Umnkantsha transplantation kwa-Israyeli

Kukanjani ukufakelwa of umnkantsha kwa-Israyeli?

Kanjani ukwenza umnkantsha ukufakelwa kwa-Israyeli? Sekukonke, inqubo wenziwa ngezindlela ezine ezihlukene. Allogeneic umnkantsha transplantation kungase kusetshenziswa donor ezihlobene donor impahla, i engahlobene noma nokusetshenziswa enkabeni intambo igazi. Lapha kuphela indlela wesibili kuyaqabukela esetshenziswa ngoba stem cells e intambo igazi - anele omdala. It is ngokuvamile elibekelwe izingane. Futhi indlela ezingavamile kakhulu, kodwa noma kunjalo lisetjenziselwa umnkantsha Ukufakelwa e-Israel - kokusebenzisa impahla ezithathwe ngokuqondile isiguli esifanayo. Le ndlela inikezwa kuphela ezimweni uma onikelayo material ofanele ayikwazi ukutholwa, noma okunye isiguli akagcini ngokuba namandla ukugcwalisa yokuzithiba, kodwa futhi self-ukuphulukiswa.

Ubani ongenza umnkantsha ukufakelwa kwa-Israyeli?

nezikhungo zezokwelapha Israeli baqiniseka zonke iziguli ezicela ukufakelwa. Ngemva kwalokho - kwenziwe ukuhlolisisa ngokucophelela isiguli kungenzeka yokufeza inqubo. Ngemva onjalo 'inhlolovo "Collegium luzakwenziwa grade wokugcina. Uma lingaphansi kuka amaphuzu 73, ke kungavunyelwe yokuqhuba kwinqubo (umthetho le-International Association of Public Health). Ngokuvamile, iziguli anjalo - lokhu abanomdlavuza emazingeni kamuva kakhulu. Uxolo, kodwa kuleli cala, umphumela akunakugwenywa ... kuphela ezimweni ezingavamile kakhulu, yokusiza umuntu ukuba aphefumule avunyelwe kulandele nokwehlisa umzimba lesiguli (ukuba ngaphezulu ngqo, yenziwa ukwelashwa op futhi zilekelele kuhlinzwa ukususa ezindaweni ezithintekile we umnkantsha).

Hhayi-ke, uma ubheka engu iziguli, odokotela Israeli ziqhuba ngempumelelo ngaphandle kokuhlinzwa kanye nezinsana, kanye nasebekhulile (iminyaka engu-75). Okuningi ngokoqobo ukufakelwa nobuchopho ubudala kamuva ezifana eminyakeni embalwa edlule - omane sinqatshiwe. Lokhu kuchazwe yi awokuthi ukwenqaba donor impahla - amaphesenti angaphezu kuka-85. Kodwa yesimanje ukufakelwa inqubo lapho yena uthembisa ukuba umnkantsha, kodwa kuphela stem cells yayo hematopoietic, kunciphisa le isilinganiso namaphesenti angu-15. Ngaphezu kwalokho - odokotela Israeli nakakhulu ukukhiqiza kanye ukuhlanzwa, nokususwa kusukela donor eyinhloko impahla okuthiwa u "T" - amaseli. Nazo ngokufanayo, kukhona izinto eyinhloko ukwenqaba impahla utshalwe.

Lapho zivela hematopoietic stem cells ngoba umnkantsha transplantation kwa-Israyeli?

Lapho ukwenza lezi hematopoietic kakhulu stem cells ngoba ukufakelwa? Kukhona 4 izindlela main ukuthola kwabo kukhona:

• kusukela enkabeni intambo igazi, okuyinto icala e izinsana nge imvume yabazali;
• lokuthi umnkantsha efanayo DNA ekwakhiweni (kuphela isihlobo-donor ingasetshenziswa Kulokhu);
• kusukela ukunikela ngezitho engahlobene (ne ezedlulayo DNA-ikhodi), futhi ngokuqondile nesineke (uma kufaneleka ukuze ukufakelwa umnkantsha engakaze ezitholakala yimuphi isizinda noma izihlobo).

