Isidakamizwa esithi "Bicalutamide": imiyalelo yokusetshenziswa, incazelo, ukwakheka nokubuyekezwa

Umdlavuza we-prostate uyisakhiwo esibi esivela epithelium yezingxenye ze-alveolar-cellular ye-prostate gland. Lokhu kuyakheka okungavamile kakhulu kobulili obunamandla. Unyaka ngamunye cishe amacala angu-400 000 omdlavuza abhalwe emhlabeni. Ukuze ukwelashwa kwawo, isidakamizwa esinjengeBicalutamide sivame ukusetshenziswa. Imiyalo yokusetshenziswa, intengo, ubufakazi, izakhiwo, izinkomba, imiphumela emibi kanye nokuphikisanayo kuboniswa ngezansi.

Ukupakishwa komkhiqizo, ifomu nokubunjwa kwalo

Ngabe imiphi imithi "Bicalutamide" eyenziwe? Imiyalo yokusetshenziswa, izibuyekezo zithi leli thuluzi lingathengwa ngesimo se-biconcave egcwele futhi sigcwele amaphilisi amhlophe aqoshwe ngamafilimu. Isithako sabo esisebenzayo yi-bicalutamide. Ngaphezu kwalokho, ukwakheka kwezidakamizwa kuhlanganisa: i-lactose monohydrate, isitashi samabele, i-sodium stearyl fumarate, i-croscarmellose sodium, i-povidone, i-opadrai emhlophe, i- polyvinyl utshwala, i- titanium dioxide, i-polyethylene glycol ne-talc.

Uma uthengiswa lo muthi ufika ngamabhodlela noma amabhodlela amnyama, afakwe uphawu ebhokisini lephepha elikhulu.

Izici zomkhiqizo wokwelapha

Kuyini iBicalutamide? Imiyalo yokusetshenziswa ibonisa ukuthi lena i-anti-androgen engeyona i-nonsteroidal engenazo ezinye izinhlobo ze-endocrine umsebenzi.

Lesi sidakamizwa sikwazi ukubopha ama-androgen receptors futhi, ngaphandle kokusebenzisa inkulumo yesiginali, cindezela umphumela oshukumisayo we-androgens. Umphumela wale nethonya ukuguqulwa kwama-neoplasms (okubi) i-prostate gland.

Kwamanye abantu, ukuyeka i-bicalutamide kuholela ekuhoxisweni kwe-anti-androgen syndrome.

Izici zengqondo zesidakamizwa

Ukubanjwa kwe "Bicalutamide" kwenzeka kuphi? Imiyalo yokusetshenziswa ibonisa ukuthi emva kokuthatha amaphilisi isisetshenziswa sabo esebenzayo siphume ngokuphelele futhi sisheshe sisuke emathunjini. Ukusetshenziswa kokudla akuthinti ukumunwa kwalesi sidakamizwa.

Ingxenye yokuphila yalesi remedy cishe izinsuku ezingu-7. Ngokudla njalo amaphilisi, ukuhlushwa kwengxenye yabo esebenzayo egazini kwanda izikhathi ezingu-10. Ngakho-ke, isikhathi eside sempilo yesidakamizwa senza ukuthi sikwazi ukuyisebenzisa kanye ngosuku.

Ukuxhumeka kwamaprotheni e-plasma kulesi sikhulu kuphezulu. It is intensively metabolized esibindi, okuholela ekubunjweni kokutholakala okungasebenzi.

Izinkomba

Isiphi isidakamizwa esithi "Bicalutamide" (amaphilisi) enqunywe? Imfundo yokusetshenziswa ibika okulandelayo:

• Umdlavuza we-prostate uvamile (osetshenziselwa ukuhlanganiswa ne-castration okuhlinzekwayo noma okufana ne-GnRH);
• Umdlavuza we-prostate uphuthukile endaweni yangakini (ngesimo se-monotherapy, ne-radiotherapy noma i- adjuvant therapy ngokuhambisana ne-prostatectomy eqinile);
• Umdlavuza we-nonmetastatic wesandulela ngculazi uphambili kakhulu (uma ukuhlushwa okuhlinzekwayo noma ezinye izindlela zokwelashwa ezingamukeleki).

Ukuvimbela ukusebenzisa ithuluzi

Uma ungaqedi umuthi "Bicalutamide"? Imiyalo yokusetshenziswa ibonisa ukuthi le mithi ayikwazi ukusetshenziselwa uma ifinyelela izithako zayo, ithathwe nge "Cisapride", "Terfenadine" noma "Astemizol", kanye nokuntuleka kwe-lactase, ebuntwaneni, ngokungahambisani ne-lactose, kwabesifazane Ubulili kanye ne-glucose-galactose malabsorption.

Ngokuqapha, amaphilisi anjalo anconywa umsebenzi wesibindi ongasebenzi kahle.

Isidakamizwa "Bicalutamide": imiyalelo yokusetshenziswa

Intengo yalo muthi iboniswa ekugcineni kwalesi sihloko. Thatha kufanele ibe ngaphakathi.

