"Biprol": izinkomba ukusetshenziswa, imfundo manual, nozakwabo yangempela. Kusukela lokho kusiza "Biprol"?

izifo zenhliziyo kukhona isikhundla aholayo phakathi ezinye izifo. They jeza izinkulungwane zabantu baseRussia. Kodwa kulokho kusiza "Biprol". He nqanda ukuthuthukiswa isifo, kunciphisa isifo senhliziyo futhi okungabizi.

Khipha ifomu kanye nokwakheka

isifo senhliziyo kanye igazi izitsha - ngakho kusukela ngaleso sikhathi kusisiza "Biprol". Ukulungiswa wenziwa Tablets Film-camera. Ingqikithi asebenzayo izenzo bisoprolol fumarate umthamo 5 no-10 mg.

Njengoba izithako ezingeziwe: corn isitashi, cellulose microcrystalline, aerosil, crospovidone, kanye magnesium stearate ludipress. Igobolondo yakhiwa polyethylene glycol, hypromellose, talc, ama-titanium dioxide, tropeolin O.

Babephethe ibhokisi kuyinto 30 noma 50 amaphilisi.

izakhiwo kwemithi

Umuthi kungokwalabo okukhethwayo beta1-blocker, ke asinawo umsebenzi eziwumgogodla sympathomimetic futhi abanalo ulwelwesi eliletha ukuthula izakhiwo.

Bisoprolol fumarate kwehlisa plasma renin kunciphisa isidingo esivimba amanzi ngoba i-oksijini, kanye kwenhliziyo uphumule noma lapho uvivinya umzimba. It possesses antihypertensive, antiarrhythmic futhi izakhiwo antianginal. Ngezinye lokuhlala aphansi kuqhathaniswa β1-adrenoceptor kudivayisi inhliziyo kunciphisa catecholamines isebenze ekamu kumiswa ATP futhi wamanje we-calcium ion engqamuzaneni. Njengoba lisetshenziswe ebulilini, okubonisa beta2-adrenoceptor ekuvimbeni izakhiwo.

Ubude semithambo neuropathy ukumelana ekuqaleni ukusetshenziswa amaphilisi, ikakhulukazi ngosuku lokuqala, liphuma, kodwa ngemva kwezinsuku ezingu-1-3 ifika esimweni sokuqala, futhi ukusetshenziswa isikhathi eside - liyancipha.

impahla Hypotensive icacisa ukwehla ngomzuzu in inani legazi, ukusebenza ezimele imithambo yegazi neuropathy, kunciphisa umsebenzi eyinkimbinkimbi renin-angiotensin-aldosterone. umsebenzi wokwakha kabusha libhekene of ezifweni Ukwehla wegazi kanye nemiphumela kwi CNS. Lapho ukwanda blood pressure is ebonwe umphumela eyinhloko ezingu-2-5 kanye uhlaliseke isimo emva kwezinsuku 30-60.

impahla Antianginal kuboniswa ukunciphisa esivimba amanzi nomoya-mpilo izidingo ngenxa ukwehla kwenhliziyo contractility kwemisipha, okwandisa diastole futhi intuthuko e perfusion esivimba amanzi, kanye ngenxa ukwanda ingcindezi diastolic ka kokuphothula umlingisi i-ventricle engakwesobunxele, andise kuyaqina of the imisipha kokubili ventricles.

isici Antiarrhythmic elihlobene ne ukususwa izimbangela arrhythmogenic anda inani ekamu, nokwehlisa excitation ethunjini itheku isigqi abashayeli deceleration AV-Umqhubi.

Ukusebenzisa izidakamizwa kule ngemithamo naphakathi zokwelapha has hhayi umphumela onamandla kangaka ezithweni ne-receptor β2-adrenergic. Umuthi akuphazamisi inani carbohydrate umzimba futhi izitobhi ekhishwa sodium ion kusuka emzimbeni. ebulilini nomuthi zivimbela β-adrenoceptor subtypes.

Incazelo okungenhla kumane we izakhiwo bisoprolol fumarate libonisa ngokuningiliziwe kulokho kusiza "Biprol".

