Proton futha inhibitor: uhlu izidakamizwa, lo mshini wezenzo, ukubuyekezwa

Kusukela izinkinga wokugaya ukudla, isilungulela kolwelwesi ehlupheka engaphezu kuka-90% yesizwe sonkana, kodwa bambalwa abantu bazi ukuthi izidakamizwa eklanyelwe ekudambiseni isimo, futhi lapho sekuyisikhathi eside esetshenziswa zokwelapha ezimweni lapho antacids musa asize. Ake sihlole lokho kuyinto inhibitor proton futha, uhlu imikhiqizo sizoxoxa.

Lapho emzimbeni womuntu zivela futha?

Proton futha, eyaziwa nangokuthi i-futha proton - lokhu amaprotheni enzyme ikhuthaza ukukhiqizwa kwe hydrochloric acid esiswini. Lesi yisinyathelo kunesidingo futhi kubalulekile inqubo ukugaya. Nokho, ngokuvamile kwenzeka ukuthi acid siqala ngobuningi, okuyinto luhambisana nomthwalo ukuzwa ezingemnandi noma ubuhlungu esiswini.

izinkomba

A-proton futha inhibitor (uhlu izidakamizwa uyoboniswa ngezansi) isetshenziswa kaningi.

Inhibitors, blocker noma i-proton futha - izidakamizwa nge okuyinto ukwelapha izifo ze-pheshana emathunjini elihlobene ne-asidi lenyuka:

- kolwelwesi, kuhlanganise erosive;

- izilonda isisu kanye duodenum;

- duodenitis - duodenal mucosa ukuvuvukala;

- Gerd - Reflux isifo, lapho okuqukethwe isisu njalo juba phezulu nga emphinjeni, yingakho ngokuhamba kwesikhathi kuqeda mucosa we emphinjeni, kuqhoqhoqho kanye pharynx;

- dyspepsia - iziyaluyalu wokugaya ukudla inqubo lapho kukhona umuzwa wagwaza / ukusika ubuhlungu epigastric (solar plexus endaweni) emva kokungenisa;

- imithelela-non-steroidal izidakamizwa eqeda ukuvuvukala (ezifana "Diclofenac") obulimaza pheshana gastro-emathunjini;

- Zollinger-Ellison Syndrome - gastrinoma - isimila esibulalayo, okubangela uketshezi anda hydrochloric acid.

Kuzo zonke lezi zimo kuboniswa ethola proton futha inhibitor.

mshini wezenzo

Tablets noma amaphilisi IPP udle ngomlomo, chaza emathunjini amancane futhi siyiswa ngegazi ngokusebenzisa isibindi zingene canaliculi secretory, lapho aqala ukuba buthelela. Ngenxa umthelela ngqo tubules, okuyinto ukukhiqiza hydrochloric acid uketshezi inhibitor ukunciphisa esihambelana yayo kunciphisa ulaka of juice esiswini.

A-proton futha inhibitor (uhlu izidakamizwa iyatholakala nganoma yisiphi ekhemisi) inikezwa udokotela.

Mshini yazo zonke izidakamizwa yalolu hlobo kuyafana, kodwa ziyahlukahluka emakamu lomcebo esebenzayo lapho igcina pH futhi ijubane umthelela. Ukuze ukhethe udokotela zabo kungenziwa kuphela emva izilinganiso asidi, wenziwa emini. Ngaphezu kwalokho izidakamizwa efanelekayo inikezwa, kanye nokusebenza yayo elibukhali. Uma impumuzo akezi, kodwa lokhu kungenzeka endabeni yokumelana nomuthi yalolu hlobo, kubalulekile ukubheka esikhundleni.

Ngokuya pH siholwa isimo asidi yokusetshenziswa pheshana emathunjini. amayunithi obuphelele 14, amanzi abathathi hlangothi, kuyinto phakathi acid-base balance kanye line-pH 7. eceleni engezansi amanzi imvelo esidi phezulu - ane-alikhali.

Ukuze izinhlobo ezahlukene yizifo ezihlobene nokungabikho umkhiqizo wawanda ka hydrochloric acid, libhekene ezahlukene amazinga pH value. Ngokwesibonelo, isilonda duodenal isibanda uyakwazi ngaso pH mkhulu kunezinhliziyo 3 emini, futhi ukubulala igciwane Helicobacter pylori, kuyadingeka ababuthakathaka imvelo esidi lapho pH mkhulu kunezinhliziyo 5.

