Izidakamizwa "allopurinol": ukubuyekezwa odokotela, izinkomba, side effects

Kuze kube manje, izidakamizwa "allopurinol" kuyinto eyisisekelo (okuyinhloko kanye pathogenetically lusekelwe) umuthi isetshenziswa ekwelapheni izifo ezifana sifo. Umuntu ngamunye ngaphambi kokuzama into entsha, uzama ukuthola ulwazi oluwusizo kakhulu ngakho. Ngakho-ke sinikeza ukubhekana ngemininingwane engaphezulu lapho ezifanayo kumele zisebenze "Allopurinol". Izibuyekezo iziguli nodokotela izokwethulwa ku-athikili yethu futhi ngeke azi ukuthi ukwesaba uma uthatha lolu izidakamizwa.

izici kwemithi zomuthi

"Allopurinol" libhekisela amalungiselelo iqembu protivopodagricakih. The main izidakamizwa esebenzayo - allopurinol futhi esebenzayo metabolite oksipurinola yayo. Le miphumela pharmacodynamic ngenxa yokwephulwa synthesis of uric acid ne umphumela ukuthuthukiswa urostaticheskogo. Lokhu ekugcineni kuholela ekuncipheni emakamu yayo, kulandele Ukuqedwa urate.

Ngenxa ezinhle solubility "allopurinol" has bioavailability okusezingeni eliphezulu. Umuthi is kahle ugxile kusukela inesikhala emathunjini amancane. Esikhathini esiswini ku kwegazi angawi. ebukhoneni plasma Kuye kwaphawulwa for isigamu sehora ngemva kokuphathwa, futhi emakamu esiphezulu waphawula ngemva 1.5 amahora. Ngakho, lo lokuhlushwa wokugcina metabolite ka allopurinol - oksipurinola waphawula amahora amathathu emva ekuphathweni ngomlomo.

Umuthi has a eside nesigamu zempilo ngoba uyakwazi cumulation. Iziguli ekuqaleni ukwelashwa, kukhona emakamu anda kwezidakamizwa kuzole emva amaviki amabili yokwelapha. Ngenxa eside ukuqedwa "Allopurinol" (ukubuyekezwa odokotela siliqinisekise) is hhayi Kunconywa ukuba isetshenziswe abantu nokwehluleka ukusebenza kwezinso. In iziguli walondoloza kwezinso umsebenzi excretory cumulation is hhayi waphawula.

"Allopurinol": izinkomba ukusetshenziswa

Izibuyekezo odokotela enquma lesi simangalo kwezidakamizwa kuyaphumelela kakhulu futhi onesizathu amacala hyperuricemia (amazinga aphezulu uric acid per unit umthamo wegazi) ku:

• gouty sokuqaqamba kwamalunga (sifo);
• izifo urate urogenital (nephropathy, urolithiasis);
• izifo oncological yegazi;
• anomalies azalwa naso kohlelo enzyme.

Kwezinye izimo, angase asebenzise izidakamizwa ekwelapheni izingane urate nephropathy, eyabonakala ku ngemuva yokwelapha wegazi yezifo azalwa naso elihlobene ne umzimba ukuphazamiseka kwengqondo ka uric acid, yesibili hyperuricemia umsuka ezahlukene.

Izici zomuthi

"Allopurinol" amaphilisi (izibuyekezo waxwayisa bawuhloniphe ngokuqinile izincomo imithi) zithathwa emva kokudla, zingabantu neze kungenzeki ukuhlafuna, kodwa kunalokho neminikelo yako yonke futhi ukuphuza okungenani ingilazi yamanzi afudumele.

Abantu kokuthatha lesi imithi, kufanele ngaso sonke isikhathi ukuqapha ukudla kwabo, futhi esimweni iphutha yokudla ezidingekayo ukulungisa umthamo yayo, kodwa kuphela ngaphansi kokuqondisa onguchwepheshe bayahlanganyela.

Umthamo ezidingekayo ukuba aphathe 'allopurinol "izidakamizwa kunqunywa kuncike okuqukethwe uric acid ekusakazeni igazi. Ngokuvamile, it zokhahlamba kusuka mg ngayinye esisodwa "allopurinol" ukulungiselela 100 kuya ku-300. Izibuyekezo iziguli nodokotela mayelana nalokhu nokushintsha kokudla nokufakwa omuhle, njengoba izidakamizwa esithathwayo kanye kuphela ngosuku.

ukwelashwa Ukuvuvukala Kwamalunga uqale nokubekwa mg 100 zomuthi kanye ngosuku. Uma kwenzeka yokuntula kwayo nokuthi abampofu ukwehlisa uric acid Isikali liyakhula kancane kancane (by mg 100 njalo ngemva kwamasonto amabili noma amathathu), okuholela laboratory ngempumelelo zokwelapha ngaphansi ukulawula amazinga acid uric. Ezimweni ezinjalo, umthamo isilinganiso kanye nokugcinwa okwalandela umthamo zokhahlamba kusuka 200 kuya 400 mg, kodwa kwezinye izimo, umthamo lingafika ku-800 mg. Kulokhu, ihlukaniswe yaba izikhathi eziningana ngosuku.

Ngo kuqokwa izidakamizwa iziguli esingamahlalakhona kwezinso kufanele ugxile imvume creatinine.

