"Propranolol": analogue, yokusetshenziswa, incazelo kanye nokubuyekeza

"Propranolol" - umuthi okuqondene iqembu blocker zikhethe. Umuthi kunemiphumela antianginal, antiarrhythmic futhi hypotensive. I nomuthi iqondiswa ngenjongo ekwelapheni isifo senhliziyo ischemic, thyrotoxicosis, umfutho wegazi ophakeme. Imithi liphumelele Neuro dystonia, migraine. Isetshenziselwa ukuqaliswa ukwelashwa ephethwe yisifo senhliziyo, pectoris angina. Umuthi bazuze umzimba isilethikusebenza. Baphatha arrhythmia futhi zenhliziyo hypertrophic. Lapho lesi siguli asifanele "Propranolol" nozakwabo abhekwa prescribers Uchwepheshe ukuthi isiguli elilungile.

ukukhululwa Ifomu

Ungathenga ezimbili izinhlobo izidakamizwa - izidakamizwa "Propranolol" futhi izidakamizwa "Propranolol Nycomed". Lona imithi efanayo akhiqizwa abakhiqizi ezahlukene ezibhebheni.

Izingxenye zomuthi

Ukulungiswa senziwa ngesisekelo esebenzayo izidakamizwa propranolol. Ulapha Isakhi esiyinhloko zingahluka - 10, 40, 80 futhi 160 mg lichaza ekwakheni ithebhulethi ngamunye.

izithako Asizayo asetshenziswe ekukhiqizeni amanye amaphilisi zihlukile futhi ancike abakhiqizi. Ukuze bazi kahle ukuthi yini uku imithi ngaphambi kokusebenzisa kubalulekile ukufunda bhukwana.

Umthelela zokwelapha zomuthi

Ibonisa ikhono ukuvimba ama-receptor beta-adrenergic kusho "Propranolol" imfundo manual. Analogue babe emzimbeni efana isenzo. Tablets nomthelela ku semithambo beta receptor izindonga 1 futhi 2. Umthelela inhibitory kulezi receptor kuholela ukuphumula izindonga imithambo yegazi, ngaleyo ndlela asuse izinkinga eziningi - high blood pressure, kukhuphuke funa inhliziyo ukuthola umoya-mpilo, ukuthengisela abampofu izakhi futhi umoya-mpilo ezicutshini eziyishumi nemitshingo.

isinyathelo Antiarrhythmic zomuthi ikhuthaza ukubukeka ushintsho oluhle emzimbeni, ezifana itheku engeyokuqala automaticity ukuzinza, wehlise conduction engeyokuqala atrioventricular, ukuqedwa excitability anda amaseli aqukethe myocardium. Ngenxa 'Propranolol "abuyiselwe operation evamile inhliziyo, akukho asabela ngayo ezintweni ezenzeka ngaphandle, okungase zibulale nesigqi somqondo.

"Propranolol" analogue kwenyuswe ukuthuthukiswa nomphumela anti-anginal okuyinto ubukisa isimo ngcono kwemisipha inhliziyo, ukunciphisa umoyampilo adingekayo ukusebenza kwawo. Lokhu kusho ukuthi inhliziyo kudinga umoya-mpilo omncane ukuba kuyehla, kanti imvamisa yale Kufinyeta kuyehla kakhulu.

isinyathelo Hypotensive kusekelwe ukwanda mafutha anciphisa isikhala esingaphakathi imithambo yegazi kanye ukuphumula izindonga zawo. Isicelo umthamo owodwa we amaphilisi kuholela ekuncipheni wegazi, umphumela okuholela lugcinwa okungenani amahora angu-20 ngobusuku obubodwa. umphumela Esitebeleni hypotensive laligujwa ngemva kwamasonto amabili yokusetshenziswa njalo amaphilisi. Umuthi asifanele ngempumuzo izimo ephelezelwa waba ukwanda okukhulu kwezincwadi ingcindezi, kukhonjiswe ukulapha eside nomfutho wegazi ophezulu.

ukusetshenziswa eside izidakamizwa kuholela ukuthuthukiswa imiphumela cardioprotective. Bonisa ukwehla ematfuba yokuphindela isilethikusebenza emva kokwelashwa okunjalo kusho "Propranolol" ukubuyekezwa, imiyalelo. Okuphawulekayo kwanciphisa ingozi ngokufa okuzumayo okwenzeka. Kuyaziwa ukuthi izidakamizwa kuye kwaba nomphumela omuhle ngaso ephakeme ingcindezi intraocular.

