Collagen - kuyini? Izimpawu, ukuxilongwa kanye nokwelashwa kwezifo

ukuxilongwa "kuyi-collagen" ngokuvamile atholakala imithi yesimanje. Kuyini lokhu? Eqinisweni leli gama iletha inqwaba izifo ezahlukene ukuthi babe ngento eyodwa - izinguquko ezicutshini, ezifana collagen fibrinoid izilonda.

Yiqiniso, iziguli ukuthi nginesifo "izicubu letindzala zezinzwa" ushayela ku isidumo. Ngakho lokuqala kufanele ufunde kabanzi mayelana nalezi zifo kanye nezici zabo. Yikuphi izifo afakiwe eqenjini sezicubu zezinzwa? Yiziphi izinjongo zazo? Yiziphi izimpawu kufanele sinake? Ngingaba ukuqeda izifo collagen phakade? Yini izibikezelo ukunikeza odokotela? Izimpendulo zale mibuzo athungatha abantu abaningi.

Collagen: kuyini?

ezicutshini is ukuba uhlobo zokwakha ukuze umzimba ezaziwayo. Ngokwesibonelo, it yakha lwamathambo kanye isikhumba womuntu, isitsha igazi izindonga stroma kwezitho zangaphakathi, futhi igcwalise interstices phakathi izakhiwo ezahlukene. Kuyinto lokhu Indwangu, futhi ngaphezu kwesigamu isisindo emzimbeni womuntu. izakhi zezinzwa imisebenzi eziningana ezibalulekile, kuhlanganise trophic, ovikelayo kwesakhiwo, ukwesekwa kanye plastic. Kuyinto zezinzwa izifo izicubu kuhlangene, igama elithi "i-collagen".

Kuyini lokhu? Lokhu iqembu pathologies anezici ezivamile futhi indlela yentuthuko. Lesi sifo eba phezu zangokwasemuva zezinhlelo ukwephula homeostasis omzimba bese ahambisana fibrinoid collagen izinguquko.

Izinhlobo izifo collagen

imithi yesimanje ezihlukahlukene collagen ezaziwayo. ngezigaba kwabo kusekelwe umsuka sifo. Ngokwesibonelo, ehlasela umzimba zezinzwa izicubu isifo kungenzeka azalwa nako. Leli qembu kuhlanganisa Stickler syndrome ne-Marfan futhi mucopolysaccharidoses futhi osteogenesis imperfecta. Izimpawu zazo zivame ukuvela ngisho utero.

Kukhona futhi izifo atholwe abonisa emva kokuzalwa - ngezinye izikhathi ebuntwaneni noma sobusha, futhi ngezinye izikhathi ngisho sengimdala. Lokhu pathologies iqembu zihlanganisa vasculitis letindzala, skerodermiyu, i-rheumatoid arthritis, rheumatism, eozinovilny fasciitis, periarteritis nodular, nabanye abaningi.

Ziyini izimbangela eziyinhloko zalokhu yesifo

Ezimweni yesifo azalwa naso ezihlobene ne izifo ezibangelwa ufuzo kokudla collagen isakhiwo. Njengoba yamafomu atholwe lesi sifo, kunesizathu kungaba zahlukahlukene kakhulu, futhi ukutadisha indlela zokugula namanje kuyaqhubeka.

Ososayensi oyikholelwayo ukuthi ifa ezithile zofuzo has cishe kubo bonke. Kodwa lesi sifo kungase kubangele ezicini eziningana. Ngokwesibonelo, kuvame ukuqala Ukungena emzimbeni izifo ezibangelwa amagciwane kanye ezibangelwa amagciwane, kuhlanganise amagciwane mumps, i-herpes, rubella, isimungumungwana, nokunye. D.

Izimbangela zingase zibe yokwanda kwama-hormone ezenzeka phakathi nesikhathi sokuthomba sokukhulelwa kwabadala, isisu nokunye. D. Kukhona nezinye izici ezibangela isifo eba. Collagen kungenzeka ukugqashuka ngumuntu ukucindezeleka eqinile, ukuhlukumezeka, ukuphatha izidakamizwa, undercooling eqinile, insolation. Ngezinye izikhathi lesi sifo eba ngemva ngokugoma.

I pathogenesis lesi sifo

Naphezu ukuhlukahluka leli qembu izifo, cishe kubo bonke, a zokugula eba kule scheme efanayo. Lapho imiphumela wesici, ukuzwela kwesimiso somzimba sokuzivikela ezifweni, okuholela kwetinhlavu ethize amaprotheni izakhiwo, abese imali kwi nolwelwesi serous futhi lwamalunga, ulwelwesi izitsha. Ukuba khona izakhiwo mzimba kuphakamisa yisishiso iguliswa ka kwezicubu. Ngakho, uhlelo umuntu sokuzivikela iqala ukuhlasela izicubu ayo zezinzwa.

Against isizinda izinqubo ngenhla echazwe izinguquko waphawula sokugembula kwezicubu. Yiqiniso, nohlobo zezinzwa izicubu isifo ngasinye inezici ezithile. Ngokwesibonelo, e-scleroderma sokuhlasela kwamasosha omzimba ukuvuvukala kuthinta izicubu isikhumba nezicubu ongama, futhi elinesimo izitsha nodosa ushintsho periarthritis.