Izimo for "Allopurinol" isiqu

Umuthi is contraindicated in iziguli ukwehluleka ezinzima kwezinso, kanye abakhulelwe kanye lactating. Liphinde akunconyelwe izidakamizwa iziguli kokuba ukusabela iguliswa noma hypersensitivity elilodwa noma ngaphezulu yezingxenye nokulungiselela. Akuvunyelwe ukusebenzisa izidakamizwa in iziguli amazinga emnceleni ka uric acid egazini plasma, ngenxa ukuncishiswa yayo ngempumelelo bungatholakala ngokulungisa ukudla.

"Allopurinol": side effects

Izibuyekezo ekubulaleni iziguli ezigulela wasebenzisa izidakamizwa okokuqala, abonisa ukuthi ngokuvamile kungenzeka exacerbation futhi ngakhula izimpawu of sifo nge ukuvela kokuhlasela okuthiwa. Kodwa lesi simo yesikhashana, futhi akudingekile ukuba wesabe ngokwanele ukuba angaqhubeki yokwelapha. Kodwa kunoma isiphi ukuqubuka, kabi noma ulahlekile izimpawu zokuqala kufanele ngokushesha azise udokotela wakho. Kulesi ndlela "Allopurinol" kumele kumiswe ngokushesha, futhi njengoba ukunyamalala izimpawu uchwepheshe ungakwazi unike kabusha izidakamizwa, kodwa umthamo elincane (kusuka 50 mg). Ukwamukelwa okufanele iqhutshwe ngaphansi kokuqondisa kwetheksthi udokotela ukuba khona futhi egunjini.

Phakathi ukusabela ezingezinhle isimiso sezinzwa futhi imisebenzi yengqondo ephakeme kungase kubangele ukucindezeleka. On the ingxenye ukuthuthukiswa yokucindezela ithambo uhlelo umnkantsha hematopoietic kuyaqabukela yabonakala okuvela thrombocytopenia, anaemia aplastic.

Lapho ethola izidakamizwa angagcina iziyaluyalu umzimba njengesifo sikashukela, amazinga aphezulu ama-fatty acid-plasma yegazi.

Cardio-semithambo uhlelo angagcina umfutho wegazi ophakeme, bradycardia.

Imvamisa ukusabela ezingezinhle emuthini luyanda khona ukwehluleka kwezinso e isiguli.

Khipha ifomu kanye umthamo

"Allopurinol" etholakala ifomu tablet (30 noma 50 nama-PC. On iphakethe) ngesikhathi umthamo mg 100 noma 300 isithako esisebenzayo iphilisi ngalinye. Ngo emakethe yasekhaya kukhona "Allopurinol Sandoz 300". Uphenyo ke omuhle, njengoba izidakamizwa e umthamo inikezwa kanye kuphela ngosuku, cishe negates kungenzeka balahlekelwe yokwamukela izidakamizwa.

Ubuthi futhi izidakamizwa ukweqisa izidakamizwa

Ubuthi akuvamile kugujwe, kodwa kunamasiko kukhona izimo umthamo owodwa we-20 amagremu zomuthi. Kulokhu, ubhekana zimpawu ezilandelayo: ukuba nesiyezi, ukuhlanza, isicanucanu, uhudo. Ngo esingamahlalakhona kwezinso, kanye nokuphathwa okuqhubekayo ebulilini zomuthi babonakala izimpawu ezinamandla lokudakwa ngesimo imfiva, ukushisa kwesibindi, ukwehluleka oyingozi kwezinso.

Ukwelashwa ubuthi oyingozi futhi ukweqisa izidakamizwa, lingaze, okuhloswe ngazo kuyashesha ukuqedwa izidakamizwa emzimbeni. Ayikho yokuvimbela ethize. Ukuze excretion ngokushesha zomuthi kusukela umzimba izindlela zelashwe kukhona ngokukhishwa kobuthi egazini ngempumelelo.

Izibuyekezo

Sikhishwe yokuthi kwenkathi ekuqongeleleni izidakamizwa egazini (ngesikhathi liningi ngokwanele ukunikeza isinyathelo zokwelapha) yisilinganiso sesifundo iviki elilodwa, iziguli sifo, kufanele kusetshenziswe cishe ukuphila "allopurinol". Izibuyekezo lodokotela kukhona ocacile: izidakamizwa ikufakazele ngokwayo kahle. Kodwa lokhu akulona "isimangaliso iphilisi" ukuthi ungaba isiphuzo bese ukhohlwa eziphathelene nokugula. Ukuvuvukala Kwamalunga - kuba kunalokho indlela yokuphila kunokuba isifo esingelapheki. Kodwa "Allopurinol" kusiza ukulawula ezingeni acidosis acid futhi ukuvimbela okubi kakhulu lesi sifo kanye nenqubekelaphambili wayo.

Ngokuya lula, lapho uya khona "Allopurinol" Ukusabela izidakamizwa kusukela odokotela futhi omuhle, ngoba ezikhathini eziningi isiguli kumele kuthathwe imithi kanye nsuku zonke. Lokhu kunciphisa ematfuba ulahlekile yokwamukela nomuthi, futhi ngenxa yalokho kukhulisa nekusebenta yokwelapha.

isiphetho

Ngakho, liyini ikhambi esiyinhloko sifo - "Allopurinol". Izibuyekezo ochwepheshe kanye neziguli, lokhu kusho ethatha, omuhle, futhi lokhu kuqinisekisa nekusebenta nomuthi nge ekwelapheni Ukuvuvukala Kwamalunga futhi uric acid umzimba iziyaluyalu. Ngenxa ukusetshenziswa kwezidakamizwa, isibalo esikhulu sezithunjwa iziguli ukuba babe nethemba ukunciphisa izinkinga zesifo sikashukela.