Umuthi 'Concor Kor ": izinkomba ukusetshenziswa, nozakwabo yangempela

izifo zenhliziyo manje cishe endaweni yokuqala izinga lokufa emhlabeni. Futhi lezi zinkinga uthole abasebasha njalo ngonyaka. Uma wathi ngaphambili isilethikusebenza, kwaba umbuzo mayelana engu-okungenani iminyaka engu-45-50, namuhla lesi sifo kungashaya, futhi oneminyaka engu-30 ubudala.

Ikhemisi Modern inobungako ukuthaka imithi yokulwa nezinkinga "inhliziyo" at ngezigaba ezahlukene zentuthuko salezi zifo. Elinye iqembu le mithi kukhona beta blocker. Umgomo we operation zalezi zimali ukuvimba la mangqamuzana beta-adrenergic enhliziyweni. Umphumela kuba ukwehla kwenhliziyo, okuholela kunciphise umfutho wegazi futhi sithuthukise isimo jikelele umuntu.

manje-Beta-blocker achazwayo ezihlukahlukene kakhulu. Omunye kabanzi ukuthuthukiswa nezinkinga zenhliziyo kuyinto "Concor Kor." Izinkomba, ukubuyekezwa nomuthi njani izidakamizwa ukuba ngokwanele ngempumelelo kufunwe phakathi iziguli isifo senhliziyo.

Izingxenye ezisemqoka kanye nefomu wokukhulula izidakamizwa

Isakhi esiyinhloko ekulungiseleleni "Concor Kor" - hemifumarate bisoprolol. Njengoba kuphuma asizayo uhlu ngokwanele enkulu izinto: corn isitashi, microcrystalline cellulose, crospovidone, magnesium stearate, colloidal Silicon dioxide, anhydrous calcium hydrogen phosphate.

Umuthi esinikezwa abathengi ngesimo ezimhlophe amaphilisi camera inhliziyo-ifilimu-camera (e ngezithako zawo - macrogol 400, dimethicone 100, gipromelaza, ama-titanium dioxide). Ubungozi nhlangothi zombili ihlukane izibhebhe ezimbili "Concor Kor." Okufakiwe nomuthi ikhiqizwa ucwecwe amashashaza, ngalinye elikwazi kungenzeka soldered 10, 14, 25 noma 30 izingcezu.

Iziguli ngokuvamile kubonakala Pharmacy imithi "Concor". Njengoba amagama le mithi ezimbili ezithi azifane kakhulu, osokhemisi ngokuvamile kufanele ukuphendula imibuzo mayelana nomehluko phakathi "Concor" kusukela "Concor Kor." Ngakho: umehluko kuphela ngenani okuqukethwe ingxenye esebenzayo main - bisoprolol. "Konkor" abathengi ungakwazi ukuthenga amaphilisi kokuba ukubunjwa kwalo 5 noma 10 mg isithako esisebenzayo, kuyilapho "Konkor Kor" - 2.5 mg.

Abathengi adinga ukwazi leyo ukuthengwa kwemithi-blocker kule ekhemisi wemithi kuzodingeka ukuba unikeze somuthi nokusetshenziswa kwawo sikadokotela.

pharmacodynamics

"Concor Kor" has a abakhethayo beta 1-adrenoceptor Ukuvinjwa ithonya. Ingqikithi imiphumela yako - ikhono ukucindezela ukudluliselwa nerve amaza e-receptor adrenergic. Ngenxa yalesi sizathu izidakamizwa uyakwazi kunethonya antihypertensive, antiarrhythmic, imiphumela antianginal.

umphumela abanomfutho wegazi ophakeme "Izibuyekezo Concor Kor 'odokotela elihlobene ne yokuthi bisoprolol kunciphisa umthamo ngomzuzu kwegazi. Ngaphezu kwalokho, okusithiyayo parallel wenza uhlelo renin-angiotensin. Okukhulu kunakho ukusebenza emitholampilo kufinyelelwa emva kwezinsuku 5 ethola izidakamizwa. BP is uhlaliseke ekupheleni lwenyanga yesibili imithi yokwelapha "Concor Kor."

