Umuthi 'Amiodarone ": analogue, imiyalelo, ukubuyekezwa

Inhliziyo, njengoba wazi, umzimba wethu oyinhloko, kodwa ngokuvamile ehluleka. Ukuze ukubuyisela kusebenta kwato evamile ukusebenzisa ezihlukahlukene izidakamizwa. Omunye wabo "Amiodarone". Analogs ibiza kakhulu, njengoba kukhiqizwa phesheya futhi akuzona ngempumelelo njalo.

Ukwakheka izidakamizwa futhi ngendlela

I nomuthi "Amiodarone", okuyinto libuyekeza ezihlukahlukene yakhiwa kwelinye esibhebheni 200 mg isithako esisebenzayo - hydrochloride amiodarone. Ukulungiswa senziwa ngaphezulu njengoba isixazululo, lapho 3 ml 5% isithako esisebenzayo.

ingxenye Asizayo sakhiwa esinye isibhebhe sibonisa yilezi: amazambane isitashi, crystalline microcellulose, i-lactose, maltodextrin, primelloza, polyvinylpyrrolidone, magnesium stearate.

Izibhebhe embozwe glaze umbala omhlophe nge okuncane, ezicashile ukhilimu umthunzi. Sinenkosi uhlobo Valium futhi isici futhi Valium. Ngakho-ke, uma kudingekile, kalula ihlukaniswe izingxenye ezimbili alinganayo.

Izidakamizwa edayiswa amakhadibhodi amabhokisi, lapho elilodwa noma amabili amabhamuza amaphilisi eziyishumi. Umuthi nayo kukhiqizwa ingilazi, polymeric and plastic amabhodlela, ezithinta 30 noma 100 amaphilisi.

Mshini kwemithi yesenzo izidakamizwa

izakhiwo Antiarrhythmic futhi antianginal 'zinezikhathi Amiodarone "analogue kwezinye izimo Ungashintshanisa kuye. isenzo sayo anti-arrhythmic kusekelwe wamanje ukunciphisa potassium ion lapho ngaphansi ulwelwesi amaseli - cardiomyocytes. Kubangela nokuncipha engeyokuqala itheku esiyingxenye bradycardia.

Ukusebenzisa izidakamizwa "Amiodarone" (amaphilisi) kungandisa ubude refractory inhliziyo conduction indlela. Kuvimbela conductivity yemizila yesibili in iziguli syndrome okunzima Wolff-Parkinson-White syndrome. Futhi, antianginal izidakamizwa umphumela yakhiwe ekunciphiseni esivimba amanzi nomoya-mpilo ukusetshenziswa kanye nokunciphisa nethonya layo imisipha ekhipha igazi enhliziyweni. Yakhiwa iodine, elisetendeni ukusetshenziswa ambalwa sishintsha okuqukethwe we-hormone yegilo, okuholela degree of umthelela wabo myocardium kuyehla.

"Amiodarone" unethonya ezuziwe, futhi ubungozi evelele ku isicelo yayo kwenzeka kuphela ngemva kweviki elilodwa ukusetshenziswa njalo zomuthi, futhi esiphezulu kufinyelelwe ngemva kwamasonto amabili nantathu.

Ngaphakathi ugxile u-40% ukuphuza umthamo, Cmax plasma livela ngemva kwamahora angu-3-7. Umthelela uyakwazi iqhubeka amasonto amaningana. izinqubo umzimba zenzeke ikakhulu esibindini, lapho yakheke isici asebenzayo dezetilamiodaron, okungukufa metabolite ezinkulu. Buyela emuva Bile ethakwa futhi umchamo, T1 / 2 - emva umthamo owodwa we izidakamizwa 3,2-20,7 h, elashwe isikhathi eside - emva 53 ± 24 amahora.

Medicine "Amiodarone": izinkomba ukusetshenziswa

Linqume izidakamizwa ngenxa nokwelashwa arrhythmias, okungase ogulela engozini izimpilo zabantu, kanye ventricular arrhythmias, flutter ventricular e Dynamics engazinzile futhi wasebenzisa isidakamizwa "Amiodarone."

Izinkomba uvumele ukusebenzisa izidakamizwa nge:

• flutter atrial;
• arrhythmias supraventricular;
• Wolff-Parkinson-White syndrome;
• okuvela tachycardia;
• fibrillyatsionnogo ventricles ukwazi;
• arrhythmia ezivukayo ngenxa esingamahlalakhona senhliziyo ebuthaka futhi yenhliziyo;
• amafomu njalo senhliziyo;
• isilethikusebenza.

