Acute wegazi myeloid

Acute wegazi - isifo kohlelo hematopoietic, esekelwe - ekwandeni angenamkhawulo isimila cells, okuyizinto substrate yayo morphological. Acute wegazi myeloid ku Fab ngezigaba sehlukaniswe eziyisikhombisa ongakhetha. Ngesisekelo ngezigaba - ezingeni yokuzihlukanisa kwamangqamuzana ngokwemisebenzi yawo kwamaseli emelela wegazi substrate. isimila Myeloblasts Clone lisuselwa stem cell, akwazi amakoloni ezikhulayo inani myeloid amaseli, megakaryocytes, erythrocyte, ama-macrophage.

The njalo kunazo waphawula yokwahluka M0-M3. Ngesisekelo nabantwana bami ababili bokuqala - amaseli ngaphandle kwamangqamuzana. differentsirovanokletochny - M2 inketho. M3 samuntu promyelocytic libhekene amaseli angavamile ukuba okusanhlamvu giant. M4 futhi M5 - wegazi myeloblastic futhi monoblastny. M6 - erythromyelosis, nge ekwandeni anda amaseli erythroid. M7 - wegazi megacaryoblastic. Kuzo zonke ongakhetha, okuyinto ethulwa nge acute wegazi myeloblastic, onalesi sifo sisihle kakhulu lapho M0-M2.

etiopathogenesis wegazi

Kuyini acute wegazi myelogenous. Lesi sifo - ekuthuthukiseni ikhono amaseli ukuze ukuguquka kwezakhi zofuzo ngenxa isenzo izici zangaphandle (kwemisebe, amagciwane, ikhemikhali) kanye nezici ezithile ukuze ukuntengantenga kwezakhi zofuzo. Lokhu kuphumela isimila cells uyakwazi division angenamkhawulo. Bakha Clone okuyinto yena, ukuguquka kwezakhi zofuzo ngokuphindaphindiwe kuphakamisa subclones.

Isimila maseli ngokuqhubekayo akhiqizwa umnkantsha, futhi wonke umuntu ephoqeleka elimazayo evamile lwegciwane hematopoiesis. Ngokuhamba kwesikhathi, bagcina ukuya igazi neuropathy iyakhula kwezitho, ukwakha foci ezingeziwe hematopoiesis ongaphilile. Ukuthuthukisa wegazi myeloid nge isici isithombe emtholampilo ngaye.

Umtholampilo acute wegazi myelogenous

Ngenxa ukuphazamiseka hematopoiesis evamile in iziguli kwegazi, isibalo neutrophil ovuthiwe nama-platelet incipha ngokucijile. isiyezi ekhathazekile. ubuthakathaka. Zikhona izimpawu ukopha: nokopha esikhumbeni futhi lwamafinyila ulwelwesi, kukhuphuke ukopha esesikhathini, umongozima. Ubuhlungu amathambo, evuvukele zamanzi bezinhlanga ezahlukene. ubende Ukwandiswa futhi isibindi. Ngenxa iziyaluyalu umsebenzi leukocyte, ukunciphisa amasosha omzimba acute myeloblastic wegazi notshwala ukubusa izifo. wayevame ububonisa angina ezinzima.

Ezigabeni kamuva anganezelelwa izimpawu nokwehluleka ukusebenza kwezinso futhi izimpawu zokungasebenzi kahle kwemizwa.

Ngo flow yayo acute wegazi myeloblastic ubabonisa isinyathelo ukubonakaliswa efakwe, ukuthethelelwa, kokushelela. Endabeni ukwelashwa ayizwakali igcina esigabeni esigungwini. Nesigaba lesi sifo libhekene izimpawu zokwelashwa ezithile futhi igazi isithombe futhi umnkantsha.

ukuxilongwa wegazi

Acute wegazi myeloid senziwa izifundo cytochemical amaseli emelela substrate futhi immunophenotyping yayo - sokunquma nakomaka myeloid. izindlela morphological ngenxa ukuthola kuqhuma amaseli ekutholeni uhlobo lomdlavuza wegazi unikezwa i value eyabonisa, yize angaqhubeka ejabulela.

Ngezinye izikhathi asetshenziswa izindlela genotypic esekelwe polymerase chain reaction. Isetshenziselwa ukucacisa ukubonakaliswa asalile lesi sifo iziguli ukuthethelelwa.

Acute myelogenous wegazi Izibikezelo ezingenawo la mathuba kuka onalesi sifo ka-acute wegazi lymph. Kufika 75% eziguli nge ukwelashwa okufanele izuzwe ukuthethelelwa. Kunobufakazi sokuphulukiswa 20% ukuthethelelwa kwafezwa baqhubeka ukwelashwa egumbini labagula kakhulu. Imiphumela ekhuthazayo etholakala umnkantsha transplantation.