Fibrates - kuyini? Ukwakheka, ukusetshenziswa, Izimo

Kuyaziwa ukuthi izifo zenhliziyo kukhona phakathi pathologies ezivamile emhlabeni. Cishe wonke umuntu osekhulile ehlupheka nomfutho wegazi ophezulu kanye angina. Abaningi banomlando kwezifo ezithwalwa ezinzima, ezifana isilethikusebenza wengozi cerebrovascular. Njengamanje iqiniso kungase kutholakale ngokwesayensi ukuthi isifo senhliziyo kuhlobene dyslipidemia. Lokhu isimo kusho ushintsho okuqukethwe i-cholesterol ne-fatty acid egazini. Ukuze kulesetayelekile ibhalansi lipid, iziguli esetshenziswa statin futhi fibrates. Leli qembu izidakamizwa bayadingeka zonke iziguli ababetholakala ukwandisa cholesterol egazini, kungakhathaliseki ubulili nobudala.

Fibrates - kuyini nokuthi yini esetshenziswa

Kuyaziwa ukuthi ekwelapheni isifo sokuqina kwemithambo yegazi akunakwenzeka ngaphandle kokusebenzisa statin. Basuke elibekelwe zonke iziguli ukuthambekela ukukhuluphala, isifo senhliziyo, thrombosis. Ngaphezu statin, kukhona elinye iqembu amalungiselelo - fibrates. indlela izenzo zaso kuhlukile kancane. Ngakho-ke, lezi imithi neze wonke. Ziyakwazi fibric acid nemikhiqizo. Mshini eyinhloko esenzweni - ukulungiswa of lipid umzimba emzimbeni. Fibrates - kuyini futhi ziyini na? Ngokusetshenziswa lesengililungiselele yabonisa ukuncipha eziphawulekayo igazi triglyceride. Mshini eyinhloko esenzweni ka fibrates e yokuthi kusebenze enzyme - Esilula lipase, kanjalo usheshisa umzimba kwamafutha. Okungukuthi kuthinte izinqubo kwamakhemikhali okwenzeka emzimbeni. Ngaphezu ukulungiswa dyslipidemia, fibrates ube eminye imiphumela. Phakathi kwabo - ekulweni radicals khulula, eqeda ukuvuvukala kanye tonic nomphumela. kunjalo futhi anticoagulants.

izinkomba fibrates

Ngenxa yokuthi le mithi nemiphumela eminingi emihle, babe uhla enkulu kwezicelo. Inkomba esiyinhloko injongo yayo umzimba syndrome. Lesi simo akusona isifo ezimele, kodwa kubhekwa ezinkulu ungalokothi uphuze isici sokuthuthukiswa pathologies senhliziyo. Indlela le syndrome umzimba:

1. ukukhuluphala besisu (usayizi okhalweni landa ngamaphesenti angu-90 cm nangaphezulu).
2. cholesterol aphezulu e ukuhlolwa igazi.
3. Ukwehlisa inani eliphezulu kwabantu lipoproteins.
4. triglyceride kuphakame LDL.

Ezimweni eziningi, le syndrome umzimba is kuhlangene abantu abanesifo sikashukela sohlobo 2, okuyinto eyenzeka kwasebekhulile. Lezi zici kubenza bavame ekuthuthukiseni isifo sokuqina kwemithambo yegazi, ie ekuqongeleleni lipids ogangeni semithambo. Fibrates - ukuthi iyini futhi ngayiphi injongo basuke iqondiswa? Ngaphezu syndrome umzimba, izinkomba ukusetshenziswa yilezi: amafomu lezinceku dyslipidemia, futhi hypertriglyceridemia. Babuye wabonisa in iziguli umlando sikashukela kanye sifo.

Kungaphansi kwaziphi izimo fibrates kuthiwa contraindicated

Naphezu kweqiniso lokuthi fibrates babe eziningi eziwusizo iqhathaniswa nezinye izidakamizwa cholesterol ephansi (ama-statin), angasetshenziswa hhayi zonke iziguli. Khumbula ukuthi le mithi nomthelela umzimba, ngakho ukuzisebenzisa akuvumelekile kwezinye izifundazwe. Fibrates babe contraindications ukusetshenziswa okulandelayo:

1. Ukukhulelwa ibele.
2. isifo sesibindi. Lokhu contraindication ngenxa yokuthi leli qembu izidakamizwa ezithinta umzimba fatty acid. Ngo isibindi sibe sesomile futhi oludakayo umsebenzi gepatoze ukuthi umzimba kakhulu ebucayini. Ngenxa yalesi sizathu, fibrates kungadala iziguli ezifana nemiphumela eqatha, kuze yokwehluleka kwesibindi.
3. cholecystitis Calculous. Omunye imithelela fibrates ukuqinisa lithogenicity, okungukuthi, ukwakheka amatshe atholakala enyongweni.
4. Okungalapheki ukwehluleka kwezinso. Fibrates ukwandisa ezingeni creatinine egazini. Ngakho-ke, kungaba babhebhethekise ezingamahlalakhona ukwehluleka kwezinso.
5. Okumele kuqashelwe kufanele libekwe fibrates ogulayo abadala. ukusetshenziswa wabo engathandeki kubantu abaphethwe utshwala ezingamahlalakhona.