"Amiodarone": yokusetshenziswa

Tablets zenzelwe abaphathi temlomo ngemva kwemizuzu engu-15 ngemuva kokudla.

Phakathi ventricular isifo fibrillation umthamo Kunconywa udokotela, kuyinto 800-1200 mg ngosuku. Kufanele kube izingxenye 3-4 reception. Le nqubo yokwelapha kulesi simo ithatha cishe izinsuku ezingu-5-10 ukuze kuqinisekiswe ukuthi lisesimweni esigculisayo isiguli singase siwathole, futhi izinga kungenziwa sehliselwe 600-800 mg ngosuku. Lokhu kwelashwa olunzulu, kamuva wabe ukukhalima, umthamo engezansi okuqukethwe izidakamizwa.

Zokwelapha isikhathi ukulungiswa izinsuku 7-14, kulesi sikhathi izidakamizwa ukuthatha 200-400 mg. ivolumu izidakamizwa leliniketwe usimamise isimo lesiguli esikhathini poslereabilitatsionny.

Ngokuvamile ikhambi "Amiodarone" okunqunyiwe lapho isiguli esibhedlela, futhi amasu nendlela yakhe ungakwazi ukulawula udokotela. Lokhu kwenza kube nokwenzeka ukunciphisa imiphumela emibi futhi ngamunye ulungise umthamo izidakamizwa.

Lapho nomuthi isifo angina zisebenzisa kabili ngosuku ngesikhathi mg 200. Ngemva kwamasonto amabili, lo umthamo lancipha laba kanye ngosuku. Umkhawulo olulodwa isilinganiso umthamo kumele singeqi 400 mg kanye nsuku zonke - 1200 mg.

Ekumiseni laba izingane izidakamizwa kufanele kukhunjulwe ukuthi iphilisi kuthinte ingane ngokushesha okuningi kunalokho umuntu omdala. Ngakho-ke, umthamo ibalwa okusekelwe isisindo ingane. Ngakho, eyodwa kilogram isisindo kumelwe bawe 10 mg nomuthi. Lokhu umthamo kufanele kugcinwe phakathi nayo yonke inkathi zokwelapha kwezinsuku eziyishumi noma kuze isimo lesiguli ngcono. Lapha, lokhu sebhithi ukunciphisa inani 5 mg ngayinye amakhilogramu isisindo isidumbu sengane. yesondlo Zokuzivikela umthamo esithathwayo futhi esekelwe eyodwa kilogram ka 2.4 mg izidakamizwa "Amiodarone."

Izinkomba emuthini ebekiwe ukusebenzisa isixazululo esekelwe isithako ka amiodarone hydrochloride e-acute arrhythmias inhliziyo. Kulokhu, lesi sidakamizwa iqondiswa ngemithambo yegazi, kancane zifakwa emzimbeni nge weThrojani. Ukuze wenze lokhu, 250 ml 5% isixazululo glucose 1 noma 2 u kancane injected izidakamizwa umthamo 5 mg ngayinye isisindo amakhilogramu umzimba. Ngalesi sikhathi, isiguli kuyaqashwa esebenzisa ECG nomfutho wegazi nesilinganiso ukufundwa.

side effects

kadokotela Ngakho abaningi "Amidaron" ezweni lethu. Analogs akuzona njalo ukwazi omunye esikhundleni sakhe. Kodwa nakuba isikhona imiphumela emihle ye izidakamizwa emzimbeni womuntu, sezihlonziwe futhi imiphumela emibi.

izimpawu Negative ngokuyinhloko ngenxa izidakamizwa ukweqisa izidakamizwa. Lokhu ukuphulwa kokunikezwa kwe-uhlelo senhliziyo nemithambo yegazi, njenge bradycardia, itheku engeyokuqala ukwehluleka umsebenzi, inhliziyo block, ukulahlekelwa kokuxhumana ukunyakaza. Futhi engxenyeni umgudu wokuphefumula livele ngokukhukhumala kwentamo interstitial cystic yamaphaphu, inyumoniya interstitial, Hamm syndrome - Rich, ubuhlungu besifuba, cystic yamaphaphu, tachypnea, zibe bronchopulmonary. ukuhluleka Hepatic laligujwa lapho ithola "Amidaron" ukulungiselela. Tablets ezimweni ezingajwayelekile kubangele jaundice, isifo sokusha kwesibindi, isifo sokusha ngezinye izikhathi.

