"Spironolactone": analogue, imfundo, ukusetshenziswa, incazelo izidakamizwa

"Spironolactone" - kuyinto potassium ne magniysberegayuschy isisu. Umuthi elinamandla isisu okuyinto evimbela leaching of umzimba nosawoti esibalulekile. Iphinde kwehlisa asidi umchamo. Kuyadingeka ukuba banake ezama ukushintsha ekwelapheni "spironolactone". Analogs zomuthi kungukuthi njalo ifa izakhiwo ezinjalo.

Sakhiwo Ukwakheka

Lesi sidakamizwa itholakala ifomu tablet. ingxenye esebenzayo spironolactone. Ngo iphilisi elilodwa liqukethe 25 noma 100 mg ketshezi. Futhi, yakhiwa izingxenye asizayo: amazambane isitashi, monohydrate, i-lactose, povidone, i-calcium stearate. Tablets oyindilinga phama ebhokisini amakhadibhodi yizicucu 20.

imiphumela kwemithi

Izidakamizwa "spironolactone" kuyinto omelene aldosterone. Kuyinto i-hormone adrenocortical. Aldosterone ngokuhlanganisa amaprotheni receptor distal nephron amaseli kunciphisa excretion sodium namanzi futhi kwandisa potassium leaching. "Spironolactone" ukuncintisana nalesi kwama-hormone izenzo lokwehlukile. Ukulungiswa usuke ethuthukisa excretion yamanzi kanye sodium emzimbeni, esaziwa ion potassium. Electrolyte ibhalansi akuyona siyabhubha.

Okwamanje wafunda kahle pharmacodynamics zomuthi. Lapho yokwemukela pheshana emathunjini ke amuncwa umzimba ngokushesha sesibopho ukuthobisa plasma amaprotheni. Bioavailability amaphilisi cishe 99%. Omunye badubule wezokudla ngesivinini ukumuncwa esebenzayo izidakamizwa izidakamizwa esebenzayo.

Umthelela zokwelapha, ngokuvumelana imfundo kwenzeka phakathi nezinsuku ezingu-5. Kudinga ekuqongeleleni yayo kancane kancane emzimbeni kuze lokuhlushwa ezithile ukucupha izidakamizwa. Kungenjalo, umkhuba imithi ubizwa ngokuthi umphumela ezuziwe. izidakamizwa Active lingena ngokushesha ku ubisi lwebele, futhi lisuselwa umzimba kanye indle kanye nomchamo. Yikuphi odokotela izifo ukunquma "spironolactone"?

izinkomba

Imiyalelo "spironolactone" kubika ukuthi izidakamizwa senzelwe ekwelapheni lezi zifo ezilandelayo kanye pathologies:

• syndrome Edematous okwenzeka on isizinda ephethwe yisifo senhliziyo.
• Hyperaldosteronism.
• nomfutho wegazi ophezulu Essential.
• hyperaldosteronism Secondary kubangelwa isifo sokusha.

Ukuze ekwelapheni isifo kumele kuqale ngemuva kokuxoxisana udokotela.

Izimo

Kwezinye izimo, it is hhayi Kunconywa ukuthatha izidakamizwa "spironolactone"? Izinkomba ukusetshenziswa ethulwa Izindaba ezingenhla azilona imbangela self-ukwelashwa. Lesi sidakamizwa inemiphumela eminingi engemihle kanye contraindications.

Imiyalelo Administration kwezidakamizwa wathi ukusebenzisa kwayo ngenhloso zokwelapha akunconyelwe abantu Addison sika isifo, hypercalcemia, isifo sikashukela. Ngokucophelela okukhulu kumele wasebenzisa izidakamizwa ukuze abesifazane nge ukuphazamiseka kokuya esikhathini, webele ukukhulisa.

Yokusetshenziswa

Lokhu nomuthi kufanelekile ekuphathweni ngomlomo. Umthamo kunqunywa udokotela umuntu ngamunye, ngokusekelwe ebucayini ukwephulwa yamanzi-electrolyte ibhalansi kanye namazinga kwama-hormone ngesikhathi isiguli.

Lapho edema okubangelwa Neurotic syndrome, ukwelashwa ithoma nge 100-200 mg zomuthi ngosuku. I Isikali kumele ihlukaniswe ngemithamo ezimbili noma ezintathu. Isikhathi kwelashwa cishe amasonto amathathu. Endabeni hyperaldosteronism futhi ongaphakeme potassium igazi nomuthi "spironolactone-Darnitsya" inikezwa ku-300 mg ngosuku.

