"Afinitor" (everolimus): the nozakwabo intengo. Lapho ukuthenga Afinitor eshibhile?

Antitumor ejenti "Umhlahlandlela Afinitor 'okuzokwenziwa okunikelwe ukunakwa kwakho kamuva esihlokweni, ekhiqizwa inkampani owaziwa" Novartis "(Switzerland).

imfuyo yayo oyinhloko esebenzayo everolimus, okuyinto inhibitor abakhethayo we kinase noSerine-threonine. Umsebenzi Last kwandisa ne emdlavuzeni pathologies womuntu eziningi. Everolimus sibopha ngamaprotheni intracellular, kanjalo uvimbele ukudala ezinye zamagama kanye isignali abo transduction, ngaphezu, kunciphisa ukukhula endothelial semithambo ukusuthisa lwesimila. Nale ukuthuthukiswa kwamuva behlisa, uma usaqhubeka.

Ucwaningo luye lwabonisa ukuthi ngokusebenzisa wokulungiselela equkethe everolimus, ngo-67% eziguli nge kwezinso umdlavuza cell kwanciphisa ingozi ukuqhubekela phambili kwesifo kanye kwandisa isikhathi sokuphila.

Ngingalutholaphi ukuthenga ejwayelekile "izidakamizwa Afinitor '

Akusiyo imfihlo ukuthi ukuthengwa semithi ebalulekile kulezi zinsuku kuyinkinga enkulu ngenxa yokubiza kwalo okusezingeni eliphezulu. Ngakho, eMoscow emuthini "Afinitor" intengo ruble 173 000. amaphilisi angu-30. Kodwa ngesikhathi sokwelashwa, isiguli kuzodingeka ezingaphezu kweyodwa iphakethe! Kulokhu, usizo kuyofika imithi ejwayelekile - ilayisensi izidakamizwa kanye isithako efanayo esebenzayo, kodwa sibhekene ishibhile.

I cheapness le mithi ngenxa yokuthi ifemu, okuyinto ngithenge ilayisensi umkhiqizo wabo, akusho bachithe imali ukuthuthukiswa, ukuhlolwa kanye nekwendluliselwa ebangeni lelilandzelako. Lokhu kusho ukuthi leli thuluzi kungenziwa recouped at ingxenyana intengo.

Isayithi WWW.ONKO24.COM ungakwazi oda futhi ukuthengwa ekhishwe yinkampani Indian owaziwa Biocon Ltd. amaphilisi Everolimus 5 mg kanye 10 mg, kokuba ngokuphelele ukwakheka efanayo futhi, ngokufanelekile, umphumela. A "Afinitor" ohlongozwayo ejwayelekile amaphilisi intengo ngokuphindwe kathathu ngaphezulu ezingabizi kuka original (uphawu) izidakamizwa.

izinkomba

Baxwayisa ngokuthi liphakamisa esihlokweni Afinitor "imiyalelo izibhebhe 'ukusetshenziswa, ngokulinganayo kusebenza Analogue yabo Indian. Ithuluzi kufanele sinikezwe nguchwepheshe. Ibonisa amaqembu athile iziguli:

• kokuba neuroendocrine izimila kwamanyikwe, wamaphaphu pheshana emathunjini;
• abaphethwe kwezinso umdlavuza cell (ngokungabi bikho nomphumela ofiselekayo kusukela ukusetshenziswa kwemishanguzo elwa angiogenic);
• esimweni ama-hormone engaphansi umdlavuza wamabele ngo postmenopausal abesifazane (lihambisana i aramatazy inhibitor);
• nge subependymal astrocytoma ezinganeni emva kweminyaka 3;
• e angiomyolipoma kwezinso futhi sclerosis tuberous.

Izibhebhe zithathwa kanye ngosuku (mhlawumbe ekuseni). Kufanele ezokugwinywa lonke ngaphandle ukuhlafuna, aphuze ngesikhathi esifanayo namanzi amaningi. Ukwelashwa kuvame ukuthatha nje kuba nomphumela emtholampilo. Umthamo isilinganiso "Afinator" ukulungiselela 10 mg kodwa khona evelele side effects ke kuyehla kube 5 mg.

side effects

Reception "Afinitor" amaphilisi ami, ukulaya ehlinzekwe kulesi sihloko, ngokuvamile kubangela engathandeki side effects:

• ikhanda;
• iziyaluyalu ubuthongo;
• anaemia;
• edema amajwabu amehlo futhi conjunctivitis;
• anda umfutho wegazi;
• iphika, ukukhwehlela, epistaxis;
• uhudo, ukungabi esesuthi, nomlomo owomile, futhi ubuhlungu besisu;
• Sipi ukubukeka ukulunywa;
• Ves ukulahlekelwa olubi nokuphela kwamanzi emzimbeni;
• ukuthuthukiswa edema;
• ukwanda amazinga egazi cholesterol.

Ngenxa yezinkinga ngenhla ukuthi kungenzeka ngesikhatsi ukwelashwa nge izidakamizwa, ukuqashwa kwakhe nokulawula isimo lesiguli kufanele sigcwaliswe nguchwepheshe.

Izimo

"Afinitor" amaphilisi awaboniswa konke. Ngakho, umsebenzi wabo akuvumelekile:

• phakathi nokukhulelwa kanye lactation;
• hypersensitivity kuya nabavoti we ekwakhiweni;
• ngaphansi kweminyaka eyi-18;
• esimweni inductors CYP3A4.

Ngaphezu kwalokho, kufanele baqaphe ngesabelo kusho "Afinitor" ngaphambi imisebenzi, ngoba angathiya isilonda sisheshe siphole. In the ukwelashwa ezinyangeni ezingu-2 emva iziguli ngobuhlobo kumele avikelwe bekhulelwe.