Tablet "Silhouette": ukubuyekezwa odokotela, imiyalelo yokusetshenziswa. Amaphilisi okulawula ukuzala "Silhouette": ukubuyekezwa nge-endometriosis

Kule nkathi yethu, owesifazane unelungelo ukuhlela sokukhulelwa kwabo. Lokhu kungenziwa ngezindlela eziningi, kodwa omunye elula kakhulu futhi ephumelelayo - kuyinto zokuvimbela inzalo hormone.

izindlela Okokuqala yokuvimbela ukukhulelwa amaphilisi equkethwe ingxenye kunalokho enkulu ketshezi asebenzayo bese nakanjani kuholela ekutheni side imiphumela efana isisindo somzimba. zokuvimbela inzalo Modern hormone zihlukile kuleyo umthamo isithako esisebenzayo kuzo azinakwa. Kuvumela owesifazane ukugcina isisindo sakho ngaphansi kolawulo. Ngaphezu kwalokho, izinto zokuvimbela inzalo temlomo isizukulwane esisha bayakwazi ukwenza ngcono isimo isikhumba nezinwele, ukuqeda ukuvuvukala encane esesikhathini.

"Silhouette" Omunye amathuluzi yesimanje ukuze ngokuvikela ukukhulelwa okungadingekile kuyinto tablet. Amazwana ngalokhu imoto ungahlangana ezihlukahlukene. Ake sihlaziye ngokuningiliziwe lokho izici zalesi izidakamizwa.

Uma sicabangela umkhiqizo ezithaka imithi ngokombono emitholampilo bohlanga ke umuthi monophasic nge izakhiwo antiandrogenic, senzelwe abaphathi ngomlomo.

Ngayiphi ifomu ikhiqizwa?

izindlela zokuvimbela inzalo amaphilisi kukhona "Silhouette", okuyinto libuyekeza ikakhulukazi ngendlela enhle, amhlophe, round biconvex ukuma libhalwe "G53" ngakolunye uhlangothi. I intshabusuku iqukethe 21 nama-PC.

isidakamizwa

Omunye ithebhulethi ekwakhiweni iqukethe izithako ezisebenzayo main ezilandelayo:

• Ethinylestradiol e isamba 30 mg.
• Dienogest e lokuhlushwa 2 mg.

Futhi esikhathini nokuthi asizayo izithako: monohydrate lactose, isitashi ummbila, hypromellose, talc, i-potassium polyarylate kanye magnesium stearate.

Njengoba imisebenzi izidakamizwa?

I-Tablet "Silhouette", ukubuyekezwa zazo zibonisa sokufaneleka yayo ethi ufuna amantombazane asemancane, iyithuluzi elihlangene ne umphumela liphinyiselwe anti-androgenic. Ngo oyiyo kukhona amahomoni ethinylestradiol, okuyinto inomsebenzi we-estrogen bese dienogest, okuyinto progestogen. Lokhu umuthi has imisebenzi elandelayo emzimbeni womuntu wesifazane:

• It kuvimbela ukukhiqizwa kwamaqanda.
• Kwandisa viscosity we isikhwehlela wesibeletho.
• Ishintsha peristalsis kuzo ngemibhobho fallopian.
• Ishintsha isakhiwo se-endometrium.

Amabili Isakhi esiyinhloko esebenzayo lihambisana nomunye nethonya incishiswe androgens e-plasma.

Abesifazane abaningi ithebhulethi "Silhouette" (kobufakazi - ubufakazi) kusiza ukuba sibhekane ngokuphumelelayo okuncane inkinga induna, kanye seborrhea.

I-hormone dienogest izidakamizwa kuyinto esuselwe norethisterone. Kuyinto izikhathi engaphansi kuka-10 affinitiven ukuba yokwamukela progesterone kuka nezinye izinto zokwenziwa yaleli qembu. Izici dienogest - ukuthi alinaso androgenic, glucocorticoid futhi izakhiwo mineralocorticoid. Ukusetshenziswa ezimele le hormone ngezilinganiso 1 mg ngelanga kuholela wehlise ukukhiqizwa kwamaqanda.

