Umuthi 'sofosbuvir ": yokusetshenziswa, mshini wezenzo, analogs

Kuze kube manje, cishe izingxenye ezintathu namashumi million abantu emhlabeni utheleleke nge sokusha kwesibindi sohlobo C. Noma kunjalo, akubona umuthi wokugomela ngokumelene nalesi sifo esiyingozi namanje.

Izici lesi sifo

igciwane Kubi ithelela amaseli kubalulekile umzimba yokuphila komuntu - kwesibindi. Ngemva kwalokho-hepatitis C kudala ikhophi kungaphezu amaseli ethintekile lokusakaza izifo.

Namuhla wembula izindlela eziningana viral ukusha kwesibindi kohlobo ukutheleleka:

• ngokumpontshelwa igazi;
• okudweba ukutshopa, nezinye izinqubo ezisetshenziswa uma izinaliti non-oyinyumba;
• kusetshenziswa inaliti eyodwa umlutha abantu;
• ngokobulili;
• kusuka kumama kuya enganeni ngesikhathi sokukhulelwa.

Izici yokwelashwa

Odokotela abaningi qhathanisa hepatitis C ne-HIV. Buyisa ku lesi sifo esibulalayo okwamanje akunakwenzeka. Noma kunjalo, kukhona kunemithi noma amaphilisi owaphuzayo ezakhelwe ukuvimbela ukusabalala igciwane.

Ngo impatho enjalo ngokuvamile sisetshenziswa imithi emibili: "interferon-alpha" futhi "Ribavirin". Eyokuqala kuvimbela ukusabalala igciwane amaseli enempilo, kanti eyesibili kuhloswe ekuvimbeleni ukukhiqizwa kabusha yayo. Nokho, ohlotsheni ukwelashwa okunjalo lenqwaba side effects kanye kusebenta ongaphakeme.

Ngakho-ke, abacwaningi ukuqhubeka ukuthuthukisa izidakamizwa ezisiza ukulwa sokusha kwesibindi sohlobo C. Enye impumelelo yakamuva imithi kuyinto ezintsha izidakamizwa "sofosbuvir". Yokusetshenziswa aqukethe lonke ulwazi olufanele mayelana nakho.

Incazelo ukulungiselela

Umuthi itholakala ifomu tablet ukuma isiyingi, ogama Kwamanzi camera ngokukhethekile oncibilikayo juice esiswini. Lolu lwazi iqukethe exhunywe izidakamizwa "sofosbuvir" imfundiso. Ukwakheka yakhiwa izidakamizwa izidakamizwa esiyingqayizivele kokuba igama elifanayo njengoba izidakamizwa futhi excipients.

Umthamo okwakufuneka umuthi mg 400 futhi tablet efanayo. Iphakheji liqukethe amaphilisi 28, okuyinto anele Inkambo yokwelashwa inyanga.

Imiphumela emzimbeni

Lichaza umphumela emzimbeni litholakale izidakamizwa "sofosbuvir" imfundo manual. Lo mshini wezenzo, ngamazwi alula singathi, ukuthi imfuyo eziyisisekelo kuyinto inhibitor nomuthi we-enzyme yesimanje sokusha kwesibindi sohlobo C. It kunomphumela eziyinkimbinkimbi umzimba ethintekile igciwane. Isiyazanywa luye lwabonisa ukuthi ngisho buthakathaka kakhulu isifo umzimba ngaphansi kwethonya izidakamizwa ubelokhu ngendlela engaguquguquki mkhuba omuhle. Lokhu kuyiqiniso ngoba HCV genotypes 1-4.

Nokho, ngenkathi ukutheleleka nge-hepatitis C futhi ukutheleleka nge-HIV, odokotela abaningi abalibheki kufaneleka ukusebenzisa lolu izidakamizwa. Iqiniso liwukuthi kuleli cala, ukusebenza yayo engakaze lawo. Kubalulekile ukuqonda ukuthi naphezu isiqondiso esiningiliziwe equkethe zemithi "sofosbuvir" yokusetshenziswa, umenzi lixwayisa enifeza kwawena. ukwelashwa olunzulu ngokumelene ifomu njalo hepatitis C angabelwa kuphela udokotela abanolwazi. Inkambo yokwelashwa wenziwa ngaphansi kokuqondisa ochwepheshe.

izidakamizwa yokusetshenziswa

Odokotela abaningi bakholelwa ukuthi lesi sidakamizwa "sofosbuvir" Kumele kuthathwe kuphela lihambisana neminye imithi. Ngenxa yalesi ngokwesiko wasebenzisa izikimu ezilandelayo, okuyinto kuxhomeke genotype lesi sifo:

• Lapho genotypes 3-6 uhlobo imithi "sofosbuvir" ezinqunyiwe izidakamizwa, "Ribavirin" futhi "interferon-alpha". ukwelashwa kulesi simo kufanele singeqi ezinyangeni 3.
• Endabeni kwesibindi 1 kanye ukungabi nakwenzeka kwento ukusetshenziswa a nomuthi ezifana "Interferon Alpha" (ebukhoneni ukungabekezelelani ngabanye noma contraindication). Kulokhu, inkambo linwetshelwe by izikhathi ezimbili.
• Uma usebenzisa inhlanganisela ka 2 genotypes uhlelo nokulungiselela "sofosbuvir" isidakamizwa "ribavirin" izinyanga 3.
• Endabeni yesiguli ukulinda ngoba ukufakelwa isibindi Kunconywa ukusebenzisa kokubili imithi, "Ribavirin" futhi "sofosbuvir". Yokusetshenziswa uncoma ukwelulwa kokwelashwa kuze ukufakelwa.

