Alpha-fetoprotein ezimweni ezivamile futhi sokugembula

Alpha-fetoprotein sisetshenziselwa izinto wamaprotheni imvelaphi okuyinto ikhiqizwa womthubi umbungu emva kokuzalwa - e ipheshana wokugaya ukudla bese kumaseli isibindi. Ngokuvamile, kuqukethwe umzimba 15 ng / ml.

Alpha-fetoprotein kunqunywa ngesikhathi sokukhulelwa ukuxilonga ukukhubazeka umbungu. Siyobona isicelo kwencazelo inkomba kanye in Oncology. Alpha-fetoprotein kuyinto oncomarker nomdlavuza wamasende futhi isibindi. Cishe ngo-70% amadoda nge izimila wamasende liphakeme, ikakhulukazi inqubo Ukudlulela.

Ekuqaleni, kuba into amaprotheni kuhlelwe ezikhiqiza amaqanda, luteum Corpus. Esikhathini Ngesonto yesihlanu, i-fetus iqala ukukhiqiza yayo. Alpha-fetoprotein ivikela umbungu kusuka izivikeli mzimba kamama, ngoba yena eyisidalwa esinenkululeko angaphandle.

okuhlushwa Its anda ngokulingana njengoba igazi embungwini igazi kwabakhulelwe. Inani kahle lokhu ipharamitha ukuze kuhlonzwe - uma sebehlanganisa amasonto angu 12-16. Eemvekeni ezi-32-34 yokukhulelwa ufinyelela ezingeni enkulu-alpha-fetoprotein. kuyinsakavukela yomuntu ephile kufinyelelwa onyakeni wokuqala wokuphila.

izindlela Ucwaningo kakhulu ezithinta kwencazelo inkomba. Ngokuvamile wamukele ukuqokwa kwezinso alpha-fetoprotein kwaba kaningi imidiyeni (umama). Imidiyeni inombolo phakathi i amagugu ngaphambilini wamaprotheni lokuhlushwa ekukhulelweni ngendlela evamile ngemva nje leli gama. Ngakho, enye ungaqhathanisa ukukhulelwa-alpha-fetoprotein emazingeni ahlukahlukeneko, futhi ihlaziya wenza laboratories ezahlukene. Amazinga yalesi Inkomba kusuka 0.5 kuya 2.5 umama ijwayelekile.

Ukwandisa AFP kungaba inkomba:

• Izimila ze- bronchi.
• Isibindi metastases.
• Umdlavuza esiswini, amanyikwe, iphaphu, isibindi, ikholoni, webele.
• wamasende embryonic ne izimila wesibeletho.

Okwesikhashana futhi lake anda-alpha-fetoprotein ku pathologies ezilandelayo:

• Isibindi sibe sesomile,
• yokwehluleka kwesibindi Ezingalapheki,
• Ukuphuza ngokweqile khona ukulimala kwesibindi,
• Okungalapheki noma sibi isifo sokusha kwesibindi kohlobo ezibangelwa amagciwane.

Lesi sibalo lenyuka ngesikhathi sokukhulelwa livela kulezi zimo ezilandelayo:

• nokukhulelwa izingane eziningi ngasikhathi.
• isifo so-renal ku-fetus.
• hernia enkabeni ku-fetus.
• Kwengane isibindi necrosis.
• Kombungu neural tube (rahishizis, anencephaly).
• Emfantwini odongeni phambi esiswini umbungu.
• Okunye kombungu.

Nokho, encishisiwe-alpha-fetoprotein ekukhulelweni kungase kubonise okulandelayo:

• sokukhulelwa Amanga.
• ukubambezeleka zokuThuthukisa.
• ukufa kwengane.
• sokukhulelwa izinyo lomhlathi.
• Ukuphuma kwesisu okuzenzekelayo.
• Trisomy chromosome 18 noma 21.

Ubuningi encishisiwe ye-alpha-fetoprotein kungase kubonise i ukuzimisela engalungile isikhathi yokukhulelwa, okungukuthi, ukukhulelwa kwenzeka kamuva.

Ngo zabesifazane ngesikhathi esiteji samanje eyinhloko asebenzayo inkomba marker fetus chromosomal iziyaluyalu kanye pathologies yokukhulelwa. Ngeziphambeko kusukela ukuthuthukiswa evamile fetus ukushintsha lokuhlushwa evamile wamaprotheni izinto egazini likamama. Yiqiniso, kufanele kube hhayi kuphela kwencazelo le nkomba, njengoba kuba ulwazi. Ngempela kudingeke aqhube ultrasound izifundo, okwenza kube lula ukuqinisekisa incazelo efanele yokusetshenziswa kwegama elithi, nokukhulelwa izingane eziningi ngasikhathi nokunye. Futhi, kubalulekile ukukhomba futhi hormone esinomhlapho (chorionic gonadotropin futhi estriol khulula), ukuvumela ukuhlolwa olunembile uhlelo fetoplacental. inhlanganisela yabo nge-alpha-fetoprotein ichazwa isivivinyo kathathu okuvumela ukunquma ingozi ezihlukahlukene kombungu ku-fetus.