Ppokazaniya nomuthi ukusetshenziswa njengoba isiqinisekiso esitebeleni imiphumela antianginal ngokunciphisa esivimba amanzi nomoya-mpilo funa ngenxa ukwehla kwenhliziyo. Futhi, mangisho ukuthi ukusetshenziswa le imithi ikhuthaza prolongation ka diastole.

umphumela Antiarrhythmic kusho "Konkor Kor" ngenxa ivimbela omubi ukuthonya izinto ezihlanganisa ithonya olungaphelele ukucindezelwa nozwela yoMnyango CNS, ukucindezelwa izinqubo ukudala pulses kagesi engeyokuqala itheku, lo okusithiyayo womsebenzi kagesi we myocardium.

Ukukhombisa izidakamizwa, futhi ubani - akukho?

Yiziphi izindlela ngaleso "Concor Kor" izinkomba ukusetshenziswa? Izibuyekezo Umthengi ukuqinisekisa ukusebenza kahle eliphezulu zomuthi. Kunconywa ukuthatha ukwelapha senhliziyo futhi kuvimbele ukuthuthukiswa izimo ezinjalo kusaqalwa. Ukuze eqondile izisebenzi zempilakahle libeke beta-blocker ukwamukela ukuze bayothola ukwelashwa nemithi inhliziyo ezingamahlalakhona nokwehluleka encishisiwe ventricular kwesokunxele systolic umsebenzi. Ngokuvamile "Konkor Kor" okunqunyiwe parallel ACE inhibitor , ama-ejenti isisu glycosides inhliziyo.

Lokho akekho babethanda ukwabela izidakamizwa ngokwayo bebodwa, ngaphandle imiyalelo udokotela wakho, kubalulekile ukuba simazi nge i uhlu umxhwele contraindications ejenti "Concor Kor."

Ngaphandle ayimpoqo yonke imiyalelo imithi yokuvimbela khona ukungabekezelelani kuya izingxenye ezakha izidakamizwa kanye nobudala lesiguli (kufika eminyakeni engu-18 okufakayo - akukho ulwazi ukuphumelela nokuphepha), kusenabantu amaningi izizathu nemibandela izidakamizwa esithathwayo Akwamukelekile ngaphansi kwazo.

"Concor Kor" yokusetshenziswa (analogue - eziphambili beta-blocker - babe iziyalezo ezifanayo ku inadmissibility yokwemukela) eyenqabela iziguli ezinesifo senhliziyo e oyingozi futhi nesifo esingamahlalakhona decompensated. Musa ukhombe lokumamukela izidakamizwa e wokugoqa futhi ukushaqeka cardiogenic (isimo esibangelwa ukungasebenzi inhliziyo). Omunye awukwazi ukuthatha i-beta-blocker ngoba ngeziphambeko enkulu AV-conduction (II, III degree AV-block) ngaphandle umshini wokulawula ukushaya kwenhliziyo. Futhi isizathu esiyinhloko sokwenqaba reception kuba phambi bradycardia (kwenhliziyo (kwenhliziyo) is esingaphansi 50 amabhithi / imiz.), Ukuvinjelwa Sinoatrial (itheku eziya ziba zimbi Impulse edabula kwakwakhe sinoatrial). Imithi contraindicated in iziguli Prinzmetal angina (spasm imithambo ukuthi ukondla inhliziyo, kuyilapho ST ingxenye kokuphakama) kanye itheku ogulayo syndrome (Sss).

Ungathathi "Concor Kor" nge ongaphakeme systolic blood pressure (ngezansi 90 mm HG. Art.), Phambi somoya ngefomu ezinzima, labo umlando amarekhodi ezingamahlalakhona obstructive isifo samaphaphu (COPD).

Ngaphezu kwalokho ukulungiselela "Konkor Kor" isicelo nengamukeleki khona kwezinso ku-peripheral isimiso sokujikeleza kwegazi (ikakhulu uphathelene izigaba kamuva) ne isifo Raynaud sika, pheochromocytoma (isimila ingozi noma abulalayo APUD-system), kanye lactic umzimba (shift asidi-base ibhalansi bebheke asidi okwandisa ngenxa ekuqongeleleni imikhiqizo esidi ezicutshini ngu ngibopha zabo noma ukungabi ekubhujisweni).

Isimiso ukwelashwa kanye ivolumu kuvunyelwe bisoprolol

Ngokusho imiyalelo, beta-blocker esithathwayo kanye ngosuku, okungcono ekuseni, ngemva kokudla. Amaphilisi "Concor Kor" (kulokho kuyoba imithi ayizange isetshenziswe - kungaba ischemic isifo senhliziyo, ezingamahlalakhona ukumelwa inhliziyo, noma umfutho wegazi ophakeme) akudingeki ukuhlafuna noma ukubabulala lonke kugwinywe futhi wageza phansi inani elincane lamanzi.

