"Passazhiks": yokusetshenziswa. "Passazhiks": izinkomba ukusetshenziswa, nozakwabo yangempela

Ukuhlanza reflex ngokuthi ukuqhuma emlonyeni (ngezinye izikhathi ngokusebenzisa ekhaleni), okuqukethwe isisu noma duodenum 12. Lesi simo esiyingqayizivele sibangelwa kungenxa imisipha ukunciphisa cindezela.

Phakathi ukuhlanza ingxenye okukhipha isisu ivaliwe futhi isidumbu sakhe ekhululekile ngokuphelele. Kulesi yokungena ivulekile, nokwandisa ingaphakathi emphinjeni futhi ngomlomo.

Zonke echazwe isenzo reflex ilawulwa isikhungo ukuhlanza, okuyinto Itholakala oblongata medulla. Lesi simo yomuntu kungabonakala izifo ezithathelwanayo, ubuthi, ukunqwabelana ubuthi egazini, ngokucasuka peritoneal, izilonda, yokudleka kolwelwesi lwesisu, abesifazane abakhulelwe kanye nabanye.

ukuhlanza episodic waziwa hhayi ephelezelwa ukopha futhi esingapholi kusongela ukuphila kwesiguli. Kodwa uma le nqubo lisematheni kakhulu, kungaholela emiphumeleni engathí sina. Lezi zihlanganisa amanzi emzimbeni futhi electrolyte ukungalingani engaholela ekufeni. Yingakho kubalulekile ukuthi ubonane nodokotela uma ukuhlanza gqwa. Futhi kudingeka ukuthi imithi ekhethekile, esiza ukuvimbela reflex.

Ethandwa kakhulu antiemetics zihlanganisa imithi efana "Passazhiks". Izinkomba ukusetshenziswa zomuthi, kanye nemiyalelo izokwethulwa ngezansi.

Khipha ifomu, ukwakheka kanye nokupakisha

Ngayiphi Lelifomu liyatholakala ekhelini izidakamizwa "Passazhiks"? Izibuyekezo Umthengi wazise ukuthi ikhambi uyadayiswa yini uhlobo amaphilisi chewable. Agcwele e amabhamuza kanye ebhokisini amakhadibhodi, ngokulandelana.

Isithako asebenzayo kubhekwe izidakamizwa izenzo domperidone. Njengoba izinto asizayo esetshenzisiwe aspartame, xylitol, lactitol, magnesium stearate futhi menthol.

izici kwemithi

Yokusetshenziswa ( "Passazhiks" kumele kusetshenziswe kuphela kadokotela) ibika ukuthi i-ejenti kubhekwa isidakamizwa anti-emetic. Kuyinto omelene ephakathi Dopamine receptor.

nomuthi Active uyakwazi okwandisa ubude Kufinyeta peristaltic ku antrum isisu kanye duodenum 12. Iphinde ngesivinini bethulula okuqukethwe ipheshana wokugaya ukudla (ngesikhathi deceleration yenqubo), aqede isicanucanu nokuhlanza, kwandisa ithoni sphincter ngomphimbo (engxenyeni engezansi).

Kufanele futhi wazi ukuthi domperidone kunalokho kahle lingena kusivimbeli gazi ebuchosheni. Yingakho ukusetshenziswa kwalesi imithi azivamile ephelezelwa ukusabela extrapyramidal.

Kufanele kuphawulwe ukuthi domperidone uyakwazi zishukumisa prolactin ukukhululwa pituitary.

Action (antiemetic) yalesi izidakamizwa ngenxa ithonya inhlanganisela gastrokinetic futhi Dopamine ukuphikisana ezonini chemoreceptor inhlamvu. Kufanele ukuthi ketshezi akunamthelela onqabayo uketshezi esiswini.

izakhiwo kinetic

Yiziphi esingokwemvelo kinetic imingcele nomuthi "Passazhiks"? Yokusetshenziswa libonisa ukuthi ngemva kokuthatha ithebhulethi chewable, isithako esebenzayo it is impela ngokushesha angena egazini.

Domperidone has bioavailability ongaphakeme (cishe 15%). okuhlushwa wobuningi siyenzeka emva kwemizuzu 65.