Ngokwe-pH evamile futhi uphethwe, udokotela ekunika umuthi othize kusukela iqembu proton futha blocker ku Isikali ezithile isikhathi esithile.

Isikhathi

Inkambo yokwelashwa ingase ihlale izinyanga eziningi noma ngisho iminyaka. Ngokwesibonelo, izidakamizwa, "Rabeprazole" umhlahlandlela uchaza isikhathi reception. Proton futha inhibitor ziphephile ngoba umzimba, ngoba usebenze endaweni futhi akuzona umlutha, kungenzeka ukuba Angesabi kulokho okubizwa ngokuthi "ukuhoxiswa syndrome" ngemva Yiqiniso. Lolu hlobo izidakamizwa musa kuliminyanise isifo, kodwa wabelapha ngokuphelele.

Manje kuyacaca ukuthi inhibitor proton futha ezinjalo. Uhlu izidakamizwa kumba eqolo.

Iqembu i-proton futha blocker

"Omeprazole" buyisidakamizwa owaziwa. Ukuthengiswa kuyinto:

- "Acre Omeprazole."

- "Omeprazole-Richter" - version enamandla kakhulu.

- "Sandoz Omeprazole". ithuluzi Kuhlanganiswe esetshenziswa ukulungisa okwengeziwe kwenaba hydrochloric acid pheshana emathunjini.

Sekuyisikhathi eside kwaziwa ukuthi "Omeprazole" - a inhibitor proton futha, kodwa namuhla kutuswa yokunika kancane, ngoba ohlotsheni olusha lwemithi ahlukile ngcono kokubili ukusebenza futhi imiphumela emibi.

It bavunyelwe ukwethula hhayi ngomlomo kuphela kodwa ngemithambo yegazi, okuyinto enomthelela yalokho okusheshayo. Ukuvela lesi sifo beziphawuleka phakathi neminyaka 10 eyalandela iziguli.

"Pantoprazole"

iphakethe ngamunye litholakale izidakamizwa "Pantoprazole" imfundo manual. Inani lentengo lomuthi yisilinganiso ruble 130.

"Pantoprazole" ngokucophelela okukhulu, kodwa ezinqunyiwe 2 no-3 trimesters sokukhulelwa ngaphandle inzuzo engaba Kusolwa mkhulu kakhulu kunanoma ingozi nengane. Ukuhlolwa kwabesifazane abakhulelwe ungazange besiba, kodwa imiphumela yokuba khona izilwane ezimbi embungwini abikwe.

Ngaphambi kokufaka isicelo "omeprazole" futhi "Pantoprazole" kudingeka ubuyekeze ngokucophelela uhla lwezindawo engazweli izidakamizwa ekuhlanganyeleni futhi athintane nodokotela uma yokwamukela noma yimuphi umuthi ohlwini sihlelelwe ngokuhlanganyela neminye imithi. Analogue - "Nolpaza".

Kungani linqume lokhu izidakamizwa? Lokhu kubuye inhibitor proton futha. Iza izinhlobo ezimbili - amaphilisi kanye izitsha eziyisikhombisa ngoba umjovo. Kodwa empeleni ampoules - a lyophilisate kuyiphi ikhambi Usululungele umjovo. Ngokuvamile engabelwe peptic isilonda isifo, kodwa iye yasetshenziswa ngempumelelo kwezinye izifo pheshana emathunjini.

Ngenxa izidakamizwa, juice esiswini ikhiqizwa ngezinga elincane, le lwamafinyila ngakho kakhulu ucasukile. Uma kukhona izilonda futhi erosions, kancane kancane zarubtsovyvayutsya. Nale umsebenzi oncomekayo "Nolpaza". Kungani linqume izidakamizwa, kwaba sobala. Analogs - "Lanzap", "Lansofed", "Loenzar-sanovel", "Epicure", "Akrilanz" njll Boundedly esetshenziswa ekwelashweni abesifazane abakhulelwe nezingane, ukusetshenziswa engathandeki uma esinye isidakamizwa Ungakhetha ..

"Rabeprazole" - omunye izidakamizwa kusukela iqembu proton futha blocker.

Ngu izidakamizwa "Rabeprazole" imfundo kubonisa ukuthi ayihambisani ne antacids ketshezi. isinyathelo Enhanced ngesikhathi esifanayo ukuthatha nge "warfarin", "diazepam" "theophylline" futhi "Phenytoin". Analogs - "kuthatha", "Zolispan", "Noflyuks" "Pariet", "Rabelok", "Hayrabezol" et al.