Ukwahluleka okuthobela nanoma Isikali kungabangela ukungalingani okukhulu kwama-hormone egilo, distireoza kanye hypothyroidism, futhi iqoqo Kilos owengeziwe. Overdose kungaholela ukuphazamiseka apharathasi ezibukwayo, okubangela ukwenyuka kwezinga lipids e-cornea ukuba umfundi. Futhi, kukhona lesikhumba evelele kwesikhumba, photosensitivity, urticaria noma i-erythema. ukuqubuka Minor ayebizwa ubuso, Alopecia, dermatitis. Imiphumela engemihle futhi kwathinta umsebenzi nekutala amadoda. Kulezi zimo kukhona orchitis, ubuthakathaka, futhi epididymitis. thrombocytopenia Abaningana impela ezingavamile, ukwehluleka kwezinso, noma angioedema vasculitis.

Izimo ukusetshenziswa

"Amiodarone" (impendulo kwaba sokufanele njalo) ikhethwa ngokuqinile ngamunye. Kunabantu ukuthi lokhu izidakamizwa awazange asize noma abazange waphawula nhlobo ushintsho isimo sezempilo, abanye yayiklinya ngemva usisebenzisa, wazizwa palpitations inhliziyo. Emazwini abo Propafenone ke uyakwazi ukuphazamisa uhlelo endocrine hormone ukwandisa. Ngakho-ke, ngaphambi kokuthatha lesi umkhiqizo okwelapha Akumelwe sigcine ngokufunda imiyalelo ngokucophelela, kodwa futhi sinake izimpawu, side effects kanye contraindications.

Ngakho, umuthi akumele zisetshenziswe uma kukhona atrioventricular block grade 2-3, usashaqekile cardiogenic, i-hyperthyroidism. Ukulungiselela "Amiodarone" alisetshenziswa ukuzwela yaso ephezulu ku-ejenti asebenzayo futhi iodo. Ban eziwukwephulwa okukhulu conduction zenhliziyo iziqephu bradycardia nge nakwisyncope. Ungasebenzisi izidakamizwa phakathi nokukhulelwa kanye lactation. Lactation, ngesikhathi imithi kufanele ayeke ibele.

izincomo ezithile

Kufanele ngokucophelela wawuqondiswa udokotela yokwelapha izidakamizwa "Amiodarone". Yokusetshenziswa uncoma ukusebenzisa amaphilisi ngemva kwesifundo-X-ray kwesibindi, amaphaphu we electrocardiogram. ukuqapha okunjalo kufanele kwenziwe esikhathini esizayo, uma isiguli uyaqhubeka ukuthatha imithi.

Kobukhulu izigameko ezingezinhle ezavela ngokuvamile kuxhomeke ekutheni umthamo, esebenzisa isiguli. Kufanele uzame ukusebenzisa izidakamizwa njengoba njalo ngangokunokwenzeka eliningi omncane. Ngokuvamile kubangela okungajwayelekile ukushaya kwenhliziyo yokukhansela "Amiodarone" izidakamizwa.

Yokusetshenziswa - Izibuyekezo bathi, naphezu imiphumela emibi, lokhu izidakamizwa kwasindisa ukuphila ezingaphezu kweyodwa - uthi isenzo kwemithi zomuthi alondolozwa ukuze kwenye amasonto amabili ngemuva yokukhansela yayo.

Tablets aqukethe iodine, okuyinto enomthelela ukunqwabelana ezingeni of radioiodine kule ndlala yegilo. Ngakho-ke, ekuqaleni le yokwelapha, ngesikhathi futhi ekupheleni kudingeka bahlale zihlolelwe inani hormone.

Phakathi kokungenela zokwelapha yini edingekayo ukuze ugweme isikhathi eside elangeni, akudingekile ukuthatha ilanga evulekile. Umuthi kufanele sinikezwe ngokuqapha kubantu asebekhulile ukubulawa kwezinzwa okuvamile noma phakathi ukuphathwa umoya-mpilo. Ngokuqapha kufanele usebenzise nabashayeli izimoto futhi abantu kabani umsebenzi lihlotshaniswa lokuhlushwa ethile.

Ezimweni ukweqisa izidakamizwa bangezwa eziya ziba zimbi yemiphumela emibi, kanye hypotension, arrhythmia. Kungenzeka bradycardia noma ukwehluleka AV conduction. Kuvele overabundance kungaholela isibindi ukungasebenzi.

Kulokhu, sincoma ngokushesha lavage esiswini, amarejista namalahle yasebenza, laxatives nosawoti Kunconywa izixazululo. Uma bradycardia imijovo atropine, agonists lisetjenziselwa receptor beta-adrenergic, ekhiqizwa EHAMBAHAMBA.

