"Z-isici": ukubuyekezwa, yokusetshenziswa, imiphumela emibi

Medicine "Z-isici" imfundo manual ichaza njengendlela-antibiotic bacteriostatic okuqondene iqembu macrolides, azalides. Umuthi has a spectrum ezibanzi yesenzo imithi elwa nawo. Mshini womsebenzi elihlobene ne-ukucindezelwa wamaprotheni zamagama kumaseli microbial, kanjalo uvimbele ukukhula nasekuvezeni izithombo zaso ezintsha zama-bacterium. Ama-antibiotic "Z-isici", ukubuyekezwa iziguli kanye nezifundiswa ngokuvamile omuhle, ngempumelelo yokulwa intra- futhi extracellular Gram-negative futhi Gram-HIV futhi abanye anaerobic eziphilayo. Khonamanjalo Amagciwane kungaqalisa kube simelane nokuhlaselwa nomuthi noma ukuthola le ukumelana ngesikhathi ukusetshenziswa kwezidakamizwa.

izakhiwo pharmacokinetic

ingxenye Active zomuthi "Z-isici" imfundo manual ngokuthi azithromycin. It is amuncwa kahle emzimbeni isakazwa ngokushesha. Ngemva umthamo owodwa we angu 500 kusho bioavailability singamaphesenti angu 37, emva amahora amabili noma amathathu e-plasma kudalwa emakamu eliphakeme - 0.4 angu ilitha. Medicine "Z-isici" lingena ulwelwesi cell futhi uyiswa isayithi ukutheleleka phagocytes, lapho khona i-ejenti ikhishwe. I nomuthi sihamba kalula gistogematicalkie izithiyo. Ngo ezicutshini futhi amaseli lokuhlushwa kayishumi mahlanu kunakunoma ebonwe plasma, ngesikhathi esifanayo umthombo ukutheleleka ivuliwe isilinganiso 24-34 angu kunaleyo izicubu zomzimba eziphilile. Kwake kwathi ngo-isibindi, isidakamizwa demethylated, ngaleyo ndlela alahlekelwe umsebenzi. Lapho ethola azithromycin e lokuhlala zokwelapha wasigcina umzimba izinsuku ezinhlanu nesikhombisa, etholakala amathumbu ikakhulu njengoba yayinjalo (amaphesenti angu-50) kanye nezinso (amaphesenti 6).

izinkomba ngoba

A nomuthi ngempumelelo e zezifo ezithathelwanayo namakhambi ukuvuvukala okubangelwa nezilwanyana ezincane ekuthonyweni izidakamizwa. Ngakho, nomuthi isetshenziswa "Z-isici" ku itheku, sinusitis, namathansela, abezindaba otitis, pharyngitis nezinye pathologies ka engenhla ipheshana zokuphefumula bese engenhla ipheshana zokuphefumula. Akunikeze imithi futhi yezifo aphansi ipheshana zokuphefumula: ukucinana kwemigudu yokuphefumula, inyumoniya, kuhlanganise nalezo okubangelwa amagciwane atypical. Ukusetshenziswa kwezidakamizwa "Z-isici" yokusetshenziswa Kunconywa ezithambile izicubu izifo, isikhumba: dermatoses, Erysipelas, impetigo; izifo of ngomgudu womchamo: cervicitis, urethritis.

ukukhululwa Ifomu

Umuthi ikhiqizwa ngesimo amaphilisi kanye amaphilisi. Tablets "Z-isici" we-lenticular wangakwesokunxele, oblong, embozwe ukukhanya igobolondo pink. Valium zahlanganiswa ngo amaphakethe of ezintathu. Amaphilisi Abonayo asemhlophe, kanzima, gelatin; okuqukethwe - inhlanganisela ibe ngumsizi granules. Zahlanganiswa ngo-6 noma 10 ku amabhamuza metering.

isakhiwo

Kokunye ithebhulethi isithako asebenzayo - azithromycin (ifomu dihydrate) - elikhona imali angu 500 capsule ngayinye futhi - 250 angu. Njengoba asekelayo izingxenye lichaza ekwakheni izibhebhe esetshenziswa povidone, magnesium stearate, dihydrate calcium phosphate, sodium lauryl sulfate, crospovidone, talc, ama-titanium dioxide, obomvu acid udayi, hydroxypropylmethylcellulose, polysorbate. izinto yesibili ehlanganisa amaphilisi isinyathelo corn isitashi, sodium lauryl sulfate, methyl parahydroxybenzoate, ubisi noshukela, acetic acid, laktopress, aerosil, magnesium stearate, povidone, ama-titanium dioxide, gelatin, futhi propyl parahydroxybenzoate.

