Sikashukela phosphate: izimbangela, izimpawu, uphethwe, ukuphathwa

Kuleli zwe lanamuhla cishe zonke abazali bayasazi lesi sifo, njengoba yamathambo. On isidingo nokuvimbela lesi sifo kuvimbela udokotela ingane ngayinye ezinyangeni zokuqala zokuphila komntwana. Yamathambo libhekisela izifo atholwe asathuthuka ngenxa cholecalciferol enganele - into eyaziwa ngokuthi kavithamini D.

Nokho, kwezinye izimo izingane kakhulu unezimpawu isifo, naphezu ukunamathela izinyathelo. Esimweni esinjalo kufanele esolwa isifo ezinjengesifo sikashukela phosphate. Ngokungafani yamathambo, lesi sifo iphathelene pathologies zofuzo. Ngakho-ke, ezifweni ezimbi kakhulu futhi zidinga ukwelashwa eziyinkimbinkimbi eside.

Uyini sikashukela phosphate?

Ngakho iqembu nezifo ngenxa yezakhi zofuzo elihlobene ne kahle amaminerali umzimba. Kwesinye zokugula ngokuthi vitamin D ukumelana yamathambo. uhlobo evelele sikashukela phosphate kwenzeka cishe ngo-1 ingane ngaphandle 20,000 izinsana. lesi sifo kwase kuqala ezichazwe 1937. Kamuva kwacaca ukuthi ukuthi kukhona nezinye izinhlobo kwezinso zofuzo. Ngokuvamile, isifo sikashukela phosphate itholwa ekuqaleni kuka ebuntwaneni. It ikhanga abazali Gait nasiphazamiso ukuhlanekezela ithambo.

Ezinye izinhlobo isifo ahambisana namanye iziyaluyalu umzimba. Ngezinye izikhathi lesi sifo asymptomatic futhi kungaba kuphela kungaziwa ukuthi kwakuyisifo sini yokuhlolwa yase-laboratory. Ukugula libhekwa nge yamathambo aluthola, hypoparathyroidism nezinye kwezinso endocrine. Ukwelashwa kufanele luhlanganiswe zisencane.

Izimbangela isifo

Imbangela eyinhloko sikashukela phosphate kungukuchotshozwa isakhiwo zofuzo. Ukuguqula izakhi zofuzo zizuzwe. Abathwali isakhi sofuzo okungavamile kungaba kwabesifazane nabesilisa. I kuguquka kwenzeka e X-chromosome exhumene, okuyinto evelele. Ezimweni ezingavamile, isifo sikashukela phosphate angayizuza. Yena ikhulela izimila mesenchymal izicubu, kwakheka utero. Kulesi zokugula ibizwa ngokuthi "yamathambo oncogenic."

Izifo kubhekisela esenzakalweni esiyisimangaliso tubulopathy iqembu - iziyaluyalu nezinso. Ngenxa namaminerali encishisiwe reabsorption ku tubule proximal, ukwakha ukuntula phosphorus emzimbeni. Ngaphezu kwalokho, siyabhubha wamathumbu ukuncela ikhono. Ngenxa yalokho, zikhona izinguquko ukwakheka amaminerali ijwabu ithambo. Kuvamise ukuthi kuphula umthetho we osteoblast umsebenzi. Abesilisa ukudlula isakhi sofuzo pathologically ezishintshwe amadodakazi wodwa, kanye nabesifazane - izingane zabo bobubili ubulili. Njengoba umthetho, kakhulu lesi sifo abafana kuka emantombazaneni.

Ukwahlukanisa sikashukela phosphate ezinganeni

Kukhona izinhlobo eziningana isifo, zehlukene zindlela zofuzo futhi emtholampilo. Ngokuvamile kutholakala ukuthi uphethwe yini X-exhumene yamathambo hypophosphatemic, esesikhundleni iphethini evelele ifa. Nokho, zikhona nezinye izinhlobo zokugula. Ukwahlukaniswa kuhlanganisa ifomu elilandelayo lesi sifo:

1. X-exhumene uhlobo evelele phosphate sikashukela. It libhekene izinguquko PHEX isakhi sofuzo, okuyinto buqonda le endopeptidase. Lokhu enzyme unesibopho ukuthuthwa namaminerali ehlukahlukene ngale kwenso neziteshi emathunjini ion. Ngoba yilesi sakhi kuguquka inqubo kubambezela, futhi isishiya ukwahluleka ion phosphate emzimbeni.
2. X-exhumene esikhubazayo. Libhekene CLCN5 ngokuguqula izakhi isakhi ukuthi buqonda iprotheni athweswe cala ngokusebenza iziteshi chlorine ion. Ngenxa yalokho yokuphambana iphazamiseke ezokuthutha izinto ngokusebenzisa ulwelwesi we tubules kwezinso. Abathwali lolu hlobo zokugula kungaba kwabesifazane nabesilisa. Nokho, lesi sifo kwenzeka kuphela abafana.
3. Autosomal iphethini evelele sikashukela phosphate. Lihlobene nokubhekana ubuso a kwezakhi chromosome 12. Ngenxa osteoblasts isici sokugembula kuyinto amaprotheni angawodwa okuyinto ikhuthaza sithuthukiswe phosphate ukususwa emzimbeni. I zokugula libhekene kuqhathaniswa oluncane, njengoba kuqhathaniswa ifomu X-ezixhunyiwe.
4. Autosomal esikhubazayo. Ezingavamile. Libhekene DMP1 isakhi sofuzo esinephutha itholakala chromosome 4. It buqonda iprotheni unesibopho ukuthuthukiswa amathambo dentin.
5. Autosomal esikhubazayo, ephelezelwa ukukhululwa kwe-calcium umchamo. Uphakanyiswa yokuphambana isakhi sofuzo esisogwini chromosome 9 futhi ophathwa iziteshi-sodium engaphansi kwezinso.