Pharmacokinetics

Ngemva kokungena ngaphakathi emzimbeni main ingxenye amuncwa umzimba izidakamizwa (90%), kuyilapho Inkomba bioavailability azinakwa. Ukuxhumana amaprotheni elihambisana 93%. Izidakamizwa kusukela umzimba esuswa umchamo, ewa metabolites. zinhlobo njalo has angaphansi kwamaphesenti omunye imithi.

ubufakazi

"Propranolol" imfundo analogue ikuvumela ukwabela ekwelapheni izimo nezifo ezithile. Babephathana nomfutho wegazi ophezulu portal futhi ophakeme, sokuwohloka esivimba amanzi, i-hyperthyroidism. Imithi kudambisa isimo ngesikhathi inesikhala ayisesemikhulu le-aorta, eliqhaqhazelayo kubalulekile, uvalo, ingasetshenziswa njengendlela ithuluzi lokusetshenziswa prophylaxis migraine. Tablets efanelekayo ukulapha enhliziyweni yesosha, isilethikusebenza, arrythmia. Umuthi iqondiswa iziguli mitral valve prolapse. Ngu izinkomba zihlanganisa tachycardia supraventricular futhi itheku. Ukwabela izindlela eyenziwa ngaso lesi sifo zokulutheka pectoris angina, akathisia, okuzovela ngenxa ukusetshenziswa neuroleptics. Imithi enqunyiwe iziguli pheochromocytoma ukulapha inhlanganisela. Umuthi isetshenziswa nobuthakathaka umsebenzi zabasebenzi ngemva kokuma ukuya esikhathini ukuqeda zako ezimbi.

Izimo

Kukhona ezinye Izimo ze- "Propranolol" izidakamizwa. Analogs kungenziwa kukhethwe ezimweni lapho izidakamizwa asifanele. Izimo zihlanganisa:

• ukungabekezelelani kusho izingxenye;
• ukushaqeka cardiogenic;
• bradycardia, ngesikhathi lapho isibalo zisaphila ngomzuzu 55 sp.
• lactic umzimba;
• ezingamahlalakhona ukuhluleka kwenhliziyo noma amafomu acute;
• vasomotor rhinitis;
• block sinoatrial, atrioventricular (2nd, degree 3rd);
• Prinzmetal angina ;
• umfutho ophansi wegazi;
• Sebenzisa insulin;
• syndrome ephelezelwa itheku;
• khona ngesikhathi samanje ngokuzila ukudla isikhathi eside;
• izinkinga nge kwegazi neuropathy (decompensation isinyathelo);
• ngaphambili idluliselwe isiqondiso isifo lapho abathintekayo ushise imigudu yomoya, isifuba somoya, bronchospasm ukutholakala.

Kukhona futhi izimo lapho ngokuqapha liyadingeka. Kulezi zimo ezilandelayo, ungakhetha esikhundleni lesi sidakamizwa "Propranolol" analogue, omqondofana:

• myasthenia gravis;
• isifo sikashukela (decompensated, subcompensation);
• imisipha inhliziyo esingamahlalakhona (isifuba somoya), isibindi, izinso,
• nesifo spastic;
• nokucindezeleka;
• block atrioventricular (idigri yokuqala);
• psoriasis;
• umsebenzi okwandisiwe indlala yegilo;
• amafomu ezingamahlalakhona Ukucinana kwemigudu yomoya emaphashini;
• ushukela wegazi ophansi;
• emphysema;
• sokuguga;
• Phakathi nenkathi yokukhulelwa, breastfeeds.

ukwelashwa izidakamizwa

Iziguli nomfutho wegazi ophezulu kufanele kuthathwe izidakamizwa umthamo kabili nsuku zonke 40 mg ngayinye umthamo owodwa. ukwanda kwalo kungenzeka zingakapheli izinsuku 14-28. Uma kudingeka, amaphilisi ziphuze wansukuzonke umthamo mg 80 160. Imvamisa indlela ethola uyefana.