Ukuze afeze izinyathelo zokwelapha ezingamahlalakhona inhliziyo ukwehluleka kanye ukusetshenziswa kwezidakamizwa "Concor Kor" kunconywa ukuba sifeze Titration umthamo. Ingqikithi inqubo kanje: ngesikhathi 1 st lweviki imali oyitholile we-beta-blocker ngokuya bisoprolol kuyinto 1.25 mg neviki-2 umthamo kabili (2.5 mg) imizuzu 3 3,75 mg. Phakathi nenkathi kusukela ngesonto 4th kuze kube sekupheleni umthamo 7th 5 mg Bisoprolol nsuku zonke; 8 th ngesonto 11 th - 7.5 mg. Kusukela ngesonto 12 yamukela obungu-10 mg. Umthamo kuyadingeka (futhi kungenzeka) ukwandisa nje siqiniseke ukuthi odlule ngokuvamile kubekezelelwe futhi akusho ezimbi ezibangela imizwa edangalisayo.

Lapha phezu - kukhona impendulo yombuzo othi kuka "Konkor" sihlukile 'Konkor Kor ": yesibili okufana (2.5 mg bisoprolol) ilungele ukuqala izinyathelo zokwelapha mayelana eziphikelelayo ezingamahlalakhona senhliziyo uthi, kuyilapho lokuqala (5 noma 10 mg) kuyinto ekahle ukuphathwa yesondlo.

Uma esikhathini esithile kwakukhona ukulungiswa umthamo inhliziyo izimpawu ukwehluleka, ochwepheshe bezokwelapha batusa umthamo efanele isisu parallel noma ACE inhibitor. Lapho ngemuva kwesikhathi esithile ukuthola isimo ngcono, kubalulekile ukuqhubeka inqubo Titration "Concor Kor."

Ukwelashwa nale izidakamizwa imvelo eside. Ukuqedwa beta-blocker okumele yenziwe kancane, ikakhulukazi ngoba iziguli ischemic isifo senhliziyo.

Ukweqiwa ngokweqile: imiphumela kanye nokwelashwa

Imiyalelo emuthini uhlale ehamba iphilisi "Concor Kor." Kusukela lapho athathe futhi yiziphi Izimo, ke echazwe ngaphambilini. Manje sizogxila yini okumele uyenze uma, ngasizathu simbe, kuyinto umthamo engamukeleki esikhulu likhishiwe.

Symptomatology simiswe ngalendlela lelandzelako: ekuthuthukiseni nomfutho wegazi ophezulu kanye bradycardia, bronchospasm, futhi awokuthi kahle kungakhuphula izinga likashukela kungenzeka ukuqala ukwehluleka oyingozi inhliziyo.

Imiphumela kokuthola ngemithamo ezinkulu zabantu ezahlukene kungahluka ezibonakalayo. Mhlawumbe, kulabo abaphethwe yisifo senhliziyo, kukhona iyashesha ukuzwela uma okweqa umthamo Kunconywa ngudokotela wakho. Isinqumo esingcono kakhulu ukuze isiguli - ukubona udokotela (uma kungenzeka ukukwenza ngokwakho) noma kubangele "fast". Kuye ngezinga elingakanani izidakamizwa sesamukelwe, udokotela ziyonquma izinyathelo ezizothathwa ukuze lula isimo lesiguli.

imisebenzi Njengoba esiphuthumayo owawuvame ukwenziwa lavage esiswini kanye yokwamukela absorbents (carbon isebenze noma analogue yayo). Ngaphezu kwalokho, kuye ngokuthi isimo, ukuphathwa bisoprolol anganqanyulwa, futhi edingekayo isikhathi, esibhedlela kuyoba yokwelapha ongisekelayo lingaze.

Imiyalo "Concor Kor" izinkomba ukusetshenziswa, ukubuyekezwa wezokwelapha kanye kweminye imithombo yokwaziswa alethwe ukunakwa abaqeqeshiwe kanye abathengi ukuthi bisoprolol kunzima ngokwanele amenable ukuba zelashwe.

ukubonakaliswa Negative isicelo "Concor Kor"

Njengoba cishe zonke izidakamizwa, iyakwazi ukunikeza "Concor Kor" side effects okushiyashiyanayo ngamandla phezu izinhlelo eziyishumi nemitshingo.