imiphumela emibi fibrates

Fibrates - kuyini nokuthi yini imiphumela emibi? Kufanele kuqashelwe ukuthi, ngokungafani nezinye izidakamizwa, leli qembu izidakamizwa kakhulu ayivamile ukubangela ukusabela nomzimba. Abakwazi ke isetshenziswe ezigulini nge umlando isifuba hay fever, nokunye. D. Noma kunjalo, fibrates benezingane eziningi nezinye imiphumela emibi. I ezivamile isicanucanu nokuhlanza, ukubuyisa, distension besisu. Bangaphinde kuthinte isimiso sezinzwa. Kwezinye izimo, abangele ikhanda, ukuqwasha, ukucindezeleka. Imiphumela engemihle ezibhekwa kanye nezinguquko kule ukuhlaziywa kwamakhemikhali kwegazi: anda creatinine, ALT, AST. In the ukungabikho isifo so-renal kanye isibindi akuyona ingozi kakhulu empilweni yesiguli.

Yini imithi fibrates iqembu?

Kuze kube manje, kukhona mayelana 10 izinhlobo leli qembu izidakamizwa. Ukuze fibrate izidakamizwa zihlanganisa: "Clofibrate", "bezafibrate", "Gemfibrozil" futhi "Fenofibrate". Ngayinye yalezi amalungiselelo kuyahluka ngenani amathuba okuba nemiphumela engemihle futhi umthamo. Tablets "Clofibrate" bebelokhu baziwa iminyaka eminingi futhi manje kuyaqabukela asetshenziswa. Naphezu kahle eliphezulu, ngokuvamile kubangela komzimba okufana iziyaluyalu ipheshana wokugaya ukudla, ubuhlungu bemisipha namalunga (myositis), ifa lithogenic okusezingeni eliphezulu. Kuyinto kancane anobuthi izidakamizwa "bezafibrate". Kodwa yena wayengekho njengoba nomphumela njengoba futhi excreted ngokushesha emzimbeni. Tablets "Gemfibrozil" hhayi Kunconywa ukuba isetshenziswe ngenxa eziningi side effects (kodwa ngaphansi kuka in isicelo nomuthi "Clofibrate"). Futhi, ngenxa isidingo ukusetshenziswa eside futhi ebulilini. omele eziningi zanamuhla yaleli qembu Isidakamizwa "Fenofibrate". It has ukusebenza kahle eliphezulu futhi cishe akukho imiphumela emibi. Ngaphezu kwalokho, it is ebekiwe iziguli sifo, ngoba kunciphisa lizinga uric acid.

Fibrates: yokusetshenziswa le mithi

Kukangaki futhi kulokho imithamo ukusebenzisa lezi imithi incike onjani ukulungiselela uqokwa udokotela ukuba khona. Ngokuvamile kudingeka zidle isikhathi esingangenyanga (noma ngaphezulu) 2-3 ezibhebheni ngosuku. Inkomba esemqoka - kuyinto umzimba syndrome. Ukuthi iziguli enjalo evame ukunikezwa fibrates. Amalungiselelo kufanele kuhlanganiswe umsoco ofanele futhi ukusebenzisa ngaphansi kokulawula lipid. Tablets "Gemfibrozil" lisetshenziswa izikhathi 1-2 ngosuku imizuzu engu-30 ngaphambi kokudla izinyanga ezimbalwa. analogue zabo ziyisiliva nemithi "Gevilon" futhi "Normolit". Ukulungiselela "bezafibrate" etholakala izibhebhe 200 mg kanye esithathwayo izikhathi 2 ngosuku inyanga eyodwa. Okunye okufakiwe kuyinto analogue - nomuthi "kuthiye ukukhula" equkethe mg 400 lomcebo asebenzayo. Izidakamizwa "Fenofibrate" has ukukhululwa 2 amafomu: amaphilisi kanye nanoparticles. Zinikeza ukumuncwa ikhiqize kakhudlwana bioavailability isicelo 1 isikhathi ngosuku (200 mg) njengoba ezinyangeni ezimbalwa. analogs Ezazimzungezile - umuthi "Traykor" futhi "Lipantil".

Fibrates: izidakamizwa ekuhlanganyeleni

Ngaphambi kokuba uqale ukusebenzisa imithi kuleli qembu, kufanele uxhumane nodokotela wakho futhi kukukhumbuza ukuthi zisetshenziselwa neminye imithi. Fibrates ayikwazi kuhlangene ejenti nephrotoxic futhi hepatotoxic. Ikakhulukazi, "Cyclosporin" izidakamizwa. Ukusetshenziswa fibrates akuyona efiselekayo iziguli ukuthatha anticoagulant "Warfarin". Futhi, leli qembu izidakamizwa akufanele kuhlangene nezinye ejenti dipolipidemicheskimi (ama-statin). Njengoba kwandisa amathuba myositis asathuthuka.

Uphenyo kodokotela kanye neziguli ku fibrate

Iziguli eziningi usebenzisa fibrates kunalokho, njengoba kuphawulwe ukwehla LDL cholesterol, triglyceride cholesterol. Odokotela batusa le mithi okwazo zonke iziguli nge umzimba syndrome ngenxa nokusebenza kahle yabo eliphezulu futhi olubanzi bohlu. I ethile kuphela kuyinto contraindication ukuba ukusetshenziswa fibrates, avamise atholakala iziguli esezikhulile.