Collagen: isithombe kanye jikelele isithombe emtholampilo

Kuyini isithombe emtholampilo? Yini izimpawu ahambisana collagen? Izimpawu Yiqiniso, ngeke ifane ngokuvumelana ezihlukahlukene isifo nendawo ukuvuvukala. Noma kunjalo, ezinye izici ezivamile zingatholakala.

Isiguli has a eziphikelelayo imfiva kuze kube degrees 38. Iziguli esekhala Ukugodola futhi ukujuluka ngokweqile. Kukhona ubuthakathaka futhi kwehle ukusebenza. Cishe noma yimuphi collagenosis ifomu eba ngokuhlanganyela kanye imisipha syndrome, esibonakala by ubuhlungu bamalunga, myalgia futhi arthralgia. ukusabela Ngezinye izikhathi nomzimba, ukubukeka ukuqubuka kwesikhumba, ubuhlungu besisu, dyspepsia.

Periarteritis nodosa kanye nezici zayo

Collagen ahlukahlukene ngokwemvelo, ngakho-ke kuhle ukucabangela izinhlobo ejwayelekile kakhulu futhi ezisindayo. Periarteritis nodosa libhekene izilonda zonke izingqimba ezintathu odongeni isitsha. Ukuvuvukala abathintekayo cishe zonke izitsha emzimbeni.

Izimpawu zincike onjani ekhipha igazi enhliziyweni nelifakayo bamangala. Uma kuziwa izitsha izinso, iziguli isaziso wokuqala ubuhlungu, ukuphazamiseka outflow umchamo. ISidlo nomfutho wegazi ophezulu kanye ukwehluleka okuqhubekayo kwezinso. Lapho ukuvuvukala Imithambo cerebral igazi e isiguli ukuthuthukisa kwempilo yengqondo. Ikota kweziguli periarthritis nodular waphawula somoya.

Omzimba izicubu erythematosus

Omzimba izicubu erythematosus - letindzala izicubu ezinzima zezinzwa. Kuyini lokhu? Lokhu isifo, okuyinto kuhambisana izilonda ephelele cishe zakho konke izinhlelo isitho. Vela esikhumbeni ngokubomvu ukuvuvukala foci (ebusweni, banayo indawo isici kakhulu izihlathi kanye nekhala ungathi IZIMPIKO zovemvane).

Kukhona ukulahleka izinwele nezinzipho, nolwelwesi lwamafinyila avele isilonda nokuguguleka kwenhlabathi. Ukuvuvukala kuhilela emalungeni encane. Lesi sifo kuhambisana iziyaluyalu amasistimu senhliziyo zokuphefumula. zokugula kwezinso ebuka futhi ukubonakala izimpawu zokungasebenzi kahle kwemizwa.

scleroderma letindzala

Scleroderma - esinye isifo sokuhlasela kwamasosha omzimba lapho ukuvuvukala zithinta isikhumba, izicubu ongama, kwakheka imithambo yegazi neuropathy, amalunga nemisipha. Kulokhu, izimpawu ezisobala kakhulu izinguquko isikhumba nje. Okokuqala, kukhona ukuvuvukala kwesikhumba. Dermis iba ugodo noma, kungenjalo, obomvu. In the isinyathelo sesibili ukuvuvukala isifo siba obukhulu kakhulu, isikhumba bushelelezi isiguli futhi yomile ukuvuvukala kwamiswa kwezicubu iyini imbangela yalokho.

Isinyathelo sesithathu sihambisana yoma of isikhumba nezicubu ongama. Umzimba womuntu isiguli iphelile, iminwe kancane kancane zikhubazekile, ubuso uthatha uhlobo buso ngenxa ukunyamalala sobuso.

Inqubo zokuxilonga

Indlela ukuhlola isifo izicubu? Ukuhlulwa imizimba ehlukahlukene ephelezelwa ukuvela izimpawu ezithile kakhulu, futhi eveza ukunakwa onguchwepheshe ukuxhumana isiguli kanye anamnesis. Ngokulandelayo, elibamba ezihlukahlukene ukuhlolwa laboratory. Ikakhulu, i-igazi nesineke womuntu sihlolelwe khona izimpawu ze-non-eqondile ukuvuvukala, okuwukuthi fibrinogen amaprotheni C-esisheshayo, alpha-2-globulin. Njengoba ucwaningo olwenziwa e khona umzimba nakomaka immunological ukuthi acace ngayinye isifo ngabanye.

Ngokuvamile, ukuze ahlaziye ngokugcwele ngezimo zesiguli, a biopsy wenziwa. Ukuthatha amasampula ukuze uyihlaziye kwemisipha izicubu, isikhumba, izinso, synovium ngokuhlanganyela.

