Umuthi 'Akineton ": yokusetshenziswa, incazelo, ukubuyekezwa

Ingqikithi asebenzayo "Akinetona" kuyinto hydrochloride biperiden. I-Tablet yokuhlala 2 mg lomcebo asebenzayo. Ngaphezu kwalokho, ukuba khona izingxenye ezengeziwe (corn isitashi, amazambane isitashi, monohydrate lactose, magnesium stearate, microcrystalline cellulose, copovidone, i-calcium hydrogen phosphate dihydrate, talc, amanzi ahlanzekile) eqala izidakamizwa "Akineton".

Yokusetshenziswa, isithombe kusikisela ukuthi ifomu i-tablet ye-izidakamizwa has umbala cishe white, ifomu Valium. Kolunye uhlangothi ithebhulethi kukhona ingozi beveled ukuma esiphambanweni.

1 ml isixazululo iqukethe lactate biperiden e isamba 5 angu. izingxenye engeziwe yilezi: ujova amanzi sodium lactate.

imiphumela kwemithi

Main isithako biperiden - holinoblokator isinyathelo emaphakathi.

Umthelela kuhilela ezicindezelayo ikhono umsebenzi cholinergic neuronal ku striatum, okuyinto iyunithi isakhi uhlelo extrapyramidal.

Umuthi kubangela umphumela ganglioblokiruyuschimi, kobukhulu imiphumela antispasmodic uphinde ungamele m-anticholinergic at azungeze (antispasmodic).

Ukusebenzisa izidakamizwa kudambisa esitho liqhaqhazela, okuyinto ephakama ukusetshenziswa kwezidakamizwa cholinergic (isib pilocarpine) kanye catalepsy futhi imisipha rigidity e seziguli ezithola neuroleptics. It has ikhono ntombazane ukuyaluza.

Pharmacokinetics

"Akineton 'nakanjani plasma amaprotheni at 91-94%. Plasma imvume kuyoba 11.6 ± 0.8 ml / imiz esisindo / kg. A umthamo owodwa we ekwakhiweni temlomo has a bioavailability of mayelana 33 ± 5%.

Ludlulele ngaphakathi ubisi lwebele.

Biperiden akheka emzimbeni womuntu ngokugcwele. Ngo umchamo, ketshezi akunqunywa ngefomu angashintshiwe. I metabolites ezinkulu kukhona bicycloheptane futhi piperidine, okuyizinto okukhipha kusuka indle kanye nomchamo.

Elliminatsiya eyenziwa ngezigaba ezimbili, ngokuphila isigamu (T 1/2) imizuzu 90 ngesikhathi sesigaba sokuqala namahora angu-24 - sesibili. Ezigulini esezikhulile, nenxenye ukuphila kungandisa kakhulu.

izinkomba

"Akineton" lisetshenziswe iziyaluyalu extrapyramidal esibangelwa nokuphathwa kunemithi noma amaphilisi owaphuzayo (neuroleptics, antipsychotics).

Futhi, izidakamizwa kuboniswa ngenxa sitholakele isifo i-Parkinson syndrome, parkinsonism (ejenti yaphathwa ukwelashwa nge isizinda)

Izimo

Inhloso yalesi izidakamizwa ayiboniswa uma wena hypersensitive kuya isithako zomuthi "Akineton".

Yokusetshenziswa yazisa ukuthi izidakamizwa kufanele kugwenywe sitholakele isifo isiguli ezifana yesinye, engela-Ukuvalwa ukufiphala izinguquko obstructive emathunjini (stenosis pylorus, kofé uhlangothi ileus genesis).

Arrhythmia, isifo sokuwa, ukuncelisa ibele, abadala, ukukhulelwa kuyizimbangela lapho "Akineton" iqondiswa ngokuqapha okukhulu.

side effects

CNS side effects ziyabonakala asthenia, ukukhathala, ukucobeka, ubuthakathaka, ukuba ndikindiki, isiyezi, nomuzwa wokukhathazeka, ukukhathazeka, inkumbulo ukungakhuli, ukudideka, ukusangana, catalepsy, sezidakamizwa izidakamizwa "Akineton".

Yokusetshenziswa ukhuluma ngani ohlangothini-imiphumela kanye ingxenye umbono - mydriasis, ukuphazamiseka yokuhlala.

uhlelo Cardio-semithambo libhekene Ukushaya of ukushaya kwenhliziyo (tachycardia); ngezinye izikhathi - deceleration (bradycardia); uma sisebenzisa ifomu umjovo we ukulungiselela - incipha wegazi (hypotension).