Pharmacokinetics

"Biprol" isidakamizwa ancibilikisa e pheshana emathunjini by 80-90%. Ngezinye ukumuncwa yayo ayitsintseki ukudla. Ubuningi eliphakeme lomcebo asebenzayo egazini waphawula ngemva kwamahora angu-1-3. Egcekeni ukuze Amaprotheni egazi kwenzeka ngo-30%. Izinto eziningi ezincane isithako esebenzayo ukungena ngokusebenzisa gazi ebuchosheni futhi isithiyo esinomhlapho, ingxenye encane is excreted ku ubisi lwebele womuntu.

It is akheka esibindini. Ingxenye -. 10-12 h Isigamu we ketshezi esebenzayo uya ezingaguquliwe emchamweni, futhi 2% - ne Bile.

Kusukela lokho kusiza "Biprol"

Umuthi ezinqunyiwe nomfutho wegazi ophezulu. Ngo ukwanda abanomfutho wegazi ophakeme abalulekile nangokuqhubekayo wegazi. "Biprol" izinkomba ukusetshenziswa futhi yenhliziyo Umthambo isifo, okuyinto evame kakhulu isetshenziselwe izinjongo tekuvimbela imivimbo.

Izimo

Kumele kuthathwe ngokuqinile ngaphansi kadokotela izidakamizwa "Biprol". Izinkomba ukusetshenziswa kwaso njengoba kuchaziwe ngenhla, futhi manje cishe Izimo. Lezi zihlanganisa i-shock we ahlukahlukene imisuka, okubala cardiogenic. Awukwazi ukuthatha amaphilisi ngesikhathi luphela, futhi edema yamaphaphu. Ukwenqatshelwa oyingozi futhi ezingalapheki inhliziyo ukwehluleka, neyesi-II-III esiteji we-AV-block. Contraindication kuyinto sitholakele ogulayo itheku syndrome, cardiomegaly, bradycardia, hypotension, lwemithambo futhi Prinzmetal angina. Engamiswanga kwezidakamizwa somoya bronchopulmonary apharathasi, obstructive wamaphaphu nesifo efomini chronic ekwamukelweni mao inhibitor. Awukwazi ukusebenzisa ke iziguli yezifo kwegazi neuropathy, ku pheochromocytoma, uma kukhona lactic umzimba, abantu abangaphansi kweminyaka eyishumi nesishiyagalombili ubudala. Ivunyelwe iziguli hypersensitivity kuya ejenti asebenzayo nezinye izingxenye izidakamizwa.

Ngokunakekela ukunquma "Biprol" ukuze iziguli yokwehluleka kwesibindi, kanye nabantu ezingamahlalakhona ukwehluleka kwezinso ngesimo iziguli myasthenia gravis futhi i-hyperthyroidism. Isexwayiso kumele kube umuntu onesifo sikashukela, mina degree AV-ukuvinjelwa kanye neziguli nokucindezeleka. Kuphela ezimweni ezikhethekile, it is ebekiwe in iziguli psoriasis, futhi engu umhlalaphansi.

Yokusetshenziswa

Kufanele kuqashelwe e ukusetshenziswa kwemithi "Biprol" izinkomba. Tablets baphuze esiswini esingenalutho ekuseni. Abenzi lutho ezokuhlafunwa wageza phansi ngamanzi.

I nomuthi ukusetshenziswa 5ml kanye nsuku zonke. Uma kubalulekile, umthamo luyanda abafika kwabangu-10 mg, abaphuza kanye ngosuku. Ebusuku ungathatha okungu-20 mg.

Ukuze abantu kahle kwezinso umsebenzi uhlelo, kanye iziguli isifo sesibindi umthamo esiphezulu 10 mg ngosuku.

izimo ezikhethekile

Kufanele kwenziwe kweso lwezokwelapha njalo ngoba iziguli abasebenzisa "Biprol". Kusukela lokho kusiza imithi iye echazwe ngenhla, futhi manje ukuthi ukubukela isimo lesiguli, ukuphuza lawo amaphilisi. Okokuqala, kumelwe kwenziwe yokukala ukushaya kwenhliziyo ingcindezi, lezi zibalo zibalulekile kakhulu ekuqaleni ukwelashwa. Iziguli wenze electrocardiogram, futhi abantu abanesifo sikashukela ukuthatha ukuhlolwa igazi for namazinga kashukela egazini. Ngo abantu abadala ukuqapha isimo kohlelo kwezinso.