Encishisiwe asidi esiswini kungehlisa ukumuncwa izidakamizwa.

Ngokusho kochwepheshe, domperidone zisakazwa kwezicubu ahlukahlukene. Njengoba ingqondo, lokuhlushwa izidakamizwa kuyinto encane. Ukuxhumana-plasma amaprotheni imayelana 92-93%.

Phawula futhi ukuthi lesi sidakamizwa "Passazhiks" (amaphilisi) is akheka esibindini futhi esiswini udonga. Lokukhipha ke nge emathunjini (mayelana 66%) kanye nezinso (cishe 33%).

Impilo kwesigamu umuthi amahora 7-8. Ngo ukwehluleka ezinzima kwezinso isikhawu esithize yinde.

ubufakazi

nomuthi Okubukwe engabelwe isicanucanu nokuhlanza zasezindaweni ezihlukahlukene, kuhlanganise nezifo organic futhi functional, ukwelashwa ngemisebe futhi ukutheleleka. Futhi, leli thuluzi kungenziwa eziphoqelelwe le toxemia, ukuthatha i-morphine, ukwephula Ukudla, ukusetshenziswa "Levodopa", "Apomorphine" futhi "Bromocriptine".

Yiziphi ezinye izimo, imithi ingase isetshenziselwe "Passazhiks"? Yokusetshenziswa abonisa ukuthi ngokuvamile leli imithi ezinqunyiwe ngesikhathi atony yokusetshenziswa pheshana emathunjini (kuhlanganise nasezinkingeni ezilandela ngemva kokuhlinzwa), hiccups, radiopaque futhi endoscopic izifundo ipheshana wokugaya ukudla. Futhi izidakamizwa kubhekwe edingekayo ukusheshisa peristalsis e izindlela zokuxilonga, iziyaluyalu dyspeptic ezivukayo ngenxa imisiwe bethulula esiswini esophagitis, futhi Reflux gastroesophageal.

Tablets "Passazhiks", izinkomba zazo kuxoxwa ngenhla kahle ukuzibonakalisa bazizwa ukugcwala esiswini, ukubuyisa, ukuvuvukala ukuzwa, gastralgia, isilungulela nokubhamuka.

Izimo

Uma ungawasebenzisi iphilisi "Passazhiks"? Yokusetshenziswa, ukubuyekezwa ubike Izimo elandelayo zomuthi olucutshungulwayo:

• hypersensitivity;
• Izingane ezingaphansi kweminyaka eyi-5, kanye nezinsana nesisindo 20 kg;
• prolactinoma;
• fenilketonuriyaiya.

Kufanele kuphawulwe ukuthi ithuluzi aluboniswa uma ukushukuma motor esiswini kungaba yingozi (ngoba ukopha emathunjini, perforation, noma isimiso mechanical).

Qaphela lokhu izidakamizwa ingasetshenziswa in iziguli esingamahlalakhona kwezinso noma hepatic phakathi nokukhulelwa kanye lactation.

Tablets "Passazhiks": yokusetshenziswa

amaphilisi Chewable "Passazhiks" Kunconywa ukuthi zilawule ¼ ihora ngaphambi kokudla.

Ngo ezingamahlalakhona dyspepsia abadala ukhombe mg 10 umthamo (1 tablet) kathathu ngosuku. Uma kudingekile, imithi zingafundwa sokulala.

Izingane abaneminyaka engama 5, leli thuluzi ukunikeza 2.5 mg ngayinye 10 kg esisindo kathathu ngosuku, futhi uma kudingeka, ngaphambi kokulala.

Ngo subacute noma uthi acute (nesicanucanu nokuhlanza) zaphathwa iziguli esezikhulile 20 mg kane ngosuku, futhi ngaphambi sokulala. Izingane abaneminyaka engama 5 Kunconywa ukuthatha 5 mg zomuthi ngayinye 10 kg esisindo kane ngosuku futhi ngesikhathi sokulala.

Ngo ukwehluleka kwezinso zidinga Isikali ukulungiswa kaningi bethola izikhathi ezingaphezu kuka 1-2 emini.

