Inhibitor Cholinesterase: ukusetshenziswa kwemithi

Kuyaziwa ukuthi isimiso sezinzwa has synapse eziningi. Ziyakwazi ezidingekile ukudluliswa inkanuko. Lokhu kuhilela izinhlobo eziningana ukuba balamuli. Phakathi kwabo, - .., acetylcholine, norepinephrine, Gaba, serotonin, njll balamuli (omoya) ayadingeka ukuze ukudluliselwa amasignali phakathi izinzwa. Ngaphezu kwalokho, ngenxa kubo lithwalwa excitation noma okusithiyayo ezicutshini. Ngo pathologies ezihlukahlukene kwemizwa umsebenzi uhlelo neurotransmitters okungenzeka ephulwa. Lokhu kwenzeka ngenxa izinqubo atrophic futhi esiwohlozayo ebuchosheni. Kulezi zimo, ukusebenzisa izidakamizwa kwadingeka kwezinhlelo yokukhulisa izwi noma attenuating isignali yokudlulisela. Ngu iqembu efanayo kwemithi kukhona cholinesterase inhibitor. Zisetshenziswa myasthenia, neuritis, yesifo sokuwohloka kwezinzwa nemisipha, isifo i-Alzheimer, pathologies zengqondo.

Umthelela cholinesterase inhibitor

inhibitor Cholinesterase - umuthi kabanzi lisetshenziswe Neurology kanye wezifo zengqondo. Basuke zihlukaniswe ngamaqembu eziningana, ngamunye okuyinto kusebenza endabeni ethile. Isenzo le mithi isinyathelo ekuvimbeni cholinesterase. Lokhu enzyme itholakala kokubili abantu abayimiqemane futhi labo abaphethwe yizifo ezihlukahlukene. Kuyadingeka ukuba ngivule neurotransmitter - acetylcholine. Ngenxa wesenzo Lidlulisela simfela choline futhi acetic acid. Ngo pathologies ezihlukahlukene yoma ubuchopho cortex kwenzeka kancane kancane. Ngenxa yalokho, ezinye izakhiwo kungenzeka lungasebenzi, kuhlanganise uhlelo cholinergic. Ngaphandle kobuchopho yoma, lokhu kuholela izinqubo esiwohlozayo sokuhlasela kwamasosha omzimba, esithathelanayo, nemvelo ezibangelwa amagciwane. Ngenxa lapho kubhujiswa lesi nuclei forebrain kukhona ukuntuleka evelele of neurotransmitter - acetylcholine. Inqobo nje uma kungenzeka wawumningi ketshezi, kubalulekile ukuthatha isinyathelo enzyme alibulale. Ngenxa yale njongo, lo cholinesterase inhibitor asetshenziswa. Siyabonga kubo, umsebenzi neurotransmitter kungase kuphikelele iminyaka eminingi.

inhibitor Cholinesterase: izidakamizwa ngezigaba

Kunezinhlobo eziningana izidakamizwa anticholinesterase. Basuke ihlukaniswa ngokweminyaka imiphumela kwemithi ku-enzayimu. Ezinye zazo zivimba cholinesterase engelapheki, abanye - okwesikhashana. Ukwabela 3 amaqembu ukuthaka imithi. Phakathi kwabo:

1. blocker emuva. Lezi inhibitor cholinesterase isinyathelo mkhosi postsynaptic. Siyabonga kubo, i-enzyme ibizwa okwesikhashana aphazamisekile. Leli qembu kuhlanganisa acridines futhi piperidine.
2. Psevdoneobratimye blocker cholinesterase. indlela yabo isinyathelo ngokuhlanganyela ingxenye onionovoy engqamuzaneni enzyme. Ngaphezu kwalokho, bayakwazi ukuhlanganisa uxhumano nomsebenzisi kwezinga receptor acetylcholine. Lezi izindawo iqembu carbamates.
3. inhibitor engelapheki ka cholinesterase. Leli qembu izidakamizwa eyaziwa ngokuthi Organo-phosphate izindlela. Umelele nomuthi "Metrifonate".

Iqembu acridines zihlanganisa "izindiza yenethiwekhi" izidakamizwa "Velnakrin". Abamele carbamates - imithi "rivastigmine", "Epistatigmin".

Izinkomba ngoba ukusetshenziswa cholinesterase inhibitor

Cholinesterase inhibitor asetshenziselwa ukwelapha izifo imisipha Lokudabuka emaphakathi, yoma futhi esiwohlozayo iziyaluyalu ebuchosheni. Ngaphezu kwalokho, eminye imishanguzo ayatholakala ngesimo amathonsi. Bewasebenzisa isigqugquzeli ingcindezi intraocular - glaucoma. Izidakamizwa ukuthi zivimbela cholinesterase esethola, wabonisa i ngokwelashwa komuntu olahlekelwa yingqondo, isifo Pick kanye Alzheimer. Oluthandwayo ukunikeza piperidine iqembu, ngoba abakhethayo futhi ube ayinayo imiphumela eminingi engemihle. Eminyakeni yamuva, i-izinkomba wokusetshenziswa kwezidakamizwa anda. Lokhu kungenxa isifundo eningiliziwe nezici zabo. Ukuze izifo lapho ebekiwe anticholinesterase izidakamizwa ahlanganisa myasthenia gravis, atony emathunjini, sokuwohloka kwemisipha, yesifo sokuwohloka kwezinzwa nemisipha, ukukhubazeka nemilenze imvelaphi esiwohlozayo. Engelapheki inhibitor asetshenziswa uma ubuthi.

Izimo ukusetshenziswa cholinesterase izidakamizwa

Imithi kuleli qembu alisetshenziswa iziyaluyalu convulsive, hyperkinesis kwanoma iyiphi omsakazo. Babuye contraindicated in iziguli ukuhluleka kwenhliziyo okukhulu, isifuba somoya, thyrotoxicosis. Kuyinto engathandeki ukuthatha anticholinesterases nge concomitant isilonda esiswini, enteritis. Imithi awaboniswa kwabesifazane abakhulelwe kanye lactating.

inhibitor Cholinesterase: kukhethwa izidakamizwa ngoba isifo i-Alzheimer

Alzheimer - kuyinto CNS atrophic, lapho kukhona ukulahlekelwa amandla okukhumbula, ubuntu isiyaluyalu nayo komqondo. Ososayensi emhlabeni wonke ukuthi uzama ukuthola ikhambi lesi sifo. Ngezinye kobukhulu okuncane noma okusesilinganisweni lesi sifo Isidakamizwa lokuzikhethela "donepezil". Libhekisela esethola cholinesterase inhibitor, kunomphumela zikhethe. A imithi esetshenziswa ngenjongo yokwelapha pathogenetic. Akayena lokukwazi ukwelapha ngokuphelele isiguli, kodwa siyehla ukuthuthukiswa izimpawu Alzheimer.