Obuqinisekisiwe umsebenzi sangaphandle ukuphefumula in iziguli umlando izifo yamaphaphu.

Iziguli ngokwabo kumelwe bafunde ukubala ukuvama ukushaya kwenhliziyo, futhi uma izinga esingaphansi 50 amabhithi ngeminithi, kufanele ufune usizo lwabezokwelapha.

Ngokuhamba yokwelapha kunganciphisa ukukhiqizwa koketshezi izinyembezi, okuyinto kufanele inake nemicengezi contact lens. Ngo abantu ngemithi isifo sikashukela singalimaza imaski tachycardia sokucasuka kahle kungakhuphula izinga likashukela. Umuthi ayikhuphuki ezenzeka ngenkathi usebenzisa insulini kahle kungakhuphula izinga likashukela futhi akusho zivimbela isinxephezelo we lokuhlushwa glucose ezingeni kwimigomo igazi.

Ngaphambi ukusebenza izidakamizwa ikhanseliwe ezinsukwini ezimbili ngaphambi ukubulawa kwezinzwa okuvamile. Uma isiguli isasetshenziswa esibhebheni ngaphambi nje kokuba ahlinzwe, umuthi wokubulala izinzwa kufanele abe okungenani negative izakhiwo inotropic.

Abantu abanezifo bronhospasticheskimi blocker cardioselective ebekiwe ngesikhathi isetshenziswe ezingafanele namanye amanxusa antihypertensive. Overdose angase avuse bronchospasm.

Abantu abadala kanye bradycardia kanye ukwehla kwezinga lalezi blood pressure, AV-ukuvinjelwa lokuhlushwa isithako esebenzayo kumele kungancipha noma ukwelashwa bayeka ngokuphelele ukusetshenziswa "Biprola". Misa nemithi ayeyidinga futhi uma kwenzeka isiguli isimo ukucindezeleka.

Musa umutsi uma kukhona ingozi arrhythmia inchubekelembili nzima, futhi isilethikusebenza. Ukungasebenzisi izidakamizwa kancane kancane lokhu kwehlisa izinga izinsuku ezingu-14. Tablets khansela kusengaphambili, uma kuhlelwe laboratory ukuhlolwa umchamo futhi igazi Normetanephrine, catecholamines, nokunye. D.

side effects

Kufanele isetshenziswe kuphela kadokotela izidakamizwa "Biprol". Ukusetshenziswa izibhebhe imithamo kuka Kunconywa futhi izifo lapho ukusetshenziswa kwalesi imithi kungavunyelwe, esiholela ekuveleni amathuba okuba nemiphumela engemihle.

Lapho eside therapy waphawula ukukhathala, ubuhlungu bekhanda, ukukhathala, ukuqwasha, ukucindezeleka, ukudideka, ukusangana, ukukhathazeka liqhaqhazela, asthenia, futhi myasthenia gravis. In iziguli okuthile okungavamile okubonakalayo apharathasi, uzwakalise wokwehla izinyembezi uketshezi, ngokweqile kome amehlo futhi soreness. Kubonakala conjunctivitis.

Lapho ukwelapha iziguli efakwe: bradycardia itheku, ngokweqile senhliziyo futhi conduction esivimba amanzi, futhi AV-block, arrhythmia, simo esiya siba sibi we isiguli esingamahlalakhona senhliziyo ebuthaka ifomu ezingamahlalakhona. Ngezinye izikhathi kuba khona buthakathaka contractility esivimba amanzi kanye nokuncipha blood pressure, hypotension orthostatic ngesimo, ubuhlungu sternum, lesi sifo lapho kwakulandelwa ukwanda oluqinile angina futhi lwemithambo ingcindezi inkomba.

