, ukuqaqamba kwamalunga omzimba.

Kuwa side effect kuyinto Cushing Syndrome. Kwenzeka ngenxa yokuthi ngesikhathi glucocorticoids kokuthola kunciphisa zamagama hormone ayo. Uma corticosteroids esetshenziswa isikhathi eside, izindlala adrenal kungenzeka umane kuphele synthesize izidakamizwa bokuphila ukuthi ngempela ezithinta impilo isiguli. Yingakho kubalulekile ukuqapha ngokucophelela umthamo wathola hormone, kanye ilungelo ukuziyeka.

Isikali ukulungiswa

Ngayiphi ngemithamo kufanele sinikezwe "Budesonide? Imiyalelo enquma inikeza le nokushintsha kokudla nokufakwa lwemithi elandelayo.

Ukusebenzisa izinhlobo ephefumula "budesonide" ngokusekelwe ebucayini lesi sifo. Umthamo elikhulu omdala kuyinto 200-800 micrograms ngosuku. esiphezulu I umthamo wansuku zonke kumele singeqi 1.5 mg. Ezinganeni, umuthi is contraindicated ukusetshenziswa, futhi analogs yayo babelwa ngokuvumelana kobukhulu icala.

Ifomu ngomlomo izidakamizwa isetshenziselwa imizuzu 30-60 ngaphambi kokudla. Sebenzisa engafika ku-3 mg 3 izikhathi ngosuku. Inkambo yokwelashwa kuyinto imithi ngomlomo izinyanga mayelana 2. Ukunqaba izidakamizwa wenziwa kancane kancane ukuze avimbele nokuqaleka.

Intranasal ngokuvamile zinikezwa "Budesonide Iziheyler". Umthamo kuyakhethwa ngamunye umuntu ngamunye, kuye ngobucayi inqubo. Ngokwesilinganiso, basebenzisa 2-3 amathonsi izidakamizwa ikhala ngalinye kabili ngelanga. Ezinganeni, leli fomu zomuthi is contraindicated. Inkambo yokwelashwa kuyinto amasonto ama-2.

Ukuxhumana nezinye izidakamizwa

Ezinye izidakamizwa lapho isetshenziswa ngesikhathi esifanayo ne "Budesonide" bungaphazamisa ukumuncwa yayo. Le mithi ihlanganisa inhibitor ka cytochrome P450. Ngokwesibonelo, uma usebenzisa kokubili "budesonide" ( "Pulmicort" - njengenhlangano analog) nezidakamizwa ezifana "Ketoconazole" "Erythromycin" kungase kukwenze wephuze excretion kusukela egazini lika-a glucocorticoid, okuyinto igcwele ukuthuthukiswa lokudakwa ama-hormone ukubonakala imiphumela ebuhlungu izidakamizwa.

Kanyekanye ithola "Budesonide" futhi abanye isisu ( "Indap") kunomthelela ukuthuthukiswa hypokalemia Isiguli, okuyinto nakanjani kuthinte umsebenzi inhliziyo.

izidakamizwa eziningana (isib antacids - "Almagel") ngenkathi usebenzisa "budesonide" kunethonya kwamanye umphumela ngamunye abasiphikisayo, isb ungavumeli nomunye abazikhandla umphumela zayo zokwelapha. Ngenxa yalokhu, kutuswa ukusebenzisa lezi izidakamizwa ngesikhathi esingaba amahora okungenani amabili (sisebenza kuphela ku-yetemlomo zomuthi).

Ukusebenzisa izidakamizwa ngoba ephefumula

Njengoba imithi sidaliwe ngokuyinhloko for ekwelapheni izifo yaleli pheshana yokuphefumula, kubalulekile ukuba siqonde ukuthi okumelwe sinikezwe ngayo kubo.

ifomu imuncwe zomuthi kwasusa eziningi, kodwa ukusetshenziswa yabo ngokuvamile converges ngezindlela eziningi.

Okokuqala, le mithi ngokuvamile iqondiswa usebenzisa nebulizer. Lo mshini ikuvumela ukungena ku yomoya umthamo ngokuqinile ifaniswe imithi. Ngokuvamile ulahlekile ingxenye eyodwa powder for ephefumula, ukubopha izimpawu yesifuba somoya noma COPD.