On the ingxenye isimiso sokugaya ukudla bungene - nomlomo owomile, izimpawu dyspeptic, ukuqunjelwa.

On the ingxenye umzimba - wehlise ukujuluka.

On the yesimiso urinary - in iziguli ukukhulisa (hypertrophy) we endlaleni engasesinyeni - kungenzeka nobunzima echama.

komzimba: awahlabi esikhumbeni, ukulunywa.

Izindlela Yokusebenzisa

Ukuze esicutshini, emthanjeni, futhi ngomlomo ithebhulethi fomu ukulungiselela kufanelekile "Akineton".

Yokusetshenziswa kusikisela ukuthi imishanguzo "Akinetonom" ngokuvamile iqala kusukela ngemithamo emincane, umthamo ngaphezulu inyuka stepwise kuncike oyifunayo nomphumela oqabulayo futhi side effects.

Abadala at ukusetshenziswa yetemlomo sokulungiselela uqale ukwelashwa umthamo 1 mg 1-2 reception emini noma 2 mg ihlukaniswe ngemithamo ezimbili ngosuku. Ngaphezu kwalokho, umthamo kungenziwa lenyuke kuya kwezingu-8 mg emibili kuya kwemine ngemithamo ehlukene ngokwenkolo. Nokho, umthamo akufanele izandisele ezingaphezu kuka 2 mg ngosuku. Musa idlule umthamo esiphezulu kusho 6 ku Th-16 mg izinsuku ezinhlanu. umthamo owodwa ifomu nemijovo izidakamizwa kumele singeqi 2.5-5 mg. Lokhu umthamo kungase kuphinde kushiwo abanye ngemva kwengxenye yehora, kodwa isibalo bentando ngelanga kumele singeqi izikhathi 4. Umthamo esiphezulu nomuthi ngefomu komjovo 20 mg izinsuku ezinhlanu. Lapho umthamo elilungile, sekufikwe inguquko lomshado "Akinetona kuthiye ukukhula."

Kodwa ungakhohlwa mayelana ndlela ngamunye isiguli ngasinye ukwelashwa aphoyintimenti biperidenom.

zokugula Extrapyramidal ezivukayo ngenxa ukungenisa kunemithi noma amaphilisi owaphuzayo (antipsychotics noma neuroleptics) kudinga isabelo into kunikezwa e umthamo owodwa we-2 mg ngomlomo noma parenterally. Phinda nokuphathwa ngemithamo wathi kungase kube njalo ingxenye yehora. Nokho, njengoba kuboniswe ngenhla, inani bentando kumele singeqi izikhathi 4. Umthamo ngomlomo kufanele ihlukaniswe ngemithamo eyodwa kuya kwemithathu.

Parkinson kuhlanganisa nokukhipha izidakamizwa ngomlomo ngesikhathi 6-8 mg e 2-4 ngemithamo ahlukaniswe usuku lonke, umthamo kungenziwa kancane kancane kuze kube 6-16 mg.

Izingane ezingaphansi injongo ngonyaka kusikisela ukuthi kungenzeka izidakamizwa ifomu nemijovo kancane, umthamo owodwa we-1 mg noma 0.2 ml. Lapho ubudala kusuka onyakeni owodwa kuya eminyakeni eyisithupha iqondiswa 2 mg noma 0.4 ml. Kusukela eminyakeni 6 kuya ku-10 - 3 mg noma 0.6 ml. Lokhu umthamo kungase kuphinde kushiwo abanye emva isigamu sehora kanye eziphuthumayo. Ephambi kwezinduna nemiphumela emibi sokuqondisa izidakamizwa kufanele kube umjovo wayekwa.
Phakathi yetemlomo yokwelapha izidakamizwa kweminyaka emibili nengu-3 kuya 15 ukuthatha umthamo 1-2 mg e amahora 1-3 emini.

Izibhebhe ayikwazi baphuze esiswini esingenalutho, futhi kumelwe baphuze esesilinganisweni yamanzi. Ngezinye okuvela engathandeki side effects kusukela isimiso sokugaya ukudla bungene kufanele athathe izidakamizwa ngemva kokudla, ukunciphisa ububi besimo sokuguquka umtselela longasimuhle kusho "Akineton".

Yokusetshenziswa kubonisa ukuthi esimweni nicotine okunoshevu abadala ejwayelekile yokwelapha eziyinkimbinkimbi nayo iqondiswa lokhu izidakamizwa, futhi umthamo salo 5-Th-TB-10 mg yamafomu nemijovo, kodwa ezimweni okusongela ukuphila kwesiguli.