Yini pharmacokinetics umuthi?

Njengoba kushiwo ngaphambili, ithebhulethi "Silhouette", ukubuyekezwa zazo ukhulume kwayo, has izinto ezimbili esebenzayo, okuyinto iziphatha emzimbeni womuntu ngezindlela ezahlukene.

Ethinylestradiol lapho ededelwa emathunjini amancane ugxile ngokushesha futhi ifinyelela lokuhlushwa walo omkhulu ngemuva kwamahora 1.5-4 kuphela. A ingxenyenamba abalulekile we ketshezi is akheka yi isibindi. Inkomba bioavailability eliphelele ethinyl estradiol kuyinto 44%. Lokhu kwaziswa kwaba 98% sibopha ukuthi albumin wegazi kwandisa lokuhlushwa globulin. Lokhu amaprotheni sibopha hormone ocansini. Engxenyeni zomuthi engayitholi Yiqiniso yesibili waphawula sifinyelele yakhoibrium okuqukethwe esiphezulu ethinyl estradiol.

Le into is akheka ku mucosa emathunjini bese isibindi ngu hydroxylation elimnandi nge inani elikhulu nemikhiqizo. imikhiqizo lokukhipha ukuwohloka yi isibindi kanye nezinso ngezigaba ezimbili:

• Umsuka 1 ihora.
• Isikhathi yesibili amahora 10-20.

Ethinylestradiol angashintshiwe nomzimba womuntu akuyona ngokukhishwa.

Dienogest futhi angena egazini ogangeni emathunjini bese ifinyelela lokuhlushwa walo omkhulu ngemuva kwamahora 2.5 kuphela ngemva edonsa nokukhandela imbeleko. ngokuhlanganyela wakhe nge bioavailability ethinylestradiol kuyinto 96%. Dienogest sibopha kuphela-albumin. zilingana yakhe maximal plasma lokuhlushwa kutfolakala ngekhatsi 4 izinsuku ukwelashwa.

Dienogest kuthiwa akheka izindlela hydroxylation futhi glucuronidation. Imikhiqizo yalesi kwamazinyo ngasebenzi futhi babaleke ngokushesha kulowo oketshezini olungenambala lwegazi.

Dienogest e okuncane ifomu ingashintshiwe excreted ngu nezinso. Nge ukusetshenziswa 0.1 mg / kg lomcebo mayelana 86% excreted ezinsukwini zokuqala 6 emathunjini kanye izinso, futhi ngosuku lokuqala umchamo isuswe mayelana 42% of the material.

Yini umthamo izidakamizwa kufanele athathwe?

izindlela zokuvimbela inzalo amaphilisi kukhona "Silhouette", ukubuyekezwa zazo akhayo, kufanele kuthathwe nsuku zonke ngesikhathi esithile. Uma kudingekile, ungakwazi uphuze esincane amanzi. Qiniseka ukuthi bagcine oda eziboniswe iphakethe.

Umhlahlandlela Zibalulekile kahle ukwamukela "Silhouette" (amaphilisi) - umyalelo. Izibuyekezo lokhu umuthi ukukhuluma ukutholakala indlela isethulo ukusetshenziswa yayo isifinyezo enamathiselwe obakhathalelayo. Iqukethe isikimu owawuthi ukulungiselela esinye isibhebhe sibonisa kuthathwe kanye ngosuku phakathi nenkathi yezinsuku ezingama-21. Okulandelayo ikhefu wezinsuku eziyisikhombisa ngaphambi kokuba uqale iphakethe entsha imithi. Phakathi nale nkathi, kukhona "ukuhoxiswa ukopha". Ngokuvamile lesi simanga iqala emva kwezinsuku 2-3 emva ithebhulethi zokugcina futhi waphothulwa ngezinsuku 4-5. Kuleli qophelo, kubalulekile ukuba ngamukele izibhebhe ka amabhamuza entsha.