Ngaphezu kwalezi izinhlobo sikashukela phosphate, kukhona ezinye izinhlobo zokugula. Ezinye izinhlobo zesifo ezingazange wafunda kuze kube manje.

Umehluko phakathi yamathambo ne phosphate sikashukela

Yamathambo nesikashukela phosphate ezinganeni - lokhu akulona ngempela into efanayo, nakuba isithombe emitholampilo ye isifo kucishe. Umehluko phakathi kwalezi pathologies e etiology futhi indlela yentuthuko. yamathambo Ordinary - litholakala isifo ezihambisana ngenxa yokuntula cholecalciferol. Le into ikhiqizwa isikhumba ngaphansi kwethonya kwelanga. umthamo Yokucwaninga vitamin D yenziwa ukuthatha nsukuzonke ukuze zonke izingane kusukela enyangeni 1 kuya eminyakeni emi-3, ngaphandle ehlobo. Ngenxa ukwehluleka cholecalciferol siyabhubha calcium ukumuncwa inqubo. Ngenxa yalokho asathuthuka ithambo ukusonteka.

Ngokungafani sikashukela phosphate ke ukuthi libhekisela yesifo azalwa naso. Uma lokhu zokugula siyabhubha ukumuncwa amaminerali izinso, ikakhulukazi - le-phosphate. Kwezinye izimo, kukhona calcium ukuntula. Ngenxa yokwephula sokuqanjwa amaminerali ithambo izicubu pathologies like izimpawu. Umehluko phakathi kwabo kungenziwa esisungulwe kuphela ngemva uphethwe laboratory.

yamathambo Hypophosphatemic ezinsaneni: izimpawu

Izimpawu zesifo ngokuvamile kutholakala ukuthi uphethwe yini phakathi nonyaka wokuphila wesibili. Ezimweni ezingavamile, kukhona yamathambo hypophosphatemic in izinsana. Izimpawu ezingaba ihlonzwe isakhasa - kwemisipha hypotonia nezitho zomzimba kokunciphisa. The main ukubonakaliswa emitholampilo yilezi:

1. Deformation we emalungeni umlenze.
2. O emise ugobile wemikhawulo aphansi.
3. Ukukhula retardation ezinganeni - iba lubonakale ngemva konyaka o-1.
4. Ukuba ugqinsi esihlakaleni futhi ubambo uqwanga - "namasongo rachitic and ubuhlalu."
5. Ubuhlungu amathambo ukhalo nomgogodla.
6. Umonakalo ka-izinyo koqweqwe lwawo.

Ngokuvamile isikhalazo eyinhloko abazali ukuthi imilenze womntwana insaliwe. Nge ukuqhubeka kwesifo kukhona ukuthambisa amathambo - osteomalacia.

Ukuxilongwa phosphate sikashukela kanye yamathambo

Ukuthola kwezinso, benza ucwaningo sokuqanjwa kwamakhemikhali kwegazi. Kuyaqapheleka hypophosphatemia. ezingeni-calcium ezimweni eziningi ezivamile, ngezinye izikhathi - kwehle. Ngesikhathi ukuphakama yamathambo kukhona nokwanda of phosphatase ane-alikhali. Lapho X-ray abonisa ukuthi ukukhumuzeka kwamathambo kwenzeka futhi bone ukukhula zone ukuhlukumeza. Esikhathini umchamo wabonisa semali zikasawoti. Ngezinye izikhathi kukhona calcium urinary.

Ukwelashwa yamathambo ne phosphate sikashukela

Ukuze ekwelapheni isifo sikashukela phosphate esetshenziswa ngemithamo enkulu cholecalciferol. Kwezinye izimo, kuboniswa calcium supplements. Qinisekisa ukuthi usebenzisa imithi aqukethe phosphorus. Ukuze uthuthukise isimo ebekiwe amavithamini namaminerali Izithako. Lezi zinto zihlanganisa "Vitrum" izidakamizwa "Duovit", "Izinhlamvu Zamagama" nokunye. D.

Lapho curvatures uzwakalise lamathambo kuboniswe Physiotherapy, elashwe ngokomzimba futhi ukuhlinzwa. Kufanele uthintane udokotela wezinyawo.

Izinyathelo nesibikezelo

Ukuze zokuvimbela izinyathelo zihlanganisa ukuhlolwa wezingane futhi udokotela ohlinzayo, ukuhamba emoyeni opholile, ukuqokwa vitamin D kusukela ngenyanga yokuqala yokuphila. Uma umndeni ugula phosphate sikashukela kufanele ibhekane ukuhlolwa zofuzo utero umbungu. Ukubikezela ikakhulukazi obuhle ukwelashwa esifike ngesikhathi.