Futhi sibonga izici ukukhula stem cells, izinqubo kakhulu manje kwenziwe ngisho awusebenzisi kuyofika emnkantsheni ithambo negazi neuropathy nge. Ngakho-ke, le nqubo manje ukuthatha impahla donor Kunjengokulinda ukuthatha banal igazi. Ngaphambili, inqubo enjalo wenziwa kuphela ngaphansi izinzwa jikelele. Ukuze ukuyiswa imijovo esetshenziswa G-SCF, okuyinto ukusebenzisa ngqo umgogodla. Le nqubo kuba buhlungu kakhulu futhi ezimweni eziningi - kwakukhona ingozi umonakalo impahla donor lapho kokukhipha isipetu. By endleleni, uma ukhuluma kahle, ukufakelwa lamaseli hematopoietic akakwazi ngokuthi ukufakelwa umnkantsha. Igama le nqubo - allogeneic lwama-stem cell ukufakelwa, kodwa umkhuba namanje ayevame igama elidala. Lena akuyona ngokuphelele ilungile, kodwa okushiwo izinqubo yokugcina ezifanayo - ke sika umnkantsha futhi ubuyisele ukusebenza yayo.

izinqubo Preparatory ngaphambi umnkantsha transplantation kwa-Israyeli

Kwa-Israyeli, ngokushesha ngaphambi umnkantsha transplantation, isiguli wenza inani izinqubo wokulungiselela, inhloso jikelele okuyinto - kuzoba ukuphenduka ibe ngcono impilo, ukuhlolwa umzimba ngoba izifo, kanye nokuhlolwa Ukudlondlobala kwalesi sifo lesiguli. Uma kuyiyo myeloma uyagula, wabe uphuzwe okwengeziwe umnkantsha isampula ukuze uhlole Ukudlulela therein. Basuke kwakhiwa khona 4 kuphela umdlavuza esiteji. Uma kunjalo, kodwa umzimba akanayo isikhathi ukusakaza, usuthola imiphumela emibi yokwelashwa ngamakhemikhali lihambisana ngemisebe. Njengoba nje isimo lesiguli kuthuthukisa - ekhiqizwa lwama-stem cell ukufakelwa.

Ukuvuselelwa kanye nokubuyiselwa umzimba ngemva ukufakelwa umnkantsha e-Israel

Kwenzekani ngemuva kokuhlinzwa? Amaseli stem uthuthe ngqo endaweni ethintekile, okuyinto ukumila futhi baqala lokuzelapha. Ukwenqabela okokusebenza utshalwe okwamanje kukhona amaphesenti 10 kuphela amacala. Yingakho impahla ukufakelwa kusuka isiguli esifanayo wenziwa kuphela ezimweni lapho ezinye izindlela umane ayikwazi ukusetshenziswa.

Emva inqubo iqala isikhathi nokuvuselelwa. Phakathi namasonto 4-6 isiguli ngaphansi kweso njalo odokotela-gomeologov. Ngalesi sikhathi, umzimba lesiguli kokuguliswa izifo Nokho, ibekwa 'kamelo elwa namagciwane. " Ngisho nalapho ebhekene isiguli, odokotela ngizodabula magciwane, ukugeza izandla ngensipho elwa namagciwane kanye nokunye. Phakathi nale nkathi isiguli wanikezwa inombolo enkulu izidakamizwa elwa namagciwane kanye imithi elwa namagciwane okuyinto kuvimbele ukulimala utshalwe izifo impahla. Akuvamile, kodwa futhi wenza yokwelapha sokubuyiselwa ukusebenza evamile pheshana emathunjini. Uma ukulahlwa indaba ningagcini, isiguli iyanqamuka ukushajwa. Phinda luhlolo wenziwa izinyanga 2, futhi ngokusebenzisa 6. Njengoba umthetho, ngalesi sikhathi welulama ngokugcwele ezilimele umnkantsha futhi resumption of ukusebenza yayo. Kwezinye izimo, ayabelwe yokwelapha immunokorektornaya (lapho ngelashwa nangemithi ezinzima wawenziwa ngaphambi inqubo kwezitho).