Kukhona imininingwane ehilelekile ezibalulekile ephawula reception kokuqala amaphilisi "Silhouette". Yokusetshenziswa (impendulo odokotela nokuvuma) kubonisa isidingo mayelana nokukhandela imbeleko ngomlomo ngosuku 1st zokuya esikhathini. Lesi simo kuyadingeka kulabo akakaze isicelo inzalo hormone noma akazange yokusebenzisa le mithi inyanga eyodwa noma ngaphezulu.

Izici zokuvimbela inzalo ngomlomo

Uma kwakuba khona ushintsho kusuka kuhlanganiswe umuthi ngomlomo isicelo kwi "Silhouette" amaphilisi, yokusetshenziswa, odokotela yangempela Sisikisela wokuqala ukuthatha izidakamizwa kwenziwe esikhathini evamile ngosuku olulandelayo ngemva ithebhulethi zokugcina iye yasetshenziswa.

Uma udinga ukuya nge izinto zokuvimbela inzalo equkethe progesterone kuphela, kungenziwa kunoma iyiphi usuku olukahle. Uma isiguli kususa nolwelwesi, ezifana Navy, ngosuku olufanayo angakwazi ukuthatha "Silhouette". Uma owesifazane enza izinto zokuvimbela inzalo ngesimo imijovo sabe sesinquma ukuhamba phezu umuthi echazwe tableted, umthamo lokuqala kufanele kuthathe ngesikhathi lapho uhlela umjovo okumelwe kwenziwe.

Uma owesifazane eke waba kwesisu e senyanga 1st yokukhulelwa, futhi yena uhlela ukuthatha i-hormone amaphilisi "Silhouette", imiyalelo, ukubuyekezwa, izincomo lodokotela akhombise ukuthi kungenzeka ukusetshenziswa ngokushesha komkhiqizo ezithaka imithi. Uma isisu okwenzeka ngemva kwezinsuku ezimbalwa, lapho-ke kudingeka ukuba athathe ikhefu 21-28 usuku kanye nokusebenzisa amakhondomu phakathi nalesi sikhathi.

Kuthiwani uma iphilisi is ezingabanjwanga?

Endabeni uma ukubambezeleka reception ingeqi amahora 12, amandla inzalo hhayi ziyancipha. Umuntu wesifazane kufanele usebenzise ithebhulethi ngokushesha ngangokunokwenzeka, futhi kufanele esiphuza ngesikhathi evamile.

Kuleso simo, uma salokhu kwaba isikhathi amahora angaphezu kuka-12, kufanele usebenze ngokuvumelana nemithetho eyisisekelo yokwemukela inzalo:

• Awukwazi ukuphazamisa ukusetshenziswa kwezimali isikhathi esingaphezu kwesonto.
• Ukuze izidakamizwa emsebenzini, udinga okungenani izinsuku 7 reception ungaphazanyiswa.

Ngakho-ke, odokotela basikisela okulandelayo:

• Uma udlulisa reception esenzeka ngesonto lokuqala usebenzisa izidakamizwa, lona wesifazane kumelwe athathe iphilisi ngokushesha, futhi kufanele kudliwe ngesikhathi evamile. Ngesikhathi esifanayo udinga ukusebenzisa ikhondomu kule sonto elizayo.
• Uma kwenzeka ngosuku lwesibili izinsuku eziyisikhombisa, bese ithebhulethi esithathwayo ngokushesha futhi indlela isithiyo inzalo akudingekile.
• On the ngesonto lesithathu, kwehluleka kwenzeka e yokwamukela ukulungiselela Kudingeka algorithm ezichazwe esigabeni sokuqala. Ngemva kwalokho kufanele uqale ibhamuza olandelayo ngaphandle kokuphazamiseka. Kulokhu, "ukuhoxiswa ukopha" Kodwa-ke, yini, kungaba lula.

Ungase futhi uyephuza ukuqala ukopha ngosizo "Silhouette" amaphilisi-mbumbulu. Uphenyo odokotela ngalokhu zokukhwabanisa Kunconywa kulesi simo ukuze uqhubeke ukuthatha izidakamizwa, ekushintsheni isiphetho ukuze ibhamuza entsha. Phakathi ukusetshenziswa, wesibili iphakethe imithi owesifazane kungenziwa kuphawulwe zokubona lesizalo khulula.