Ngokuphathelene esimiso senhliziyo nemithambo yegazi, izikhalazo njalo iningi iziguli okuvela bradycardia kanye nomfutho wegazi ophezulu (ikakhulukazi abantu abaphethwe ezingamahlalakhona ukuhluleka kwenhliziyo), ingaqala vasospasm. Ngezinga elincane kungenzeka ukuhlukumeza AV-conduction, decompensation inhliziyo, ephelezelwa edema neuropathy.

Indlela Abasabela Ngayo CNS izidakamizwa kubonakala kancane evelele futhi ingase iqukathe ukukhathala, ukuphathwa ikhanda nesiyezi, ukukhathala, ukuphazamiseka kokulala, futhi ezikhathini eziningi ulokhu uphaphama. Kakhulu akuvamile, iziguli esekhala amajaqamba, amaphupho amabi futhi babone izinto ezingekho. Ezimweni eziningi, lezi zimpawu ungenayo i coloration okukhulu futhi lwahlolwa ngemva kwamasonto 1-2 zisuka yokwelapha nge "Concor Kor."

Izinkomba ukusetshenziswa kanye nohlu Izimo ukugxilisa ingqondo ukunakwa iziguli umlando ulwazi COPD kanye somoya, kukhona kungenzeka bronchospasm. Akuvamile ukhulume ukubukeka rhinitis iguliswa.

On the ingxenye ipheshana wokugaya ukudla ngokuvamile kungase kubangele isicanucanu, ukuhlanza, ukuqunjelwa, uhudo, umuzwa kome lwamafinyila ku ngalo ingaphakathi ngomlomo. Ngaphansi ngokuvamile ukukhuluma mayelana nokuthuthukiswa kwesibindi ukushintsha e enzyme isibindi.

Ngaphezu kwakho konke lokhu okungenhla, iziguli ukubika ukuphazamiseka visual kanye conjunctivitis (ezingavamile), mayelana amajaqamba imisipha ithole ukuba buthakathaka kwezicubu, ukwephulwa kwamalungelo potency (kakhulu ezingavamile).

Komzimba nezinto ngokuvamile kungenzeka amawala, ukulunywa futhi ububomvu.

"Concor Kor" nokukhulelwa

Beta-blocker "Concor Kor" ngesikhathi sokukhulelwa kungenzeka kuphela ezimweni lapho inzuzo kulindeleke ukuba unina impilo yakhe naphezu kwengozi engase ivele ukuba umntwana okhulayo.

Noma yimuphi beta-blocker (futhi "Concor Kor" phakathi kwabo), ukunciphisa ukushuba ukugeleza kwegazi e-placenta futhi ngaleyo ndlela ungase ube nomthelela ongemuhle enganeni e utero. Uma namanje eyabelwe ukuze bathole imishanguzo engabasiza abesifazane abakhulelwe, abasebenzi bezempilo kumele sihlale njalo siqaphele ukugeleza kwegazi e-placenta kanye kwesibeletho, kanye ukugcina ukukhula nokuthuthuka kwengane. Esimeni yimaphi zici ezimbi ngoba owesifazane nengane kufanele udlulela nezinye, izindlela zokwelapha.

Ngemva kokuzalwa kwengane kumele ahlolisisa. Phakathi 3 izinsuku lokuqala ingane kunganciphisa ezingeni glucose egazini, kungenzeka bradycardia (encishisiwe kwenhliziyo) izimpawu.

Njengoba abesifazane ukuncelisa, ulwazi ukwabiwa bisoprolol nge ubisi lwebele noma ukulondeka kwawo ayitholakali ingane. Ngakho-ke, uma kudingeka, thola izindlela "Concor Kor" ngalesi sikhathi, kubalulekile ukunquma ekunqanyulweni kwe lactation.

izidakamizwa ezifanayo

Esikhathini izidakamizwa "Concor Kor" nozakwabo (ziningi) zivame kakhulu esisogwini isithako main - bisoprolol. imithi Self ikhiqizwa eJalimane naseNorway. izidakamizwa ezifana "Aritel" livame ukusetshenziswa kwe-nozakwabo isiRashiya, futhi "Aritel Kor", "Biprol", "bisoprolol-Prana". Nakuba yokugcina itholakala emazweni amaningi emhlabeni wonke, "bisoprolol Teva" - Hungary, Israyeli, "bisoprolol-ni" - Ukraine. Empeleni, i-analogo eqondile "Concor".