Ubuhlobo neminye imithi

Okumele kuqashelwe kumele kusetshenziswe izidakamizwa kanyekanye nezinye izidakamizwa, ikakhulukazi uma kukhona kusukela iqembu elifanayo antiarrhythmic. Akubalulekile ukuba sihlanganise ngayo ukwamukela "erythromycin", "pentamidine" futhi "vincamine." Kukhona ingozi polymorphic ventricular tachycardia lihambisana "sultopride". It is hhayi Kunconywa ukuba sihlanganise engayitholi CCB ne-beta-blocker nge "Amphotericin B" nezidakamizwa okudala umphumela laxative, isisu. Ngokunakekela ukusebenzisa imithi lihambisana corticosteroids, antidepressant, "Astemizole", "terfenadine." Akwazi kakhulu ukuthuthukisa imiphumela izidakamizwa ezifana "Warfarin", "Phenytoin" "Tacrolimus" noma "Digoxin". Lapho isetshenziswa ngesikhathi esifanayo ne "cimetidine" kubambezela inqubo umzimba emzimbeni.

amazinga Life futhi isitoreji

I nomuthi "Amiodarone", ogama senzo iqondiswe ku nokuqedwa tachycardia, fibrillation ventricular, tachyarrhythmia futhi atrial flutter ukunciphisa, libhekisela amalungiselelo isigaba "B" iqembu. Shelf-ukuphila umuthi esingaphansi kweminyaka emithathu. Tablets kufanele agcinwe endaweni epholile, emnyama futhi aphume kude nezingane.

ukusetshenziswa "Amiodarone" izidakamizwa kumele kulawulwe. Indlela ukuyisebenzisa ubhala ngaphandle udokotela. Kulokhu, self kumele ayifakiwe ngokuphelele.

Analogs nomuthi

Uma ngokungazelelwe akaphenduli izidakamizwa kungenziwa "Amiodarone" analogs atholakala kunoma iyiphi ekhemisi. Phakathi kwabo kukhona izidakamizwa ezifana: "Amiodarone Belupo" futhi "Amiodarone Aldaron", "Angoron" futhi "Atlans" futhi esikhundleni salo imithi yayikwazi "Kordaron" noma "Kordinil". Ngokufana "Amiodarone" emphumeleni wokusebenza kwalo emzimbeni womuntu "Medakoron" futhi "Palpitin". Kwezinye izimo, umuthi esikhundleni "Sedakoronom" futhi "Sandoz".

Le mithi noma ukuqukatha unesimo esifana esebenzayo noma ezifanayo umphumela yabo antiarrhythmic wezokwelapha "Amiodarone". Analogue bavame ekhiqizwa phesheya futhi izikhathi eziningana ezibizayo.

nobufakazi

Iziguli eziningi bathi kuqiniswa yesimo sabo ngemuva kokuthatha imithi, "Amiodarone". Yokusetshenziswa - ngokuvamile izidakamizwa analogs akhethiwe esekelwe izici ngamunye umzimba - uthembisa kujwayeleke ukushaya kwenhliziyo, ingcindezi. Lapho reception ngezikhathi ngemithamo emincane, ngokuvamile ayikho inkinga, futhi izenzo izidakamizwa ngempumelelo.

Ngemva ukusetshenziswa isikhathi eside zomuthi kwezinye iziguli uvele iphika, palpitations inhliziyo, uvalo nokucindezeleka, ukushintshashintsha kwemizwelo, anda yegilo i-hormone, ukuphazamiseka pheshana emathunjini, futhi kwezinye izimo, isicanucanu nokuhlanza.

abantu abaningi kakhulu ukuyisebenzisa ekwelapheni angina, futhi uqaphele ukuthi akukho bubi nakakhulu manje kunaseminyakeni nozakwabo amazwe. Amanye amadoda bayasaba ukuthatha izidakamizwa, ngoba kubo, uyakwazi ukubangela eziningi zomdlavuza. Kukholakala ukuthi izidakamizwa kufanele athathwe kuphela ngaphansi isimo okusongelayo ukuphila komuntu, kuzo zonke ezinye izimo, kufanele abheke kwenye indawo. Ngaphezu kwalokho, i-tablet ungaba nethonya elibi endleleni umsebenzi owesilisa zokuzala, okuyilona elisebenzayo futhi ukuze kubhekwe reception yabo.

Nokho izidakamizwa eziningi "Amiodarone" kwaba panacea, sibonga nakulelo lesi sifo esebohlile, kodwa le ndoda yaqhubeka uyaphila. Hhayi yokuthi analogue kungaba ngendlela efanayo. Ngakho-ke, ekwelapheni isifo senhliziyo, enganciphisa izidakamizwa off, ikakhulukazi uma udokotela uncoma ke.