Kuke kwenzeke yini kube ukweqisa izidakamizwa?

I ubuthi ngemithamo ephakeme hormone ezakha "UMFANEKISO okhangayo" amaphilisi uphansi. Endabeni ka ukweqisa izidakamizwa waphawula isicanucanu, ukuhlanza, khulula lwesitho sangasese sowesifazane noma ukopha. Asikho isidingo yokwelapha.

Kungenzeka yini ukuba umuntu "Silhouette" ezithathwe nge lezinye izidakamizwa ke?

Kwaphawulwa ukuthi co-ekuphathweni nezidakamizwa isebenze microsomal enzyme, kungaholela ukopha ukufohla imvelo nokunciphisa umthelela umuthi. Le mithi kukhona "Phenobarbital", "Rafampitsin", "Hydantoin", "primidone", "carbamazepine", "Rifabutin", "EFV", "i-nevirapine", "Oksikarbazepin", "felbamate," "Griseofulvin" "Topiramate "" Ritonavir "futhi fitodrug Hypericum perforatum.

Ukuthatha nemithi ethile elwa namagciwane, ezifana tetracycline noma ampicillin, kanye "Silhouette" futhi kunciphisa ukusebenza kwawo ngempumelelo. Endabeni inhlanganisela nanoma yimiphi ukwakhiwa ngenhla isidingo olwengeziwe lokuvikela isithiyo esikhathini esiyizinsuku ezingu-7, nge "rifamycins" - ezinsukwini ezingu-28.

Yiziphi imiphumela emibi izidakamizwa?

Kuyinto engenakwenzeka ukunquma kukhethwa izindlela zokuvimbela inzalo. Khumbula ukuthi "Silhouette" - hormone okuthiwa i amaphilisi. Odokotela mayelana imiphumela emibi umuthi zisikisela ukuthi Akhuthaza ukwakheka kwe-amahlule e ekhipha igazi enhliziyweni nelifakayo. Lesi simo esiyingqayizivele sibangelwa kungenziwa ukucasulwa ukubhema, umfutho wegazi ophakeme, ukungakhuli igazi ekunqandeni evamile, emithanjeni varicose, ukukhuluphala thrombosis futhi thrombophlebitis.

Phakathi ohlangothini ezivamile imiphumela laphawula:

• Migraine.
• Ukucanuzela kwenhliziyo nokuhlanza.
• Kwesisindo;
• Soreness kule ndlala mammary futhi ukwanda kwabo;
• Ukungazinzi Ngokomzwelo;
• Ubuhlungu emuva;
• Amajaqamba imisipha ithole.

Abesifazane abaningi bayenqaba ukusebenzisa izinto zokuvimbela inzalo ngomlomo ngenxa yokwesaba ukuthi ube ngcono. Ingabe lezi ukwesaba esizwakalayo sokuthukuthela? Omunye wemithombo ebaluleke kakhulu ulwazi ngokuthi kungenzeka ukuze isisindo sakhe sithi ekuthatheni "Silhouette" ithebhulethi - ukubuyekezwa. Kwesisindo kuphawulwe Ingxenye yakhe kunalokho elikhulu labesifazane. Yingakho umphumela kokuthatha lesi umuthi yikho okuvame kakhulu.

Ngezinye imvamisa ukubonakaliswa ezahlukene ezigulini elandelayo imiphumela emibi ekuthatheni "Silhouette" ukulungiselela:

• Hypotension noma umfutho wegazi ophakeme.
• Thrombophlebitis futhi varicose emithanjeni.
• Migraine futhi inzululwane.
• Ukucasuka.
• Ubuhlungu besisu.
• Izifo ezithathelwanayo kohlelo urinary.
• Induna, amawala, dermatitis kanye akneiformny nomzimba, Alopecia, erythema, pruritus, chloasma.
• isifiso yanda noma kwesisindo.
• candidiasis kwesitho sangasese, lezinkinobho.
• Ukukhathala, ukucobeka edema.
• ukopha Acyclic futhi kubuhlungu, Hyperplasia endometrial, endometritis, salpingitis.