Kube ngokweqile nomlomo owomile nohudo, ukucanuzela kwenhliziyo, ubuhlungu besisu, ukuqunjelwa kanye nokunye .. Kwezinye izimo, ukuminyana acinene futhi nobunzima bokuphefumula umiselwe. Ngezinye izikhathi iziguli ngokuthi komzimba ngendlela amawala, ukulunywa futhi isifuba. Kube ukujuluka ngokweqile, epidermis ngamanzi, amawala, psoriasis.

ukweqisa izidakamizwa

Lutusa umthamo enqunyiwe ngu yakho udokotela uma ethatha imithi "Biprol" imfundo manual. Izibuyekezo bathi lokhu umuthi azinake. He is kahle futhi engabizi, kodwa uma usebenzisa umthamo kunakunoma yiziphi qobo oqokiwe, kungase kube nezimpawu of ukweqisa izidakamizwa. Basuke ivezwa ngendlela arrhythmia, arrhythmia ka ventricular nemvelo, bradycardia sobala. Overdosing kungabangela AV-ukuvinjelwa imakwe ukwehla komfutho wegazi, ukuhluleka kwenhliziyo, cyanosis nail ipuleti, bronchospasm, ukuquleka, isiyezi, nobunzima bokuphefumula.

Endabeni ka ukweqisa izidakamizwa lavage esiswini futhi wenze adsorbents ebekiwe. ukwelashwa okunezimpawu. Uma kukhona AV-block, bese wenza 1-2 mg atropine, okungase indawo epinephrine noma ukufaka umshini wokulawula ukushaya kwenhliziyo yesikhashana. Zacindezelwa encishisiwe, abantu lwemithambo ibekwa isikhundla Trendelenburg nezisombululo plasma-abambele iphathwa ngemithambo yegazi. Ngo senhliziyo ukuncoma isisu, glycosides noma glucagon. Ngo Ukudlikizela iqondiswa "Diazepam" akhulule bronchospasm ngu ephefumula.

izimo Isitoreji eshalofini yokuphila

Ululeka hhayi ukusebenzisa izidakamizwa "Biprol" yokusetshenziswa emva usuku lokuphelelwa yisikhathi. Analogs iyakhokheleka futhi zingatholakala ngasiphi ekhemisi.

impilo eshalofini zomuthi sekuyiminyaka emithathu kusukela ngosuku ukukhiqizwa. Umuthi kufanele agcinwe endaweni epholile futhi amnyama ezingafinyeleleki izingane ezingeni lokushisa hhayi ephakeme kunaleyo +25 ° C.

"Biprol": nozakwabo

Uma izidakamizwa ngesizathu esisodwa noma kwenye bengakwamukeli umzimba wakho, esikhundleni kungenzeka ukuthola umuthi nge izakhiwo efanayo. Miselela "Biprol" (analogue zifana kuye ingxenye esebenzayo futhi isenzo) kungenzeka kuphela emva kokubonisana udokotela wakho imithi ezilandelayo: "Tiresias", "Aritel", "Niperten", "Bidop", "coronal", "Bisogamma", "Kordinorm "" Bisoprol "" Concor ". Umehluko phakathi izindlela kuphela intengo kanye umkhiqizi.

izindleko

Intengo zomuthi imayelana 150 ruble amaphilisi 30 10 mg. Dragees 5 mg kubiza ruble mayelana 80 ngamunye izingcezu ezingu-30.

nobufakazi

Cishe kuzo zonke izimo Ungashintshanisa "Biprol" nozakwabo. Izibuyekezo ngalokhu izidakamizwa ngokuyinhloko omuhle. Abanye abantu bakhetha esikhundleni yokuqala, njengoba inemiphumela eminingi engemihle. Labo abasaya banquma ukuvuma ukusebenza "Biprola" izidakamizwa asibekezeleleki kahle. It yaphawula kahle yaso ephezulu yi ezinhle. Kukhona ezigulini eziye indawo yabo amazwe "Concor".

Ochwepheshe ukukhuluma mayelana imithi kahle. Kuthiwa ehlala kahle aqede angina futhi ayivamile ukubangela engemihle. Ngokuyinhloko, kuyinkinga.

"Biprol" - yezindlela ethandwa kakhulu futhi ngempumelelo. Lapho iqondiswa kahle futhi lo mkhosi okuqinile yonke imiyalelo kadokotela inikeza umphumela ozinzile futhi ikhumbuleka isikhathi eside.