Izici isicelo, umthamo

Umuthi kumele kuthathwe ngomlomo kanye ngosuku, ihora elilodwa ngaphambi kokudla noma amahora amabili ngemuva. Ukuze izifo yaleli pheshana yokuphefumula, engenhla izitho zokuphefumula, izicubu zomzimba ezithambile nesikhumba linqume umthamo zonke izinsuku we-500 mg, therapy is kwaqhubeka izinsuku ezintathu. Inkambo yokwelashwa ka erythema migrans okulandelayo: ngosuku lokuqala ukuthatha 1000 mg, kusukela yesibili ngosuku lwesihlanu - mg 500 nsuku zonke. Ngo ayinzima cervicitis urethritis kube mono- noma ukuthatha 1000 mg zomuthi. Iziguli ngokulinganisela ukusebenza kwezinso, ukulungiswa umthamo liyadingeka.

Imiphumela engemihle. Izibuyekezo

Of okuvela ukusabela ezingezinhle ngemuva kokuthatha izidakamizwa, "Z-isici" kukhona izimpendulo ezahlukene. Kaningi, iziguli esekhala nohudo, ukucanuzela kwenhliziyo, ukuhlanza, ubuhlungu besisu, ukuqunjelwa, ukozela. Ezinye iziguli ukubika imiphumela emibi njengokuba nesiyezi, amajaqamba, nekhanda. Ngo ezingavamile amacala hyperactivity, uvalo, tinnitus, izinkinga kokuzwa, bezibona kahle iphunga nokunambitheka. I yokusetshenziswa phakathi kungenzeka side effects efakwe futhi ezifana paresthesia, asthenia, sokuzincisha ukudla, nesifo pseudomembranous, necrosis hepatic, arrhythmia, ukuntuleka kwegazi emzimbeni, nephritis, neutropenia, lezinkinobho, arthralgia, photosensitivity, angioedema, isifo sokusha kwesibindi, ezinobuthi epidermal necrolysis, erythema multiforme . iziguli ngamunye ukukhombisa "Z-isici" livela khona, ubudlova nokukhathazeka emva ukudla izidakamizwa. Ukubuyekeza, phakathi kwezinye izinto, aqukethe ulwazi ngalokho izidakamizwa ungakwazi avuse ushintsho ngolimi umbala, ukuqunjelwa, ukuqubuka kanye ukulunywa.

Izimo

Ungayisebenzisi abantu nomuthi nge hypersensitivity kuya macrolides nge kanzima kahle izinso umsebenzi / isibindi. Izidakamizwa "Z-isici" ezinganeni kuze iminyaka eyishumi nambili akuyona esimisiwe. Futhi, musa ukuthatha izidakamizwa ukuze abesifazane esikhathini lactation, kanye dihydroergotamine futhi ergotamine amakhulu, iziguli ezinemishini lactase ukuntuleka kwamavithamini, ukungezwani a ukungabekezelelani kwezakhi galactose malabsorption glyukozogalaktoznoy. Okumele kuqashelwe ebekiwe imithi kubantu abaphethwe iziyaluyalu sibi kwezinso / hepatic, arrhythmia noma nezici ezithile nalokho. Ngo ekhulelwe, izidakamizwa isetshenziswa kuphela uma inzuzo elindelekile ukuba unina mkhulu sengcupheni sokuthuthukiswa umbungu.

ukweqisa izidakamizwa

Nohudo, ukucanuzela kwenhliziyo, ukuhlanza angagcina uma ethola ngemithamo ngokweqile ukulungiswa "Z-factor." Izibuyekezo abantu afakaze ukuvela kwalesi uphawu njengoba ukulahlekelwa okwesikhashana ekuzweni. Ngo ukweqisa izidakamizwa iqondiswa yokwelapha lingaze.

Ukusebenzisana neminye imithi

Antacids ukunciphisa ngamaphesenti angu-30 lokuhlushwa azithromycin e-plasma, ngakho nomuthi "Z-isici" Kumele kuthathwe okungenani ibe ihora elilodwa ngaphambi noma amahora amabili ngemuva ukusetshenziswa kwalezi izidakamizwa nokudla. Lokuhlushwa e-plasma didanosine, methylprednisolone, carbamazepine, rifabutin, lapho lusetshenziswa ndawonye, azithromycin ayiphazamiseki. Nokho, asikwazi ngakususi umphumela wawo lokuhlushwa cimetidine, indinavir, triazolam, i-fluconazole, midazolam, efavirenz, trimethoprim. Uma ufuna ukusebenzisa imithi, "Z-isici" kanyekanye ne cyclosporine noma digoxin, kubalulekile ukuqapha plasma esidlule, futhi lapho asetshenziswe kanye warfarin Kunconywa ukuqapha ngokucophelela isikhathi prothrombin. ukuphatha ngesikhathi esisodwa terfenadine futhi azithromycin kungabangela arrhythmia, kanye kwelulwa isikhawu qt.