Uma iziguli tachyarrhythmia omdala baphuza kathathu noma kane nsuku zonke kusuka 10 kuya 30 mg reception ngayinye "propranolol" kusho. Analogs ingasetshenziswa, uma lo mkhiqizo ayilingani. iziguli Omncane nge inkinga efanayo izidakamizwa yaphathwa imali kusukela mg ngayinye isisindo amakhilogramu umzimba 0.2 kuya 0.4. Imvamisa isicelo kusho - njengoba kathathu noma kane ngosuku.

Njengoba isilinganiso izifo ezigulini sezihlonziwe angina ukhombe ezine kokuthatha lesi imithi nsuku zonke. A umthamo owodwa we-mg 20. ukwanda kwalo kungenzeka izinsuku eziyisikhombisa. 40 mg izidakamizwa esithathwayo ngezinga elifanayo, 80 mg - kancane kancane kaningi (kabili).

Ngemva esivimba amanzi infarction prophylaxis edingekayo. Qalisa kungaba nomuthi "Propranolol". Usayizi umthamo owodwa ofanele 40 mg, le reception izidakamizwa ngelanga kufanele sinikezwe ezintathu. Khulisa umthamo kuze kube esiphezulu 80 mg.

izinyathelo Migraine zokuvimbela kufanele uhlangane nokusetshenziswa 40 mg zomuthi kabili ngosuku. Dinga ukwanda umthamo kuya ku-80 mg, ukuphuza imithi nsuku zonke kungenzeka ezimbili noma ezintathu, futhi izingane - ezintathu noma ezine. Ukubalwa umthamo iziguli ezincane zenziwa ngokucabangela isisindo sabo, kilogram of ngalinye - kusuka 1.5 kuya 2 mg.

Thyrotoxicosis - isifo lapho izidakamizwa unikezwa 10 mg kodwa hhayi ngaphezulu kuka-40 ukuze uthole kathathu noma kane ngosuku.

Uma uhlela ukuba yokwelapha pheochromocytoma, umuthi kuhlanganiswa nama-blocker-alpha.

side effects

Kufanele sinake ukuthi inquma imiphumela emibi izidakamizwa "Propranolol" imfundo manual. Analogs Izibuyekezo - akuyona Imininingwane ezingabalulekile kangako, sithonye kukhethwa imithi onikwe yona. Ukuze ingozi ukusabela ezingezinhle komzimba incane, kubalulekile ukufunda ngokucophelela imiyalelo, kuyasiza kakhulu sokuba bajwayelane.

Imithi uma esetshenziswa ngendlela engafanele ungakulimaza esimiso senhliziyo nemithambo yegazi kubangelwa yokuphazamiseka ohlelweni sezinzwa, ohlelweni endocrine. ukubonakaliswa ezingezinhle ezingenzeka phezu ingxenye ipheshana wokugaya ukudla, ungase uphazamise nolwelwesi lwamafinyila kanye isikhumba. Phakathi side effects ezisohlwini imiyalelo - izinkinga zokuphefumula. Kungenzeka kukhona ezinye imiphumela emibi.

intengo Analogs

Ngaphambi kokuba uthenge "Propranolol" izidakamizwa analogue, intengo ngokuvamile wafunda iziguli. Thenga amaphilisi kungabangwa ruble 16-75. Inani kunqunywa inani amaphilisi iphakethe ngalinye. Buyisela izidakamizwa kungaba "Propranobene" imithi "obzidan" noma "Inderal". Ungase futhi wenze ukwelashwa "Inderalom LA", "Inderalom".

Ngu ebhekisela izidakamizwa "Propranolol" yokusetshenziswa, intengo, analogs ukunikeza ulwazi esibalulekile-esisisiza ukuba isinqumo esingcono lapho ukhetha imithi kanye lokwelatshwa.

Izibuyekezo

Izibuyekezo ikakhulukazi omuhle. Babika ukuthi lezi imithi ngokuvamile kuyaphumelela. Ngaphezu kwalokho, abaningi weneliseka intengo nemithi ongaphakeme. "Propranolol" uphatha ukugcina umfutho wegazi ezingeni evamile, ngokushesha balahle palpitations inhliziyo. Imithi kunciphisa izimpawu yesifo senhliziyo, aqede imizwelo yomuntu. Izibuyekezo ezingezinhle ngokuvamile abantu ashiye ngenxa nemiphumela emibi ukuthi kungenzeka ngesikhathi yokwelapha. Ngezinye izikhathi kukhona ubuthakathaka ezinzima, nezinkinga ukulala, amaphupho amabi.