Lesi sidakamizwa sinqunywa kuphela kubantu abadala, kuhlanganise neziguli ezigugile.

Ngomdlavuza ophezulu we-prostate kuhlanganiswe ne-castration (ukuhlinzwa) noma i-analogue ye-GnRH, le mithi inconywa ukuthatha ama-50 mg kanye ngosuku.

Ukwelashwa nalesi sidakamizwa kufanele kuqalwe kanye nokwamukela i-analogue ye-GnRH noma i-castration (yokuhlinzwa).

Esikhathini somdlavuza we-prostate, imithi yokwelashwa yendawo yakhiwe 150 mg kanye ngosuku. Isikhathi sokwelashwa nalesi sidakamizwa kufanele sigcine okungenani iminyaka emibili.

Uma lesi sifo siqhubeka, ukuthatha amaphilisi kufanele kusimiswe.

Ngomsebenzi wokuqeda ukukhubazeka nokuphulwa komzimba kwesibindi, ukulungiswa kwesilinganiso akudingekile. Kubantu abanokukhubazeka okunzima nokulinganisela kokusebenza kwesibindi, ukukhuphuka kwe-bicalutamide kungase kuphawulwe.

Izenzakalo ezimbi

Zikhona yini imiphumela emibi ye-drug Bicalutamide? Imiyalo yokusetshenziswa ibonisa ukusabela okubi okulandelayo:

• I-Gynecomastia, "amathanga" egazini ebusweni, isisindo sezinsipho ezincelisayo;
• I-diarrhea, i-cholestasis, i-nausea, i-jaundice, inzuzo yesisindo, i-itching, i-alopecia, i-asthenia, ukungasebenzi kocansi, ukwehlisa isifiso sobulili;
• I-Angioedema, ubuhlungu besisu, izinyosi, i-stenocardia, izifo zamaphaphu ezingaphakathi, izi-arrhythmias zenhliziyo, ukucindezeleka, i-hematuria, i-dyspepsia;
• Ukuvuthwa, ukungakwazi kahle, isikhumba esomile, thrombocytopenia;
• Ukuqothulwa, ukwehluleka kwenhliziyo, i-anorexia, i-dysphagia, umlomo omile, i-flatulence, indigestion;
• Ukuzivocavoca, ukuphefumula, ukukhanda ikhanda, ukulala okukhulu, ukulala;

• I-nocturia, i-anemia, ukutheleleka kwamagciwane, ukugcinwa kwamanzi, i-dysuria, i-leukopenia, ukuvuthwa okuvamile, i-hydronephrosis, i-polyuria;
• I-Rash, i-hyperglycemia, i-sweating eyanda, umsebenzi okwandisiwe we-transaminases "yesibindi," i-hirsutism;
• Ubuhlungu esiswini, emuva, esifubeni, endaweni ye-pelvic, ukuvuvukala, ukwanda noma ukwehla kwesisindo somzimba, umkhuhlane, isifo sikashukela.

Izindleko zemithi kanye nezidakamizwa ezifanayo

Intengo yomuthi obuzwayo ingahluka kusuka kuma-pharmacy kuya kuma-pharmacy. Ngokwesilinganiso, izindleko zamaphilisi angu-30 (50 mg) we-Bicalutamide ahluka phakathi kwe-590 no-830 ruble iphakheji ngayinye. Lapho uthenga inani elifanayo lemithi, kodwa ngesilinganiso sika 150 mg kuzodingeka ukhokhe cishe ama-ruble angu-1100-1400.

Ngokuphathelene nezidakamizwa ezifanayo, zifaka imithi elandelayo: Bikalan, Casodex, Bikulid, Bilumid, Biculutera, Kalumid, Bicalutamide Kanon. Imiyalo yokusetshenziswa kwezidakamizwa ingase ihluke kuleyo yeBicalutamide. Ngakho-ke, khetha kuphela ochwepheshe onolwazi.

Ukubuyekezwa kochwepheshe kanye nabathengi mayelana nomuthi

Iningi leziguli zishiya izibuyekezo ezihle kakhulu mayelana nomuthi obuzwayo. Ngokombono wabathengi nabathengi, ukuthatha izidakamizwa ezibuzwayo kubangela ukuxolelwa okuqhubekayo.

Ngokuqondene nezici ezimbi, iziguli zibhekisela kuzo ukuba nenani elikhulu lemiphumela emibi. Ngokuvamile, ukuthatha imithi enjalo ngokuvamile kubangela ubuhlungu besisu, ubuthakathaka, i-jaundice nokuncipha kwe-hemoglobin. Ngaphezu kwalokho, amadoda amaningi kakhulu akhononda ngezindleko eziphakeme zamathebulethi. Njengoba kunikezwe ukuthi kudingeka bathathe okungenani iminyaka emibili, ukwelashwa komdlavuza wesi-prostate kuyabiza kakhulu.