Lapho ushevu organic phosphorus Izingxube nokushintsha kokudla nokufakwa biperiden Kwenziwa ngamunye kuncike kobukhulu izilonda. Qala kusuka umthamo 5 mg esimweni ekuphathweni emthanjeni, abaphathi okuphindaphindiwe uqhubeke kuze kube nezimpawu zinyamalale ubuthi.

ukweqisa izidakamizwa

Overdose ububonisa imiphumela evelele anticholinergic okubangelwa imithi "Akineton".

Yokusetshenziswa, odokotela yangempela banake yokuthi ukwelapha lesi posimptomnaya isimo (nokugcinwa senhliziyo izinhlelo zokuphefumula, ukwelashwa oksijini, komzimba nokulungisa, urinary ipayipi isethi, uma kunesidingo). Idinga ukwethulwa a inhibitor cholinesterase (physostigmine ngokuyinhloko) .

ukuxhumana

"Akineton" ngenkathi ukusetshenziswa m-holinoblokatorami, izidakamizwa nokuba antihistamine kanye isinyathelo antiepileptic ithuthukisa inkulumo yokugcina. Nokho, isicelo ngesikhathi esisodwa metoclopramide kunciphisa umphumela zayo zokwelapha. Kube esichazayo izidakamizwa ukungavumelani ne-ethanol. Ukuqokwa quinidine inyuka ezikhathini ingozi yokuba izimpawu dyskinesia. umphumela M-cholinergic buyaqina lapho ekusebenziseni levodopa.

Ukugcinwa Kwazo Ngenjongo ukudayiswa

Ukuze uthenge le izidakamizwa kudinga kadokotela ukunikeza wemithi. Ukuze sigcine "Akinetona" kumele zithobele lokushisa, t. E. Ambient lokushisa kumele singeqi degrees 25 (Celsius isikali). Sidinga kude nezingane ukuba isikhungo "Akineton".

Manual onika umuntu ukuphila eshalofini zomuthi - iminyaka emihlanu.

Izixwayiso

Ukuqokwa biperiden ngenkathi bekhulelwe nangenkathi bencelisa (lactation) kudinga izinkomba esiqinile.

Biperiden Ungathola ingane ngokusebenzisa ubisi lwebele, okubangela ukuhluleka yesikhashana ibele kuze ukuqedwa lesi sidakamizwa "Akineton".

Incazelo yomkhiqizo uveza ukuthi sinquma Yokuqashwa biperiden phakathi nokukhulelwa kanye lactation acabangele engaba ingozi usana, i-fetus.

Asebekhulile iba ingozi ngoba impatho nale izidakamizwa. Ngakho-ke ukhethe "Akineton" leli qembu labantu ngokuqapha okukhulu.

Kickaha yokungabikho kobufakazi ukusetshenziswa ukuphepha ebuntwaneni, isizathu ukuthi asisebenzi izidakamizwa izingane "Akineton".

Incazelo ukulungiselela (imfundo manual) icacisa yokuthi ngokuqapha iyadingeka uma usebenzisa lokhu izidakamizwa in iziguli isithuthwane noma fibrillation.

Ngekusetjentiswa isikhathi eside zingase ukuthuthukisa sezidakamizwa.

Ubungozi lokuhoxa syndrome kuhilela ukumisa kancane kancane yokwelapha "Akinetonom".

ukusebenzisa uphuzo utshwala equkethe kufanele kugwenywe phakathi ukwelashwa.

Ukwelashwa nale izidakamizwa kudinga ekuzileni ukushayela izimoto kanye nemidlalo nemisebenzi ezidinga emakamu eliphezulu futhi ngokushesha lengqondo ukusabela, ngoba ihambisana ezingase zivele ngenxa ingozi isiyezi.

"Akineton". Yokusetshenziswa. analogs

Synonyms sokulungiselela kukhona izinto ezilandelayo: "Biperiden" "Mendileks" "hydrochloride biperiden".

"Akineton". Izibuyekezo

Umuthi iphumelela kakhulu ekwelapheni Parkinsonism ukuzamazama esitho inqanyulwa emva emfushane umkhawulo wesikhathi. Ethi kahle ibekezelelwe izidakamizwa "Akineton".

Impendulo ku-izinkundla ukhuluma mayelana nokwenzeka ukubonakaliswa ezinye imiphumela emibi ngenkathi ngokuthatha izidakamizwa.

Inani "Akinetona". lapho ukuthenga

Izindleko yesixazululo kungenzeka bangu-800 ruble.

Inani ekwakhiweni ngomlomo "Akinetona" - ruble 560-580.