Ngaphezu kwalokho, kusukela njalo kunazo wasebenzisa izindlela ezifanayo kungenziwa ngokuthi "Bidop" futhi "Bidop Kor" "Biol" "Bisogamma", "Bisomor", "Kordinorm" futhi "Kordinorm Kor", "Tiresias", "Niperten".

Ngokuvamile, uhlu analogue (omqondofana) libanzi impela futhi zihlukahlukene, kodwa ukuxazulula umbuzo yini ukuba esikhundleni "Concor Kor" self engamukeleki. Kukhethwa ilungelo nomuthi ngoba esikhundleni okungokukaNkulunkulu kuphela udokotela ukuba khona.

Ukuxhumana nezinye izidakamizwa

On kusebenta ezinhle futhi tolerability we-beta-blocker kungathinta ukusetshenziswa kwezidakamizwa ezimbili ngesikhathi esisodwa. Ngokuphathelene izidakamizwa "Concor Kor" (izinkomba ukusetshenziswa, ukunakekelwa abasebenzi bezempilo yangempela kanye neziguli uqinisekise ukusabela ngaleyo ndlela) ukungabekezelelani singenzeka ngisho noma ezifanayo isimiso ithonya zidakamizwa ziye zithathwe ngokusebenzisa esincane isikhathi nomunye.

Ngaphezu kwalokho, iziguli ukuthatha bisoprolol, kubalulekile ukwazi ukuthi izinto ezixabana nomzimba ngoba immunotherapy noma izinto ezikhishwe ukuhlolwa isikhumba babekwazi kubangele ukuthuthukiswa okukhulu letindzala komzimba noma anaphylaxis. Kungabangela ukushaqeka anaphylactic futhi isicelo ngesikhathi esisodwa bisoprolol nekuphikisana iodinated ejenti kwezokuphatha emthanjeni.

Isisu, izidakamizwa sympatholytic nezinye antihypertensive, bisoprolol isetshenziswa ngesikhathi esifanayo ne, kungabangela ngokweqile ukwehlisa wegazi.

Tetracycline antidepressant, antipsychotics, sedatives futhi hypnotics izidakamizwa sicindezeleke isimiso sezinzwa esiyinhloko. Effect insulin noma ezinye izidakamizwa ezifanayo hypoglycemic kwezokuphatha temlomo ngesikhatsi ukwelashwa nge nomuthi "Konkor Kor" kungase kwandise. Symptomatology ekuthuthukiseni kahle kungakhuphula izinga likashukela (tachycardia ngokukhethekile) kungenziwa ukuyiveza noma simaskwe.

Yini oyibhekayo?

Abantu ababeka "Concor Kor" inikezwe isicelo inadmissible bebodwa uphazamise ekwelapheni noma ashintshe isilinganiso semithi oyidlayo Kunconywa ngaphandle kokubheka nodokotela wakho. Ezimweni ezinjalo kungenzeka eziya ziba zimbi womsebenzi inhliziyo. Lokhu kuyiqiniso ikakhulukazi iziguli yenhliziyo Umthambo isifo. Uma kuba khona isidingo sokuqeda imithi yokwelapha "Concor Kor", umenzi incoma ukuthi wenze lokhu, elokhu enciphisa umthamo.

Ngezinye ukubhema iziguli ukusebenza kwe-beta-blocker ukaleso abangabhemi.

Labo ukugqoka contact lens, kufanele ugcine engqondweni ukuthi beta-blocker kungabangela ukwehla ekukhiqizeni uketshezi izinyembezi.

Uma isiguli eba isidingo ukuhlinzwa kobuholi, ethola 'Concor Kor "kumelwe ayeke ukuthatha amahora zonke hhayi ngaphansi kuka-48 ngaphambi kokuba ukubulawa izinzwa jikelele. Uma ukuhlinzwa is bawadinga ngokuphuthumayo, kanti isiguli kakade lithole beta-blocker, ngokuba ukubulawa kwezinzwa okuvamile kubalulekile ukukhetha izidakamizwa nge negative sakugcina ithonya inotropic.

Sengiphetha ngifuna ukusho ukuthi yini kwakudingeka imithi "Concor Kor" ukufundwa, ukubuyekezwa ukusebenza kahle phezulu ingxenye iziguli kanye nabasebenzi bezempilo, isinqumo Yokuqashwa igama ngalinye umuntu lomuntu kusho "Concor Kor 'hhayi kunoma yimuphi omunye beta blocker, kufanele eyakho kuphela udokotela ukuba khona.