Izizathu, pathogenesis nezimpawu sifo

Kokunye leqembu lezifo rheumatism zihlanganisa okuthiwa microcrystalline noma sokuqaqamba kwamalunga umzimba. Omunye walena uwukuba sifo samathambo, izimpawu kanye kuwukubonakaliswa esevele owaziwa kusukela sikaHippocrates. Lesi sifo kwenzeka ngenxa umzimba kahle ka uric acid kwekuqukethe okusezingeni eliphezulu egazini, kanye sebethule sokugembula amakristalu (urate) emisipheni. Ngakho-ke izimpawu sifo emtholampilo nesenzakalo manifest arthritis acute, kanye kumiswa tophi, gouty ISIZINDA ethize.

AmaGreki awunika igama lokuthi lesi sifo. Eyokuqala okwaziwayo namuhla, incazelo isifo wanika udokotela ngesiGreki Saranus. Lokhu isifo wahlupheka Macedonian, Newton nezinye izibalo abaningi abaziwa kahle emlandweni.

Inani labantu abazithola izimpawu sifo njalo ngonyaka kwandisa. Kunalokho, singasho sithi nokwenza ngcono izinga lempilo namandla. Akumangalisi-ke ukuthi isifo ubizwa nangokuthi "isifo aristocrats."

Inkinga-ke lesi sifo uphethwe yayo sekwephuzile, ngokuvamile kakade esigabeni amahlala khona, uma inqubo sifo nje amalunga kuphela abathintekayo.

Izimpawu zokuqala sifo ngokuvamile uqale ukuphazamisa amadoda oseqinile. Kodwa lesi sifo kakhulu "ngezicabha" muva nje. It kungatholakala abantu abasha amathathu. Eningini efuna usizo sifo kuhlasela iqala ukubonakala ubuhlungu nokuvuvuka lokuqala (elikhulu) uzwane. Lena yi-version zakudala. Zonke ezinye ibhalwe ubuhlungu ngezinye emalungeni ngezinyawo, kanye emalungeni enkulu nasemilenzeni.

Ukuze siqonde pathogenesis lesi sifo, udinga ukuba kuvisisa umzimba ejwayelekile uric acid. Kubantu, kuba umphumela wokuqhekeka purines. Ngo umzimba wethu imithombo ukwakha acid ezifana babambeke ukudla contact eziqukethe purines (inyama, okusabhontshisi, newayini elibomvu, izinhlanzi, njalonjalo), Nucleoproteins amaseli. Excreted uric acid kuyinto okukhipha ngokusebenzisa emathunjini kugaywe izitshalo emathunjini, futhi umchamo (ingxenye yayo enkulu).

Izimbangela zesifo

Kuyaziwa ukuthi kukhona izimpawu of sifo ngokuhlanganisa ngokweqile uric acid emzimbeni kanye nokunciphisa excretion yayo umchamo ezaziwayo. Okwandisa ukwakheka acid kungenzeka kubangelwa ukusetshenziswa ngokweqile nokudla okune purines nangaphezulu, synthesis engaphakathi purines emzimbeni.

Ukwaba oyinhloko nesikhali hyperuricemia yesibili. Ukuvuvukala Kwamalunga kuwumphumela samuntu kuqala. Secondary nesanda uric acid egazini ngokuvamile umphumela ukwehluleka kwezinso, myeloma amaningi, uhlobo oluthile lomdlavuza wegazi futhi anemia bubonakala isicelo amalungiselelo ezithile zokwelashwa, isibonelo, isisu.

Ngokweqile acid egazini kuholela sebethule yayo kwezitho nezicubu. Ngesimo sodium urate is zibekwe Bursa ingena phakathi uketshezi lwamalunga. Urata ukungena uqwanga, okubangela ukuvuvukala umonakalo.

Izimpawu ze-sifo

Njengoba kuphawulwe ngenhla, inguqulo yakudala iyisifo ahlangene uzwane enkulu. Ngu uqobo, ngokweqile uric acid emzimbeni musa zibangele noma iyiphi izimpawu, futhi kuqhakambisa kokunqotshwa lokhu ngokuhlanganyela ethile. Ngokuvamile kokugqashuka senziwa isiminzi, adle hypothermia, ukuhlukumezeka noma izifo ezithile. Ngokuvamile sokuqaqamba kwamalunga kuhlasela kwenzeka ngokumelene isizinda ephelele inhlalakahle, nakuba ngezinye izikhathi imakwe izimpawu-kokumethemba ezifana izinguquko njalo kwemizwa, ukucasuka ngokweqile, njll

Ngokuvamile ubuhlungu avele ebusuku ngokungazelelwe. Ubuhlungu buba bukhulu kakhulu kangangokuba akunakwenzeka ukuba uthinte ngokuhlanganyela. Ngesikhathi esifanayo kukhona ukuvuvukala kanye ububomvu. Ngemuva kwezinsuku eyodwa noma ezimbili, ubuhlungu amuke. Isici nobuntu ubuhlungu arthritic kuyinto kwaqala okuzumayo ngokuzumayo futhi ekupheleni okungazelelwe. Uma amalunga omzimba ezinkulu iyathinteka, isithombe sokucindezeleka okusikhumbuza phlegmon. Emalungeni zingase zimiswe tophi. Ziyakwazi uhlevane ngokufanele ngaphansi kwesikhumba noma amalunga omzimba (urate ezifakwa). I ephakeme amazinga igazi uric acid.

ukwelashwa

Ngo-acute kuhlasela esetshenziswa colchicine, eqeda ukuvuvukala, izidakamizwa analgesic (ama-NSAID). Kuyinto yokudla ngaphandle ukudla inyama, utshwala byproducts ibalulekile.

Isinyathelo sesibili siwukuthi ukuqokwa izidakamizwa ukuthi ukunciphisa ukukhiqizwa umzimba ukuba uric acid. Ngakho umuthi allopurinol noma analogs yayo. Lesi sidakamizwa isetshenziselwa ukwelashwa okuqhubekayo futhi eside ..