Ngezinye a syndrome hydropic, elihlobene ne imvelo njalo esingamahlalakhona senhliziyo ebuthaka, kwelashwa izinsuku 5. Izibhebhe ephathwa ngendlela umthamo 100-200 mg. Ngaphezu kwalokho, iziguli kuvame anqunyiwe thiazide futhi iluphu isisu. Lapho Dynamics omuhle ka umthamo yokutakula kancane kancane sehle 25 mg ngosuku.

side effects

Yiziphi imiphumela emibi iye "spironolactone"? Analogs yalesi izidakamizwa has ukuphatheka abampofu. "Spironolactone" Ngokuphambene, libhekene ukumuncwa okusheshayo nomphumela omuhle zokwelapha. Ngezikhathi ezithile kutholakala ukuthi uphethwe yini imiphumela engemihle, okuyinto efomini enwetshiwe kuchaziwe ngezansi.

1. Umzimba: ushintsho acid-base balance, hyperuricemia.
2. CNS: anda ukozela, ukuphathwa ikhanda, ukucobeka.
3. Ihlelo lokukhambisa iingazi: megaloblastoz, thrombocytopenia.
4. GI: ubuhlungu besisu, izilonda, amajaqamba emathunjini, uhudo.
5. uhlelo endocrine: ukungasebenzi Erectile, webele carcinoma ivoti brutalization.
6. komzimba: ukulunywa, ukuqubuka, isifuba.

Uma uhlangabezana izimpawu kufanele kudokotela njengoba kuchaziwe ngenhla. Njengomthetho, onguchwepheshe enquma esikhundleni "spironolactone". Analogs yalesi izidakamizwa futhi imiphumela emibi, kodwa waveza ngezinga elincane.

Izixwayiso

Phakathi ukwelashwa "spironolactone":

• Kunconywa ukuba ugweme ukudla ukudla abacebile potassium.
• Nhlobo kukhona zonke izinhlobo zotshwala.
• Kufanele uyeke isicelo ngesikhathi esisodwa ukuthaka imithi lichaza ekwakheni okuyinto potassium likhona.

Uma ukwelashwa ama-NSAID okwengeziwe kunikezelwe, kubalulekile ukuqapha ukusebenza nezinso izinkomba electrolyte egazini.

Esigabeni sokuqala ukwelashwa kutuswa uyeke ukushayela izimoto ukusebenza izindlela ezinkulu ezidinga izinga lengqondo ukusabela nokunakwa. Isikhathi imingcele enjalo isethwe ngamunye, esekelwe tolerability, "Spironolactone".

Intengo zomuthi kanye nemibandela isitoreji

Izindleko zomuthi kuhluka umthamo yayo. Ngoba kufike umuntu mumbe isembozo amaphilisi kuyodingeka bakhokhe engama-ruble angu-30 kuya ku-50. Izindleko Imininingwane kuphinda kuncike wekhasi, okuyinto lihlelwe ekhemisi amaketanga eziningi.

Ngokusho imiyalelo, ukulungiswa zizogcinwa ezingeni lokushisa hhayi degrees ephakeme kunaleyo 20, nalapho kufinyelela zezingane izandla endaweni. Shelf ukuphila iminyaka 3.

izidakamizwa analogue

Yimiphi imithi kungenziwa indawo "spironolactone"? Analogs we nomuthi ezimweni eziningi ube Ukwakheka ezifanayo futhi lokuhlushwa Isakhi esiyinhloko. Lezi zihlanganisa izidakamizwa ezilandelayo: "Veroshpilakton", "aldactone", "Veroshpiron". Lesi sakamuva uvame ukusetshenziswa esikhundleni ukubika kulesi sihloko izidakamizwa.

Phakathi kwezidakamizwa ejwayelekile owaziwa zihlanganisa lezi ezilandelayo: "Dekriz", "Inspra", "Espirit", "Epletor". Mshini wezenzo afane "spironolactone". Izinkomba kanye bioavailability okufanayo. Lezi isisu zisho ephumelelayo for ukuzinza wegazi, ukuhoxiswa uketshezi okweqile kusukela umzimba. Kodwa, ejwayelekile cishe ngeke ukuvikela leaching of potassium ne-magnesium, odokotela abaningi bakhetha ukusebenzisa izidakamizwa yasekuqaleni.

Kufinyeta

Manje ngoba sewuyazi ukuthi ngaphansi kwaziphi pathologies neziyaluyalu ukhombe "spironolactone". Intengo zomuthi nokutholakala kwayo abantu abaningi. - nenqubo ezimbili eziyinhloko ngawo iziguli eziningi uthanda ke lokhu nomuthi. Izibuyekezo eziningi ezinhle futhi afakazele kuyaphumelela "spironolactone".