"Lansoprazole" - isidakamizwa ngempumelelo izifo yaleli pheshana emathunjini. Ukhicita ekuvimbeni ukukhiqizwa of juice esiswini. Lokhu kuqinisekisa ukuthi lesi sidakamizwa "Lansoprazole" imfundiso. Ngaphezu kwalokho, izidakamizwa nobunzima igciwane Helicobacter pylori. omzimba athile ke achazwayo uye wakwenza ngenxa isenzo izidakamizwa. Ubuningi egijima izinsuku zokuqala ezimbalwa nokulungiselela nge kokuqala reception. Analogs -. "Emanera", "Nexium", "Losek", "Sanpraz", njll Abanye imithi kuthathwe kanyekanye "Lansoprazole" kungandisa plasma yayo okuhlushwa ukuthuthukisa ukusebenza. Lokhu "Imipramine", "clomipramine" "Citalopram". "Diazepam" futhi "Phenytoin" ukwandisa okuqukethwe kancane, futhi "ketoconazole", "Itraconazole" futhi "clarithromycin" kungehlisa ukusebenza imithi. Lichaza "Lansoprazole" imfundo manual.

"Esomeprazole" - umuthi kuhle izilonda esiswini kanye nezilonda duodenal. Ingasetshenziselwa ngokuhlanganyela antibiotic. It ephatha izifo e exacerbation isigaba futhi lisetshenziswa ukuvimbela. Kuvimbela ekwandeni Helicobacter pylori. Ukulungiselela "esomeprazole" (amaphilisi kanye isixazululo umjovo) esetshenziselwa esingangenyanga umthamo 40 mg ngosuku. Ngokuba nokuvimbela umthamo kungenziwa aba nguhhafu.

izinyathelo zokuqapha

I blocker ukwelashwa, izimpawu umdlavuza proton futha ingavuthi nje lubonakale, ngakho ngaphambi kokuqala ukwelashwa kufanele bahlolwe ukuvimbela ukuvela izimila. Ngaphezu kwalokho, ucwaningo esiphuthumayo iyadingeka ukuhlanza njalo, ikakhulukazi nge kwesitulo igazi sifo, ngokushintsha umbala waso iphunga, kanye ebukhali kwesisindo. Ngakho, kudingeka siqaphe kufanele kwamukelwe "rabeprazole sodium."

Leli qembu izidakamizwa, ngokusho izifundo zamuva, kwandisa fragility lamathambo, ngokulandelana, futhi ingozi ukwa, kanye letsintsa sohudo ezihambisana (ie, kubangelwa edonsa kunemithi noma amaphilisi owaphuzayo), hypomagnesemia, futhi ukubonakaliswa komqondo kwasebekhulile.

Ngenxa yalesi sizathu, udokotela kufanele uqale ukwabela aphansi umthamo kungenzeka noma mhlawumbe esikhathi esifushane eyamukelayo futhi ubukele umphumela.

Ukusetshenziswa imithi elwa namagciwane

Proton futha inhibitor (izidakamizwa isizukulwane esisha) asetshenziswa ukwelapha izifo okubangelwa igciwane Helicobacter pylori, okungase kokubili neqhaza ezinkingeni pheshana emathunjini, futhi avuse umuntu uyahluleka uma elwa baye ezibonakala ezifweni. Kulokhu, imithi ngokweqile zifana nokuthela ukungezwa ukwelashwa, ikakhulukazi tetracycline.

Lena iqembu kwamaphilisi eqinile, ngakho noma kunjalo akunakwenzeka ukuba amise yena nabo kuphela.

side effects

Njenganoma iyiphi imithi, kufanele blocker, i-proton futha kukhona eziningana imiphumela engemihle engase ibe:

• okwandisa ukozela - ngakho lolu hlobo izidakamizwa banqatshelwe wamukela abantu omisebenzi kudinga ukunakwa nesivinini yokusabela, ezifana abashayeli;

• ikhanda, lathinta migraines - protivomigrenoznye izimali azivunyelwe ukuthola kanyekanye ne PPI, kodwa ukubonisana udokotela kuyinto efiselekayo;

• isiyezi noma ubuthakathaka;

• ubuhlungu emilenzeni, emgogodleni, amalunga;

• ukuqunjelwa - uhudo noma ukuqunjelwa, ukucanuzela kwenhliziyo;

• izinguquko ukunambitheka;

• nomlomo owomile;

• komzimba - urticaria, ukulunywa;

• ingasheshi ukwakheka kwamangqamuzana egazi - egazi amhlophe nezinhlayiya zegazi;

• ukujuluka anda, Ukugodola.