Umthamo esiphezulu imithi ngelanga abadala kuyinto 80 mg (ie amaphilisi 8). Ngokuphathelene nezingane, akufanele futhi iyophakama kuno-10 mg ngayinye 10 kg isisindo ingane.

side effects

ukuthi ukusabela ezingezinhle amaphilisi chewable "Passazhiks" kubangele? ochwepheshe lezivakashi bathi leli thuluzi kungabangela imiphumela emibi ngesimo:

• amajaqamba lezivakashi emathunjini;
• imiphumela extrapyramidal;
• ukwandisa prolactin lokuhlushwa plasma;
• galactorrhea, gynecomastia futhi dysmenorrhea;
• ukuqubuka, kanye urticaria.

Izimpawu ukweqisa izidakamizwa

Yiziphi izimpawu ukweqisa izidakamizwa kungabangela imithi "Passazhiks"? Manual ithi izenzakalo ezinjalo zihlanganisa ukozela, disorientation nezimpendulo extrapyramidal.

kunconywa ukuthatha namalahle ocushiwe futhi xhumana nodokotela ekwelapheni izimo ezinjalo.

Ukuxhumana nezinye izidakamizwa

Kanyekanye ukwelashwa imithi "Passazhiks" nge anticholinergics singadambisa umphumela wokuqala.

Inhlanganisela nge antacids kunciphisa bioavailability yayo.

Lapho kuhlangene futhi domperidone ukuthaka imithi ezivimbela CYP3A4 isozyme (isib macrolides ngemithi elwa namagciwane, antifungals azole iqembu, i antidepressant "Nefazodone" protease inhibitor HIV), isiguli bangezwa ukwanda lokuhlushwa izidakamizwa esebenzayo egazini.

imithi Okubukwe akuphazamisi lokuhlushwa digoxin ku-plasma bese-paracetamol. It is hhayi ngaphandle ukuthi kungase kuthinte ukumuncwa izidakamizwa (kanyekanye isicelo ngomlomo) ekukhishweni imisiwe isithako esisebenzayo noma enteric-camera.

Ibele nokukhulelwa

Izidakamizwa "Passazhiks" sinqatshiwe ukuthatha ngesikhathi sokukhulelwa.

Ngesikhathi bubuhle ubulili domperidone lokuhlushwa ubisi kane ngaphansana plasma. Kuyinto ongaziwa ukuthi lokhu kunomthelela omubi izingane. Ngakho-ke, uma kudingekile, ukusetshenziswa kwezidakamizwa ngesikhathi lactation ibele kufanele inqanyulwe.

Tablets "Passazhiks": nozakwabo kanye nezindleko

Lokho okwakudingeka ukuze kukhokhwe izimali kuyinto ruble mayelana 220-360. Uma wayefisa, lo izidakamizwa antiemetic ungayithola enye ngomunye imithi efana "Motilium", "Domstal", "Kinedril", "Avioplant", "Doprokin C", "Diskineton", "Emeset", "Motinol" nokunye. d.

Kumele wakhumbula ukuthi zonke lezi zimali angase abe nezici zabo. Ngakho-ke, ukuzisebenzisa esikhundleni "Passazhiksa" kufanele kube kuphela emva kokubonisana udokotela.

Izibuyekezo sokulungiselela

Iningi leziguli ziphathwe imithi embuzweni, ukhulume kahle yaso ephezulu. Ngokusho abasebenzisi, lokhu kusho pretty masinyane ukuqeda umuzwa nesicanucanu enqanda ukuhlanza.

Kufanele kuqashelwe ukuthi le imithi zingafundwa nezinye izimpawu. Ngokwesibonelo, ngokuvamile sisetshenziswa at isisindo esiswini noma distention besisu. Kulokhu, izibhebhe chewable ukuncoma ukuthatha eyodwa ngesikhathi kathathu ngosuku izinsuku ezinhlanu.

I nemiphumela ethile engathandeki eyinhloko ukulungiswa "Passazhiks" libhekisela side effects ezivukayo ngokumelene reception yayo, kanye khona Izimo ezahlukene.