Kwakukhona nezinye, kodwa kancane njalo side effects ekuthatheni iphilisi "Silhouette". Yokusetshenziswa, kobufakazi nesineke futhi odokotela ubheke imiphumela elandelayo engathandeki:

• Isifo sokulahlekelwa yigazi.
• Izifo uhlelo senhliziyo nemithambo yegazi.
• Ukuphulwa kwegazi cerebral palsy.
• ukuphazamiseka visual.
• Sinusitis, ukucinana kwemigudu yokuphefumula, isifuba somoya.
• iziyaluyalu wokugaya ukudla.
• Hypertrichosis, eczema, seborrhea, angioedema.
• Kwehliswe iphango.
• Yokungezwani komzimba.
• Kwabiwa Liwubala, ushintsho futhi isimila mammary, leiomyoma.
• Ukuqwasha, ukucindezeleka.
• Arthralgia, myalgia.

Kukhona ezingavamile kakhulu imithi emizimbeni yabo ukuthi kungenzeka ngenxa "UMFANEKISO okhangayo" zomuthi. Tablets Izibuyekezo uqinisekise lesi, nge imvamisa engaphansi kuka-1 icala aphume 10,000 kungase kumkhathaze ukuhlaselwa isifo senhliziyo, amatshe atholakala enyongweni, cholecystitis nomdlavuza endometrial.

Izimo

Umuthi 'Silhouette "ngeke kuthathwe ababephethwe izifo ezithile. Ziyakwazi:

• Tifo letibangwa emithanjeni yegazi, propensity kuya thrombosis.
• Pancreatitis.
• Porphyria.
• Jaundice noma hyperbilirubinemia, syndromes azalwa nako.
• Ukubhema emva kweminyaka 35.
• isifo sesibindi Sinzima, ezihlanganisa nomdlavuza.
• Kwesitho sangasese ukopha genesis yayingaziwa nhlobo.
• Migraine.
• Isifo sokuwa.
• Isikela cell anemia.
• Nokukhulelwa kanye lactation.
• ukungabekezelelani lactase.
• I yokungezwani komzimba emuthini.

Uma noma iyiphi yalezi izifo izinto zokuvimbela inzalo ngomlomo "Silhouette" is contraindicated.

ukwelashwa i-endometriosis

Endometriosis - isimo ukuthi akuve kuvamile ukuba abesifazane. It iphathwa ngu izindlela olandelanayo noma kuhlinzwa, kuye ngezimo yokugula. "Silhouette" (amaphilisi) izilinganiso endometriosis wathola omuhle. Lesi sidakamizwa ngokuvamile iqondiswa iziguli kunalokho, njengenhlangano Analogue we umuthi "Janine." Kulokhu, gynecologists uthi nokuphepha yayo ehlobene nokusebenza okuhle.

"Silhouette" kuholela yoma okuqhubekayo endometriosis, kungakhathaliseki ukuthi zikuphi. Kunciphisa zamagama estrogen, suppresses ukukhiqizwa kwamaqanda futhi amabhlogo ekwandeni amaseli ijwabu ngaphandle komgodi lesizalo. Futhi, kuba nomphumela omuhle eqeda ukuvuvukala sokugibela "UMFANEKISO okhangayo" zomuthi. Tablets izibuyekezo endometriosis kufanele omuhle - abesifazane ukubika ukunyamalala izimpawu dysmenorrhea, polimenorei nobuhlungu ngesikhathi ocansini.

Ngaphezu kwalokho, izingxenye asebenzayo ekulungisweni "Silhouette" encishisiwe liningi igazi endometriosis. Ngenxa yalokhu izicubu uyayeka ezikhulayo. Kubuyiselwe amazinga evamile e-hemoglobin.

Kufanele futhi kuqashelwe ukuthi ukuthathwa lokhu izidakamizwa kumele ezinconywe udokotela emva ephelele Ukuhlolwa abekezele izifo kanye nezimo ezandulela kubo. Ukusetshenziswa okungagunyaziwe zokuvimbela inzalo hormone kungabangela nemiphumela eyingozi kakhulu emibi emzimbeni.