Kulezi zimo ngempela uyazisile udokotela ukuba khona, ubani, ngokuvamile esabela elinye izidakamizwa efanelekayo IPP.

Kufanele kukhunjulwe ukuthi side effects awatholatholakali futhi ngokuvamile omnene okwanele zonke, ngakho-ke, ngaphansi kokuqondisa udokotela kusebenza nakwesinye isimo ngokuvamile kungenzeka.

Uma kusetshenziswa i-proton futha inhibitor (a ohlotsheni olusha lwemithi), imiphumela emibi ezingavamile.

Izimo

Izimo General kubo bonke proton futha inhibitor:

- inkathi lactation nokukhulelwa, ikakhulukazi 1 yokuthathu, ukusetshenziswa kwezidakamizwa kuleli qembu ngo 2 no-3 trimesters ngokuzikhethela ngokuvunyelwa udokotela. Le mithi kukhona bioavailable kakhulu, ukuthi uyakwazi ukungena ngokusebenzisa izicubu, kuhlanganise placenta futhi buthelela ubisi lwebele. Nakuba azikho idatha waqinisekisa ngezingozi lezi zimali ezingenzeka embungwini, akukho impendulo ngaphandle ucwaningo nge izilwane.

- Izingane ezingaphansi kweminyaka eyi-12, kusukela umsebenzi nezindlala endocrine lungaphansi kokuthuthukiswa futhi ekwakhekeni, ngakho noma yikuphi ukuphazamiseka kungabangela ukungasebenzi.

- Umzimba ongezwani nezinto noma hypersensitivity emuthini.

Ngokwesibonelo, ichaza zonke emuthini "Pantoprazole" imfundo manual.

intengo

Amanani blocker izidakamizwa proton futha ziyahlukahluka, kodwa zitholakala kalula. Ngokwesilinganiso, izindleko kuyinto ruble 90. ukupakisha "Omeprazole" kuze ruble 500. ukupakisha neminye imikhiqizo isizukulwane esisha.

Intengo lincike inani amaphilisi / amaphilisi iphakethe futhi ezweni lendabuko. Ngokwesibonelo, imithi ejwayelekile Russian zingathengwa for ruble 20-100, kodwa Kufanele kwaziwe kodwa ukuthi imithi ejwayelekile -. Akuyona indlela yokuqala. Ngokuvamile aphumelela ngokuya kuncipha ukubekezelelana, kunokwenzeka kakhulu ukuthi babe engemihle.

Izibuyekezo

Amalungiselelo yaleli qembu ngokuyinhloko kubangelwa okubuyayo. Ziyakwazi ngempumelelo ngempela yezifo pheshana emathunjini. Izindleko kwamukelekile kakhulu.

Kukhona Yiqiniso, abanye imiphumela emibi, njengesifo sohudo. Kodwa kwenzeka ezimweni ezingajwayelekile, kodwa uma uthathe umthamo ilungelo, ngeke kube ngaso sonke.

isiphetho

Proton futha inhibitor njalo ngcono. Lokhu kwakuhilela ososayensi ezivela emazweni ehlukene zezwe. izidakamizwa "Dekslansoprazol" kwakhululwa eminyakeni engaba ngu-6 edlule. It is hhayi okwamanje evunyiwe ukusetshenziswa ngaphandle kokuvinjelwa, kodwa gastroesophageal Reflux isifo ngosizo iphathwa ngempela ngempumelelo.

Okwamanje eJapane athuthukile "tenatoprazole," okuyinto ibekwe njengoba blocker ephumelela kunazo zonke-proton futha.

Korean "Ilaprazol" usebenza seziyashelela futhi ngokushesha "omeprazole" Nokho eRussia, e-US nase-EU kwenqatshelwe zisebenzisa ngezizathu ezingaziwa.

Amalungiselelo yaleli qembu zithathwa kaningi izikhathi 1-2 ngosuku, okwenza ukusetshenziswa yabo ekahle. Kodwa kumele ukhethe udokotela emva anamnesis futhi ucwaningo, ngoba izidakamizwa ngamunye impahla yayo, futhi wonke umuntu izici zawo siqu lesi sifo. Sahlola ngokuningiliziwe proton futha inhibitor. Lo mshini wezenzo uphindze uchazwe.