Izixwayiso

Uma isiguli ukhohlwe ukuphuza imithi, kumele athathe umthamo aphuthelwe ngokushesha ngangokunokwenzeka, kanti elandelayo - ne esingaba usuku (amahora angu-24). In the ukwelashwa nge azithromycin, kanye ukuqaliswa noma iyiphi indlela yokwelapha ngemithi elwa namagciwane, kukhona ingozi superinfection ukubusa, kuhlanganise fungal. Ukuze ekwelapheni namathansela kanye pharyngitis kubangelwa Streptococcus pyogenes, futhi nokuvikela fever rheumatism ngokuvamile ebekiwe penicillin akuzange kusize. Kufanele kuqashelwe ukuthi azithromycin siyasebenza ezifweni streptococcal, kodwa asifanele nokuvimbela imfiva rheumatism.

"Z-isici" izidakamizwa. analogs

Ngavele kumelwe bathi kusho "Z-isici" akulona izidakamizwa yasekuqaleni. Ingabe izidakamizwa yasekhaya ejwayelekile "Sumamed", ithuthukiswe 1980 ngochwepheshe we Croatian ezithaka imithi inkampani "Pliva". Kuze kube manje, ukudayiswa baningi analogue "Sumamed": ngaphezu izidakamizwa "Z-isici", bahlanganisa izidakamizwa ezifana "Azitroks", "Hemomitsin", "Azitsid", "Sumatrolid soljutab", "Zitrolid", " azivok "," safocid "," Azitral "," Sumamoks "," Sumametsin "nabanye. Ngakho kukhona umehluko yokuthi ukwamukela: ejwayelekile "Z-isici" noma "Sumamed", okuvamise ukuthi kube izidakamizwa loqobo? Impendulo isobala kule mibuzo ingucha. Ngokwe izakhiwo kwemithi le mithi ayafana, umehluko kuphela nomkhiqizi futhi intengo. Nokho, iziguli eziningi ukuthola ukuthi analog nge ncazelo sibi ukwedlula sasekuqaleni, ngoba enza yayo kungukuthi baqhuba izifundo kanye zokwelapha. Uma ugxila intengo, kungcono uthenge esebenzisa "Z-isici": intengo amaphilisi eziyisithupha okuyisilinganiso sabangu-ruble 171-187, kuyilapho amaphilisi eziyisithupha "Sumamed" kufanele ukhokhe ruble 448-530.

Imibono iziguli mayelana izidakamizwa "Z-isici"

Izibuyekezo zabantu ngemithi ngokuyisisekelo okuhle. Iningi labo abake wasebenzisa izidakamizwa, phakathi zako uqaphele kahle eliphezulu ngentengo ephansi. Iziguli abonisa ukuthi umuthi ikakhulukazi kusiza angina. Ezwe ngosuku olulandelayo ngemva kokwamukela izimali is kakhulu ngcono, kukhona umphimbo obuhlungu, ukukhwehlela, ukuqaqamba kwamalunga. Futhi imithi ngempumelelo aqede sinusitis: ngosuku sesibili sokwelashwa aqede acinene ukuminyana, ayeke ikhanda. Phakathi naleso sikhathi, akuzona zonke izibuyekezo omuhle ngakho. Abanye abantu bakhuluma ngokuthuthukisa ekuthuthukiseni a iziyaluyalu eqinile wokugaya ukudla e seziguli ezithola izindlela "Z-factor." iziguli ngamunye kubikwa ukuthi ngemva kokuba enqobe amaphilisi / amaphilisi waqala ukuzizwa ezimbi: kwakukhona izimpawu ezifana ukwethuka, iphika, palpitations inhliziyo, ukhathazekile, wesaba. Ezimweni ezinjalo, umuthi kumele kunqanyulwe futhi nokufuna usizo lochwepheshe.

ulwazi olwengeziwe

Medicine "Z-isici" Pharmacy ku kadokotela. Ikhono ukushayela izindlela izimoto ukulungiselela akunamthelela. Impilo kwakhululwa iminyaka emibili, imithi kufanele agcinwe aphume kude nezingane futhi bavikelekile elangeni ezingeni lokushisa esingeqile 25 degrees Celsius.