Ngenxa yale njongo, ngokuvamile asetshenziselwa "Budesonide-bomdabu." Lesi sidakamizwa is nelungelo lobunikazi by the ngokuqinile Russian. Ngo ngezithako zawo izidakamizwa ithwala ekumisweni (noma powder) "Budesonide". I nebulizer ukulayishwa cassette ne izidakamizwa ke ejenti inspiratory engena bronchi kanye namaphaphu.

izidakamizwa eziningana ayatholakala ngesimo aerosol, okuyinto iqukethe "budesonide". igama Trade kubo ingase ibe khona ehlukile komunye nomunye, kodwa isithako esebenzayo kusese glucocorticoid efanayo. Uma ukusebenzisa umuthi onjalo, kufanele sikhumbule ukuthi umthamo owodwa we-aerosol iqukethe 0.05 ml budesonide (kubalulekile ukukwazi ukuze abangele ukweqisa izidakamizwa of glucocorticoids).

Lokho okwakudingeka ukuze kukhokhwe izidakamizwa

Ngenxa yobukhulu umsinga imithi emakethe akunzima eyolanda bona, "Budesonide" ngoba lapho ephefumula. Intengo Kwalo analogue yayo zingase zehluke, kodwa kufanele sikhumbule ukuthi zonke ofanayo isakhiwo sabo isithako esebenzayo eyinhloko esikhathazeka ngayo budesonide. Izindleko izidakamizwa kuzoncika owenza imithi, futhi noma ngabe izidakamizwa lobunikazi noma imithi ejwayelekile.

Umuthi okuthengiswa kuphela Pharmacy. Singakanani ngeke Kubiza "Budesonide"? Intengo Kwalo analogue yayo kuyinto isilinganiso kusukela 300 2000 ruble. Konke kuncike ngubani umenzi kanye okuyifomu wokukhulula izidakamizwa. Ngokwesibonelo, izidakamizwa ezifana "benacort" ikhiqizwa ngendlela amaphilisi nge powder for ephefumula. Ngokwesilinganiso, kubiza ruble 400. izidakamizwa British ibiza kakhulu. Ngokwesibonelo, "Budesonide Formoterol" yokukhiqiza British itholakala ngaphakathi ruble 2,000, ukuthi akuyena wonke umuntu angaba namandla okuwunikela. Vele ukuthenga imikhiqizo Slovenian, okuyinto musa ihluke ekusebenzeni, futhi ishibhile.

Esikhathini izifundo liye kungase kutholakale ukuthi izidakamizwa ezibiza kakhulu cishe neze kunabayeni kunemifuziselo yako isabelomali. Ngakho-ke, lokho izidakamizwa ukuthenga - kukhethwa ngamunye, kuye ngezidingo nokuphepha kwakhe.

Izibuyekezo amalungiselelo

izidakamizwa Glucocorticoid Sekuyisikhathi eside esetshenziswa iziguli eziningi sifo ka obstructive esingamahlalakhona noma somoya. Cishe zonke iziguli elinefomu okunzima esinye salezi zifo eyabelwe "budesonide". analogue yayo hlala yeseli sasivumela ububanzi encwadini okubhalwa kuyo imithi ngokumelene lezi zifo, ukuze zivame lizwakale yonke indawo. Lo muthi ezifana, isibonelo, "Apulein" "Benakap" "Buderin", kakade ngenhla "Pulmicort" futhi "benacort" njll

Ngokusho iziguli eziningi, le mithi kukhona okungcono ekwelapheni izifo yaleli pheshana zokuphefumula. Izimo zethu zihluke kakhulu abantu abambalwa ababengeke ziye zasiza ifomu ephefumula we glucocorticoid noma inhlanganisela yayo beta-agonists.

Nge efanele imithi nokushintsha kokudla nokufakwa wakwazi ukufeza ukuba ngcono okukhulu kulezi iziguli. Okwamanje, abantu abaningi abakwazi ukucabanga ngokuphila futhi ukuphila okuvamile ngaphandle ukusetshenziswa kwalezi izidakamizwa.

Nokho, naphezu Izibuyekezo eminingi emihle, kukhona obubi zomuthi ngokuthi "Budesonide" - intengo.

Kwaphela isikhathi eside kwakukhona ukuthambekela aphoyintimenti khulula somoya imithi iziguli ezidinga. Zonke iziguli kungenzeka eze ekhemisi, naphezu isethulo idokhumenti efanele ukuze uthole imithi khulula izidingo zabo siqu.

Okwamanje, libuye wayekwenza, kodwa akuxhomekile, ngubani banelungelo ukukhulula lezi izidakamizwa kakhulu ayisesemikhulu. Manje le mithi mahhala kuphela kubantu abanokukhubazeka 1 namaqembu 2, kanye nezingane; Abanye abantu kufanele athenge imithi imali yabo. Njengoba sazi ukuthi ukulungiselela kuthatha impela eningi, hhayi wonke umuntu angakwazi ukukhokhela ukwelashwa okunjalo.