Umuthi 'MabThera'. Imiyalo yokusetshenziswa

Isigaba sezidakamizwa eziphikisanayo sihlanganisa nomuthi "MabThera". Incazelo yesidakamizwa ibonisa ikhono layo lokubophezela ngokuqondile kwi-transmembrane antigen ekhona kuma-95% we-non-Hodgkin's lymphomas yefomu le-B-cell. Isithako esisebenzayo yi-rituximab.

Umuthi "MabThera". Imfundo: izinkomba

Imithi imiselwe iB-cell engeyona i-Hodgkin's lymphoma:

- i-chemo-resistant noma ephindaphindiwe, i-CD20-positive ngezinga eliphansi lokulimala noma i-follicular;

- isigaba se-follicular yesithathu sesine ngokuhlanganiswa ne-chemotherapy ezigulini ezingelashwa;

- i-follicular emva kokuphendula ngokuthathwa kwe-induction njenge-agent esekelayo;

- i-CD20-positive cell-B enkulu ngokuhlanganiswa ne-CHOP chemotherapy.

Ithuluzi elithi "MabThera" imfundo uncoma ukusetshenziswa kwegazi elingelapheki i-lymphocytic leukemia :

- kuhlanganiswe ne-chemotherapy ezigulini ezingagcini ukwelashwa okujwayelekile;

- ukuphindela kabusha noma ukumelana ne-chemo ngokuhambisana ne-chemotherapy.

Isidakamizwa siboniswa kubantu abadala abanefomu elisebenzayo le-arthritis ye-rheumatoid ngokubambisana nomuthi "Methotrexate" ngezimpendulo ezinganele noma ukungezwani kwemigomo yokwelashwa esetshenzisiwe.

Ukungafani

Ithuluzi elithi "MabThera" alincoma ukufundiswa kokungaboni ngaso sonke isikhathi.

Ukuqapha kufanele kugcinwe lapho kubeka izidakamizwa iziguli ezine-arrhythmia, angina, ukungapheli kwenhliziyo okungapheli, ukucindezeleka kwegazi okuphakeme noma okuphansi, i-thrombocytopenia, i-neutropenia, i-COPD (ngenxa ye-bronchospasm).

Imiphumela emibi

Ngokusetshenziswa kwezidakamizwa "MabThera", ukuhlukunyezwa, ubuhlungu besisu, nokuhlanza kungenzeka. Izimpawu ezimbi zihlanganisa hypotension orthostatic, arrhythmia, tachycardia, bradycardia, i-renal function disorder, i-edema ye-peripheral, ubuhlungu esifubeni nomgogodla we-lumbosacral. Isidakamizwa esithi "MabThera" singabangela i-peripheral neuropathy, neuritis, ukulala noma ukulala, ukuphazamiseka noma ukucindezeleka, ukukhathazeka, ubuthakathaka, isizungu, ikhanda. Izenzakalo ezimbi ziyindlela yokuguqula. Imiyalo ihlanganisa i-rhinitis, ukuvuvukala kwe-pharynx noma ulimi, ukuphefumula, i-bronchospasm, ukukhwabanisa isikhumba, ukulahlekelwa isisindo, ukunambitheka kwesifo, ukuthuthumela, ukukhukhumeza, umkhuhlane, ubuhlungu esifundeni sezintamo nasesimweni sesifo esiyingozi endaweni, ukuthuthukiswa kwesisu Izifo.

Isilinganiso

Isidakamizwa senziwa kancane kancane nge-intravenously infusion. Lapho i-monotherapy isetshenziswa kanye ngesonto ku-375 mg amasonto amane. Isilinganiso sokuqala sokuphathwa kokuqala ngu-50 mg / h. Ukwanda kuya phezulu (400 mg / h) ijubane kufanele kwenziwe kancane kancane.

Imiyalo ekhethekile

Ngemizuzu engamashumi amathathu kuya kwamashumi ayisithupha ngaphambi kwesingeniso, ukulungiswa (ukulungiselela) nge-analgesics nama-antihistamine kunconywa.

Ngesikhathi sokwelapha futhi kungakapheli izinyanga eziyishumi nambili emva kokuqedwa kwayo, abesifazane abaneminyaka yobudala yokubeletha kufanele basebenzise izisu zokubeletha ezinokwethenjelwa.

Izidakamizwa ezixubile kumele zikhishwe amahora angaphansi kweyishumi nambili ngaphambi kokusungulwa kwesidakamizwa "MabThera."

Ukusebenza nokuphepha kwezidakamizwa ezinganeni azange zisungulwe.

Mayelana nomuthi "MabThera" ukubuyekezwa kochwepheshe kukhona okuhle kakhulu. Ngaphezu kwalokho, ngesikhathi sokucwaninga kwatholakala ukuthi ukuphathwa okusheshayo kwezidakamizwa njenge-monotherapy, kanye nokusetshenziswa okulandelayo njengelungu elixhasayo iminyaka emibili, kunciphisa amathuba okudlulela kokugeleza kwe- follicular lymphoma.