Kukhona namathuluzi okucwaninga ukuze lisize izifo ezifana kuyi-collagen. Sifo kuhlanganisa-X-ray Ukuhlola emalungeni namathambo. In the izithombe udokotela zingabuka izici ezithile zezinzwa izicubu zempilo, kuhlanganise kwamathambo, izinguquko articular evele futhi necrosis aseptic ukuvala ukuqhekeka ngokuhlanganyela nokunye. D.

Njengoba ngokuvamile collagen kuhambisana izilonda zangaphakathi kubalulekile njengoba ultrasound esiswini, izinso, ingaphakathi pleural wenhliziyo (echocardiography). Ngaphezu kwalokho babelwe ikhompyutha noma resonance kazibuthe tomography, okuvumela ukuba ahlole isimo umzimba, kanye umonakalo odalwe izibilini skeleton.

imithi yezifo collagen

Yikuphi yokwelapha zidinga collagen? Ukwelashwa kwezifo of leli qembu kumelwe nakanjani babe eziyinkimbinkimbi. ukwelashwa uhlelo senziwa ngamunye, njengoba incike kundlela kanye nesigaba lesi sifo, khona izifo concomitant, ubudala lesiguli.

Kusukela kollagenozah waphawula ukuvuvukala zezinzwa izicubu izakhiwo, iziguli lokuqala kuyabekwa izidakamizwa eqeda ukuvuvukala. Ngo kusaqalwa yentuthuko imithi eminye esebenza ngempumelelo non-steroidal, ikakhulukazi labo aqukethe ibuprofen.

Kulezo zimo, uma isifo siqhubeka ngokushesha okukhulu, kule scheme yokwelapha iqondiswa glucocorticosteroids, has a izakhiwo evelele eqeda ukuvuvukala. Ngokuvamile wasebenzisa "prednisolone" (umthamo sangemihla is hhayi ningi than 15 mg).

Imiphumela emihle etholakala ngokuzikhandla ngemithi cytotoxic ( "Azathioprine", "Tsiklofofamid"). Ukuphathwa kanjalo iqondiswa uma steroid enganikanga umphumela oyifunayo noma kubangelwa ukusabela kabi komzimba ezingezinhle.

Ukwelashwa lesi sifo acute kwenziwa esibhedlela. Iziguli esibhedlela kuphela emva uzokwazi ukubhekana kangcono nale izimpawu eziyinhloko. Kubalulekile ukuba banamathele imodi efanele emsebenzini kanye nokuphumula, kanye balandele yokudla, hhayi kuphela e-acute kodwa kukho konke ukuphila.

Ezinye izindlela ukwelashwa

Yiziphi ezinye izindlela zokwelapha ezivamile zidinga collagen? Ukwelashwa kuyadingeka hhayi kuphela e-acute kodwa ngesikhathi isihlobo inhlalakahle umzimba. Ukuze kancane ukuqhubeka kwesifo, hemocorrection wasebenzisa izindlela, e hemosorbtion ethile futhi plasmapheresis. Ezinye iziguli batuse athole ukwelashwa komzimba. Izimo zethu zihluke kakhulu imiphumela emihle ingatholakala ngokusebenzisa izifundo evamile ye magnetotherapy, iontophoresis, phonophoresis.

Ngo-rheumatoid arthritis namanye izifo kungaba wusizo umsebenzi zokwelapha, ezosiza ukugcina ukuhamba evamile. Iziguli belulekwa ukuba njalo ukwelashwa spa ezikhungweni elihambisana iphrofayli. Kwezinye izifo collagen nomphumela omuhle kunikezwa Radon, hydrogen sulfide ne-ne-carbon dioxide nokugeza. Yiqiniso, le mishanguzo kufanele kunqunywa udokotela kuncike zinhlobo isifo, yobudala kanye nesimo umuntu ogulayo.

Izinyathelo futhi izibikezelo iziguli

isifo collagen (noma iyiphi inhlobo yayo) libhekene lesichubekako, Yiqiniso ezingamahlalakhona. yokwelapha izidakamizwa kwenza kube nokwenzeka ukuba sinciphise ukubukeka kwalesi sifo futhi bafinyelele kancane ukuthethelelwa ngaphezulu noma eside. Nokho, ukuyeka ngokuphelele lesi sifo cishe kungenakwenzeka. kuyingozi ngokukhethekile yizihloko collagen letindzala, okuyinto ngokuvamile bagcina ukuthuthukiswa zokuphefumula oyingozi noma ukuhluleka inhliziyo.

Ukuthatha amahomoni immumodulyatorov ngokuqinisekile kubalulekile. Kodwa iziguli kufanele ukuqapha isimo sezempilo futhi athethelelwe, njengoba lokho kuyosisiza hlehlisa okubi kakhulu entsha. Iziguli kufanele belulekwe bakugweme kakhulu ukuchayeka kubo nezici ayeke ukunisa, noma ngabe lilethwa ukucindezeleka eqinile futhi ukuphazamiseka kwama-hormone noma hypothermia ezinzima futhi ukuzichaya elangeni. Ephambi kwezinduna yisiphi isifo esithathelwanayo, ngokushesha afune usizo lwezokwelapha. Foci ukuvuvukala ezingamahlalakhona futhi kufanele ukunqotshwa yokwelapha ezanele.