Esimeni lapho kukhona emibi ehambisana ukuthatha omunye yokwelapha izidakamizwa inhlanganisela kufanele yokwelapha inqanyulwe. Idatha kusebenta ukwelashwa ezigulini azifinyelelanga yobudala, emhlabeni akekho.

Umuthi 'sofosbuvir "thatha isikhathi esingu-1 ngosuku umthamo ebekwe udokotela. Kukhona imithetho okumele ilandelwe kulokhu:

• Akufanele ukuhlafuna noma bahlukanise amaphilisi, njengoba abe ukunambitheka okumunyu kakhulu. Imithi iqondiswa esidlweni.
• Endabeni ka emesis emahoreni amabili ngemva nomuthi kufanele baphuze umthamo owengeziwe.
• Yeqa imithi, uma ukubambezeleka lingaphansi kuka 18 amahora, ukuthatha ithebhulethi aphuthelwe. Uma sekudlule isikhathi ngaphezulu - thatha umthamo olandelayo ngesikhathi esibekiwe.

Izixwayiso

Zonke izinhlobo ulwazi olwengeziwe kubalulekile ukwazi lapho ukuthatha izidakamizwa, iqukethe exhunywe izidakamizwa "sofosbuvir" imfundiso. Izinkomba ukusetshenziswa zomuthi e yokwelapha eziyinkimbinkimbi zinquma engemihle.

Ngo imithi, kufanele wazi lokhu okulandelayo:

• encishisiwe lokuhlushwa nesivinini yokusabela, ngakho kufanele ukuyeka ukushayela futhi eminye imisebenzi;
• sokukhulelwa akuyona kufiseleka, ngakho kufanele siqinisekise ukuthi izindlela eziqinile zokuvimbela inzalo.

side effects

Namuhla akazange embule yonke imiphumela emibi ukulungiselela "sofosbuvir". Yokusetshenziswa liqukethe idatha bathembele inhlanganisela izidakamizwa kanye neminye imithi.

Endabeni ngokuhlanganisa izidakamizwa kanye izidakamizwa, "Ribavirin" yathi:

• ngaphezulu kuka-10% amacala - ukwehla-hemoglobin ezingeni kanye nesanda bilirubin egazini, isicanucanu, ukutubeka komzimba, sokulala thuthuva, ikhanda, uvalo;
• 1% amacala - ukuvuvukala ulwelwesi lwesisu, kwenze ekhaleni nomphimbo, ukunciphisa izinga lezakhi zensimbi egazini, ukucindezeleka, ukukhwehlela, uphatheke kabi nigxile, izinkinga ukusebenza ipheshana wokugaya ukudla, ukuqothuka kwezinwele, ukulunywa, cramping, imfiva.

Nge ekuphathweni ezengeziwe zomuthi kule scheme "Interferon Alpha" kunobungozi ukuthi kuyoba:

• kwegazi, ukuqwasha, isiyezi, kwehle isibalo neutrophil nama-platelet ne-lymphocyte, anda bilirubin egazini, amawala, ukulunywa, imfiva, uhudo, ukuhlanza, umkhuhlane;
• kwesisindo, ukucindezeleka futhi bethukile disorder, migraine, ukuqunjelwa, iphika, ubuhlungu kanye nezinye izici.

Okuningi ngokuningiliziwe yonke imiphumela emibi lochazwe exhunywe izidakamizwa "sofosbuvir" imfundo manual.

analogs

Kunezindlela eziningana analogue zomuthi "sofosbuvir". Abakwazi ahlukaniswe abe amaqembu 2. Analogs we ketshezi esebenzayo yilezi: "Viropak", "Grateziano", "Hepsinat", "Hopetavir". Uhlu imithi ukuthi babe okufanayo "sofosbuvir" nomphumela oqabulayo ubanzi kakhulu. Ukuze igama nje ezinye zazo: "Algeron", "Ledipasvir", "Neovir", "TSikloferon" kanye nabanye abaningi.

Nokho, ungagqamisa eziningi eziwusizo "sofosbuvir" phambi kozakwabo:

• Ukubulala amagciwane of genotypes ezahlukene hepatitis C;
• ukusebenza kahle eliphezulu;
• esikhathi esifushane sokwelashwa uma kuqhathaniswa nezinye izidakamizwa eziningi;
• kubekezelelwe kahle;
• It akuphazamisi izinga lesiguli zokuphila.

izindleko

imithi yesimanje akazi izidakamizwa eziningi kangaka ngempumelelo ezisiza ngempumelelo ukulwa ne-hepatitis C, baye badlula ku esigabeni ezingamahlalakhona. imithi German "sofosbuvir" efanelekayo iziguli omdala. Yokusetshenziswa ikuvumela ukuqhathanise neminye imithi efanayo.

Ngenxa yokuthi lokhu izidakamizwa sikhombisa kahle kuqhathaniswa eliphezulu, kunezinzuzo ezicacile, uma kulinganiswa nokwenu analogue, izindleko zayo kuphezulu kakhulu. Omunye Yiqiniso izobiza isiguli zamadola eziyizinkulungwane ezimbalwa kuphela. Yingakho ukuze uthole imithi "sofosbuvir" Pharmacy cishe kungenakwenzeka.

Namuhla, lesi sidakamizwa ephelele kakhulu futhi iphephile ukuthi isetshenziswa ekwelapheni isifo sokusha kwesibindi kohlobo C, kuyindlela. Lolu lwazi kufakazela enamathiselwe nomuthi "sofosbuvir" imfundiso. Analogs, ngokuvumelana odokotela, ungavumeli ukufeza imiphumela enjalo ephawulekayo.

Yingenxa yalesi izidakamizwa yaziwa njengenye lenqwaba odokotela emhlabeni wonke. Bakholelwa ukuthi namuhla umuthi okwengeziwe okungase kakhulu lula ukuphila iziguli nezibi, alikho nje.